RHAMM/hyaluronan inhibit β-catenin degradation, enhance downstream signaling, and facilitate fibrosarcoma cell growth
Mol Biol Rep. 2023 Sep 14. doi: 10.1007/s11033-023-08763-0. Online ahead of print.ABSTRACTIncreased hyaluronan deposition (HA) in various cancer tissues, including sarcomas, correlates with disease progression. The receptor for hyaluronic acid-mediated motility (RHAMM) expression is elevated in most human cancers. β-catenin is a critical downstream mediator of the Wnt signaling pathways, facilitating carcinogenic events characterized by deregulated cell proliferation. We previously showed that low molecular weight (LMW) HA/RHAMM/β-catenin signaling axis increases HT1080 fibrosarcoma cell growth. Here, focusing on mechani...
Source: Molecular Biology Reports - September 14, 2023 Category: Molecular Biology Authors: Aikaterini Berdiaki Lydia-Nefeli Thrapsanioti Eirini-Maria Giatagana Nikos K Karamanos Rashmin C Savani George N Tzanakakis Dragana Nikitovic Source Type: research
RHAMM/hyaluronan inhibit β-catenin degradation, enhance downstream signaling, and facilitate fibrosarcoma cell growth
Mol Biol Rep. 2023 Sep 14. doi: 10.1007/s11033-023-08763-0. Online ahead of print.ABSTRACTIncreased hyaluronan deposition (HA) in various cancer tissues, including sarcomas, correlates with disease progression. The receptor for hyaluronic acid-mediated motility (RHAMM) expression is elevated in most human cancers. β-catenin is a critical downstream mediator of the Wnt signaling pathways, facilitating carcinogenic events characterized by deregulated cell proliferation. We previously showed that low molecular weight (LMW) HA/RHAMM/β-catenin signaling axis increases HT1080 fibrosarcoma cell growth. Here, focusing on mechani...
Source: Mol Biol Cell - September 14, 2023 Category: Molecular Biology Authors: Aikaterini Berdiaki Lydia-Nefeli Thrapsanioti Eirini-Maria Giatagana Nikos K Karamanos Rashmin C Savani George N Tzanakakis Dragana Nikitovic Source Type: research
RHAMM/hyaluronan inhibit β-catenin degradation, enhance downstream signaling, and facilitate fibrosarcoma cell growth
Mol Biol Rep. 2023 Sep 14. doi: 10.1007/s11033-023-08763-0. Online ahead of print.ABSTRACTIncreased hyaluronan deposition (HA) in various cancer tissues, including sarcomas, correlates with disease progression. The receptor for hyaluronic acid-mediated motility (RHAMM) expression is elevated in most human cancers. β-catenin is a critical downstream mediator of the Wnt signaling pathways, facilitating carcinogenic events characterized by deregulated cell proliferation. We previously showed that low molecular weight (LMW) HA/RHAMM/β-catenin signaling axis increases HT1080 fibrosarcoma cell growth. Here, focusing on mechani...
Source: Molecular Biology Reports - September 14, 2023 Category: Molecular Biology Authors: Aikaterini Berdiaki Lydia-Nefeli Thrapsanioti Eirini-Maria Giatagana Nikos K Karamanos Rashmin C Savani George N Tzanakakis Dragana Nikitovic Source Type: research
Topical Diclofenac to Manage Opioid-Refractory Pain in a Rare Pancreatic Fibrosarcoma
Journal of Palliative Medicine, Ahead of Print. (Source: Journal of Palliative Medicine)
Source: Journal of Palliative Medicine - September 11, 2023 Category: Palliative Care Authors: Syed H. Ali Tyler Jorgensen Rohit K. Prasad Gregory Wallingford Source Type: research
Nuclear factor E2-associated factor 2 and musculoaponeurotic fibrosarcoma K mediate regulation glutathione peroxidase of Cristaria plicata after microcystin-induced oxidative stress
In conclusion, Nrf2 and MafK mediate regulation of GPx play a crucial role in protecting bivalves from MC.PMID:37689170 | DOI:10.1016/j.cbpc.2023.109742 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Xinying Cao Jinhua An Shanshan Zhu Maolin Feng Yang Gang Chungen Wen Baoqing Hu Source Type: research
Nuclear factor E2-associated factor 2 and musculoaponeurotic fibrosarcoma K mediate regulation glutathione peroxidase of Cristaria plicata after microcystin-induced oxidative stress
In conclusion, Nrf2 and MafK mediate regulation of GPx play a crucial role in protecting bivalves from MC.PMID:37689170 | DOI:10.1016/j.cbpc.2023.109742 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Xinying Cao Jinhua An Shanshan Zhu Maolin Feng Yang Gang Chungen Wen Baoqing Hu Source Type: research
Nuclear factor E2-associated factor 2 and musculoaponeurotic fibrosarcoma K mediate regulation glutathione peroxidase of Cristaria plicata after microcystin-induced oxidative stress
In conclusion, Nrf2 and MafK mediate regulation of GPx play a crucial role in protecting bivalves from MC.PMID:37689170 | DOI:10.1016/j.cbpc.2023.109742 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Xinying Cao Jinhua An Shanshan Zhu Maolin Feng Yang Gang Chungen Wen Baoqing Hu Source Type: research
Nuclear factor E2-associated factor 2 and musculoaponeurotic fibrosarcoma K mediate regulation glutathione peroxidase of Cristaria plicata after microcystin-induced oxidative stress
In conclusion, Nrf2 and MafK mediate regulation of GPx play a crucial role in protecting bivalves from MC.PMID:37689170 | DOI:10.1016/j.cbpc.2023.109742 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Xinying Cao Jinhua An Shanshan Zhu Maolin Feng Yang Gang Chungen Wen Baoqing Hu Source Type: research
Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells
NAR Cancer. 2023 Sep 6;5(3):zcad048. doi: 10.1093/narcan/zcad048. eCollection 2023 Sep.ABSTRACTNonsense-mediated mRNA decay (NMD) is a eukaryotic RNA decay pathway with roles in cellular stress responses, differentiation, and viral defense. It functions in both quality control and post-transcriptional regulation of gene expression. NMD has also emerged as a modulator of cancer progression, although available evidence supports both a tumor suppressor and a pro-tumorigenic role, depending on the model. To further investigate the role of NMD in cancer, we knocked out the NMD factor SMG7 in the HT1080 human fibrosarcoma cell l...
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Sofia Nasif Martino Colombo Anne-Christine Uldry Markus S Schr öder Simone de Brot Oliver M ühlemann Source Type: research
GSE232333 Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells
Contributors : Sofia Nasif ; Martino Colombo ; Anne-Christine Uldry ; Markus S Schr öder ; Simone de Brot ; Oliver MühlemannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNonsense-mediated mRNA decay (NMD) is a eukaryotic RNA degradation pathway that targets for degradation faulty mRNAs with premature termination codons as well as many physiological mRNAs encoding full-length proteins. Consequently, NMD functions in both, quality control and post-transcriptional regulation of gene expression, and it has been implicated in the modulation of cancer progression. To investigate th...
Source: GEO: Gene Expression Omnibus - September 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Molar ‐incisor‐malformation in a paediatric cancer patient: Case report
ConclusionsMedical interventions during hospitalization for cancer treatment, other than chemo/radiotherapy, may cause MIM by adversely affecting the function of Hertwig's epithelial root sheath. Regular dental screening in paediatric cancer patients may reveal more MIM cases and help in elucidating its pathogenesis. (Source: Oral Surgery)
Source: Oral Surgery - September 4, 2023 Category: ENT & OMF Authors: Athina Tosiou,
Andriana Mastrokalou,
Hari S. Prasad,
Konstantinos I. Tosios,
Ioannis G. Koutlas Tags: CASE REPORT Source Type: research
Cross-species evaluation of fibroblast activation protein alpha as potential imaging target for soft tissue sarcoma: a comparative immunohistochemical study in humans, dogs, and cats
ConclusionThis study represents the first cross-species target evaluation of FAP for STS. Our results demonstrate that FAP expression is increased in various STS subtypes compared to non-cancerous tissues across species, thereby validating dogs and cats as suitable animal models. Based on a TASC score, FAP could be considered a target for FGS. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research
BCL2 inhibition reveals a dendritic cell-specific immune checkpoint that controls tumor immunosurveillance
In conclusion, genetic and pharmacological BCL2 inhibition unveils a DC-specific immune checkpoint that restrains tumor immunosurveillance.PMID:37623817 | DOI:10.1158/2159-8290.CD-22-1338 (Source: Cancer Control)
Source: Cancer Control - August 25, 2023 Category: Cancer & Oncology Authors: Liwei Zhao Peng Liu Misha Mao Shuai Zhang Camille Bigenwald Charles-Antoine Dutertre Christian H K Lehmann Hui Pan Nicolas Paulhan Lukas Amon Aitziber Buque Takahiro Yamazaki Lorenzo Galluzzi Benoit Kloeckner Aymeric Silvin Yuhong Pan Hui Chen Ai-Ling Tia Source Type: research
A Case of Fibrosarcoma Arising in Giant Cell Tumor of Bone: a Rare Entity
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 23, 2023 Category: Cancer & Oncology Source Type: research
Sclerosing Epithelioid Fibrosarcoma
Sclerosing epithelioid fibrosarcoma (SEF) is a distinctive sarcoma that may arise in nearly any soft tissue site or bone. While there has been past controversy as to whether it is related to low-grade fibromyxoid sarcoma (LGFMS), it has been shown to behave far more aggressively than LGFMS. SEF has a propensity to metastasize to the lungs and bone and arise within the abdominal cavity. Histologically, it is characterized by uniform nuclei embedded in a densely collagenous stroma simulating osteoid. By immunohistochemistry, it is often strongly positive for MUC4. The majority (75%) have EWSR1 gene rearrangement, most common...
Source: Surgical Pathology Clinics - August 5, 2023 Category: Pathology Authors: Laura M. Warmke, Wendong Yu, Jeanne M. Meis Source Type: research
