Validation of LymphGen classification on a 400-gene clinical next-generation sequencing panel in diffuse large B-cell lymphoma: real-world experience from a cancer center
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2023.284565. Online ahead of print.ABSTRACTNot available.PMID:38497151 | DOI:10.3324/haematol.2023.284565 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Meng-Lei Zhu Esther Drill Erel Joffe Gilles Salles Alfredo Rivas Delgado Andrew Zelenetz Maria Lia Palomba Maria Arcila Ahmet Dogan Source Type: research
Bendamustine and rituximab as first-line treatment for symptomatic splenic marginal zone lymphoma: long-term outcome and impact of early unmeasurable minimal residual disease attainment from the BRISMA/IELSG36 phase II study
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2023.284109. Online ahead of print.ABSTRACTNot available.PMID:38497158 | DOI:10.3324/haematol.2023.284109 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Emilio Iannitto Simone Ferrero C ôme Bommier Daniela Drandi Martina Ferrante Krimo Bouabdallah Sylvain Carras Guido Gini Vincent Camus Salvatrice Mancuso Luigi Marcheselli Angela Ferrari Michele Merli Benoit Tessoulin Caterina Stelitano Kheira Beldjord G Source Type: research
Classical meets malignant hematology: a case of acquired εγδβ-thalassemia in clonal hematopoiesis
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2024.285083. Online ahead of print.ABSTRACTHemoglobinopathies including thalassemias are among the most frequent genetic disorders worldwide. Primarily, these entities result from germline variants in the globin gene clusters and their cis-acting regulatory elements, and thus the WHO classifies thalassemias as inherited diseases. Non-inherited disorders of globin chain synthesis mimicking the phenotype of thalassemias have also been described and are referred to as acquired thalassemias. These forms mainly affect the alpha-globin genes and are observed at much lower frequen...
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Armin P Piehler Marietta Truger Jan-Hendrik Kozik Sandra Weissmann Martin Schwonzen Manja Meggendorfer Wolfgang Kern Torsten Haferlach Gregor Hoermann Claudia Haferlach Source Type: research
Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment
In conclusion, in a cohort of pediatric SCD patients with efficient stroke screening strategy, half of occurring ischemic strokes were related to causes other than CA. They affected a different population of SCD children and systematic long-term transfusion programs may not be necessary in these cases.PMID:38497171 | DOI:10.3324/haematol.2023.283773 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Sarah Liane Linguet Suzanne Verlhac Florence Missud Laurent Holvoet-Vermaut Valentine Brousse Ghislaine Ithier Alexandra Ntorkou Emmanuelle Lesprit Malika Benkerrou Mano ëlle Kossorotoff Berengere Koehl Source Type: research
Targeting glycolysis to rescue 2-hydroxyglutarate immunosuppressive effects in dendritic cells and acute myeloid leukemia
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2023.284893. Online ahead of print.ABSTRACTNot available.PMID:38497144 | DOI:10.3324/haematol.2023.284893 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Angela Maria Savino Lucille Stuani Source Type: research
Low-dose non-steroidal anti-inflammatory drugs: a promising approach for the treatment of symptomatic bone marrow failure in Ghosal hematodiaphyseal dysplasia
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2023.284098. Online ahead of print.ABSTRACTNot available.PMID:38497148 | DOI:10.3324/haematol.2023.284098 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Jonathan Bordat Felipe Suarez Val érie Cormier-Daire Regis Peffault De Latour Jean Soulier Veronique Meignin Mathilde Doyard Lise Larcher Stephane Vanderbecken Flore Sicre De Fontbrune Source Type: research
Efficacy of intravenous high-dose methotrexate in preventing relapse to the central nervous system in R-CHOP(-like)-treated, high-risk, diffuse large B-cell lymphoma patients and its effect on mortality: a systematic review and meta-analysis
CONCLUSION: Our data indicate that HD-MTX does not prevent, or at best, only slightly reduces the risk of CNS relapse and confers no survival benefit.PMID:38497149 | DOI:10.3324/haematol.2023.284281 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Elisabeth R Tolley Christian Lewinter Lars M Pedersen Torsten Holm Nielsen Source Type: research
Imatinib treatment and longitudinal growth in pediatric patients with chronic myeloid leukemia: Influence of demographic, pharmacological, and genetic factors in the German CML-PAED cohort
This study examines demographic, pharmacological, and genetic factors associated with impaired longitudinal growth in a uniform pediatric cohort treated with imatinib. We analyzed 94 pediatric patients with chronic myeloid leukemia (CML) diagnosed in the chronic phase and treated with imatinib for >12 months who participated in the Germany-wide CML-PAEDII study between February 2006 and February 2021. During imatinib treatment, significant height reduction occurred, with medians of -0.35 standard deviation score (SDS) at 12 months and -0.76 SDS at 24 months. Cumulative height SDS change (Δheight SDS) showed a more pron...
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Sophie Stiehler Stephanie Sembill Oliver Schleicher Michaela Marx Manfred Rauh Manuela Krumbholz Axel Karow Meinolf Suttorp Joachim Woelfle Carlo Maj Markus Metzler Source Type: research
Validation of LymphGen classification on a 400-gene clinical next-generation sequencing panel in diffuse large B-cell lymphoma: real-world experience from a cancer center
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2023.284565. Online ahead of print.ABSTRACTNot available.PMID:38497151 | DOI:10.3324/haematol.2023.284565 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Meng-Lei Zhu Esther Drill Erel Joffe Gilles Salles Alfredo Rivas Delgado Andrew Zelenetz Maria Lia Palomba Maria Arcila Ahmet Dogan Source Type: research
Bendamustine and rituximab as first-line treatment for symptomatic splenic marginal zone lymphoma: long-term outcome and impact of early unmeasurable minimal residual disease attainment from the BRISMA/IELSG36 phase II study
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2023.284109. Online ahead of print.ABSTRACTNot available.PMID:38497158 | DOI:10.3324/haematol.2023.284109 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Emilio Iannitto Simone Ferrero C ôme Bommier Daniela Drandi Martina Ferrante Krimo Bouabdallah Sylvain Carras Guido Gini Vincent Camus Salvatrice Mancuso Luigi Marcheselli Angela Ferrari Michele Merli Benoit Tessoulin Caterina Stelitano Kheira Beldjord G Source Type: research
Classical meets malignant hematology: a case of acquired εγδβ-thalassemia in clonal hematopoiesis
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2024.285083. Online ahead of print.ABSTRACTHemoglobinopathies including thalassemias are among the most frequent genetic disorders worldwide. Primarily, these entities result from germline variants in the globin gene clusters and their cis-acting regulatory elements, and thus the WHO classifies thalassemias as inherited diseases. Non-inherited disorders of globin chain synthesis mimicking the phenotype of thalassemias have also been described and are referred to as acquired thalassemias. These forms mainly affect the alpha-globin genes and are observed at much lower frequen...
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Armin P Piehler Marietta Truger Jan-Hendrik Kozik Sandra Weissmann Martin Schwonzen Manja Meggendorfer Wolfgang Kern Torsten Haferlach Gregor Hoermann Claudia Haferlach Source Type: research
Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment
In conclusion, in a cohort of pediatric SCD patients with efficient stroke screening strategy, half of occurring ischemic strokes were related to causes other than CA. They affected a different population of SCD children and systematic long-term transfusion programs may not be necessary in these cases.PMID:38497171 | DOI:10.3324/haematol.2023.283773 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Sarah Liane Linguet Suzanne Verlhac Florence Missud Laurent Holvoet-Vermaut Valentine Brousse Ghislaine Ithier Alexandra Ntorkou Emmanuelle Lesprit Malika Benkerrou Mano ëlle Kossorotoff Berengere Koehl Source Type: research
Targeting glycolysis to rescue 2-hydroxyglutarate immunosuppressive effects in dendritic cells and acute myeloid leukemia
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2023.284893. Online ahead of print.ABSTRACTNot available.PMID:38497144 | DOI:10.3324/haematol.2023.284893 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Angela Maria Savino Lucille Stuani Source Type: research
Low-dose non-steroidal anti-inflammatory drugs: a promising approach for the treatment of symptomatic bone marrow failure in Ghosal hematodiaphyseal dysplasia
Haematologica. 2024 Mar 14. doi: 10.3324/haematol.2023.284098. Online ahead of print.ABSTRACTNot available.PMID:38497148 | DOI:10.3324/haematol.2023.284098 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Jonathan Bordat Felipe Suarez Val érie Cormier-Daire Regis Peffault De Latour Jean Soulier Veronique Meignin Mathilde Doyard Lise Larcher Stephane Vanderbecken Flore Sicre De Fontbrune Source Type: research
Efficacy of intravenous high-dose methotrexate in preventing relapse to the central nervous system in R-CHOP(-like)-treated, high-risk, diffuse large B-cell lymphoma patients and its effect on mortality: a systematic review and meta-analysis
CONCLUSION: Our data indicate that HD-MTX does not prevent, or at best, only slightly reduces the risk of CNS relapse and confers no survival benefit.PMID:38497149 | DOI:10.3324/haematol.2023.284281 (Source: Haematologica)
Source: Haematologica - March 18, 2024 Category: Hematology Authors: Elisabeth R Tolley Christian Lewinter Lars M Pedersen Torsten Holm Nielsen Source Type: research
