Clonal evolution of leukemia from G6PD studies
Haematologica. 2023 Dec 1;108(12):3191-3192. doi: 10.3324/haematol.2023.284215.NO ABSTRACTPMID:38037797 | PMC:PMC10690888 | DOI:10.3324/haematol.2023.284215 (Source: Haematologica)
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Tal Bacharach Liran I Shlush Source Type: research
Introduction to the peripheral T-cell lymphoma review series: advances in molecular characterization, classification refinement and treatment optimization
Haematologica. 2023 Dec 1;108(12):3204-3210. doi: 10.3324/haematol.2023.282719.NO ABSTRACTPMID:38037798 | PMC:PMC10690918 | DOI:10.3324/haematol.2023.282719 (Source: Haematologica)
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Kerry J Savage Laurence De Leval Source Type: research
Past, present and future therapeutic approaches in nodal peripheral T-cell lymphomas
Haematologica. 2023 Dec 1;108(12):3211-3226. doi: 10.3324/haematol.2021.280275.ABSTRACTPeripheral T-cell lymphomas (PTCL) encompass over 30 different entities and although they share post-thymic T- or NK-cell derivation, the disease biology and genomic landscape are very diverse across subtypes. In Western populations, nodal PTCL are the most frequently encountered entities in clinical practice and although important achievements have been made in deciphering the underlying biology and in therapeutic advances, there are still large gaps in disease understanding and clinical scenarios in which controversy over best practice...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Henry S Ngu Kerry J Savage Source Type: research
Pathobiology of nodal peripheral T-cell lymphomas: current understanding and future directions
Haematologica. 2023 Dec 1;108(12):3227-3243. doi: 10.3324/haematol.2023.282716.ABSTRACTPredominantly nodal is the most common clinical presentation of peripheral T- (and NK-) cell lymphomas (PTCL), which comprise three main groups of diseases: (i) systemic anaplastic large cell lymphomas (ALCL), whether positive or negative for anaplastic lymphoma kinase (ALK); (ii) follicular helper T-cell lymphomas (TFHL); and (iii) PTCL, not otherwise specified (NOS). Recent advances in the genomic and molecular characterization of PTCL, with enhanced understanding of pathobiology, have translated into significant updates in the latest ...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Bettina Bisig Kerry J Savage Laurence De Leval Source Type: research
Few and far between: clinical management of rare extranodal subtypes of mature T-cell and NK-cell lymphomas
Haematologica. 2023 Dec 1;108(12):3244-3260. doi: 10.3324/haematol.2023.282717.ABSTRACTWhile all peripheral T-cell lymphomas are uncommon, certain subtypes are truly rare, with less than a few hundred cases per year in the USA. There are often no dedicated clinical trials in these rare subtypes, and data are generally limited to case reports and retrospective case series. Therefore, clinical management is often based on this limited literature and extrapolation of data from the more common, nodal T-cell lymphomas in conjunction with personal experience. Nevertheless, thanks to tremendous pre-clinical efforts to understand ...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Robert Stuver Zachary D Epstein-Peterson Steven M Horwitz Source Type: research
Biology and genetics of extranodal mature T-cell and NKcell lymphomas and lymphoproliferative disorders
Haematologica. 2023 Dec 1;108(12):3261-3277. doi: 10.3324/haematol.2023.282718.ABSTRACTThe extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders represent a unique group of rare neoplasms with both overlapping and distinct clinicopathological, biological, and genomic features. Their predilection for specific sites, such as the gastrointestinal tract, aerodigestive tract, liver, spleen, and skin/soft tissues, underlies their classification. Recent genomic advances have furthered our understanding of the biology and pathogenesis of these diseases, which is critical for accurate diagnosis, prognosti...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Natasha E Lewis Ting Zhou Ahmet Dogan Source Type: research
Clonal evolution of leukemia from G6PD studies
Haematologica. 2023 Dec 1;108(12):3191-3192. doi: 10.3324/haematol.2023.284215.NO ABSTRACTPMID:38037797 | PMC:PMC10690888 | DOI:10.3324/haematol.2023.284215 (Source: Haematologica)
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Tal Bacharach Liran I Shlush Source Type: research
Introduction to the peripheral T-cell lymphoma review series: advances in molecular characterization, classification refinement and treatment optimization
Haematologica. 2023 Dec 1;108(12):3204-3210. doi: 10.3324/haematol.2023.282719.NO ABSTRACTPMID:38037798 | PMC:PMC10690918 | DOI:10.3324/haematol.2023.282719 (Source: Haematologica)
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Kerry J Savage Laurence De Leval Source Type: research
Past, present and future therapeutic approaches in nodal peripheral T-cell lymphomas
Haematologica. 2023 Dec 1;108(12):3211-3226. doi: 10.3324/haematol.2021.280275.ABSTRACTPeripheral T-cell lymphomas (PTCL) encompass over 30 different entities and although they share post-thymic T- or NK-cell derivation, the disease biology and genomic landscape are very diverse across subtypes. In Western populations, nodal PTCL are the most frequently encountered entities in clinical practice and although important achievements have been made in deciphering the underlying biology and in therapeutic advances, there are still large gaps in disease understanding and clinical scenarios in which controversy over best practice...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Henry S Ngu Kerry J Savage Source Type: research
Pathobiology of nodal peripheral T-cell lymphomas: current understanding and future directions
Haematologica. 2023 Dec 1;108(12):3227-3243. doi: 10.3324/haematol.2023.282716.ABSTRACTPredominantly nodal is the most common clinical presentation of peripheral T- (and NK-) cell lymphomas (PTCL), which comprise three main groups of diseases: (i) systemic anaplastic large cell lymphomas (ALCL), whether positive or negative for anaplastic lymphoma kinase (ALK); (ii) follicular helper T-cell lymphomas (TFHL); and (iii) PTCL, not otherwise specified (NOS). Recent advances in the genomic and molecular characterization of PTCL, with enhanced understanding of pathobiology, have translated into significant updates in the latest ...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Bettina Bisig Kerry J Savage Laurence De Leval Source Type: research
Few and far between: clinical management of rare extranodal subtypes of mature T-cell and NK-cell lymphomas
Haematologica. 2023 Dec 1;108(12):3244-3260. doi: 10.3324/haematol.2023.282717.ABSTRACTWhile all peripheral T-cell lymphomas are uncommon, certain subtypes are truly rare, with less than a few hundred cases per year in the USA. There are often no dedicated clinical trials in these rare subtypes, and data are generally limited to case reports and retrospective case series. Therefore, clinical management is often based on this limited literature and extrapolation of data from the more common, nodal T-cell lymphomas in conjunction with personal experience. Nevertheless, thanks to tremendous pre-clinical efforts to understand ...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Robert Stuver Zachary D Epstein-Peterson Steven M Horwitz Source Type: research
Biology and genetics of extranodal mature T-cell and NKcell lymphomas and lymphoproliferative disorders
Haematologica. 2023 Dec 1;108(12):3261-3277. doi: 10.3324/haematol.2023.282718.ABSTRACTThe extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders represent a unique group of rare neoplasms with both overlapping and distinct clinicopathological, biological, and genomic features. Their predilection for specific sites, such as the gastrointestinal tract, aerodigestive tract, liver, spleen, and skin/soft tissues, underlies their classification. Recent genomic advances have furthered our understanding of the biology and pathogenesis of these diseases, which is critical for accurate diagnosis, prognosti...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Natasha E Lewis Ting Zhou Ahmet Dogan Source Type: research
Clonal evolution of leukemia from G6PD studies
Haematologica. 2023 Dec 1;108(12):3191-3192. doi: 10.3324/haematol.2023.284215.NO ABSTRACTPMID:38037797 | DOI:10.3324/haematol.2023.284215 (Source: Haematologica)
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Tal Bacharach Liran I Shlush Source Type: research
Introduction to the peripheral T-cell lymphoma review series: advances in molecular characterization, classification refinement and treatment optimization
Haematologica. 2023 Dec 1;108(12):3204-3210. doi: 10.3324/haematol.2023.282719.NO ABSTRACTPMID:38037798 | DOI:10.3324/haematol.2023.282719 (Source: Haematologica)
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Kerry J Savage Laurence De Leval Source Type: research
Past, present and future therapeutic approaches in nodal peripheral T-cell lymphomas
Haematologica. 2023 Dec 1;108(12):3211-3226. doi: 10.3324/haematol.2021.280275.ABSTRACTPeripheral T-cell lymphomas (PTCL) encompass over 30 different entities and although they share post-thymic T- or NK-cell derivation, the disease biology and genomic landscape are very diverse across subtypes. In Western populations, nodal PTCL are the most frequently encountered entities in clinical practice and although important achievements have been made in deciphering the underlying biology and in therapeutic advances, there are still large gaps in disease understanding and clinical scenarios in which controversy over best practice...
Source: Haematologica - December 1, 2023 Category: Hematology Authors: Henry S Ngu Kerry J Savage Source Type: research
