Daratumumab ‑resistant multiple myeloma with extramedullary disease successfully treated with combination elotuzumab, pomalidomide and dexamethasone: A case report
Oncol Lett. 2024 Apr 3;27(6):248. doi: 10.3892/ol.2024.14381. eCollection 2024 Jun.ABSTRACTDespite the emergence of monoclonal antibodies, the prognosis of patients with multiple myeloma (MM) with extramedullary disease remains poor. The present report describes a rare case of daratumumab-refractory MM that was successfully treated with elotuzumab, pomalidomide and dexamethasone. A 66-year-old male patient diagnosed with MM was treated with bortezomib, lenalidomide and dexamethasone, followed by high-dose chemotherapy and autologous stem cell transplantation. Thereafter, the patient was treated with lenalidomide and dexame...
Source: Oncology Letters - April 19, 2024 Category: Cancer & Oncology Authors: Masataka Sakashita Naohi Sahara Jun Aoki Takashi Matsunaga Seiichiro Kobayashi Shinsuke Kitahara Tomoki Fujii Nobuhiro Ohno Source Type: research
Dexamethasone sodium phosphate loaded nanoparticles for prevention of nitrogen mustard induced corneal injury
Exp Eye Res. 2024 Apr 17:109902. doi: 10.1016/j.exer.2024.109902. Online ahead of print.ABSTRACTNitrogen mustard (NM) is a potent vesicating chemical warfare agent that is primarily absorbed through skin, inhalation, or ocular surface. Ocular exposure of NM can cause acute to chronic keratopathy which can eventually lead to blindness. There is a current lack of effective countermeasures against ocular exposure of NM despite their imperative need. Herein, we aim to explore the sustained effect of Dexamethasone sodium phosphate (DSP)-loaded polymeric nanoparticles (PLGA-DSP-NP) following a single subconjunctival injection in...
Source: Experimental Eye Research - April 19, 2024 Category: Opthalmology Authors: Sagun Poudel Ehsan Kaffash Long Zhao Rudra Pangeni Woon Nam Chow Qingguo Xu Source Type: research
Combination Therapy with Anti-VEGF and Intravitreal Dexamethasone Implant for Macular Edema Secondary to Retinal Vein Occlusion
CONCLUSIONS: Ranibizumab combined with dexamethasone injection sustainably improved the BCVA of retinal vein occlusion patients with a good safety profile.PMID:38639040 | DOI:10.1080/02713683.2024.2343055 (Source: Current Eye Research)
Source: Current Eye Research - April 19, 2024 Category: Opthalmology Authors: Xiaohui Cai Jing Zhao Yalong Dang Source Type: research
Response to & quot;Dexamethasone and Dexmedetomidine: A Synergistic Approach to Reduce Postoperative Nausea and Vomiting in Bariatric Surgery Patients & quot;
(Source: Obesity Surgery)
Source: Obesity Surgery - April 19, 2024 Category: Surgery Source Type: research
Efficacy and Safety of Weekly Bortezomib-dexamethasone as the Third-Line Therapy for Warm Autoimmune Hemolytic Anemia: a Case Series of 5 Patients
AbstractBackgroundWarm autoimmune hemolytic anaemia (wAIHA) is a chronic condition. Despite the high initial responses seen with the first two treatment lines (corticosteroids and rituximab), relapses are frequent. Anecdotal data suggests the efficacy of bortezomib in relapsed/refractory (RR) wAIHA. This case series aimed to evaluate bortezomib as a third-line therapy in wAIHA in terms of efficacy, safety, and prospects of achieving treatment-free remission (TFR). Five adult patients ≥ 18 years of age with RR wAIHA after corticosteroids and rituximab were included over 1.5 years. Patients were treated uniformly wi...
Source: Indian Journal of Hematology and Blood Transfusion - April 19, 2024 Category: Hematology Source Type: research
Iguratimod inhibits protein citrullination and inflammation by downregulating NBCe2 in patients with rheumatoid arthritis
CONCLUSIONS: Bicarbonate promotes protein citrullination and inflammation in RA via NBCe2, and IGU can downregulate NBCe2.PMID:38636399 | DOI:10.1016/j.biopha.2024.116551 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tiane Peng Bingtong Li Liqi Bi Fangze Zhang Source Type: research
The incidences of nausea and vomiting after general anesthesia with remimazolam versus sevoflurane: a prospective randomized controlled trial
CONCLUSIONS: Compared to sevoflurane, opting for remimazolam as an intraoperative hypnotic may decrease the incidence of PONV and reduce antiemetic use for 24 h after laparoscopic surgery.PMID:38637272 | DOI:10.4097/kja.23939 (Source: Korean Journal of Anesthesiology)
Source: Korean Journal of Anesthesiology - April 18, 2024 Category: Anesthesiology Authors: Yeong Min Yoo Jae Hong Park Ki Hwa Lee Ah Hyeon Yi Tae Kyun Kim Source Type: research
Iguratimod inhibits protein citrullination and inflammation by downregulating NBCe2 in patients with rheumatoid arthritis
CONCLUSIONS: Bicarbonate promotes protein citrullination and inflammation in RA via NBCe2, and IGU can downregulate NBCe2.PMID:38636399 | DOI:10.1016/j.biopha.2024.116551 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tiane Peng Bingtong Li Liqi Bi Fangze Zhang Source Type: research
Assessing the impact of COVID-19 era drug combinations on hepatic functionality: A thorough investigation in adult Danio rerio
Environ Pollut. 2024 Apr 16;349:123997. doi: 10.1016/j.envpol.2024.123997. Online ahead of print.ABSTRACTCurrent and thorough information on the ecotoxicological consequences of pharmaceuticals is accessible globally. However, there remains a substantial gap in knowledge concerning the potentially toxic effects of COVID-19 used drugs, individually and combined, on aquatic organisms. Given the factors above, our investigation assumes pivotal importance in elucidating whether or not paracetamol, dexamethasone, metformin, and their tertiary mixtures might prompt histological impairment, oxidative stress, and apoptosis in the ...
Source: Environmental Pollution - April 18, 2024 Category: Environmental Health Authors: Diana Belen Onofre-Camarena Gustavo Axel Elizalde-Vel ázquez Leobardo Manuel G ómez-Oliván Sandra Garc ía-Medina Marcela Galar-Mart ínez Jos é Roberto Jerónimo Juárez Selene Elizabeth Herrera-V ázquez Source Type: research
The incidences of nausea and vomiting after general anesthesia with remimazolam versus sevoflurane: a prospective randomized controlled trial
CONCLUSIONS: Compared to sevoflurane, opting for remimazolam as an intraoperative hypnotic may decrease the incidence of PONV and reduce antiemetic use for 24 h after laparoscopic surgery.PMID:38637272 | DOI:10.4097/kja.23939 (Source: Korean Journal of Anesthesiology)
Source: Korean Journal of Anesthesiology - April 18, 2024 Category: Anesthesiology Authors: Yeong Min Yoo Jae Hong Park Ki Hwa Lee Ah Hyeon Yi Tae Kyun Kim Source Type: research
Robotic Biliary Stricturoplasty and Roux-en-Y Hepaticojejunostomy After Hepatic Artery Infusion Pump Injury
CONCLUSIONS: Robotic biliary stricturoplasty with RY hepaticojejunostomy for treatment of biliary sclerosis after HAIP chemotherapy is safe and feasible. Appropriate experience in minimally invasive hepatobiliary surgery is necessary to achieve this goal.PMID:38632219 | DOI:10.1245/s10434-024-15258-0 (Source: Ann Oncol)
Source: Ann Oncol - April 17, 2024 Category: Cancer & Oncology Authors: Emanuel Shapera Sharona Ross Tara Pattilachan Maria Christodoulou Iswanto Sucandy Source Type: research
Effects of < em > Crocus sativus < /em > and its constituent, safranal, and pioglitazone, on systemic inflammation and oxidative stress induced by paraquat aerosol in rats
CONCLUSION: C. sativus and safranal improved inhaled PQ-induced systemic inflammation and oxidative stress similar to those of dexamethasone and showed synergic effects with pioglitazone suggesting the possible PPARγ receptor-mediated effects of the plant and its constituent.PMID:38629099 | PMC:PMC11017852 | DOI:10.22038/IJBMS.2024.72996.15867 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 17, 2024 Category: Information Technology Authors: Arghavan Memarzia Seydeh Zahra Ghasemi Fatemeh Amin Zahra Gholamnezhad Mohammad Hossein Boskabady Source Type: research
Robotic Biliary Stricturoplasty and Roux-en-Y Hepaticojejunostomy After Hepatic Artery Infusion Pump Injury
CONCLUSIONS: Robotic biliary stricturoplasty with RY hepaticojejunostomy for treatment of biliary sclerosis after HAIP chemotherapy is safe and feasible. Appropriate experience in minimally invasive hepatobiliary surgery is necessary to achieve this goal.PMID:38632219 | DOI:10.1245/s10434-024-15258-0 (Source: Ann Oncol)
Source: Ann Oncol - April 17, 2024 Category: Cancer & Oncology Authors: Emanuel Shapera Sharona Ross Tara Pattilachan Maria Christodoulou Iswanto Sucandy Source Type: research
Effects of < em > Crocus sativus < /em > and its constituent, safranal, and pioglitazone, on systemic inflammation and oxidative stress induced by paraquat aerosol in rats
CONCLUSION: C. sativus and safranal improved inhaled PQ-induced systemic inflammation and oxidative stress similar to those of dexamethasone and showed synergic effects with pioglitazone suggesting the possible PPARγ receptor-mediated effects of the plant and its constituent.PMID:38629099 | PMC:PMC11017852 | DOI:10.22038/IJBMS.2024.72996.15867 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 17, 2024 Category: Information Technology Authors: Arghavan Memarzia Seydeh Zahra Ghasemi Fatemeh Amin Zahra Gholamnezhad Mohammad Hossein Boskabady Source Type: research
Effects of < em > Crocus sativus < /em > and its constituent, safranal, and pioglitazone, on systemic inflammation and oxidative stress induced by paraquat aerosol in rats
CONCLUSION: C. sativus and safranal improved inhaled PQ-induced systemic inflammation and oxidative stress similar to those of dexamethasone and showed synergic effects with pioglitazone suggesting the possible PPARγ receptor-mediated effects of the plant and its constituent.PMID:38629099 | PMC:PMC11017852 | DOI:10.22038/IJBMS.2024.72996.15867 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 17, 2024 Category: Information Technology Authors: Arghavan Memarzia Seydeh Zahra Ghasemi Fatemeh Amin Zahra Gholamnezhad Mohammad Hossein Boskabady Source Type: research
