A sericin hydrogel scaffold for sustained dexamethasone release modulates macrophage polarization to promote mandibular bone defect repair in rats
CONCLUSION: The SMH-CD/DEX scaffold capable of sustained dexamethasone release promotes osteogenic differentiation of stem cells and bone defect repair in rats by regulating M2 polarization.PMID:38597445 | PMC:PMC11006699 | DOI:10.12122/j.issn.1673-4254.2024.03.15 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Fan M Luo D Huang L Liu B Fu X Wang M Guan H Li Source Type: research
A sericin hydrogel scaffold for sustained dexamethasone release modulates macrophage polarization to promote mandibular bone defect repair in rats
CONCLUSION: The SMH-CD/DEX scaffold capable of sustained dexamethasone release promotes osteogenic differentiation of stem cells and bone defect repair in rats by regulating M2 polarization.PMID:38597445 | PMC:PMC11006699 | DOI:10.12122/j.issn.1673-4254.2024.03.15 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Fan M Luo D Huang L Liu B Fu X Wang M Guan H Li Source Type: research
GSE260739 Characterization of a new selective glucocorticoid receptor modulator with anorexigenic activity
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity, a worldwide epidemic, leads to various metabolic disorders threatening human health. In response to stress or fasting, glucocorticoid (GC) levels are elevated to promote food intake. This involves GC-induced expression of the orexigenic neuropeptides in agouti-related protein (AgRP) neurons of the hypothalamic arcuate nucleus (ARC) via the GC receptor (GR). Here, we report a selective GR modulator (SGRM) that suppresses GR-induced transcription of genes with non-classical glucocorticoid response elements (GREs) such as Agrp-GRE,...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Enhancing Endogenous Hyaluronic Acid in Osteoarthritic Joints with an Anti ‐Inflammatory Supramolecular Nanofiber Hydrogel Delivering HAS2 Lentivirus
Degradation of the HAS2@DexP-Gel results in the release of the HAS2 lentivirus and DexP molecules. Transfected FLS shows increased endogenous HA production facilitated by the HAS2 lentivirus. Furthermore, DexP molecules inhibit M1 macrophages through modulation of the PI3K/AKT/mTOR/HIF-1 α pathway. Synergistic effects of HAS2@DexP-Gel collectively suppress synovitis and delay cartilage degeneration. AbstractOsteoarthritis (OA) management remains challenging because of its intricate pathogenesis. Intra-articular injections of drugs, such as glucocorticoids and hyaluronic acid (HA), have certain limitations, including the r...
Source: Small - April 9, 2024 Category: Nanotechnology Authors: Feng Zhou,
Muchao Chen,
Yufan Qian,
Kai Yuan,
Xuequan Han,
Weishan Wang,
Jiong Jiong Guo,
Qian Chen,
Bin Li Tags: Research Article Source Type: research
Characterization of brain development with neuroimaging in a female mouse model of chemotherapy treatment of acute lymphoblastic leukemia
CONCLUSIONS: The results demonstrate feasibility of modeling pediatric ALL treatment in a preclinical model and highlight the potential of using preclinical neuroimaging models to gain insight into brain development throughout survivorship.PMID:38590373 | PMC:PMC10998997 | DOI:10.21037/tp-23-458 (Source: Cancer Control)
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Kellen Gandy Timothy R Koscik Tyler Alexander Jeffrey D Steinberg Kevin R Krull Ellen van der Plas Source Type: research
Evaluation of different media compositions promoting hepatocyte differentiation in the canine liver organoid model
Heliyon. 2024 Mar 25;10(7):e28420. doi: 10.1016/j.heliyon.2024.e28420. eCollection 2024 Apr 15.ABSTRACTOrganoids are 3-dimensional (3D) self-assembled structures capable of replicating the microanatomy and physiology of the epithelial components of their organ of origin. Adult stem cell (ASC) derived organoids from the liver have previously been shown to differentiate into primarily mature cholangiocytes, and their partial differentiation into functional hepatocytes can be promoted using specific media compositions. While full morphological differentiation of mature hepatocytes from ASCs has not yet been reported for any s...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Vojtech Gabriel Addison Lincoln Christopher Zdyrski Abigail Ralston Hannah Wickham Sydney Honold Basant H Ahmed Karel Paukner Ryan Feauto Maria M Merodio Pablo Pi ñeyro David Meyerholz Karin Allenspach Jonathan P Mochel Source Type: research
TRIM21 silencing inhibits the apoptosis and expedites the osteogenic differentiation of dexamethasone ‑induced MC3T3‑E1 cells by activating the Keap1/Nrf2 pathway
In conclusion, TRIM21 silencing might activate Keap1/Nrf2 signaling to protect against steroid-induced ONFH.PMID:38590560 | PMC:PMC11000457 | DOI:10.3892/etm.2024.12502 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Jiaqi Shi Li Chen Xu Wang Xin Ma Source Type: research
Evaluation of different media compositions promoting hepatocyte differentiation in the canine liver organoid model
Heliyon. 2024 Mar 25;10(7):e28420. doi: 10.1016/j.heliyon.2024.e28420. eCollection 2024 Apr 15.ABSTRACTOrganoids are 3-dimensional (3D) self-assembled structures capable of replicating the microanatomy and physiology of the epithelial components of their organ of origin. Adult stem cell (ASC) derived organoids from the liver have previously been shown to differentiate into primarily mature cholangiocytes, and their partial differentiation into functional hepatocytes can be promoted using specific media compositions. While full morphological differentiation of mature hepatocytes from ASCs has not yet been reported for any s...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Vojtech Gabriel Addison Lincoln Christopher Zdyrski Abigail Ralston Hannah Wickham Sydney Honold Basant H Ahmed Karel Paukner Ryan Feauto Maria M Merodio Pablo Pi ñeyro David Meyerholz Karin Allenspach Jonathan P Mochel Source Type: research
Safety outcomes and improvement in pain scores after radiologist-performed fluoroscopy-guided interlaminar cervical epidural steroid injection
ConclusionRadiologist-performed fluoroscopy-guided interlaminar cervical ESI at the C7-T1 level is a safe and effective tool in the management of patients with cervical pathology. (Source: Skeletal Radiology)
Source: Skeletal Radiology - April 9, 2024 Category: Radiology Source Type: research
Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures
Leukemia, Published online: 09 April 2024; doi:10.1038/s41375-024-02243-5Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures (Source: Leukemia)
Source: Leukemia - April 9, 2024 Category: Hematology Authors: Saurabh Zanwar Morie A. Gertz Eli Muchtar Francis K. Buadi Taxiarchis Kourelis Wilson Gonsalves Ronald S. Go Suzanne Hayman Prashant Kapoor Moritz Binder Joselle Cook David Dingli Nelson Leung Yi Lin Rahma Warsame Amie Fonder Miriam Hobbs Yi Lisa Hwa Robe Source Type: research
Perioperative Intravenous Dexamethasone Use Is Not Associated with Periprosthetic Joint Infection or Wound Healing Complications Following Shoulder Arthroplasty
Perioperative intravenous (IV) dexamethasone is commonly used in lower extremity total joint arthroplasty to manage postoperative pain and nausea/vomiting, and recent studies have demonstrated that its use may lower rates of acute postoperative medical complications. However, there is limited information regarding the safety and efficacy of IV dexamethasone in patients undergoing total shoulder arthroplasty (TSA). Additionally, there is concern surrounding corticosteroid use prior to surgery as preoperative corticosteroid injections have been associated with adverse outcomes after TSA, including periprosthetic joint infect...
Source: Journal of Shoulder and Elbow Surgery - April 9, 2024 Category: Orthopaedics Authors: Ryan D. Freshman, Jacob L. Kotlier, Cory K. Mayfield, Amir Fathi, Aamir Ahmad, Christian Cruz, Joseph N. Liu, Frank A. Petrigliano Tags: Original Article Source Type: research
Opioid-induced respiratory depression suspected of drug interaction in a prostate cancer patient: a case report
CONCLUSIONS: The cause of respiratory depression in this case was thought to be a combination of factors, including drug interactions between oxycodone and antiemetics, and oxycodone accumulation due to renal dysfunction.PMID:38584476 | DOI:10.21037/apm-23-581 (Source: Pain Physician)
Source: Pain Physician - April 8, 2024 Category: Anesthesiology Authors: Hiroshi Hamada Eisuke Suzuki Mitsufumi Endo Yukiko Mihara Sayaka Iketani Miki Ishida Akime Miyasato Kanako Miyazaki Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Atherosclerosis - April 7, 2024 Category: Cardiology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
