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Honokiol induces apoptosis and autophagy in dexamethasone-resistant T-acute lymphoblastic leukemia CEM-C1 cells
Conclusion: The combination of honokiol and DEX were better than DEX alone in DEX-resistant CEM-C1 cell lines. Honokiol may regulate T-ALL-related dexamethasone resistance by affecting c-Myc.PMID:38573223 | DOI:10.1080/16078454.2024.2337307 (Source: Hematology)
Source: Hematology - April 4, 2024 Category: Hematology Authors: Yang Liu Suqian Zhang Yajuan Tan Source Type: research

Dexamethasone treatment for COVID-19 is related to increased mortality in hematologic malignancy patients: results from the EPICOVIDEHA Registry
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284678. Online ahead of print.ABSTRACTNot available.PMID:38572549 | DOI:10.3324/haematol.2023.284678 (Source: Haematologica)
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Tommaso Francesco Aiello Jon Salmanton-Garcia Francesco Marchesi Barbora Weinbergerova Andreas Glenthoj Jens Van Praet Francesca Farina Julio Davila-Valls Sonia Martin-Perez Shaimaa El-Ashwah Martin Schonlein Iker Falces-Romero Jorge Labrador Uluhan Sili Source Type: research

CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research

Equisetum arvense standardized dried extract hinders age-related osteosarcopenia
Biomed Pharmacother. 2024 Apr 3;174:116517. doi: 10.1016/j.biopha.2024.116517. Online ahead of print.ABSTRACTAge-associated osteosarcopenia is an unresolved syndrome characterized by the concomitant loss of bone (osteopenia) and skeletal muscle (sarcopenia) tissues increasing falls, immobility, morbidity, and mortality. Unbalanced resorption of bone in the remodeling process and excessive protein breakdown, especially fast type II myosin heavy chain (MyHC-II) isoform and myofiber metabolic shift, are the leading causes of bone and muscle deterioration in the elderly, respectively. Equisetum arvense (EQ) is a plant traditio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 4, 2024 Category: Drugs & Pharmacology Authors: Laura Salvadori Martina Paiella Beatrice Castiglioni Maria Laura Belladonna Tommaso Manenti Catia Ercolani Luca Cornioli Nausicaa Clemente Andrea Scircoli Roccaldo Sardella Leonardo Tensi Andrea Astolfi Maria Letizia Barreca Sara Chiappalupi Giulia Gentil Source Type: research