SOX71, A Biocompatible Succinyl Derivative of the Triarylmethyl Radical OX071 for In Vivo Quantitative Oxygen Mapping Using Electron Paramagnetic Resonance

ConclusionSOX71, a succinylated derivative of OX071 was synthesized, characterized, and applied forin vivo EPR tumor oxygen imaging. SOX71 is highly biocompatible, and shows decreased sensitivity to oxygen and self-relaxation. This first report suggests that SOX71 is superior to OX071 for absolute oxygen mapping under a broad range ofpO2 values.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research