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Correction: LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 26, 2024 Category: Molecular Biology Authors: Tao Jiang, Hao Xiao, Bin Li, Hangyuan He, Hui Wang and Liaobin Chen Tags: Correction Source Type: research

Intracellular Zn 2+ Promotes Extracellular Matrix Remodeling in Dexamethasone-Treated Trabecular Meshwork
Am J Physiol Cell Physiol. 2024 Mar 25. doi: 10.1152/ajpcell.00725.2023. Online ahead of print.ABSTRACTGiven the widespread application of glucocorticoids in ophthalmology, the associated elevation of intraocular pressure (IOP) has long been a vexing concern for clinicians, yet the underlying mechanisms remain inconclusive. Much of the discussion focuses on the extracellular matrix (ECM) of trabecular meshwork (TM). It's widely agreed that glucocorticoids impact the expression of Matrix metalloproteinases (MMPs), leading to ECM deposition. Since Zn2+ is vital for MMPs, we explored its role in ECM alterations induced by dex...
Source: American Journal of Physiology. Cell Physiology - March 25, 2024 Category: Cytology Authors: Canying Liu Jiahui Tang Yuze Chen Qi Zhang Jicheng Lin Siting Wu Jiaxu Han Zhe Liu Caiqing Wu Yehong Zhuo Yiqing Li Source Type: research

Intracellular Zn 2+ Promotes Extracellular Matrix Remodeling in Dexamethasone-Treated Trabecular Meshwork
Am J Physiol Cell Physiol. 2024 Mar 25. doi: 10.1152/ajpcell.00725.2023. Online ahead of print.ABSTRACTGiven the widespread application of glucocorticoids in ophthalmology, the associated elevation of intraocular pressure (IOP) has long been a vexing concern for clinicians, yet the underlying mechanisms remain inconclusive. Much of the discussion focuses on the extracellular matrix (ECM) of trabecular meshwork (TM). It's widely agreed that glucocorticoids impact the expression of Matrix metalloproteinases (MMPs), leading to ECM deposition. Since Zn2+ is vital for MMPs, we explored its role in ECM alterations induced by dex...
Source: Am J Physiol Cell Ph... - March 25, 2024 Category: Cytology Authors: Canying Liu Jiahui Tang Yuze Chen Qi Zhang Jicheng Lin Siting Wu Jiaxu Han Zhe Liu Caiqing Wu Yehong Zhuo Yiqing Li Source Type: research

Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota
This study presents hydroxyethyl starch-curcumin microspheres (HC-MSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19.91 %), for combination therapy of UC. The microspheres were successfully engineered, retaining the anti-oxidative and anti-inflammatory activities of parental CUR and demonstrating excellent biocompatibility and controlled release properties, notably triggered by α-amylase, facilitating targeted drug delivery to inflamed sites. In a mouse UC mod...
Source: International Journal of Biological Macromolecules - March 25, 2024 Category: Biochemistry Authors: Da Huang Yongming Wang Chenlan Xu Minglang Zou Yangcan Ming Fang Luo Zhenjin Xu Ying Miao Na Wang Zhenyu Lin Zuquan Weng Source Type: research

Intracellular Zn 2+ Promotes Extracellular Matrix Remodeling in Dexamethasone-Treated Trabecular Meshwork
Am J Physiol Cell Physiol. 2024 Mar 25. doi: 10.1152/ajpcell.00725.2023. Online ahead of print.ABSTRACTGiven the widespread application of glucocorticoids in ophthalmology, the associated elevation of intraocular pressure (IOP) has long been a vexing concern for clinicians, yet the underlying mechanisms remain inconclusive. Much of the discussion focuses on the extracellular matrix (ECM) of trabecular meshwork (TM). It's widely agreed that glucocorticoids impact the expression of Matrix metalloproteinases (MMPs), leading to ECM deposition. Since Zn2+ is vital for MMPs, we explored its role in ECM alterations induced by dex...
Source: Am J Physiol Cell Ph... - March 25, 2024 Category: Cytology Authors: Canying Liu Jiahui Tang Yuze Chen Qi Zhang Jicheng Lin Siting Wu Jiaxu Han Zhe Liu Caiqing Wu Yehong Zhuo Yiqing Li Source Type: research