A phase I study of the fully human, fragment crystallizable-engineered, anti-CD-33 monoclonal antibody BI 836858 in patients with previously-treated acute myeloid leukemia
Haematologica. 2021 Dec 2. doi: 10.3324/haematol.2020.274118. Online ahead of print.ABSTRACTNot available.PMID:34854276 | DOI:10.3324/haematol.2020.274118 (Source: Haematologica)
Source: Haematologica - December 2, 2021 Category: Hematology Authors: Sumithira Vasu Jessica K Altman Geoffrey L Uy Martin S Tallman Ivana Gojo Gerard Lozanski Ute Burkard Annika Osswald Pamela James Bj örn Rüter William Blum Source Type: research

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements
Haematologica. 2021 Dec 2. doi: 10.3324/haematol.2021.276048. Online ahead of print.ABSTRACTAberrant expression of Ecotropic Viral Integration Site 1 (EVI1) is a hallmark of acute myeloid leukemia (AML) with inv(3) or t(3;3), which is a disease subtype with especially poor outcome. In studying transcriptomes from AML patients with chromosome 3q rearrangements, we identified a significant upregulation of the Nuclear Receptor Interacting Protein 1 (NRIP1) as well as its adjacent non-coding RNA LOC101927745. Utilizing transcriptomic and epigenomic data from over 900 primary patient samples as well as genetic and transcription...
Source: Haematologica - December 2, 2021 Category: Hematology Authors: Sarah Grasedieck Ariene Cabantog Liam MacPhee Junbum Im Christoph Ruess Burcu Demir Nadine Sperb Frank G R ücker Konstanze D öhner Tobias Herold Jonathan R Pollack Lars Bullinger Arefeh Rouhi Florian Kuchenbauer Source Type: research

Biallelic CXCR2 loss-of-function mutations define a distinct congenital neutropenia entity
Haematologica. 2021 Dec 2. doi: 10.3324/haematol.2021.279254. Online ahead of print.ABSTRACTNot available.PMID:34854278 | DOI:10.3324/haematol.2021.279254 (Source: Haematologica)
Source: Haematologica - December 2, 2021 Category: Hematology Authors: Viviana Marin-Esteban Jenny Youn Blandine Beaupain Agnieszka Jaracz-Ros Vincent Barlogis Odile Fenneteau Thierry Leblanc Florence Bellanger Philippe Pellet Julien Buratti H élène Lapillonne Fran çoise Bachelerie Jean Donadieu Christine Bellann é-Chant Source Type: research

Guideline for management of non-Down syndrome neonates with a myeloproliferative disease on behalf of the I-BFM AML Study Group and EWOG-MDS
Haematologica. 2021 Dec 2. doi: 10.3324/haematol.2021.279507. Online ahead of print.ABSTRACTNot available.PMID:34854279 | DOI:10.3324/haematol.2021.279507 (Source: Haematologica)
Source: Haematologica - December 2, 2021 Category: Hematology Authors: Eline J M Bertrums C Michel Zwaan Daisuke Hasegawa Valerie De Haas Dirk N Reinhardt Franco Locatelli Barbara De Moerloose Michael Dworzak Arjan Buijs Petr Smisek Alexandra Kolenova Cornelis Jan Pronk Jan-Henning Klusmann Ana Carbon é Alina Ferster Evange Source Type: research

Dissociated humoral and cellular immune responses after a three-dose schema of BNT162b2 vaccine in patients receiving anti-CD20 monoclonal antibody maintenance treatment for B-cell lymphomas
Haematologica. 2021 Dec 2. doi: 10.3324/haematol.2021.280139. Online ahead of print.ABSTRACTNot available.PMID:34854280 | DOI:10.3324/haematol.2021.280139 (Source: Haematologica)
Source: Haematologica - December 2, 2021 Category: Hematology Authors: Sophie Candon Veronique Lemee Emilie Leveque Pascaline Etancelin Cedric Paquin Marion Carette Nathalie Contentin Victor Bobee Mustafa Alani Nathalie Cardinael Stephane Lepretre Vincent Camus Florian Bouclet Edwige Boulet Anne-Lise Menard Helene Lanic Aspa Source Type: research

Images from the Haematologica Atlas of Hematologic Cytology: hemophagocytic syndrome
Haematologica. 2021 Dec 1;106(12):3029. doi: 10.3324/haematol.2021.279797.NO ABSTRACTPMID:34847658 | DOI:10.3324/haematol.2021.279797 (Source: Haematologica)
Source: Haematologica - December 1, 2021 Category: Hematology Authors: Rosangela Invernizzi Source Type: research

Predicting risk of progression in relapsed multiple myeloma using traditional risk models, focal lesion assessment with PET-CT and minimal residual disease status
Haematologica. 2021 Dec 1;106(12):3215-3218. doi: 10.3324/haematol.2021.278779.NO ABSTRACTPMID:34847659 | DOI:10.3324/haematol.2021.278779 (Source: Haematologica)
Source: Haematologica - December 1, 2021 Category: Hematology Authors: David Baker Milan Bimali Luis Carrillo Archana Sachedina Daisy Alapat Md Shadiqul Hoque Mathew Kottarathara Richa Parikh Amani Erra Angel A Mitma Pankaj Mathur Yetunde Ogunsesan Lakshmi Yarlagadda Sravani Gundarlapalli Sharmilan Thanendrarajan Maurizio Za Source Type: research

Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels
Haematologica. 2021 Dec 1;106(12):3249-3252. doi: 10.3324/haematol.2021.279509.NO ABSTRACTPMID:34847660 | DOI:10.3324/haematol.2021.279509 (Source: Haematologica)
Source: Haematologica - December 1, 2021 Category: Hematology Authors: Jonathan Douxfils Caroline Vayne Claire Pouplard Thomas Lecompte Julien Favresse Florence Potier Emy Gasser Val érie Mathieux Jean-Michel Dogn é Yves Gruel J érôme Rollin Fran çois Mullier Source Type: research

Images from the Haematologica Atlas of Hematologic Cytology: hemophagocytic syndrome
Haematologica. 2021 Dec 1;106(12):3029. doi: 10.3324/haematol.2021.279797.NO ABSTRACTPMID:34847658 | DOI:10.3324/haematol.2021.279797 (Source: Haematologica)
Source: Haematologica - December 1, 2021 Category: Hematology Authors: Rosangela Invernizzi Source Type: research

Predicting risk of progression in relapsed multiple myeloma using traditional risk models, focal lesion assessment with PET-CT and minimal residual disease status
Haematologica. 2021 Dec 1;106(12):3215-3218. doi: 10.3324/haematol.2021.278779.NO ABSTRACTPMID:34847659 | DOI:10.3324/haematol.2021.278779 (Source: Haematologica)
Source: Haematologica - December 1, 2021 Category: Hematology Authors: David Baker Milan Bimali Luis Carrillo Archana Sachedina Daisy Alapat Md Shadiqul Hoque Mathew Kottarathara Richa Parikh Amani Erra Angel A Mitma Pankaj Mathur Yetunde Ogunsesan Lakshmi Yarlagadda Sravani Gundarlapalli Sharmilan Thanendrarajan Maurizio Za Source Type: research

Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels
Haematologica. 2021 Dec 1;106(12):3249-3252. doi: 10.3324/haematol.2021.279509.NO ABSTRACTPMID:34847660 | DOI:10.3324/haematol.2021.279509 (Source: Haematologica)
Source: Haematologica - December 1, 2021 Category: Hematology Authors: Jonathan Douxfils Caroline Vayne Claire Pouplard Thomas Lecompte Julien Favresse Florence Potier Emy Gasser Val érie Mathieux Jean-Michel Dogn é Yves Gruel J érôme Rollin Fran çois Mullier Source Type: research

m < sup > 6 < /sup > A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279300. Online ahead of print.ABSTRACTNot available.PMID:34818872 | DOI:10.3324/haematol.2021.279300 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Qinglin Dang Qiong Wu Fang Yu Yue Sheng Chunjie Yu Guangzhong Song Kimberly Paulsen Jianxin Lyu Zhijian Qian Source Type: research

The von Willebrand Factor A-1 domain binding aptamer BT200 elevates plasma levels of VWF and Factor VIII: a first-in-human trial
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279948. Online ahead of print.ABSTRACTVon Willebrand Factor (VWF) and Factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary haemostasis and clotting respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and a long half-life in non-human primates. This first-in-human, randomised, placebo-controlled, double-blind trial tested the hypothesis that BT200 is well tolerated and has favourable pharmacokinetic and pharmacodynamic effects in 112 volunteers. Participants received one of the following...
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Katarina D Kovacevic J ürgen Grafeneder Christian Sch örgenhofer Georg Gelbenegger Gloria Gager Christa Firbas Peter Quehenberger Petra Jilma-Stohlawetz Andrea Bileck Shuhao Zhu James C Gilbert Martin Beliveau Bernd Jilma Ulla Derhaschnig Source Type: research

Decoding m < sup > 6 < /sup > A, one reader at a time
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280166. Online ahead of print.ABSTRACTNot available.PMID:34818874 | DOI:10.3324/haematol.2021.280166 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Hanzhi Luo Michael G Kharas Source Type: research

How to keep the FVIII/VWF complex in the circulation
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280222. Online ahead of print.ABSTRACTNot available.PMID:34818875 | DOI:10.3324/haematol.2021.280222 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: C écile V Denis Peter J Lenting Source Type: research

m < sup > 6 < /sup > A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279300. Online ahead of print.ABSTRACTNot available.PMID:34818872 | DOI:10.3324/haematol.2021.279300 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Qinglin Dang Qiong Wu Fang Yu Yue Sheng Chunjie Yu Guangzhong Song Kimberly Paulsen Jianxin Lyu Zhijian Qian Source Type: research

The von Willebrand Factor A-1 domain binding aptamer BT200 elevates plasma levels of VWF and Factor VIII: a first-in-human trial
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279948. Online ahead of print.ABSTRACTVon Willebrand Factor (VWF) and Factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary haemostasis and clotting respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and a long half-life in non-human primates. This first-in-human, randomised, placebo-controlled, double-blind trial tested the hypothesis that BT200 is well tolerated and has favourable pharmacokinetic and pharmacodynamic effects in 112 volunteers. Participants received one of the following...
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Katarina D Kovacevic J ürgen Grafeneder Christian Sch örgenhofer Georg Gelbenegger Gloria Gager Christa Firbas Peter Quehenberger Petra Jilma-Stohlawetz Andrea Bileck Shuhao Zhu James C Gilbert Martin Beliveau Bernd Jilma Ulla Derhaschnig Source Type: research

Decoding m < sup > 6 < /sup > A, one reader at a time
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280166. Online ahead of print.ABSTRACTNot available.PMID:34818874 | DOI:10.3324/haematol.2021.280166 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Hanzhi Luo Michael G Kharas Source Type: research

How to keep the FVIII/VWF complex in the circulation
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280222. Online ahead of print.ABSTRACTNot available.PMID:34818875 | DOI:10.3324/haematol.2021.280222 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: C écile V Denis Peter J Lenting Source Type: research

m < sup > 6 < /sup > A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279300. Online ahead of print.ABSTRACTNot available.PMID:34818872 | DOI:10.3324/haematol.2021.279300 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Qinglin Dang Qiong Wu Fang Yu Yue Sheng Chunjie Yu Guangzhong Song Kimberly Paulsen Jianxin Lyu Zhijian Qian Source Type: research

The von Willebrand Factor A-1 domain binding aptamer BT200 elevates plasma levels of VWF and Factor VIII: a first-in-human trial
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279948. Online ahead of print.ABSTRACTVon Willebrand Factor (VWF) and Factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary haemostasis and clotting respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and a long half-life in non-human primates. This first-in-human, randomised, placebo-controlled, double-blind trial tested the hypothesis that BT200 is well tolerated and has favourable pharmacokinetic and pharmacodynamic effects in 112 volunteers. Participants received one of the following...
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Katarina D Kovacevic J ürgen Grafeneder Christian Sch örgenhofer Georg Gelbenegger Gloria Gager Christa Firbas Peter Quehenberger Petra Jilma-Stohlawetz Andrea Bileck Shuhao Zhu James C Gilbert Martin Beliveau Bernd Jilma Ulla Derhaschnig Source Type: research

Decoding m < sup > 6 < /sup > A, one reader at a time
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280166. Online ahead of print.ABSTRACTNot available.PMID:34818874 | DOI:10.3324/haematol.2021.280166 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Hanzhi Luo Michael G Kharas Source Type: research

How to keep the FVIII/VWF complex in the circulation
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280222. Online ahead of print.ABSTRACTNot available.PMID:34818875 | DOI:10.3324/haematol.2021.280222 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: C écile V Denis Peter J Lenting Source Type: research

m < sup > 6 < /sup > A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279300. Online ahead of print.ABSTRACTNot available.PMID:34818872 | DOI:10.3324/haematol.2021.279300 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Qinglin Dang Qiong Wu Fang Yu Yue Sheng Chunjie Yu Guangzhong Song Kimberly Paulsen Jianxin Lyu Zhijian Qian Source Type: research

The von Willebrand Factor A-1 domain binding aptamer BT200 elevates plasma levels of VWF and Factor VIII: a first-in-human trial
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279948. Online ahead of print.ABSTRACTVon Willebrand Factor (VWF) and Factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary haemostasis and clotting respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and a long half-life in non-human primates. This first-in-human, randomised, placebo-controlled, double-blind trial tested the hypothesis that BT200 is well tolerated and has favourable pharmacokinetic and pharmacodynamic effects in 112 volunteers. Participants received one of the following...
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Katarina D Kovacevic J ürgen Grafeneder Christian Sch örgenhofer Georg Gelbenegger Gloria Gager Christa Firbas Peter Quehenberger Petra Jilma-Stohlawetz Andrea Bileck Shuhao Zhu James C Gilbert Martin Beliveau Bernd Jilma Ulla Derhaschnig Source Type: research

Decoding m < sup > 6 < /sup > A, one reader at a time
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280166. Online ahead of print.ABSTRACTNot available.PMID:34818874 | DOI:10.3324/haematol.2021.280166 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Hanzhi Luo Michael G Kharas Source Type: research

How to keep the FVIII/VWF complex in the circulation
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280222. Online ahead of print.ABSTRACTNot available.PMID:34818875 | DOI:10.3324/haematol.2021.280222 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: C écile V Denis Peter J Lenting Source Type: research

m < sup > 6 < /sup > A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279300. Online ahead of print.ABSTRACTNot available.PMID:34818872 | DOI:10.3324/haematol.2021.279300 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Qinglin Dang Qiong Wu Fang Yu Yue Sheng Chunjie Yu Guangzhong Song Kimberly Paulsen Jianxin Lyu Zhijian Qian Source Type: research

The von Willebrand Factor A-1 domain binding aptamer BT200 elevates plasma levels of VWF and Factor VIII: a first-in-human trial
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.279948. Online ahead of print.ABSTRACTVon Willebrand Factor (VWF) and Factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary haemostasis and clotting respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and a long half-life in non-human primates. This first-in-human, randomised, placebo-controlled, double-blind trial tested the hypothesis that BT200 is well tolerated and has favourable pharmacokinetic and pharmacodynamic effects in 112 volunteers. Participants received one of the following...
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Katarina D Kovacevic J ürgen Grafeneder Christian Sch örgenhofer Georg Gelbenegger Gloria Gager Christa Firbas Peter Quehenberger Petra Jilma-Stohlawetz Andrea Bileck Shuhao Zhu James C Gilbert Martin Beliveau Bernd Jilma Ulla Derhaschnig Source Type: research

Decoding m < sup > 6 < /sup > A, one reader at a time
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280166. Online ahead of print.ABSTRACTNot available.PMID:34818874 | DOI:10.3324/haematol.2021.280166 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: Hanzhi Luo Michael G Kharas Source Type: research

How to keep the FVIII/VWF complex in the circulation
Haematologica. 2021 Nov 25. doi: 10.3324/haematol.2021.280222. Online ahead of print.ABSTRACTNot available.PMID:34818875 | DOI:10.3324/haematol.2021.280222 (Source: Haematologica)
Source: Haematologica - November 25, 2021 Category: Hematology Authors: C écile V Denis Peter J Lenting Source Type: research

Mechanical unloading aggravates bone destruction and tumor expansion in myeloma
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.278295. Online ahead of print.ABSTRACTNot available.PMID:34788982 | DOI:10.3324/haematol.2021.278295 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Kotaro Tanimoto Masahiro Hiasa Hirofumi Tenshin Jumpei Teramachi Asuka Oda Takeshi Harada Yoshiki Higa Kimiko Sogabe Masahiro Oura Ryohei Sumitani Tomoyo Hara Itsuro Endo Toshio Matsumoto Eiji Tanaka Masahiro Abe Source Type: research

Survival in mantle cell lymphoma after frontline treatment with Rbendamustine, R-CHOP and the Nordic MCL2 regimen - a real world study on patients diagnosed in Sweden 2007-2017
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.279037. Online ahead of print.ABSTRACTNot available.PMID:34788983 | DOI:10.3324/haematol.2021.279037 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Alexandra Albertsson-Lindblad Thorgerdur Palsdottir Karin E Smedby Caroline E Weibull Ingrid Glimelius Mats Jerkeman Source Type: research

Genetic and genomic analysis of acute lymphoblastic leukaemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.279177. Online ahead of print.ABSTRACTDespite being predominantly a childhood disease, the incidence of ALL has a second peak in adults aged 60 years and over. These older adults fare extremely poorly with existing treatment strategies and very few studies have undertaken a comprehensive genetic and genomic characterisation to improve prognosis in this age group. We performed cytogenetic, single nucleotide polymorphism (SNP) array and next generation sequencing (NGS) analyses on samples from 210 patients aged ≥60 years from the UKALL14 and UKALL60+ clinical trials. ...
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Thomas Creasey Emilio Barretta Sarra L Ryan Ellie Butler Amy A Kirkwood Daniel Leongamornlert Elli Papaemmanuil Pip Patrick Laura Clifton-Hadley Bela Patel Tobias Menne Andrew K McMillan Christine J Harrison Clare J Rowntree Nick Morley David I Marks Adel Source Type: research

Mutational landscape of high-grade B-cell lymphoma with < em > MYC < /em > -, < em > BCL2 < /em > and/or < em > BCL6 < /em > rearrangements characterized by whole-exome sequencing
This study elucidates a recurrent pattern of mutational events driving FL into MYC-driven BCL2 rearranged HGBL, unveiling the mutational pathogenesis of this provisional entity. Through this refinement of the molecular taxonomy for aggressive, germinal-center derived B-cell lymphomas, this calls into question the current WHO-classification system, especially regarding the status of MYC/BCL6 rearranged HGBL.PMID:34788985 | DOI:10.3324/haematol.2021.279631 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Axel K ünstner Hanno M Witte J örg Riedl Veronica Bernard Stephanie St ölting Hartmut Merz Vito Olschewski Wolfgang Peter Julius Ketzer Yannik Busch Peter Trojok Nikolas von Bubnoff Hauke Busch Alfred C Feller Niklas Gebauer Source Type: research

GNE-related thrombocytopenia: evidence for a mutational hotspot in the ADP/substrate domain of the GNE bifunctional enzyme
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.279689. Online ahead of print.ABSTRACTNot available.PMID:34788986 | DOI:10.3324/haematol.2021.279689 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Roberta Bottega Antonio Marzollo Maddalena Marinoni Emmanouil Athanasakis Ilaria Persico Anna Monica Bianco Michela Faleschini Erica Valencic Daniela Simoncini Linda Rossini Fabio Corsolini Martina La Bianca Giuseppe Robustelli Maria Gabelli Massimo Agost Source Type: research

A third anti-SARS-Cov2 mRNA dose does not overcome the pejorative impact of anti-CD20 therapy and/or low immunoglobulin levels in patients with lymphoma or chronic lymphocytic leukemia
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.280026. Online ahead of print.ABSTRACTNot available.PMID:34788987 | DOI:10.3324/haematol.2021.280026 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Milena Kohn Marc Delord Maureen Chbat Amina Guemriche Fatiha Merabet Anne-Laure Roupie Naelle Lombion Hassan Farhat Thomas Longval Aur élie Cabannes-Hamy Juliette Lambert St éphanie Marque-Juillet Victoria Raggueneau Jennifer Osman Marc Spentchian Sophi Source Type: research

Response to "Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients"
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.280199. Online ahead of print.ABSTRACTNot available.PMID:34788988 | DOI:10.3324/haematol.2021.280199 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Andrea Visentin Livio Trentin Source Type: research

When timing is more important than quantity in COVID-19 vaccination
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.280264. Online ahead of print.ABSTRACTNot available.PMID:34788989 | DOI:10.3324/haematol.2021.280264 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Raul Cordoba Source Type: research

Response to "Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients"
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.280310. Online ahead of print.ABSTRACTNot available.PMID:34788990 | DOI:10.3324/haematol.2021.280310 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Jennifer R Brown Source Type: research

Mechanical unloading aggravates bone destruction and tumor expansion in myeloma
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.278295. Online ahead of print.ABSTRACTNot available.PMID:34788982 | DOI:10.3324/haematol.2021.278295 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Kotaro Tanimoto Masahiro Hiasa Hirofumi Tenshin Jumpei Teramachi Asuka Oda Takeshi Harada Yoshiki Higa Kimiko Sogabe Masahiro Oura Ryohei Sumitani Tomoyo Hara Itsuro Endo Toshio Matsumoto Eiji Tanaka Masahiro Abe Source Type: research

Survival in mantle cell lymphoma after frontline treatment with Rbendamustine, R-CHOP and the Nordic MCL2 regimen - a real world study on patients diagnosed in Sweden 2007-2017
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.279037. Online ahead of print.ABSTRACTNot available.PMID:34788983 | DOI:10.3324/haematol.2021.279037 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Alexandra Albertsson-Lindblad Thorgerdur Palsdottir Karin E Smedby Caroline E Weibull Ingrid Glimelius Mats Jerkeman Source Type: research

Genetic and genomic analysis of acute lymphoblastic leukaemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.279177. Online ahead of print.ABSTRACTDespite being predominantly a childhood disease, the incidence of ALL has a second peak in adults aged 60 years and over. These older adults fare extremely poorly with existing treatment strategies and very few studies have undertaken a comprehensive genetic and genomic characterisation to improve prognosis in this age group. We performed cytogenetic, single nucleotide polymorphism (SNP) array and next generation sequencing (NGS) analyses on samples from 210 patients aged ≥60 years from the UKALL14 and UKALL60+ clinical trials. ...
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Thomas Creasey Emilio Barretta Sarra L Ryan Ellie Butler Amy A Kirkwood Daniel Leongamornlert Elli Papaemmanuil Pip Patrick Laura Clifton-Hadley Bela Patel Tobias Menne Andrew K McMillan Christine J Harrison Clare J Rowntree Nick Morley David I Marks Adel Source Type: research

Mutational landscape of high-grade B-cell lymphoma with < em > MYC < /em > -, < em > BCL2 < /em > and/or < em > BCL6 < /em > rearrangements characterized by whole-exome sequencing
This study elucidates a recurrent pattern of mutational events driving FL into MYC-driven BCL2 rearranged HGBL, unveiling the mutational pathogenesis of this provisional entity. Through this refinement of the molecular taxonomy for aggressive, germinal-center derived B-cell lymphomas, this calls into question the current WHO-classification system, especially regarding the status of MYC/BCL6 rearranged HGBL.PMID:34788985 | DOI:10.3324/haematol.2021.279631 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Axel K ünstner Hanno M Witte J örg Riedl Veronica Bernard Stephanie St ölting Hartmut Merz Vito Olschewski Wolfgang Peter Julius Ketzer Yannik Busch Peter Trojok Nikolas von Bubnoff Hauke Busch Alfred C Feller Niklas Gebauer Source Type: research

GNE-related thrombocytopenia: evidence for a mutational hotspot in the ADP/substrate domain of the GNE bifunctional enzyme
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.279689. Online ahead of print.ABSTRACTNot available.PMID:34788986 | DOI:10.3324/haematol.2021.279689 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Roberta Bottega Antonio Marzollo Maddalena Marinoni Emmanouil Athanasakis Ilaria Persico Anna Monica Bianco Michela Faleschini Erica Valencic Daniela Simoncini Linda Rossini Fabio Corsolini Martina La Bianca Giuseppe Robustelli Maria Gabelli Massimo Agost Source Type: research

A third anti-SARS-Cov2 mRNA dose does not overcome the pejorative impact of anti-CD20 therapy and/or low immunoglobulin levels in patients with lymphoma or chronic lymphocytic leukemia
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.280026. Online ahead of print.ABSTRACTNot available.PMID:34788987 | DOI:10.3324/haematol.2021.280026 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Milena Kohn Marc Delord Maureen Chbat Amina Guemriche Fatiha Merabet Anne-Laure Roupie Naelle Lombion Hassan Farhat Thomas Longval Aur élie Cabannes-Hamy Juliette Lambert St éphanie Marque-Juillet Victoria Raggueneau Jennifer Osman Marc Spentchian Sophi Source Type: research

Response to "Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients"
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.280199. Online ahead of print.ABSTRACTNot available.PMID:34788988 | DOI:10.3324/haematol.2021.280199 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Andrea Visentin Livio Trentin Source Type: research

When timing is more important than quantity in COVID-19 vaccination
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.280264. Online ahead of print.ABSTRACTNot available.PMID:34788989 | DOI:10.3324/haematol.2021.280264 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Raul Cordoba Source Type: research

Response to "Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients"
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.280310. Online ahead of print.ABSTRACTNot available.PMID:34788990 | DOI:10.3324/haematol.2021.280310 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Jennifer R Brown Source Type: research

Mechanical unloading aggravates bone destruction and tumor expansion in myeloma
Haematologica. 2021 Nov 18. doi: 10.3324/haematol.2021.278295. Online ahead of print.ABSTRACTNot available.PMID:34788982 | DOI:10.3324/haematol.2021.278295 (Source: Haematologica)
Source: Haematologica - November 18, 2021 Category: Hematology Authors: Kotaro Tanimoto Masahiro Hiasa Hirofumi Tenshin Jumpei Teramachi Asuka Oda Takeshi Harada Yoshiki Higa Kimiko Sogabe Masahiro Oura Ryohei Sumitani Tomoyo Hara Itsuro Endo Toshio Matsumoto Eiji Tanaka Masahiro Abe Source Type: research