Uterine infusion strategies for infertile patients with recurrent implantation failure: a systematic review and network meta-analysis
CONCLUSIONS: Intrauterine infusion of HCG, PBMC, G-CSF, and PRP are promising strategies for improving pregnancy outcomes for infertile patients with recurrent implantation failure. Among these treatments, PRP may be the best. More researches are required to explore the effect of drug combinations and less commonly used drugs as well.TRIAL REGISTRATION: Our study was registered in PROSPERO and the ID was CRD42023467188.PMID:38627790 | DOI:10.1186/s12958-024-01221-x (Source: Reproductive Biology)
Source: Reproductive Biology - April 16, 2024 Category: Reproduction Medicine Authors: Qin Xie Xiaozhen Quan Yanli Lan Xuezhou Yang Source Type: research
Risk Factors Associated with Thromboembolic Complications After total Hip Arthroplasty: An Analysis of 1,129 Pulmonary Emboli
This study aimed to identify risk factors of developing pulmonary embolism (PE) and deep vein thrombosis (DVT) after THA using a modern cohort of patients reflecting contemporary practices.METHODS: The Premier Healthcare Database was queried for primary, elective THAs from January 1st, 2015, to December 31st, 2021. Patients who developed PE or DVT within 90 days of THA were compared with patients who did not develop any postoperative VTE. Differences in patient demographics, comorbidities, hospital factors, perioperative medications, chemoprophylactic agents, and allogeneic blood transfusion were compared between cohorts. ...
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 16, 2024 Category: Orthopaedics Authors: Kevin C Liu Neelesh Bagrodia Mary K Richardson Amit S Piple Nicholas Kusnezov Jennifer C Wang Jay R Lieberman Nathanael D Heckmann Source Type: research
The potentiating effect of intravenous dexamethasone upon preemptive pudendal block analgesia for hypospadias surgery in children managed with Snodgrass technique: a randomized controlled study
The objective of the current study was to investigate the potentiating effect o... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - April 16, 2024 Category: Anesthesiology Authors: Sonia Ben Khalifa, Ahmed Ben Slimene, Hajer Blaiti, Refka Kaddour, Amjed Fekih Hassen, Pierre Pardessus, Christopher Brasher and Souhayl Dahmani Tags: Research Source Type: research
Evaluation of chemotherapy-induced nausea and vomiting in pediatric patients with high-grade glioma treated with lomustine —a case series
ConclusionIn this case series, we identified lomustine as a highly emetogenic chemotherapeutic agent. According to the current guidelines, CINV prophylaxis with a 5-HT3 receptor antagonist in combination with dexamethasone and (fos)aprepitant is recommended. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 16, 2024 Category: Cancer & Oncology Source Type: research
Infectious Diseases: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0679. Online ahead of print.ABSTRACTIn 2023, published research on COVID-19 remains prominent. The aim of this article is to highlight important developments in infectious disease evidence unrelated to COVID-19 that were published in 2023. The literature was screened for sound new evidence relevant to internal medicine specialists and subspecialists whose focus of practice is not infectious diseases. The highlighted publications relate to various organisms and patient populations. One article provides insight into the updated guidelines for the diagnosis and management of infec...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Amena Alhammadi Rasha Alshawaf Swati Chavda Sonya Ramondino Mindy Schuster Source Type: research
Cystoid macular edema occurring after intracameral bimatoprost implantation
CONCLUSION: The use of bimatoprost implant may lead to the occurrence of CME. Ophthalmologists must vigilantly monitor patients post-implantation, especially if they exhibit visual symptoms or have risk factors for a CME.PMID:38619930 | DOI:10.1177/11206721241247588 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 15, 2024 Category: Opthalmology Authors: Emmanuel Bettach Rony Wiener Koby Brosh David Zadok Mordechai Goldberg Source Type: research
Infectious Diseases: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0679. Online ahead of print.ABSTRACTIn 2023, published research on COVID-19 remains prominent. The aim of this article is to highlight important developments in infectious disease evidence unrelated to COVID-19 that were published in 2023. The literature was screened for sound new evidence relevant to internal medicine specialists and subspecialists whose focus of practice is not infectious diseases. The highlighted publications relate to various organisms and patient populations. One article provides insight into the updated guidelines for the diagnosis and management of infec...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Amena Alhammadi Rasha Alshawaf Swati Chavda Sonya Ramondino Mindy Schuster Source Type: research
Infectious Diseases: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0679. Online ahead of print.ABSTRACTIn 2023, published research on COVID-19 remains prominent. The aim of this article is to highlight important developments in infectious disease evidence unrelated to COVID-19 that were published in 2023. The literature was screened for sound new evidence relevant to internal medicine specialists and subspecialists whose focus of practice is not infectious diseases. The highlighted publications relate to various organisms and patient populations. One article provides insight into the updated guidelines for the diagnosis and management of infec...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Amena Alhammadi Rasha Alshawaf Swati Chavda Sonya Ramondino Mindy Schuster Source Type: research
Infectious Diseases: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0679. Online ahead of print.ABSTRACTIn 2023, published research on COVID-19 remains prominent. The aim of this article is to highlight important developments in infectious disease evidence unrelated to COVID-19 that were published in 2023. The literature was screened for sound new evidence relevant to internal medicine specialists and subspecialists whose focus of practice is not infectious diseases. The highlighted publications relate to various organisms and patient populations. One article provides insight into the updated guidelines for the diagnosis and management of infec...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Amena Alhammadi Rasha Alshawaf Swati Chavda Sonya Ramondino Mindy Schuster Source Type: research
Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis
This study aimed to identify drivers of PGE2 and its role in the inadvertent MSC misdifferentiation into hypertrophic chondrocytes. PGE2 release, which rose in the first three weeks of MSC chondrogenesis, was jointly stimulated by endogenous BMP, WNT, and hedgehog activity that supported the exogenous stimulation by TGF-β1 and insulin to overcome the PGE2 inhibition by dexamethasone. Experiments with PGE2 treatment or the inhibitor celecoxib or specific receptor antagonists demonstrated that PGE2, although driven by prohypertrophic signals, exerted broad autocrine antihypertrophic effects. This chondroprotective effect ma...
Source: European Journal of Cell Biology - April 12, 2024 Category: Cytology Authors: Sven Schmidt Felicia A M Klampfleuthner Tobias Renkawitz Solvig Diederichs Source Type: research
Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis
This study aimed to identify drivers of PGE2 and its role in the inadvertent MSC misdifferentiation into hypertrophic chondrocytes. PGE2 release, which rose in the first three weeks of MSC chondrogenesis, was jointly stimulated by endogenous BMP, WNT, and hedgehog activity that supported the exogenous stimulation by TGF-β1 and insulin to overcome the PGE2 inhibition by dexamethasone. Experiments with PGE2 treatment or the inhibitor celecoxib or specific receptor antagonists demonstrated that PGE2, although driven by prohypertrophic signals, exerted broad autocrine antihypertrophic effects. This chondroprotective effect ma...
Source: European Journal of Cell Biology - April 12, 2024 Category: Cytology Authors: Sven Schmidt Felicia A M Klampfleuthner Tobias Renkawitz Solvig Diederichs Source Type: research
Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis
This study aimed to identify drivers of PGE2 and its role in the inadvertent MSC misdifferentiation into hypertrophic chondrocytes. PGE2 release, which rose in the first three weeks of MSC chondrogenesis, was jointly stimulated by endogenous BMP, WNT, and hedgehog activity that supported the exogenous stimulation by TGF-β1 and insulin to overcome the PGE2 inhibition by dexamethasone. Experiments with PGE2 treatment or the inhibitor celecoxib or specific receptor antagonists demonstrated that PGE2, although driven by prohypertrophic signals, exerted broad autocrine antihypertrophic effects. This chondroprotective effect ma...
Source: European Journal of Cell Biology - April 12, 2024 Category: Cytology Authors: Sven Schmidt Felicia A M Klampfleuthner Tobias Renkawitz Solvig Diederichs Source Type: research
Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis
This study aimed to identify drivers of PGE2 and its role in the inadvertent MSC misdifferentiation into hypertrophic chondrocytes. PGE2 release, which rose in the first three weeks of MSC chondrogenesis, was jointly stimulated by endogenous BMP, WNT, and hedgehog activity that supported the exogenous stimulation by TGF-β1 and insulin to overcome the PGE2 inhibition by dexamethasone. Experiments with PGE2 treatment or the inhibitor celecoxib or specific receptor antagonists demonstrated that PGE2, although driven by prohypertrophic signals, exerted broad autocrine antihypertrophic effects. This chondroprotective effect ma...
Source: European Journal of Cell Biology - April 12, 2024 Category: Cytology Authors: Sven Schmidt Felicia A M Klampfleuthner Tobias Renkawitz Solvig Diederichs Source Type: research
