The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance
We present new insights into the protein repair-only function(s) of the Hsp70 system, perhaps to minimize protein degradation in mature erythrocytes to warrant their optimal function and survival in the vasculature under healthy conditions. The work also discusses the modulatory roles of this chaperone system in a wide range of hematological diseases and the therapeutic gain of targeting Hsp70.PMID:33832207 | DOI:10.3324/haematol.2019.233056 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Yasith Mathangasinghe Bruno Fauvet Stephen M Jane Pierre Goloubinoff Nadinath B Nillegoda Source Type: research

Comparison of immune reconstitution between anti-T-lymphocyte globulin and post-transplant cyclophosphamide as acute graft-versus-host disease prophylaxis in allogeneic myeloablative peripheral blood stem cell transplantation
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2020.271445. Online ahead of print.ABSTRACTAnti T-cell lymphocyte globulin (ATLG) and post-transplant cyclophosphamide (PTCy) are now widely used strategies to prevent graft-versus-host disease after allogeneic stem cell transplantation. Data comparing immune reconstitution (IR) between ATLG and PTCy is scarce. This retrospective study conducted at the University Medical-Center Hamburg- Eppendorf (UKE) compares after myeloablative PBSC allogeneic stem cell transplant between PTCy (n=123) and ATLG (n=476). Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT...
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Radwan Massoud Nico Gagelmann Ulrike Fritzsche-Friedland Gaby Zeck Silke Heidenreich Christine Wolschke Francis Ayuk Maximilian Christopeit Nicolaus Kr öger Source Type: research

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278389. Online ahead of print.ABSTRACTNot available.PMID:33832210 | DOI:10.3324/haematol.2021.278389 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Tanguy Corre Belen Ponte Edward Pivin Menno Pruijm Daniel Ackermann Georg Ehret Katharina Spanaus Murielle Bochud Roland H Wenger Source Type: research

Do we need more Genome Wide Association Studies?
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278642. Online ahead of print.NO ABSTRACTPMID:33832211 | DOI:10.3324/haematol.2021.278642 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Stephan Menzel Source Type: research

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278492. Online ahead of print.NO ABSTRACTPMID:33832219 | DOI:10.3324/haematol.2021.278492 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Rebecca J Shaw Simon T Abrams James Austin Joseph M Taylor Steven Lane Tina Dutt Colin Downey Min Du Lance Turtle J Kenneth Baillie Peter J M Openshaw Guozheng Wang Malcolm G Semple Cheng-Hock Toh Source Type: research

The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance
We present new insights into the protein repair-only function(s) of the Hsp70 system, perhaps to minimize protein degradation in mature erythrocytes to warrant their optimal function and survival in the vasculature under healthy conditions. The work also discusses the modulatory roles of this chaperone system in a wide range of hematological diseases and the therapeutic gain of targeting Hsp70.PMID:33832207 | DOI:10.3324/haematol.2019.233056 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Yasith Mathangasinghe Bruno Fauvet Stephen M Jane Pierre Goloubinoff Nadinath B Nillegoda Source Type: research

Comparison of immune reconstitution between anti-T-lymphocyte globulin and post-transplant cyclophosphamide as acute graft-versus-host disease prophylaxis in allogeneic myeloablative peripheral blood stem cell transplantation
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2020.271445. Online ahead of print.ABSTRACTAnti T-cell lymphocyte globulin (ATLG) and post-transplant cyclophosphamide (PTCy) are now widely used strategies to prevent graft-versus-host disease after allogeneic stem cell transplantation. Data comparing immune reconstitution (IR) between ATLG and PTCy is scarce. This retrospective study conducted at the University Medical-Center Hamburg- Eppendorf (UKE) compares after myeloablative PBSC allogeneic stem cell transplant between PTCy (n=123) and ATLG (n=476). Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT...
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Radwan Massoud Nico Gagelmann Ulrike Fritzsche-Friedland Gaby Zeck Silke Heidenreich Christine Wolschke Francis Ayuk Maximilian Christopeit Nicolaus Kr öger Source Type: research

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278389. Online ahead of print.ABSTRACTNot available.PMID:33832210 | DOI:10.3324/haematol.2021.278389 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Tanguy Corre Belen Ponte Edward Pivin Menno Pruijm Daniel Ackermann Georg Ehret Katharina Spanaus Murielle Bochud Roland H Wenger Source Type: research

Do we need more Genome Wide Association Studies?
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278642. Online ahead of print.NO ABSTRACTPMID:33832211 | DOI:10.3324/haematol.2021.278642 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Stephan Menzel Source Type: research

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278492. Online ahead of print.NO ABSTRACTPMID:33832219 | DOI:10.3324/haematol.2021.278492 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Rebecca J Shaw Simon T Abrams James Austin Joseph M Taylor Steven Lane Tina Dutt Colin Downey Min Du Lance Turtle J Kenneth Baillie Peter J M Openshaw Guozheng Wang Malcolm G Semple Cheng-Hock Toh Source Type: research

The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance
We present new insights into the protein repair-only function(s) of the Hsp70 system, perhaps to minimize protein degradation in mature erythrocytes to warrant their optimal function and survival in the vasculature under healthy conditions. The work also discusses the modulatory roles of this chaperone system in a wide range of hematological diseases and the therapeutic gain of targeting Hsp70.PMID:33832207 | DOI:10.3324/haematol.2019.233056 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Yasith Mathangasinghe Bruno Fauvet Stephen M Jane Pierre Goloubinoff Nadinath B Nillegoda Source Type: research

Comparison of immune reconstitution between anti-T-lymphocyte globulin and post-transplant cyclophosphamide as acute graft-versus-host disease prophylaxis in allogeneic myeloablative peripheral blood stem cell transplantation
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2020.271445. Online ahead of print.ABSTRACTAnti T-cell lymphocyte globulin (ATLG) and post-transplant cyclophosphamide (PTCy) are now widely used strategies to prevent graft-versus-host disease after allogeneic stem cell transplantation. Data comparing immune reconstitution (IR) between ATLG and PTCy is scarce. This retrospective study conducted at the University Medical-Center Hamburg- Eppendorf (UKE) compares after myeloablative PBSC allogeneic stem cell transplant between PTCy (n=123) and ATLG (n=476). Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT...
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Radwan Massoud Nico Gagelmann Ulrike Fritzsche-Friedland Gaby Zeck Silke Heidenreich Christine Wolschke Francis Ayuk Maximilian Christopeit Nicolaus Kr öger Source Type: research

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278389. Online ahead of print.ABSTRACTNot available.PMID:33832209 | DOI:10.3324/haematol.2021.278389 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Tanguy Corre Belen Ponte Edward Pivin Menno Pruijm Daniel Ackermann Georg Ehret Katharina Spanaus Murielle Bochud Roland H Wenger Source Type: research

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278389". Online ahead of print.ABSTRACTNot available.PMID:33832210 | DOI:
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Tanguy Corre Belen Ponte Edward Pivin Menno Pruijm Daniel Ackermann Georg Ehret Katharina Spanaus Murielle Bochud Roland H Wenger Source Type: research

Do we need more Genome Wide Association Studies?
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278642. Online ahead of print.NO ABSTRACTPMID:33832211 | DOI:10.3324/haematol.2021.278642 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Stephan Menzel Source Type: research

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278492. Online ahead of print.NO ABSTRACTPMID:33832219 | DOI:10.3324/haematol.2021.278492 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Rebecca J Shaw Simon T Abrams James Austin Joseph M Taylor Steven Lane Tina Dutt Colin Downey Min Du Lance Turtle J Kenneth Baillie Peter J M Openshaw Guozheng Wang Malcolm G Semple Cheng-Hock Toh Source Type: research

The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance
We present new insights into the protein repair-only function(s) of the Hsp70 system, perhaps to minimize protein degradation in mature erythrocytes to warrant their optimal function and survival in the vasculature under healthy conditions. The work also discusses the modulatory roles of this chaperone system in a wide range of hematological diseases and the therapeutic gain of targeting Hsp70.PMID:33832207 | DOI:10.3324/haematol.2019.233056 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Yasith Mathangasinghe Bruno Fauvet Stephen M Jane Pierre Goloubinoff Nadinath B Nillegoda Source Type: research

Comparison of immune reconstitution between anti-T-lymphocyte globulin and post-transplant cyclophosphamide as acute graft-versus-host disease prophylaxis in allogeneic myeloablative peripheral blood stem cell transplantation
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2020.271445. Online ahead of print.ABSTRACTAnti T-cell lymphocyte globulin (ATLG) and post-transplant cyclophosphamide (PTCy) are now widely used strategies to prevent graft-versus-host disease after allogeneic stem cell transplantation. Data comparing immune reconstitution (IR) between ATLG and PTCy is scarce. This retrospective study conducted at the University Medical-Center Hamburg- Eppendorf (UKE) compares after myeloablative PBSC allogeneic stem cell transplant between PTCy (n=123) and ATLG (n=476). Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT...
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Radwan Massoud Nico Gagelmann Ulrike Fritzsche-Friedland Gaby Zeck Silke Heidenreich Christine Wolschke Francis Ayuk Maximilian Christopeit Nicolaus Kr öger Source Type: research

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278389. Online ahead of print.ABSTRACTNot available.PMID:33832209 | DOI:10.3324/haematol.2021.278389 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Tanguy Corre Belen Ponte Edward Pivin Menno Pruijm Daniel Ackermann Georg Ehret Katharina Spanaus Murielle Bochud Roland H Wenger Source Type: research

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278389". Online ahead of print.ABSTRACTNot available.PMID:33832210 | DOI:
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Tanguy Corre Belen Ponte Edward Pivin Menno Pruijm Daniel Ackermann Georg Ehret Katharina Spanaus Murielle Bochud Roland H Wenger Source Type: research

Do we need more Genome Wide Association Studies?
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278642. Online ahead of print.NO ABSTRACTPMID:33832211 | DOI:10.3324/haematol.2021.278642 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Stephan Menzel Source Type: research

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278492. Online ahead of print.NO ABSTRACTPMID:33832219 | DOI:10.3324/haematol.2021.278492 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Rebecca J Shaw Simon T Abrams James Austin Joseph M Taylor Steven Lane Tina Dutt Colin Downey Min Du Lance Turtle J Kenneth Baillie Peter J M Openshaw Guozheng Wang Malcolm G Semple Cheng-Hock Toh Source Type: research

The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance
We present new insights into the protein repair-only function(s) of the Hsp70 system, perhaps to minimize protein degradation in mature erythrocytes to warrant their optimal function and survival in the vasculature under healthy conditions. The work also discusses the modulatory roles of this chaperone system in a wide range of hematological diseases and the therapeutic gain of targeting Hsp70.PMID:33832207 | DOI:10.3324/haematol.2019.233056 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Yasith Mathangasinghe Bruno Fauvet Stephen M Jane Pierre Goloubinoff Nadinath B Nillegoda Source Type: research

Comparison of immune reconstitution between anti-T-lymphocyte globulin and post-transplant cyclophosphamide as acute graft-versus-host disease prophylaxis in allogeneic myeloablative peripheral blood stem cell transplantation
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2020.271445. Online ahead of print.ABSTRACTAnti T-cell lymphocyte globulin (ATLG) and post-transplant cyclophosphamide (PTCy) are now widely used strategies to prevent graft-versus-host disease after allogeneic stem cell transplantation. Data comparing immune reconstitution (IR) between ATLG and PTCy is scarce. This retrospective study conducted at the University Medical-Center Hamburg- Eppendorf (UKE) compares after myeloablative PBSC allogeneic stem cell transplant between PTCy (n=123) and ATLG (n=476). Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT...
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Radwan Massoud Nico Gagelmann Ulrike Fritzsche-Friedland Gaby Zeck Silke Heidenreich Christine Wolschke Francis Ayuk Maximilian Christopeit Nicolaus Kr öger Source Type: research

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278389. Online ahead of print.ABSTRACTNot available.PMID:33832209 | DOI:10.3324/haematol.2021.278389 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Tanguy Corre Belen Ponte Edward Pivin Menno Pruijm Daniel Ackermann Georg Ehret Katharina Spanaus Murielle Bochud Roland H Wenger Source Type: research

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278389". Online ahead of print.ABSTRACTNot available.PMID:33832210 | DOI:
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Tanguy Corre Belen Ponte Edward Pivin Menno Pruijm Daniel Ackermann Georg Ehret Katharina Spanaus Murielle Bochud Roland H Wenger Source Type: research

Do we need more Genome Wide Association Studies?
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278642. Online ahead of print.NO ABSTRACTPMID:33832211 | DOI:10.3324/haematol.2021.278642 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Stephan Menzel Source Type: research

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Haematologica. 2021 Apr 8. doi: 10.3324/haematol.2021.278492. Online ahead of print.NO ABSTRACTPMID:33832219 | DOI:10.3324/haematol.2021.278492 (Source: Haematologica)
Source: Haematologica - April 9, 2021 Category: Hematology Authors: Rebecca J Shaw Simon T Abrams James Austin Joseph M Taylor Steven Lane Tina Dutt Colin Downey Min Du Lance Turtle J Kenneth Baillie Peter J M Openshaw Guozheng Wang Malcolm G Semple Cheng-Hock Toh Source Type: research

Red cell transfusion and alloimmunization in sickle cell disease
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.270546. Online ahead of print.ABSTRACTRed cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for splenic sequestration, acute chest syndrome, and acute stroke are guided by expert consensus recommendations. Despite overall improvements in blood inventory safety, adverse effects of transfusion are prevalent among patients with sickle ce...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Grace E Linder Stella T Chou Source Type: research

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.274258. Online ahead of print.ABSTRACTB-cell non-Hodgkin's lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B-NHL such as diffuse large B-cell lymphoma (DLBCL) have been comprehensively interrogated at the genomic level. But rarer subtypes such as mantle cell lymphoma (MCL) remain sparsely characterized. Furthermore, multiple B-NHL subtypes have thus far not been comprehensively compared using the same methodology to identify conserved or subtype-specific patterns of ...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Man Chun John Ma Saber Tadros Alyssa Bouska Tayla Heavican Haopeng Yang Qing Deng Dalia Moore Ariz Akhter Keenan Hartert Neeraj Jain Jordan Showell Sreejoyee Ghosh Lesley Street Marta Davidson Christopher Carey Joshua Tobin Deepak Perumal Julie M Vose Mat Source Type: research

Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.274506. Online ahead of print.ABSTRACTPrimary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) is a rare variant of cutaneous T-cell lymphoma with an aggressive clinical course and a very poor prognosis. Until now, neither a systematic characterization of genetic alterations driving pcAECyTCL has been performed, nor effective therapeutic regimes for patients have been defined. Here, we present the first high-resolution genetic characterization of pcAECyTCL by using whole-genome sequencing and RNA sequencing. Our study provides a comprehensi...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Armando N Bastidas Torres Davy Cats Jacoba J Out-Luiting Daniele Fanoni Hailiang Mei Luigia Venegoni Rein Willemze Maarten H Vermeer Emilio Berti Cornelis P Tensen Source Type: research

European Myeloma Network perspective on CAR T-Cell therapies for multiple myeloma
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.276402. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR) T cells (CAR-T) have dramatically changed the treatment landscape of B-cell malignancies, providing a potential cure for relapsed/refractory patients. Long-term responses in patients with acute lymphoblastic leukemia and non Hodgkin lymphomas have encouraged further development in myeloma. In particular, B-cell maturation antigen (BCMA)-targeted CAR-T have established very promising results in heavily pre-treated patients. Moreover, CAR-T targeting other antigens (i.e., SLAMF7 and CD44v6) are currentl...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Benedetto Bruno Ralph W äsch Monika Engelhardt Francesca Gay Luisa Giaccone Mattia D'Agostino Luis-Gerardo Rodr íguez-Lobato Sophia Danhof Nico Gagelmann Nicolaus Kr öger Rakesh Popat Niels W C J Van de Donk Evangelos Terpos Meletios A Dimopoulos Piete Source Type: research

A phase II study of brentuximab vedotin in patients with relapsed or refractory Epstein-Barr virus-positive and CD30-positive lymphomas
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2021.278301. Online ahead of print.ABSTRACTNot available.PMID:33792222 | DOI:10.3324/haematol.2021.278301 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Miso Kim Jeong-Ok Lee Jiwon Koh Tae Min Kim Ji Yun Lee Yoon Kyung Jeon Bhumsuk Keam Dong-Wan Kim Jong Seok Lee Dae Seog Heo Source Type: research

One third of alloantibodies in patients with sickle cell disease transfused with African blood are missed by the standard red blood cell test panel
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2021.278451. Online ahead of print.ABSTRACTNot available.PMID:33792223 | DOI:10.3324/haematol.2021.278451 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Lilian A Boateng Henk Schonewille Peter C Ligthart Ahmad Javadi Barbera Veldhuisen Alex Osei-Akoto Yvonne Dei-Adomakoh Imelda Bates C Ellen Van der Schoot Source Type: research

Images from the Haematologica Atlas of Hematologic Cytology: plasma cell myeloma
Haematologica. 2021 Apr 1;106(4):925. doi: 10.3324/haematol.2021.278331.NO ABSTRACTPMID:33792224 | PMC:PMC8017813 | DOI:10.3324/haematol.2021.278331 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Rosangela Invernizzi Source Type: research

BETing on rational combination therapy in mutant < em > FLT3 < /em > acute myeloid leukemia
Haematologica. 2021 Apr 1;106(4):931-932. doi: 10.3324/haematol.2020.274753.NO ABSTRACTPMID:33792225 | PMC:PMC8017812 | DOI:10.3324/haematol.2020.274753 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Richard M Stone Source Type: research

Comment on "Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study."
Haematologica. 2021 Apr 1;106(4):1226-1227. doi: 10.3324/haematol.2020.278203.NO ABSTRACTPMID:33792226 | PMC:PMC8018111 | DOI:10.3324/haematol.2020.278203 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Marco Picardi Claudia Giordano Source Type: research

A real world multicenter retrospective study on extramedullary disease from Balkan Myeloma Study Group and Barcelona University: analysis of parameters that improve outcome
Haematologica. 2021 Apr 1;106(4):1228. doi: 10.3324/haematol.2020.278272.NO ABSTRACTPMID:33792227 | PMC:PMC8018150 | DOI:10.3324/haematol.2020.278272 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Meral Beksac Guldane Cengiz Seval Nicholas Kanellias Daniel Coriu Laura Rosi ñol Gulsum Ozet Vesselina Goranova-Marinova Ali Unal Jelena Bila Hayri Ozsan Arben Ivanaj Lejla Ibricevic Bali ć Efstathios Kastritis Joan Blad é Meletios Athanasios Dimopoulo Source Type: research

Red cell transfusion and alloimmunization in sickle cell disease
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.270546. Online ahead of print.ABSTRACTRed cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for splenic sequestration, acute chest syndrome, and acute stroke are guided by expert consensus recommendations. Despite overall improvements in blood inventory safety, adverse effects of transfusion are prevalent among patients with sickle ce...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Grace E Linder Stella T Chou Source Type: research

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.274258. Online ahead of print.ABSTRACTB-cell non-Hodgkin's lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B-NHL such as diffuse large B-cell lymphoma (DLBCL) have been comprehensively interrogated at the genomic level. But rarer subtypes such as mantle cell lymphoma (MCL) remain sparsely characterized. Furthermore, multiple B-NHL subtypes have thus far not been comprehensively compared using the same methodology to identify conserved or subtype-specific patterns of ...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Man Chun John Ma Saber Tadros Alyssa Bouska Tayla Heavican Haopeng Yang Qing Deng Dalia Moore Ariz Akhter Keenan Hartert Neeraj Jain Jordan Showell Sreejoyee Ghosh Lesley Street Marta Davidson Christopher Carey Joshua Tobin Deepak Perumal Julie M Vose Mat Source Type: research

Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.274506. Online ahead of print.ABSTRACTPrimary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) is a rare variant of cutaneous T-cell lymphoma with an aggressive clinical course and a very poor prognosis. Until now, neither a systematic characterization of genetic alterations driving pcAECyTCL has been performed, nor effective therapeutic regimes for patients have been defined. Here, we present the first high-resolution genetic characterization of pcAECyTCL by using whole-genome sequencing and RNA sequencing. Our study provides a comprehensi...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Armando N Bastidas Torres Davy Cats Jacoba J Out-Luiting Daniele Fanoni Hailiang Mei Luigia Venegoni Rein Willemze Maarten H Vermeer Emilio Berti Cornelis P Tensen Source Type: research

European Myeloma Network perspective on CAR T-Cell therapies for multiple myeloma
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.276402. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR) T cells (CAR-T) have dramatically changed the treatment landscape of B-cell malignancies, providing a potential cure for relapsed/refractory patients. Long-term responses in patients with acute lymphoblastic leukemia and non Hodgkin lymphomas have encouraged further development in myeloma. In particular, B-cell maturation antigen (BCMA)-targeted CAR-T have established very promising results in heavily pre-treated patients. Moreover, CAR-T targeting other antigens (i.e., SLAMF7 and CD44v6) are currentl...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Benedetto Bruno Ralph W äsch Monika Engelhardt Francesca Gay Luisa Giaccone Mattia D'Agostino Luis-Gerardo Rodr íguez-Lobato Sophia Danhof Nico Gagelmann Nicolaus Kr öger Rakesh Popat Niels W C J Van de Donk Evangelos Terpos Meletios A Dimopoulos Piete Source Type: research

A phase II study of brentuximab vedotin in patients with relapsed or refractory Epstein-Barr virus-positive and CD30-positive lymphomas
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2021.278301. Online ahead of print.ABSTRACTNot available.PMID:33792222 | DOI:10.3324/haematol.2021.278301 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Miso Kim Jeong-Ok Lee Jiwon Koh Tae Min Kim Ji Yun Lee Yoon Kyung Jeon Bhumsuk Keam Dong-Wan Kim Jong Seok Lee Dae Seog Heo Source Type: research

One third of alloantibodies in patients with sickle cell disease transfused with African blood are missed by the standard red blood cell test panel
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2021.278451. Online ahead of print.ABSTRACTNot available.PMID:33792223 | DOI:10.3324/haematol.2021.278451 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Lilian A Boateng Henk Schonewille Peter C Ligthart Ahmad Javadi Barbera Veldhuisen Alex Osei-Akoto Yvonne Dei-Adomakoh Imelda Bates C Ellen Van der Schoot Source Type: research

Images from the Haematologica Atlas of Hematologic Cytology: plasma cell myeloma
Haematologica. 2021 Apr 1;106(4):925. doi: 10.3324/haematol.2021.278331.NO ABSTRACTPMID:33792224 | PMC:PMC8017813 | DOI:10.3324/haematol.2021.278331 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Rosangela Invernizzi Source Type: research

BETing on rational combination therapy in mutant < em > FLT3 < /em > acute myeloid leukemia
Haematologica. 2021 Apr 1;106(4):931-932. doi: 10.3324/haematol.2020.274753.NO ABSTRACTPMID:33792225 | PMC:PMC8017812 | DOI:10.3324/haematol.2020.274753 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Richard M Stone Source Type: research

Comment on "Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study."
Haematologica. 2021 Apr 1;106(4):1226-1227. doi: 10.3324/haematol.2020.278203.NO ABSTRACTPMID:33792226 | PMC:PMC8018111 | DOI:10.3324/haematol.2020.278203 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Marco Picardi Claudia Giordano Source Type: research

A real world multicenter retrospective study on extramedullary disease from Balkan Myeloma Study Group and Barcelona University: analysis of parameters that improve outcome
Haematologica. 2021 Apr 1;106(4):1228. doi: 10.3324/haematol.2020.278272.NO ABSTRACTPMID:33792227 | PMC:PMC8018150 | DOI:10.3324/haematol.2020.278272 (Source: Haematologica)
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Meral Beksac Guldane Cengiz Seval Nicholas Kanellias Daniel Coriu Laura Rosi ñol Gulsum Ozet Vesselina Goranova-Marinova Ali Unal Jelena Bila Hayri Ozsan Arben Ivanaj Lejla Ibricevic Bali ć Efstathios Kastritis Joan Blad é Meletios Athanasios Dimopoulo Source Type: research

Red cell transfusion and alloimmunization in sickle cell disease
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.270546. Online ahead of print.ABSTRACTRed cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for splenic sequestration, acute chest syndrome, and acute stroke are guided by expert consensus recommendations. Despite overall improvements in blood inventory safety, adverse effects of transfusion are prevalent among patients with sickle ce...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Grace E Linder Stella T Chou Source Type: research

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.274258. Online ahead of print.ABSTRACTB-cell non-Hodgkin's lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B-NHL such as diffuse large B-cell lymphoma (DLBCL) have been comprehensively interrogated at the genomic level. But rarer subtypes such as mantle cell lymphoma (MCL) remain sparsely characterized. Furthermore, multiple B-NHL subtypes have thus far not been comprehensively compared using the same methodology to identify conserved or subtype-specific patterns of ...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Man Chun John Ma Saber Tadros Alyssa Bouska Tayla Heavican Haopeng Yang Qing Deng Dalia Moore Ariz Akhter Keenan Hartert Neeraj Jain Jordan Showell Sreejoyee Ghosh Lesley Street Marta Davidson Christopher Carey Joshua Tobin Deepak Perumal Julie M Vose Mat Source Type: research