Young Cancer Patient's Tenacity Inspires Family, Friends and Strangers

Jimmy E. is a remarkable man. Inspired by the doctors who helped him overcome a rare form of childhood cancer, he forged a career as a skilled surgical nurse in southern California, driven by an urge to serve others. But more than 30 years after beating cancer, Jimmy developed a persistent fever, pneumonia and fluid around his lungs. This time, the diagnosis was a more insidious disease — malignant pleural mesothelioma. Jimmy, who recently turned 38, is far too young for a disease that typically strikes the elderly. As he struggles to rise above each setback, now it's Jimmy inspiring others around him, including family, friends and strangers he never met, and never will. In the last three months, 122 people have contributed more than $12,200 to his “Please Help Jimmy!” campaign on GoFundMe.com. The goal is to reach $25,000 to cover medical costs. "I never knew, never guessed, that there were so many people who cared and would reach out to help," said Linda, his mother and primary caregiver. "There are people all over the world who are praying for him now. It's been amazing to see how people have responded. In a way, it's been inspiring to see." First Encounter with Cancer Cancer first struck Jimmy at age six. Doctors told his parents he had fibrosarcoma, a rare, soft-tissue cancer that originated around his jaw. They said there was a 70 percent chance he would die soon. Multiples surgeries, high-dose radiation and several rounds of...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Stories from Survivors Source Type: news

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Publication date: Available online 21 March 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Pourseyed Aghaei Fatematossadat, Mahnaz Mohammadi, S. Ehsan RoozmehAbstractIn this paper, we study magnetic and structural properties of silver and gold-coated iron nanoparticle as novel drug delivery systems for the two commercially famous cancer treatment drugs, using the density functional theory (DFT) computations.Our calculations show that silver and gold-coated iron nanoparticle have magnetization and the magnetic moment of the Fe atom in the Fe@(Ag/Au)n core-shells saturated to a value of about 3 μB. Thus...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Publication date: Available online 21 March 2019Source: Redox BiologyAuthor(s): Tsung-Ming Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, Ming-Hsi Chuang, Chun-Hung Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Shinn-Zong LinAbstractLeft ventricular hypertrophy (LVH) in hypertension has prognostic significance on cardiovascular mortality and morbidity. Recently, we have shown that n-butylidenephthalide (BP) improves human adipose-derived stem cell (hADSC) engraftment via attenuated reactive oxygen species (ROS) production. This prompted us to investigate whether remote transplantation of BP-pretreated hADSCs confers attenuated LVH at an est...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 21 March 2019Source: Carbohydrate PolymersAuthor(s): Shuo Tang, Ting Wang, Caoxing Huang, Chenhuan Lai, Yimin Fan, Qiang YongAbstractA highly branched arabinogalactan isolated from Larix principis-rupprechtii and subjected to sulfation derivatization to promote their antitumor bioactivity. Several structural features of the sulfated arabinogalactans (S-LAG) were investigated: molecular weight, monosaccharide constitution, and chemical structures. Spectral analysis indicated that sulfate groups were successfully introduced on arabinogalactan. Sulfated products showed different degrees of s...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 21 March 2019Source: The Journal of Supercritical FluidsAuthor(s): Daniel Ribeiro Grijó, Danielle Lazarin Bidoia, Celso Vataru Nakamura, Ignacio Vieitez Osorio, Lúcio Cardozo-FilhoAbstractThe inhibitory effects of Cannabis flower extracts, obtained by supercritical carbon dioxide (scCO2) with and without modifier, on various human tumour cells and non-tumour cells were evaluated. Different techniques were used to optimize the polarity interaction between solute and solvent before extraction. An increase in the cannabinoid content of interest (CBD/THC) was evaluated by decarb...
Source: The Journal of Supercritical Fluids - Category: Chemistry Source Type: research
Publication date: Available online 22 March 2019Source: European Polymer JournalAuthor(s): Qian Zou, Fangli Hou, Hong Wang, Yonggui Liao, Qin Wang, Yajiang YangAbstractMultifunctional alginate microspheres encapsulated with in situ-formed bismuth sulfide nanoparticles (denoted as Bi2S3@BCA) were developed in this work. In comparison with conventional hybrid polymer microspheres usually involved in complicate preparation process, Bi2S3@BCA microspheres can be easily one-step prepared using a droplet-based microfluidic technique with alginate as a soft template and microspheric matrix. As-prepared Bi2S3@BCA microspheres has ...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 March 2019Source: European Polymer JournalAuthor(s): Aliyeh Ghamkhari, Farideh Mahmoodzadeh, Marjan Ghorbani, Hamed HamishehkarAbstractGold nanoparticles have been used for centuries in medicine for clinical procedures. In this context, gold nanorods are considered as very promising in cancer therapy. For this purpose, gold nanorods (GNRs) coated by stimuli-responsive thiol-end capped ABC triblock copolymer [poly (metacrylic acid)-block-poly (N-isopropylacrylamide)-block-poly (N,N-dimethylaminoethyl methacrylate)-SH; P(MAAc-b-NiPAAM-b-DMAEMA)-SH] for intracellular delivery of doxorubic...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 March 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Yongchao Zhang, Zhenfen Tian, Xiaotong Zhao, Na Li, Vasil M. Garamus, Peihao Yin, Aihua ZouAbstractBufalin, a traditional oriental medicine, has been incorporated into liposomes for better targeted drug delivery. Bufalin-loaded liposome (L-BF), bufalin-loaded PEGylated liposome (L-PEG-BF) and bufalin-loaded RGD targeted PEGylated liposome (L-RGD-PEG-BF) were successfully developed with homogeneous particle size and sufficient physical stability in 30 days. The entrapment efficiency (EE) and dru...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
In this study, we reported a dual HDAC and DNMT inhibitor 208 and found it induced G1 cell cycle arrest and apoptosis in U937 cells. Proteome and bioinformatic analyses revealed that the combined inhibition of DNMT1 and HDAC by 208 affected the expression of a series of proteins involved in many biological processes. We observed that several proteins associated with G1 cell cycle arrest and apoptosis were down regulated after 208 treatment, including p85α, MEK, and CDK4, suggesting that 208 induces cell cycle arrest and apoptosis through the p85α/MEK-mediated pathway in U937 cells. Moreover, biological function...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC01442J, CommunicationKeonwook Nam, Taehyung Kim, Young Min Kim, Kyungjik Yang, Deokyoung Choe, Lawrence B. Mensah, Ki Young Choi, Young Hoon Roh The size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery were synthesizedvia sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Study involving reimplanting testicular tissue later in life hailed as breakthroughTesticular tissue taken from young monkeys, which is then frozen and grafted back into their bodies later in their life, can give rise to sperm and allow them to father live young, scientists have revealed.While the approach has previously been successful in other animals, including mice, it is the first time a primate has produced offspring from the procedure. The team report the baby rhesus macaque that was born is a healthy female that has been named Grady, after “graft-derived” and “baby”.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Science Fertility problems Health Society Cancer Young people Animals World news Source Type: news
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