Time from diagnosis to treatment has no impact on survival in newly diagnosed acute myeloid leukemia treated with venetoclax-based regimens
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285225. Online ahead of print.ABSTRACTIn newly diagnosed acute myeloid leukemia, immediate initiation of treatment is standard of care. However, deferral of antileukemic therapy may be indicated to assess comorbidities or pre-therapeutic risk factors. We explored the impact of time from diagnosis to treatment on outcomes in newly diagnosed acute myeloid leukemia undergoing venetoclax-based therapy in two distinct cohorts. By querying the Study Alliance Leukemia database and the global health network TriNetX, we identified 138 and 717 patients respectively with an avera...
Source: Haematologica - April 24, 2024 Category: Hematology Authors: David Baden Sven Zukunft Gema Hernandez Nadine Wolgast Sophie Steinhauser Alexander Pohlmann Christoph Schliemann Jan-Henrik Mikesch Bjorn Steffen Tim Sauer Maher Hanoun Kerstin Schafer-Eckart Stefan W Krause Mathias Hanel Hermann Einsele Edgar Jost Tim H Source Type: research
Central nervous system prophylaxis: it's time to start from scratch
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285425. Online ahead of print.ABSTRACTNot available.PMID:38654662 | DOI:10.3324/haematol.2024.285425 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Diego Villa Source Type: research
Differential activation of basal and IL-7-induced PI3K/Akt/mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2023.284102. Online ahead of print.ABSTRACTNot available.PMID:38654666 | DOI:10.3324/haematol.2023.284102 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Marta B Fernandes A Margarida Gomes Mariana L Oliveira Joana Caldas Paulo L úcio Rathana Kim Aur élie Caye-Eude Filomena Pereira Aida B De Sousa Alessia De Stefano Matilde Y Follo Maria V Soares Jo ão F Lacerda Joana Desterro H élène Cavé Emmanuelle Source Type: research
Monocyte response to SARS-CoV-2 protein ORF8 is associated with severe COVID-19 infection in patients with chronic lymphocytic leukemia
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2023.284617. Online ahead of print.ABSTRACTThe open reading frame 8 (ORF8) protein, encoded by the SARS-CoV-2 virus after infection, stimulates monocytes/macrophages to produce pro-inflammatory cytokines. We hypothesized that a positive ex vivo monocyte response to ORF8 protein pre-COVID-19 would be associated with subsequent severe COVID-19. We tested ORF8 ex vivo on peripheral blood mononuclear cells (PBMCs) from 26 anonymous healthy blood donors and measured intracellular cytokine/chemokine levels in monocytes by flow cytometry. The % monocytes staining positive in the s...
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Gordon J Ruan Xiaosheng Wu Kimberly A Gwin Michelle K Manske Jithma P Abeykoon Vaishali Bhardwaj Taylor L Witter Matthew J Schellenberg Kari G Rabe Neil E Kay Sameer A Parikh Thomas E Witzig Source Type: research
Do it once, but do it right
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285246. Online ahead of print.ABSTRACTNot available.PMID:38654683 | DOI:10.3324/haematol.2024.285246 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Layal Yasin Arndt Borkhardt Source Type: research
Evaluation of the < em > ATM < /em > L2307F germline variant in 121 Italian pedigrees with familial myeloproliferative neoplasms
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285539. Online ahead of print.ABSTRACTNot available.PMID:38654656 | DOI:10.3324/haematol.2024.285539 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Oscar Borsani Roland J äger Daniela Pietra Ines Flieder Giacomo Riccaboni Robert Kralovics Elisa Rumi Source Type: research
Follicular lymphoma treatment decisions: put GELF on the shelf?
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285286. Online ahead of print.ABSTRACTNot available.PMID:38654659 | DOI:10.3324/haematol.2024.285286 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Brian K Link Source Type: research
Time from diagnosis to treatment has no impact on survival in newly diagnosed acute myeloid leukemia treated with venetoclax-based regimens
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285225. Online ahead of print.ABSTRACTIn newly diagnosed acute myeloid leukemia, immediate initiation of treatment is standard of care. However, deferral of antileukemic therapy may be indicated to assess comorbidities or pre-therapeutic risk factors. We explored the impact of time from diagnosis to treatment on outcomes in newly diagnosed acute myeloid leukemia undergoing venetoclax-based therapy in two distinct cohorts. By querying the Study Alliance Leukemia database and the global health network TriNetX, we identified 138 and 717 patients respectively with an avera...
Source: Haematologica - April 24, 2024 Category: Hematology Authors: David Baden Sven Zukunft Gema Hernandez Nadine Wolgast Sophie Steinhauser Alexander Pohlmann Christoph Schliemann Jan-Henrik Mikesch Bjorn Steffen Tim Sauer Maher Hanoun Kerstin Schafer-Eckart Stefan W Krause Mathias Hanel Hermann Einsele Edgar Jost Tim H Source Type: research
Central nervous system prophylaxis: it's time to start from scratch
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285425. Online ahead of print.ABSTRACTNot available.PMID:38654662 | DOI:10.3324/haematol.2024.285425 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Diego Villa Source Type: research
Differential activation of basal and IL-7-induced PI3K/Akt/mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2023.284102. Online ahead of print.ABSTRACTNot available.PMID:38654666 | DOI:10.3324/haematol.2023.284102 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Marta B Fernandes A Margarida Gomes Mariana L Oliveira Joana Caldas Paulo L úcio Rathana Kim Aur élie Caye-Eude Filomena Pereira Aida B De Sousa Alessia De Stefano Matilde Y Follo Maria V Soares Jo ão F Lacerda Joana Desterro H élène Cavé Emmanuelle Source Type: research
Monocyte response to SARS-CoV-2 protein ORF8 is associated with severe COVID-19 infection in patients with chronic lymphocytic leukemia
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2023.284617. Online ahead of print.ABSTRACTThe open reading frame 8 (ORF8) protein, encoded by the SARS-CoV-2 virus after infection, stimulates monocytes/macrophages to produce pro-inflammatory cytokines. We hypothesized that a positive ex vivo monocyte response to ORF8 protein pre-COVID-19 would be associated with subsequent severe COVID-19. We tested ORF8 ex vivo on peripheral blood mononuclear cells (PBMCs) from 26 anonymous healthy blood donors and measured intracellular cytokine/chemokine levels in monocytes by flow cytometry. The % monocytes staining positive in the s...
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Gordon J Ruan Xiaosheng Wu Kimberly A Gwin Michelle K Manske Jithma P Abeykoon Vaishali Bhardwaj Taylor L Witter Matthew J Schellenberg Kari G Rabe Neil E Kay Sameer A Parikh Thomas E Witzig Source Type: research
Do it once, but do it right
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285246. Online ahead of print.ABSTRACTNot available.PMID:38654683 | DOI:10.3324/haematol.2024.285246 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Layal Yasin Arndt Borkhardt Source Type: research
Evaluation of the < em > ATM < /em > L2307F germline variant in 121 Italian pedigrees with familial myeloproliferative neoplasms
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285539. Online ahead of print.ABSTRACTNot available.PMID:38654656 | DOI:10.3324/haematol.2024.285539 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Oscar Borsani Roland J äger Daniela Pietra Ines Flieder Giacomo Riccaboni Robert Kralovics Elisa Rumi Source Type: research
Follicular lymphoma treatment decisions: put GELF on the shelf?
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285286. Online ahead of print.ABSTRACTNot available.PMID:38654659 | DOI:10.3324/haematol.2024.285286 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Brian K Link Source Type: research
Time from diagnosis to treatment has no impact on survival in newly diagnosed acute myeloid leukemia treated with venetoclax-based regimens
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2024.285225. Online ahead of print.ABSTRACTIn newly diagnosed acute myeloid leukemia, immediate initiation of treatment is standard of care. However, deferral of antileukemic therapy may be indicated to assess comorbidities or pre-therapeutic risk factors. We explored the impact of time from diagnosis to treatment on outcomes in newly diagnosed acute myeloid leukemia undergoing venetoclax-based therapy in two distinct cohorts. By querying the Study Alliance Leukemia database and the global health network TriNetX, we identified 138 and 717 patients respectively with an avera...
Source: Haematologica - April 24, 2024 Category: Hematology Authors: David Baden Sven Zukunft Gema Hernandez Nadine Wolgast Sophie Steinhauser Alexander Pohlmann Christoph Schliemann Jan-Henrik Mikesch Bjorn Steffen Tim Sauer Maher Hanoun Kerstin Schafer-Eckart Stefan W Krause Mathias Hanel Hermann Einsele Edgar Jost Tim H Source Type: research
