CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
Dexamethasone treatment for COVID-19 is related to increased mortality in hematologic malignancy patients: results from the EPICOVIDEHA Registry
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284678. Online ahead of print.ABSTRACTNot available.PMID:38572549 | DOI:10.3324/haematol.2023.284678 (Source: Haematologica)
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Tommaso Francesco Aiello Jon Salmanton-Garcia Francesco Marchesi Barbora Weinbergerova Andreas Glenthoj Jens Van Praet Francesca Farina Julio Davila-Valls Sonia Martin-Perez Shaimaa El-Ashwah Martin Schonlein Iker Falces-Romero Jorge Labrador Uluhan Sili Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
Cryptobuchanosides A –G: seven previously undescribed triterpene glycosides from Cryptolepis buchananii R.Br. ex Roem. and Schult. with nitric oxide production inhibition activity
In this study, nine triterpene glycosides including seven previously undescribed compounds (1–7), were isolated from leaves ofCryptolepis buchananii R.Br. ex Roem. and Schult. using various chromatographic methods. The chemical structures of the compounds were elucidated to be 3-O- β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyluncargenin C 28-O- α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl ester (1), 3-O- β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosyluncargenin C 28-O- α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl ester (2), 3-O- β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosylu...
Source: Journal of Natural Medicines - April 4, 2024 Category: Drugs & Pharmacology Source Type: research
Drug repurposing for the treatment of patients infected with SARS-CoV-2
AbstractThis paper presents a systematic analysis of the possibility of repurposing commercial drugs through Molecular Docking and Quantitative Structure and Activity Relationship (QSAR) explorations for the treatment of patients infected with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). To do this, we checked the chances of inhibiting the main protease (Mpro) of SARS-CoV-2, the cyclo-oxygenase-2 (COX-2) enzyme, and the spike viral protein by commercial drugs. The molecular structures of the ligands were obtained from the DrugBank database. All ligand molecular structures were previously optimised usin...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - April 4, 2024 Category: Bioinformatics Source Type: research
Lactobacillus gasseri BNR17 Ameliorates Dexamethasone-Induced Muscle Loss in BALB/c Mice and C2C12 Myotubes
Journal of Medicinal Food, Ahead of Print. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - April 4, 2024 Category: Nutrition Authors: Hyeon-Yeong Lee Jongkyu Lee Hyemi Lim Hye-Young Kim Yeon-Su Koo Ji-Su Lim Yoosik Yoon Source Type: research
In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis- à-vis normal garlic
AbstractSnow mountain garlic (SMG) is atrans-Himalayan medicinal plant used in the traditional medicine system for several ailments, including inflammatory arthritis. Research studies are insufficient to validate its folk medicinal applications. In the present study, the comparative abundance of its key bioactive phytocompounds, viz., S-allyl-L-cysteine (SAC), alliin, and S-methyl-L-cysteine (SMC) against normal garlic were assessed using the LC –MS/MS-MRM method. In addition, the study also explored the antioxidant and anti-inflammatory potency of crude extract of SMG and purified signature phytocompounds (i.e., SMC, SA...
Source: Inflammopharmacology - April 2, 2024 Category: Drugs & Pharmacology Source Type: research
Protocol for a randomised controlled trial: optimisation of perioperative analgesia protocol for uniportal video-assisted thoracoscopic surgery
Introduction
Postoperative pain after thoracic surgery impairs patients’ quality of life and increases the incidence of respiratory complications. Optimised analgesia strategies include minimally invasive incisions, regional analgesia and early chest tube removal. However, little is known about the optimal analgesic regimen for uniportal video-assisted thoracoscopic surgery (uVATS).
Methods and analysis
We will conduct a single-centre, prospective, single-blind, randomised trial. The effects of postoperative analgesia will be tested using thoracic paravertebral block (PVB) in combination with patient-controlled intr...
Source: BMJ Open - April 2, 2024 Category: General Medicine Authors: Wang, L. F., Feng, H. X., Shi, Y. H., Li, Y., Zheng, M. T., Bu, T., Zhang, Z. R. Tags: Open access, Anaesthesia Source Type: research
Dexamethasone and Dexmedetomidine: A Synergistic Approach to Reduce Postoperative Nausea and Vomiting in Bariatric Surgery Patients
(Source: Obesity Surgery)
Source: Obesity Surgery - April 2, 2024 Category: Surgery Source Type: research
A real ‐world retrospective–prospective analysis of efficacy and safety of combined ixazomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma: The northern Italy experience
ConclusionIRd might be effective and safe in RRMM pts with an indolent disease, in early lines of treatment, and who proved Len-sensitive, independent of age, and cytogenetic risk. (Source: Cancer Medicine)
Source: Cancer Medicine - April 1, 2024 Category: Cancer & Oncology Authors: Anna Furlan,
Michele Cea,
Laura Pavan,
Monica Galli,
Cristina Clissa,
Silvia Mangiacavalli,
Anna Maria Cafro,
Stefania Girlanda,
Francesca Patriarca,
Claudia Minotto,
Giovanni Bertoldero,
Gregorio Baril à,
Anna Pascarella,
Albana Lico,
Ross Tags: RESEARCH ARTICLE Source Type: research
Effect of CYP2C19 polymorphism on response to bortezomib-based therapy in multiple myeloma patients
CONCLUSIONS: Polymorphism in CYP2C19 enzyme is likely to have an impact on bortezomib treatment response and peripheral neuropathy. The study suggests the role of pharmacogenetics in personalised treatment of MM.PMID:38561047 | DOI:10.1016/j.amjms.2024.03.022 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Lavisha Goel Pooja Gupta Lalit Kumar Thirumurthy Velpandian Archana Singh Kalpana Luthra Yogendra Kumar Gupta Source Type: research
Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation
Eur J Pharmacol. 2024 Mar 30:176525. doi: 10.1016/j.ejphar.2024.176525. Online ahead of print.ABSTRACTDepression is a debilitating mental disease that negatively impacts individuals' lives and society. Novel hypotheses have been recently proposed to improve our understanding of depression pathogenesis. Impaired neuroplasticity and upregulated neuro-inflammation add-on to the disturbance in monoamine neurotransmitters and therefore require novel anti-depressants to target them simultaneously. Recent reports demonstrate the antidepressant effect of the anti-diabetic drug liraglutide. Similarly, the natural flavonoid naringen...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Yara S Abdelkawy Mona Elharoun Eman Sheta Ihab Talat Abdel-Raheem Hisham A Nematalla Source Type: research
Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation
Eur J Pharmacol. 2024 Mar 30:176525. doi: 10.1016/j.ejphar.2024.176525. Online ahead of print.ABSTRACTDepression is a debilitating mental disease that negatively impacts individuals' lives and society. Novel hypotheses have been recently proposed to improve our understanding of depression pathogenesis. Impaired neuroplasticity and upregulated neuro-inflammation add-on to the disturbance in monoamine neurotransmitters and therefore require novel anti-depressants to target them simultaneously. Recent reports demonstrate the antidepressant effect of the anti-diabetic drug liraglutide. Similarly, the natural flavonoid naringen...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Yara S Abdelkawy Mona Elharoun Eman Sheta Ihab Talat Abdel-Raheem Hisham A Nematalla Source Type: research
Effect of CYP2C19 polymorphism on response to bortezomib-based therapy in multiple myeloma patients
CONCLUSIONS: Polymorphism in CYP2C19 enzyme is likely to have an impact on bortezomib treatment response and peripheral neuropathy. The study suggests the role of pharmacogenetics in personalised treatment of MM.PMID:38561047 | DOI:10.1016/j.amjms.2024.03.022 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Lavisha Goel Pooja Gupta Lalit Kumar Thirumurthy Velpandian Archana Singh Kalpana Luthra Yogendra Kumar Gupta Source Type: research
Effect of CYP2C19 polymorphism on response to bortezomib-based therapy in multiple myeloma patients
CONCLUSIONS: Polymorphism in CYP2C19 enzyme is likely to have an impact on bortezomib treatment response and peripheral neuropathy. The study suggests the role of pharmacogenetics in personalised treatment of MM.PMID:38561047 | DOI:10.1016/j.amjms.2024.03.022 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Lavisha Goel Pooja Gupta Lalit Kumar Thirumurthy Velpandian Archana Singh Kalpana Luthra Yogendra Kumar Gupta Source Type: research
