Multidrug resistance in the standardized treatment of colon cancer harboring a rare fibrosarcoma B-type (BRAF) p.N581I mutation: a case report
In this report, we present an unusual case of that a midlife female patient who was initially diagnosed with stage IIIC colon cancer, and multiple metastases were found 25 months after radical surgery. Next-generation sequencing (NGS) revealed the BRAF p.N581I (c.1742A>T) mutation. She received chemotherapy, targeted therapy, and immunotherapy. However, the disease progressed rapidly with rare metastasis of the bone and cerebellum. This case highlights that the BRAF non-V600 mutations, such as BRAF p.N581I mutant, may lead to resistance to epidermal growth factor receptor (EGFR) inhibitors and result in a rapid course i...
Source: Frontiers in Oncology - July 14, 2023 Category: Cancer & Oncology Source Type: research
Neurotrophic tropomyosin receptor kinase (NTRK) fusion positive tumors: a historical cohort analysis
CONCLUSIONS: NTRK-fusion positive tumors are rare but detection is improved through RNA sequencing. TRKi could be considered at diagnosis for CNS NTRK-fusion positive tumors, some IFS and Other-MT.TRIAL REGISTRATION: not adapted.PMID:37434345 | DOI:10.1080/14737140.2023.2236305 (Source: Expert Review of Anticancer Therapy)
Source: Expert Review of Anticancer Therapy - July 12, 2023 Category: Cancer & Oncology Authors: Lauriane Lemelle Delphine Guillemot Anne-Laure Hermann Arnaud Gauthier Matthieu Carton Nad ège Corradini Ang élique Rome Pablo Berlanga Anne Jourdain Aude Marie Cardine Sarah Jannier H élène Boutroux Anne Sophie Defachelles Isabelle Aerts Birgit Geoer Source Type: research
Identification and validation of a nomogram predicting cancer-specific survival for elderly patients with adult fibrosarcoma: a multicenter retrospective study
ConclusionWe successfully constructed a highly accurate nomogram to predict the CSS of AFS patients at 3-, 5-, and 8 years. The nomogram can greatly help clinicians and patients with AFS. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - July 12, 2023 Category: Cancer & Oncology Source Type: research
Similar additive effects of doxorubicin in combination with photon or proton irradiation in soft tissue sarcoma models
High-precision radiotherapy with proton beams is frequently used in the management of aggressive soft tissue sarcoma (STS) and is often combined with doxorubicin (Dox), the first-line chemotherapy for STS. However, current treatment approaches continue to result in high local recurrence rates often occurring within the treatment field. This strongly indicates the need of optimized treatment protocols taking the vast heterogeneity of STS into account, thereby fostering personalized treatment approaches. Here, we used preclinical STS models to investigate the radiation response following photon (X) or proton (H) irradiation ...
Source: Frontiers in Oncology - July 12, 2023 Category: Cancer & Oncology Source Type: research
Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90α and Hsp90β
Biochem Biophys Res Commun. 2023 Jun 24;674:62-68. doi: 10.1016/j.bbrc.2023.06.076. Online ahead of print.ABSTRACTHeat shock protein 90 (Hsp90) fulfils essential housekeeping functions in the cell associated with the folding, stabilization, and turnover of various proteins. In mammals, there exist two Hsp90 isoforms, stress-inducible Hsp90α and constitutively expressed Hsp90β. In an attempt to identify cellular processes dependent on Hsp90α and Hsp90β, we generated a panel of clones of human fibrosarcoma HT1080 cells with the knocked out HSP90AA1 or HSP90AB1 genes encoding, respectively, Hsp90α and Hsp90β. The knocko...
Source: Cell Research - July 5, 2023 Category: Cytology Authors: Viktoria Petrenko Veronika Vrublevskaya Marina Bystrova Irina Masulis Elizaveta Kopylova Yuri Skarga Mariya Zhmurina Oleg Morenkov Source Type: research
Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90α and Hsp90β
Biochem Biophys Res Commun. 2023 Jun 24;674:62-68. doi: 10.1016/j.bbrc.2023.06.076. Online ahead of print.ABSTRACTHeat shock protein 90 (Hsp90) fulfils essential housekeeping functions in the cell associated with the folding, stabilization, and turnover of various proteins. In mammals, there exist two Hsp90 isoforms, stress-inducible Hsp90α and constitutively expressed Hsp90β. In an attempt to identify cellular processes dependent on Hsp90α and Hsp90β, we generated a panel of clones of human fibrosarcoma HT1080 cells with the knocked out HSP90AA1 or HSP90AB1 genes encoding, respectively, Hsp90α and Hsp90β. The knocko...
Source: Biochemical and Biophysical Research communications - July 5, 2023 Category: Biochemistry Authors: Viktoria Petrenko Veronika Vrublevskaya Marina Bystrova Irina Masulis Elizaveta Kopylova Yuri Skarga Mariya Zhmurina Oleg Morenkov Source Type: research
Adaptation of the Tumor Antigen Presentation Machinery to Ionizing Radiation
J Immunol. 2023 Jul 3:ji2100793. doi: 10.4049/jimmunol.2100793. Online ahead of print.ABSTRACTIonizing radiation (IR) can reprogram proteasome structure and function in cells and tissues. In this article, we show that IR can promote immunoproteasome synthesis with important implications for Ag processing and presentation and tumor immunity. Irradiation of a murine fibrosarcoma (FSA) induced dose-dependent de novo biosynthesis of the immunoproteasome subunits LMP7, LMP2, and Mecl-1, in concert with other changes in the Ag-presentation machinery (APM) essential for CD8+ T cell-mediated immunity, including enhanced expression...
Source: Journal of Immunology - July 3, 2023 Category: Allergy & Immunology Authors: Mi-Heon Lee Duang Ratanachan Zitian Wang Jacob Hack Lobna Adbulrahman Nicholas P Shamlin Mirna Kalayjian Jean Philippe Nesseler Ekambaram Ganapathy Christine Nguyen Josephine A Ratikan Nicolas A Cacalano David Austin Robert Damoiseaux Benjamin J DiPardo D Source Type: research
Adaptation of the Tumor Antigen Presentation Machinery to Ionizing Radiation
J Immunol. 2023 Jul 3:ji2100793. doi: 10.4049/jimmunol.2100793. Online ahead of print.ABSTRACTIonizing radiation (IR) can reprogram proteasome structure and function in cells and tissues. In this article, we show that IR can promote immunoproteasome synthesis with important implications for Ag processing and presentation and tumor immunity. Irradiation of a murine fibrosarcoma (FSA) induced dose-dependent de novo biosynthesis of the immunoproteasome subunits LMP7, LMP2, and Mecl-1, in concert with other changes in the Ag-presentation machinery (APM) essential for CD8+ T cell-mediated immunity, including enhanced expression...
Source: Journal of Immunology - July 3, 2023 Category: Allergy & Immunology Authors: Mi-Heon Lee Duang Ratanachan Zitian Wang Jacob Hack Lobna Adbulrahman Nicholas P Shamlin Mirna Kalayjian Jean Philippe Nesseler Ekambaram Ganapathy Christine Nguyen Josephine A Ratikan Nicolas A Cacalano David Austin Robert Damoiseaux Benjamin J DiPardo D Source Type: research
Adaptation of the Tumor Antigen Presentation Machinery to Ionizing Radiation
J Immunol. 2023 Jul 3:ji2100793. doi: 10.4049/jimmunol.2100793. Online ahead of print.ABSTRACTIonizing radiation (IR) can reprogram proteasome structure and function in cells and tissues. In this article, we show that IR can promote immunoproteasome synthesis with important implications for Ag processing and presentation and tumor immunity. Irradiation of a murine fibrosarcoma (FSA) induced dose-dependent de novo biosynthesis of the immunoproteasome subunits LMP7, LMP2, and Mecl-1, in concert with other changes in the Ag-presentation machinery (APM) essential for CD8+ T cell-mediated immunity, including enhanced expression...
Source: Journal of Immunology - July 3, 2023 Category: Allergy & Immunology Authors: Mi-Heon Lee Duang Ratanachan Zitian Wang Jacob Hack Lobna Adbulrahman Nicholas P Shamlin Mirna Kalayjian Jean Philippe Nesseler Ekambaram Ganapathy Christine Nguyen Josephine A Ratikan Nicolas A Cacalano David Austin Robert Damoiseaux Benjamin J DiPardo D Source Type: research
Infantile fibrosarcoma of the perineum with dorsal metastasis in a neonate: a case report original
Infantile fibrosarcoma is a rare pediatric soft tissue tumor and usually appears in children before one year of age. Distal extremities constitute the most frequently affected locations, and other tissues such... (Source: BMC Pediatrics)
Source: BMC Pediatrics - June 29, 2023 Category: Pediatrics Authors: Juan Geng, Dan Chen, Limin Wang, Xiangjiao Liu, Wenjing Chen, Hongyi Gao and Shangjie Xiao Tags: Case Report Source Type: research
Long-term Development of Fibrosarcoma in the Practice of Emergency Medical Teams: a Case Report
We present data from three medical rescue team interventions to a patient with a tumour in the left lower leg. The data was obtained from the documentation generated during the interventions: dispatch order record (DOR) and medical emergency treatment report (METR). The patient had a history of the following chronic diseases (ICD-10): E11.8, I50.9, I10, and M15. Two interventions involved patient transportation to a hospital, whereas the third intervention was completed in the patient's home. The fibrosarcoma caused only slight pain. Frequent bleeding from an open cancerous wound was the main problem in this patie...
Source: Ortopedia Traumatologia Rehabilitacja - June 22, 2023 Category: Orthopaedics Authors: Łukasz Dudziński Łukasz Czyżewski Tomasz Kubiak Source Type: research
