Molecular Alterations in Thyroid Carcinoma
This article provides a concise and updated summary of the main genetic alterations in thyroid carcinoma. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - September 27, 2019 Category: Pathology Authors: Mohamed Rizwan Haroon Al Rasheed, Bin Xu Source Type: research

Treatment of Differentiated Thyroid Carcinomas
Differentiated thyroid cancer (DTC) is the most common thyroid cancer and is frequently encountered in clinical practice. The incidence of DTC has increased significantly over the past three decades. Surgical resection, radioactive iodine (RAI), and levothyroxine suppression therapy remain the primary modalities for DTC treatment. Active surveillance for low-risk thyroid cancer may be an alternative to immediate surgery for appropriately selected patients. Patient characteristics influence treatment selection and intensity. In the subset of patients with progressive distant metastatic disease, not amenable to treatment wit...
Source: Surgical Pathology Clinics - September 27, 2019 Category: Pathology Authors: Melissa G. Lechner, Stephanie Smooke Praw, Trevor E. Angell Source Type: research

A Diagnostic Approach to Adrenocortical Tumors
This article focuses on a practical approach to the evaluation of adrenocortical tumors with an emphasis on clinical and imaging findings, morphologic characteristics, and multifactorial diagnostic schemes and algorithms. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - September 27, 2019 Category: Pathology Authors: Anjelica Hodgson, Sara Pakbaz, Ozgur Mete Source Type: research

Parathyroid Pathology
Proliferative pathologic lesions of parathyroid glands encompass a spectrum of entities ranging from benign hyperplastic processes to malignant neoplasia. This review article outlines the pathophysiologic classification of parathyroid disorders and describes histologic, immunohistochemical, and molecular features that can be assessed to render accurate diagnoses. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - September 27, 2019 Category: Pathology Authors: Julie Guilmette, Peter M. Sadow Source Type: research

Treatment of Adrenocortical Carcinoma
Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. ACC is capable of secreting excess adrenocortical hormones, which can compound morbidity and compromise clinical outcomes. By the time most ACCs are diagnosed, there is usually locoregional or metastatic disease. Surgery is the most important treatment to offer possibility of cure or prolong survival. Several adjuvant therapies are used depending on grade and stage of the tumor and other patient-related factors. This review provides an overview of treatment approaches for ACC, highlighting evidence to support each treatment and acknowledging where m...
Source: Surgical Pathology Clinics - September 27, 2019 Category: Pathology Authors: Anand Vaidya, Matthew Nehs, Kerry Kilbridge Source Type: research

Neuroendocrine Tumors of the Lung
Neuroendocrine tumors of the lung constitute approximately 20% of all primary lung tumors and include typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. Given their morphologic overlap with diverse mimics, neuroendocrine tumors of the lung can be diagnostically challenging. This review discusses the clinical, histologic, immunophenotypic, and molecular features of pulmonary neuroendocrine tumors, along with common diagnostic pitfalls and strategies for avoidance. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - September 27, 2019 Category: Pathology Authors: Yin P. Hung Source Type: research

Prognostic Parameters in Differentiated Thyroid Carcinomas
Differentiated thyroid carcinomas make up most thyroid malignancies. The AJCC staging system and the ATA risk prediction system are the best predictors of mortality and recurrence, respectively. Key factors to be identified and reported by pathologists are reviewed in this article and include: (1) aggressive histologic variants of papillary thyroid carcinoma (including tall cell, columnar cell, and hobnail variants); (2) presence of gross extrathyroidal extension (into skeletal muscle or adjacent organs); (3) angioinvasion (including number of foci); (4) number, anatomic level, and size of lymph node metastases; (4) extran...
Source: Surgical Pathology Clinics - September 18, 2019 Category: Pathology Authors: Nicole A. Cipriani Source Type: research

Endocrine Pathology: Advances, Updates, and Diagnostic Pearls
It has been an exciting decade to practice endocrine pathology. Advances in our understanding of the molecular basis of thyroid tumors have changed the field. Recent iterations of molecular tests have further improved the triaging of patients with cytologically indeterminate nodules to surgery or surveillance. Insight into the molecular basis of thyroid tumors has also played a pivotal role in the reclassification of tumors, such as encapsulated follicular variant of papillary thyroid carcinoma, and is increasingly being used to refine risk stratification and inform treatment strategies. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - September 6, 2019 Category: Pathology Authors: Justine A. Barletta Tags: Preface Source Type: research

EBV –Associated Lymphoproliferative Disorders
Although about 90% of the world ’s population is infected by EBV only a small subset of the related infections result in neoplastic transformation. EBV is a versatile oncogenic agent involved in a multitude of hematopoietic, epithelial, and mesenchymal neoplasms, but the precise role of EBV in the pathogenesis of many of the ass ociated lymphoid/histiocytic proliferations remains hypothetical or not completely understood. Additional studies and use of evolving technologies such as high-throughput next-generation sequencing may help address this knowledge gap and may lead to enhanced diagnostic assessment an...
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Authors: Sherif A. Rezk, Lawrence M. Weiss Source Type: research

Recent Advances in Cutaneous T-cell Lymphoma
This review describes the latest advances in the diagnosis of cutaneous T-cell lymphoma focusing on the most clinically useful features introduced since the publication of the World Health Organization revision in 2017. Clinical entities described include mycosis fungoides, S ézary syndrome, lymphomatoid papulosis, primary cutaneous anaplastic large cell lymphoma, primary cutaneous gamma delta T-cell lymphoma, primary cutaneous acral CD8+ T-cell lymphoma, primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder, and hydroa-vacciniforme-like lymphoprolifer ative disorder. Distinguishing histologic clue...
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Authors: Margaret Cocks, Pierluigi Porcu, Mark R. Wick, Alejandro A. Gru Source Type: research

Acute Leukemias of Ambiguous Lineage
This article provides an overview of the diagnosis of ALAL and focuses on the data accounting for the current lineage-assignment criteria for blasts harboring more than one lineage-associated marker. In addition, the currently known molecular data are reviewed, which show that MPAL-associated gene mutations, methylation signatures, and expression profiles are a mixture of those seen in both acute myeloid leukemia and acute lymphoblastic leukemia. Finally, the prognosis and current treatments of MPAL are briefly discussed. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Authors: Jason H. Kurzer, Olga K. Weinberg Source Type: research

Hematopathology
While hematopathology has long required the melding of morphology, routine laboratory test results, and advanced molecular/genetic data, recent years have brought an explosion of new ideas and information to the field. It has become ever more challenging for those in practice to sort out the emerging data for clinically relevant and actionable knowledge. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Authors: Mina L. Xu Tags: Preface Source Type: research

Hematopathology
SURGICAL PATHOLOGY CLINICS (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Authors: Mina L. Xu Source Type: research

Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Source Type: research

Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Source Type: research

Contents
Mina L. Xu (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Source Type: research

Forthcoming Issues
Endocrine Pathology (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Source Type: research

Histiocytic and Dendritic Cell Neoplasms
Histiocytic and dendritic cell neoplasms are very rare, belonging to a group that share morphologic, immunophenotypic, and ultrastructural characteristics of mature histiocytic/dendritic neoplasms. Histiocytic and dendritic cell neoplasms may arise de novo or in association with B-cell, T-cell, or myeloid neoplasms. Recent molecular findings, particularly the discoveries of the mutations in the RAS-RAF-MEK-ERK pathway, have greatly advanced the diagnosis and treatment options. Histiocytic and dendritic cell neoplasms may closely resemble each other, non-hematopoietic neoplasms, and even reactive processes. Therefore, it is...
Source: Surgical Pathology Clinics - June 8, 2019 Category: Pathology Authors: Zenggang Pan, Mina L. Xu Source Type: research

Castleman Disease
Castleman disease (CD) is divided clinically into unicentric or multicentric type. Pathologically, CD is divided into hyaline-vascular and plasma cell variants. Unicentric CD is most common, about 75% of these cases are hyaline-vascular variant, and surgical excision is often curative. In contrast, there are a number of types of multicentric CD including HHV8-associated, idiopathic, and a subset of cases that arise in association with POEMS syndrome. Therapy is required for most patients with multicentric CD, but there is no consensus approach currently. As is evidence, the designation Castleman disease encompasses a heter...
Source: Surgical Pathology Clinics - May 23, 2019 Category: Pathology Authors: Wei Wang, L. Jeffrey Medeiros Source Type: research

Defining the Boundary Between Myelodysplastic Syndromes and Myeloproliferative Neoplasms
In this article we provide a practical and comprehensive review of myeloid neoplasms with overlapping myelodysplastic (MDS) and myeloproliferative (MPN) features, with emphasis on recent updates in classification, particularly the utility of morphologic, cytogenetic, and molecular findings in better defining and classifying these disease entities. We provide the reader with a summary of the most recent developments and updates that have helped further our understanding of the genomic landscape, clinicopathologic features, and prognostic elements of myeloid neoplasms with MDS/MPN features. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 23, 2019 Category: Pathology Authors: Sanam Loghavi, Sa A. Wang Source Type: research

New/Revised Entities in Gastrointestinal Lymphoproliferative Disorders
This article explores new and revised entities in gastrointestinal lymphoproliferative disorders. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 23, 2019 Category: Pathology Authors: Sarmad H. Jassim, Lauren B. Smith Source Type: research

Prognostic and Predictive Biomarkers in Diffuse Large B-cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in the Western world, accounting for 25% to 40% of adult non-Hodgkin lymphomas (NHLs), with at least 25,000 new cases in the United States estimated in 2016.1,2 The disease is remarkably heterogeneous, with a variety of pathogenetic mechanisms, presentations, and outcomes. Since the introduction of cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab (R-CHOP) as the standard therapy for DLBCL, approximately 60% of patients are now curable. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 23, 2019 Category: Pathology Authors: Alex Chan, Ahmet Dogan Source Type: research

Challenges in the Diagnosis of Gray Zone Lymphomas
This article clarifies some of the diagnostic conundrum surrounding GZL and provides an evidence-based approach to GZL diagnosis using morphology and immunohistochemistry. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 23, 2019 Category: Pathology Authors: Kyle Parker, Girish Venkataraman Source Type: research

Bone Pathology for Hematopathologists
This article provides a conceptual and practical overview of selective bone disorders commonly encountered in the differential diagnosis of hematologic diseases. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 21, 2019 Category: Pathology Authors: Deniz Peker, Shi Wei, Gene P. Siegal Source Type: research

Optimal Measurable Residual Disease Testing for Acute Myeloid Leukemia
This article discusses MRD testing, highlights the challenges in adopting MRD testing in clinical practice, and provides insights into the future of the field. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 18, 2019 Category: Pathology Authors: Wenbin Xiao, Kseniya Petrova-Drus, Mikhail Roshal Source Type: research

Human Immunodeficiency Virus-Associated Lymphoproliferative Disorders
This article reviews the diagnostic features and summarizes current biologic understanding of HIV-associated lymphomas. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 17, 2019 Category: Pathology Authors: Amy J. Lilly, Yuri Fedoriw Source Type: research

Early Events in Lymphoid Neoplasms and Indolent Follicular Lymphomas
Technical advances in diagnostic modalities have led to the characterization of indolent lymphoid disorders similar to the in situ lesions described in epithelial malignancies. These early and indolent lymphoid lesions share clinicopathologic characteristics with well-characterized lymphoid malignancies such as chronic lymphocytic leukemia and follicular lymphoma. The in situ lesions have an indolent clinical course with only a minor subset shown to progress to frank malignancies. In addition to the in situ lesions, new indolent lymphoproliferative disorders have been recently characterized. Diagnosis and characterization ...
Source: Surgical Pathology Clinics - May 15, 2019 Category: Pathology Authors: Sudhir Perincheri Source Type: research

Cervical Glandular Neoplasia
Endocervical adenocarcinomas (EAs) account for 25% of all primary cervical carcinomas. Approximately 85% of EAs are driven by high-risk human papillomavirus (HPV) infection, the most common of which is the so-called usual type endocervical adenocarcinomas. Non-HPV-driven subtypes harbor distinct clinicopathologic features and prognosis and have been increasingly recognized in recent years, which has led to efforts to improve classification of EA based on clinically relevant and reproducible criteria. This review discusses a recently proposed classification system, the International Endocervical Adenocarcinoma Criteria and ...
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Gulisa Turashvili, Kay J. Park Source Type: research

Uterine Mesenchymal Tumors
This article discusses their clinical relevance, recent insights into their molecular biology, and the most important differential diagnoses. Regarding the latter, immunohistochemistry and (increasingly) molecular diagnostics play a role in the diagnostic workup. We conclude with a few considerations on intraoperative consultation and macroscopic examination, as well as pathologic staging and grading of uterine sarcomas as per the most recent American Joint Cancer Commission and the F édération Internationale de Gynécologie et d’Obstétrique staging systems. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Carlos Parra-Herran, Brooke E. Howitt Source Type: research

Germ Cell Tumors of the Female Genital Tract
This article reviews the histologic and immunohistochemical features of the most common ovarian germ cell tumors. The differential diagnoses for each are discussed. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Elizabeth D. Euscher Source Type: research

Fallopian Tube Neoplasia and Mimics
This review discusses select fallopian tube entities and their associated mimics. It first focuses on adenomatoid tumors, the most common benign tumor of the fallopian tube. High-grade serous carcinoma and its precursor, serous tubal intraepithelial carcinoma, are then addressed. Finally, attention is turned to endometrioid proliferations of the fallopian tube. A diagnostic approach is provided for these lesions, with an emphasis on differential diagnoses and situations in which a benign lesion may appear malignant, and vice-versa. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: David L. Kolin, Marisa R. Nucci Source Type: research

Ovarian High-Grade Serous Carcinoma
High-grade serous (HGSC) stands apart from the other ovarian cancer histotypes in being the most frequent, in occurring as part of a genetic predisposition in a significant proportion of cases, and in having the poorest clinical outcomes. Although the pathologic diagnosis of HGSC is now made with high accuracy, there remain areas of disagreement regarding viewpoints on tissue site of origin and designation of primary site, with impact on staging in low-stage cases, as well as difficulties in reproducible and clinically relevant reporting of HGSC in specimens taken after neoadjuvant chemotherapy. These areas are discussed i...
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Laura Casey, Naveena Singh Source Type: research

Mucinous Ovarian Tumors
Ovarian mucinous tumors range from benign cystadenomas to borderline tumors to frankly malignant adenocarcinomas, and may display either intestinal-type morphology or, less frequently, endocervical-type differentiation. The latter category has been the subject of recent controversy owing to its morphologic overlap with so-called “seromucinous” ovarian tumors, a group that shares more molecular features with endometrioid tumors than it does with either serous or mucinous ovarian neoplasias. Endocervical-type differentiation in ovarian mucinous tumors may also represent an endocervical metastasis. Distinction of ...
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Anne M. Mills, Elisheva D. Shanes Source Type: research

Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary
This review is an appraisal of the current state of knowledge of 2 enigmatic histotypes of ovarian carcinoma: endometrioid and clear cell carcinoma. Both show an association endometriosis and the hereditary nonpolyposis colorectal cancer (Lynch) syndrome, and both typically present at an early stage. Pathologic and immunohistochemical features that distinguish these tumors from high-grade serous carcinomas, each other, and other potential mimics are discussed, as are staging, grading, and molecular pathogenesis. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Oluwole Fadare, Vinita Parkash Source Type: research

Human Papilloma Virus –Associated Squamous Neoplasia of the Lower Anogenital Tract
This article discusses the LAST project recommendations, challenges associated with their application, and site specific diagnostic challenges in their relevant clinical context. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Eric J. Yang Source Type: research

Endometrial Carcinoma
This article gives an overview of the pathologic assessment of resection specimens removed for uterine carcinoma. Areas of controversy and recent developments in pathologic staging are addressed. This includes assessment of myometrial invasion in the setting of adenomyosis, fallopian tube involvement, and vascular invasion. An overview of the role and evaluation of sentinel node assessments in the staging of endometrial carcinoma is provided. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Vinita Parkash, Oluwole Fadare Source Type: research

High-Grade Endometrial Carcinomas
This article provides an overview of the current diagnosis of endometrial carcinoma subtypes and provides updates, including the most recent molecular findings from The Cancer Genome Atlas and others. Interpretation of relevant immunohistochemistry and critical diagnostic differential diagnosis with pitfalls are discussed. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Joseph W. Carlson, Denis Nastic Source Type: research

Smooth Muscle Tumors of the Female Genital Tract
This article provides an overview of smooth muscle tumors of each major organ of the gynecologic tract and discusses diagnostic challenges. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Kelly A. Devereaux, J. Kenneth Schoolmeester Source Type: research

Practical Review of Ovarian Sex Cord –Stromal Tumors
This article describes the various types of ovarian sex cord–stromal tumors and i ncludes practical approaches to differential diagnoses and updates in classification. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Krisztina Z. Hanley, Marina B. Mosunjac Source Type: research

Low-grade Serous Neoplasia of the Female Genital Tract
Low-grade serous neoplasia of the gynecologic tract includes benign (serous cystadenomas), borderline, and malignant lesions (low-grade serous carcinoma). Classification of these lesions relies on rigorous attention to several pathologic features that determine the prognosis and the need for adjuvant therapy. Risk stratification of serous borderline tumor behavior based on histologic findings and criteria for low-grade serous carcinoma are the primary focus of this article, including the redesignation of invasive implants of serous borderline tumor as low-grade serous carcinoma based on the similar survival rates. The mole...
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Ann K. Folkins, Teri A. Longacre Source Type: research

Practical Issues and Updates in Gynecologic Pathology
I am pleased to serve as the editor for this issue of Surgical Pathology Clinics, focusing on selected practical issues and updates in gynecologic pathology. Gynecologic specimens account for a significant volume of general surgical pathology case load and encompass a wide variety of entities frequently encountered in cervical and endometrial biopsies and resections as well as rarely encountered tumors such as uterine sarcomas and germ cell tumors. It is an exciting time to be a gynecologic pathologist as we continue to expand our understanding of molecular underpinnings of gynecologic tumors and preinvasive lesions. (Sour...
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Brooke E. Howitt Tags: Preface Source Type: research

Gynecologic Pathology: Practical Issues and Updates
SURGICAL PATHOLOGY CLINICS (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Brooke E. Howitt Source Type: research

Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Source Type: research

Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Source Type: research

Contents
Brooke E. Howitt (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Source Type: research

Forthcoming Issues
Hematopathology (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Source Type: research

Human Papillomavirus –Independent Squamous Lesions of the Vulva
The pathogenesis of vulvar squamous neoplasia has 2 pathways: human papillomavirus (HPV)-dependent and HPV-independent. The HPV-dependent pathway in the vulva follows the same progression as HPV-dependent lesions elsewhere in the gynecologic tract —HPV infection results in high-grade squamous intraepithelial lesion with subsequent progression to basaloid squamous cell carcinoma. The HPV-independent pathway is more complex, with a variety of precursor lesions and molecular alterations. Although the most recognized form of HPV-independent vul var lesion is differentiated vulvar intraepithelial neoplasia, recent explora...
Source: Surgical Pathology Clinics - April 5, 2019 Category: Pathology Authors: Jaclyn C. Watkins Source Type: research

Benign and Premalignant Lesions of the Endometrium
In this review, we highlight the benign and premalignant lesions of the endometrium that the pathologist may encounter in daily practice. We begin by detailing our current understanding of excess estrogen in the progression of endometrial neoplasia. We outline the currently accepted terminology to be used when evaluating proliferative endometrial lesions, while highlighting their key features. Attention is then turned to the molecular underpinnings of neoplastic progression and how this can be exploited with immunohistochemical stains when appropriate. Finally, we discuss types of metaplasia and their associations, includi...
Source: Surgical Pathology Clinics - April 3, 2019 Category: Pathology Authors: Wesley Daniel Mallinger, Charles Matthew Quick Source Type: research

SWI/SNF Complex-Deficient Soft Tissue Neoplasms
Loss of different components of the Switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex has been increasingly recognized as a central molecular event driving the initiation and/or dedifferentiation of mostly lethal but histogenetically diverse neoplasms in different body organs. This review summarizes and discusses the morphologic and phenotypic diversity of primary soft tissue neoplasms characterized by SWI/SNF complex deficiency with an emphasis on convergent and divergent cytoarchitectural patterns. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - January 30, 2019 Category: Pathology Authors: Abbas Agaimy Source Type: research

Mesenchymal Tumors with EWSR1 Gene Rearrangements
Among the various genes that can be rearranged in soft tissue neoplasms associated with nonrandom chromosomal translocations, EWSR1 is the most frequent one to partner with other genes to generate recurrent fusion genes. This leads to a spectrum of clinically and pathologically diverse mesenchymal and nonmesenchymal neoplasms, variably manifesting as small round cell, spindle cell, clear cell or adipocytic tumors, or tumors with distinctive myxoid stroma. This review summarizes the growing list of mesenchymal neoplasms that are associated with EWSR1 gene rearrangements. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - January 30, 2019 Category: Pathology Authors: Khin Thway, Cyril Fisher Source Type: research