Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
GSE230417 Effect of Dexamethasone, IL-1B and Dex+IL-1B on gene expression in Th17 cells
Contributor : William A Miller-LittleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the response of Th17 cells to IL-1B and Dexamethasone, and the ability of IL-B to alter the steroid-responsiveness of Th17 cells (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Impact of the Addition of Daratumumab to the Standard Bortezomib-Thalidomide-Dexamethasone Regimen on Hematopoietic Stem Cell Mobilization and Collection, Post-Transplant Engraftment and Infectious Complications: A Case-Control Multicentre Real-Life Analy
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 30, 2024 Category: Hematology Authors: Gianluca Cavallaro Source Type: research
Viruses, Vol. 16, Pages 718: Nirmatrelvir Resistance in an Immunocompromised Patient with Persistent Coronavirus Disease 2019
We present a patient who independently acquired a T21I mutation in the 3CL protease after nirmatrelvir exposure. The T21I mutation in the 3CL protease is one of the most frequent mutations responsible for nirmatrelvir resistance. However, limited reports exist on actual cases of SARS-CoV-2 with T21I and other mutations in the 3CL protease. The patient, a 55 year-old male, had COVID-19 during chemotherapy for multiple myeloma. He was treated with nirmatrelvir early in the course of the disease but relapsed, and SARS-CoV-2 with a T21I mutation in the 3CL protease was detected in nasopharyngeal swab fluid. The patient had tem...
Source: Viruses - April 30, 2024 Category: Virology Authors: Chie Yamamoto Masashi Taniguchi Keitaro Furukawa Toru Inaba Yui Niiyama Daisuke Ide Shinsuke Mizutani Junya Kuroda Yoko Tanino Keisuke Nishioka Yohei Watanabe Koichi Takayama Takaaki Nakaya Yoko Nukui Tags: Brief Report Source Type: research
230. Cortisol and ACTH Response to Dex/CRH Testing and 24-Hour Urine Free Cortisol Levels in Women With and Those Without Premenstrual Dysphoric Disorder
In this study, we characterized the HPA axis in women with PMDD using the combined dexamethasone suppression and CRH stimulation (Dex/CRH) test and 24-hour urine free cortisol (UFC). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Constance Zou, Pedro Martinez, Xiaobai Li, Gioia Guerrieri, Rivka Ben Dor, Rhasaan Bowell, Jessica Naredo, Peggy McLuggage, Natalie Kress, Lynnette Neiman, David Rubinow, Peter Schmidt Source Type: research
Enhanced osteogenic differentiation potential of Arnica montana and Bellis perennis in C3H10T1/2 multipotent mesenchymal stem cells
CONCLUSIONS: Our findings suggest that homoeopathic compounds Arnica montana and Bellis perennis can augment osteogenesis individually as well as in combination.PMID:38683461 | DOI:10.1007/s11033-024-09509-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Bhat K Deepika Nagendra H Apoorva Pinto R Joel Bipasha B Shenoy P Sudheer Source Type: research
Enhanced osteogenic differentiation potential of Arnica montana and Bellis perennis in C3H10T1/2 multipotent mesenchymal stem cells
CONCLUSIONS: Our findings suggest that homoeopathic compounds Arnica montana and Bellis perennis can augment osteogenesis individually as well as in combination.PMID:38683461 | DOI:10.1007/s11033-024-09509-2 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Bhat K Deepika Nagendra H Apoorva Pinto R Joel Bipasha B Shenoy P Sudheer Source Type: research
Lithium rescues cultured rat metatarsals from dexamethasone-induced growth failure
CONCLUSIONS: LiCl has the potential to partially rescue from dexamethasone-induced bone growth impairment in an ex vivo model. Transcriptomics identified cell renewal and proliferation as candidates for the underlying mechanisms. Our observations may open up the development of a new treatment strategy for bone growth disorders.IMPACT: LiCl is capable to prevent glucocorticoid-induced growth failure in rat metatarsals in vitro. The accompanying drug-induced transcriptomic changes suggested cell renewal and proliferation as candidate underlying mechanisms. Wnt/beta-catenin pathway could be one of those novel mechanisms.PMID:...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Ondrej Soucek Ondrej Cinek Lilly Velentza Valerij Semjonov Martin Bezdicka Farasat Zaman Lars S ävendahl Source Type: research
Lithium rescues cultured rat metatarsals from dexamethasone-induced growth failure
CONCLUSIONS: LiCl has the potential to partially rescue from dexamethasone-induced bone growth impairment in an ex vivo model. Transcriptomics identified cell renewal and proliferation as candidates for the underlying mechanisms. Our observations may open up the development of a new treatment strategy for bone growth disorders.IMPACT: LiCl is capable to prevent glucocorticoid-induced growth failure in rat metatarsals in vitro. The accompanying drug-induced transcriptomic changes suggested cell renewal and proliferation as candidate underlying mechanisms. Wnt/beta-catenin pathway could be one of those novel mechanisms.PMID:...
Source: Pediatric Research - April 29, 2024 Category: Pediatrics Authors: Ondrej Soucek Ondrej Cinek Lilly Velentza Valerij Semjonov Martin Bezdicka Farasat Zaman Lars S ävendahl Source Type: research
Enhanced osteogenic differentiation potential of Arnica montana and Bellis perennis in C3H10T1/2 multipotent mesenchymal stem cells
CONCLUSIONS: Our findings suggest that homoeopathic compounds Arnica montana and Bellis perennis can augment osteogenesis individually as well as in combination.PMID:38683461 | DOI:10.1007/s11033-024-09509-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Bhat K Deepika Nagendra H Apoorva Pinto R Joel Bipasha B Shenoy P Sudheer Source Type: research
Enhanced osteogenic differentiation potential of Arnica montana and Bellis perennis in C3H10T1/2 multipotent mesenchymal stem cells
CONCLUSIONS: Our findings suggest that homoeopathic compounds Arnica montana and Bellis perennis can augment osteogenesis individually as well as in combination.PMID:38683461 | DOI:10.1007/s11033-024-09509-2 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Bhat K Deepika Nagendra H Apoorva Pinto R Joel Bipasha B Shenoy P Sudheer Source Type: research
