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The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB
Triple-negative breast cancer (TNBC) is particularly aggressive and difficult to treat. For example, the transforming growth factor–β (TGF-β) pathway is implicated in TNBC progression and metastasis, but its opposing role in tumor suppression in healthy tissues and early-stage lesions makes it a challenging target. Therefore, additional molecular characterization of TNBC may lead to improved patient prognosis by informing the development and optimum use of targeted therapies. We found that musculoaponeurotic fibrosarcoma (MAF) oncogene family protein K (MAFK), a member of the small MAF family of transcripti...
Source: Signal Transduction Knowledge Environment - April 11, 2017 Category: Science Authors: Okita, Y., Kimura, M., Xie, R., Chen, C., Shen, L. T.-W., Kojima, Y., Suzuki, H., Muratani, M., Saitoh, M., Semba, K., Heldin, C.-H., Kato, M. Tags: STKE Research Articles Source Type: news

PharmaMar presents positive results with ADC MI130110 in CD13-expressing tumor cells
(Pharmamar) PharmaMar, a world leader in the discovery, development and commercialization of new anti-tumor compounds of a marine origin, has announced that its antibody-drug conjugate (ADC) has demonstrated a remarkable in vitro antitumoral activity in a CD13, fibrosarcoma positive animal model. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 1, 2016 Category: Cancer & Oncology Source Type: news

Invasive Infantile Fibrosarcoma of the Forearm Invasive Infantile Fibrosarcoma of the Forearm
This case of infantile fibrosarcoma of the left forearm provides insight into the differential diagnoses and management strategies for this type of tumor.ePlasty, Open Access Journal of Plastic Surgery (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 22, 2016 Category: Pathology Tags: Hematology-Oncology Journal Article Source Type: news

Young Cancer Patient's Tenacity Inspires Family, Friends and Strangers
Jimmy E. is a remarkable man. Inspired by the doctors who helped him overcome a rare form of childhood cancer, he forged a career as a skilled surgical nurse in southern California, driven by an urge to serve others. But more than 30 years after beating cancer, Jimmy developed a persistent fever, pneumonia and fluid around his lungs. This time, the diagnosis was a more insidious disease — malignant pleural mesothelioma. Jimmy, who recently turned 38, is far too young for a disease that typically strikes the elderly. As he struggles to rise above each setback, now it's Jimmy inspiring others around him, including fami...
Source: Asbestos and Mesothelioma News - August 13, 2014 Category: Environmental Health Authors: Tim Povtak Tags: Stories from Survivors Source Type: news

Claims of a universal cure for cancer 'misleading'
Conclusion This research has demonstrated the unique abilities of the blind mole rat to resist cancer, even when directly given potent cancer-causing chemicals. In the laboratory, the researchers also demonstrated how connective tissue cells called fibroblasts taken from the animal seem to play an important role in this cancer resistance. These cells prevented the growth of human cancer cells when the two types of cells were grown together in the laboratory. A similar study in a closely related species – the naked mole rat – has also demonstrated similar cancer protection. Scientists have been studying th...
Source: NHS News Feed - January 17, 2014 Category: Consumer Health News Tags: Cancer Source Type: news

MENIN regulates MAFA expression
The protein MENIN is the product of the multiple endocrine neoplasia type I (MEN1) gene. Altered MENIN expression is one of the few events that are clearly associated with foregut neuroendocrine tumours (NETs), as classical oncogenes or tumour suppressors are not involved. One of the current challenges is to understand how alteration of MENIN expression contributes to the development of these tumours. Hamze and colleagues hypothesised that MENIN might regulate factors maintaining endocrine-differentiated functions. Choosing the insulinoma model, a paradigmatic example of well-differentiated pancreatic NETs, they studied wh...
Source: Society for Endocrinology - December 10, 2013 Category: Endocrinology Source Type: news

Brain abnormalities after Cushing’s disease
The protein MENIN is the product of the multiple endocrine neoplasia type I (MEN1) gene. Altered MENIN expression is one of the few events that are clearly associated with foregut neuroendocrine tumours (NETs), as classical oncogenes or tumour suppressors are not involved. One of the current challenges is to understand how alteration of MENIN expression contributes to the development of these tumours. Hamze and colleagues hypothesised that MENIN might regulate factors maintaining endocrine-differentiated functions. Choosing the insulinoma model, a paradigmatic example of well-differentiated pancreatic NETs, they studied wh...
Source: Society for Endocrinology - December 10, 2013 Category: Endocrinology Source Type: news