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Mutual regulation of CD4+ T cells and intravascular fibrin in infections
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284619. Online ahead of print.ABSTRACTInnate myeloid cells especially neutrophils and their extracellular traps are known to promote intravascular coagulation and thrombosis formation in infections and various other conditions. Innate myeloid cell dependent fibrin formation can support systemic immunity while its dysregulation enhances the severity of infectious diseases. Less is known about the immune mechanisms preventing dysregulation of fibrin homeostasis in infection. During experimental systemic infections local fibrin deposits in the liver microcirculation cause ...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Tonina T Mueller Mona Pilartz Manovriti Thakur Torben LangHeinrich Junfu Luo Rebecca Block Jonathan K L Hoeflinger Sarah Meister Flavio Karaj Laura Garcia Perez Rupert Öllinger Thomas Engleitner Jakob Thoss Michael Voelkl Claudia Tersteeg Uwe Koedel Alex Source Type: research

Universal germline genetic testing in patients with hematologic malignancies using DNA isolated from nail clippings
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285055. Online ahead of print.ABSTRACTNot available.PMID:38572560 | DOI:10.3324/haematol.2024.285055 (Source: Haematologica)
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Ozge Ceyhan-Birsoy Elise Fiala Satshil Rana Margaret Sheehan Jennifer Kennedy Zarina Yelskaya Vikas Rai Yirong Li Ciyu Yang Donna Wong Ivelise Rijo Jacklyn Casanova Joshua Somar Nikita Mehta Hyeonjin Park Silvana Ostafi Kanika Arora Angelika Padunan Mark Source Type: research

A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285014. Online ahead of print.ABSTRACTAzacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechanism. Pevonedistat inhibits MCL-1 through activation of NOXA, and pevonedistat/azacitidine has previously shown activity in AML. To assess the tolerability and efficacy of adding pevonedistat to azacitidine/venetoclax in relapsed/refractory AML, we conducted a phase I multicenter openlabe...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Guru Subramanian Guru Murthy Antoine N Saliba Aniko Szabo Alexandra Harrington Sameem Abedin Karen Carlson Laura Michaelis Lyndsey Runaas Arielle Baim Alex Hinman Sonia Maldonado-Schmidt Annapoorna Venkatachalam Karen S Flatten Kevin L Peterson Paula A Sc Source Type: research

HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.283432. Online ahead of print.ABSTRACTHematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the activity of various transcription factors, such as members of the Hairy/Enhancer of Split (HES) family, and important roles for both HES1 and HES4 have been shown in normal and malignant hematopoiesis. Here, we investigated the role of HES6 in human hematopoiesis using in vitro and in vivo models. Using bulk and scRNA-seq data, we show that HES6 is expressed during erythroid/m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Tamara De Vos Nicole Oatman Lena Boehme Tom Putteman Imke Velghe Yana Van Droogenbroeck Stijn De Munter Michaela Cesnekova Filip Van Nieuwerburgh Bart Vandekerckhove Jan Philippe Tom Taghon Source Type: research

Outcomes after chimeric antigen receptor T-cell therapy across large B-cell lymphoma subtypes
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285010. Online ahead of print.ABSTRACTNot available.PMID:38572567 | DOI:10.3324/haematol.2024.285010 (Source: Haematologica)
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Christianne Bourlon Claire Roddie Tobias Menne Jane Norman Maeve O'Reilly Adam Gibb Caroline Besley Sridhar Chaganti Carlos Gonzalez Arias Ceri Jones Abdalla Dikair Sharon Allen Frances Seymour Wendy Osborne Amrith Mathew William Townsend Piers Em Patten Source Type: research

Soluble B-cell maturation antigen in lacrimal fluid as a potential biomarker and mediator of keratopathy in multiple myeloma
In this study, we provide the first evidence for soluble BCMA (sBCMA) in lacrimal fluid and report on its correlation with tumor burden in myeloma patients. We confirm that corneal cells do not express BCMA, and show that sBCMA-belantamab complexes may rather be internalized by corneal epithelial cells through receptor-ligand independent pinocytosis. Using an hTcEpi corneal cell-line model, we show that the pinocytosis inhibitor EIPA significantly reduces belantamab-specific cell killing. As a proof of concept, we provide detailed patient profiles demonstrating that, after belantamab-induced cell killing, sBCMA is released...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Umair Munawar Johanna Theuersbacher Maximilian J Steinhardt Xiang Zhou Seungbin Han Silvia Nerreter Cornelia Vogt Shilpa Kurian Thorsten Keller Ann-Katrin Regensburger Eva Teufel Julia Mersi Max Bittrich Franziska Seifert Malik S Haider Leo Rasche Jost Hi Source Type: research

Diagnostic challenges and proposed classification of myeloid neoplasms with overlapping features of thrombocytosis, ring sideroblasts and concurrent del(5q) and SF3B1 mutations
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284599. Online ahead of print.ABSTRACTNot available.PMID:38572547 | DOI:10.3324/haematol.2023.284599 (Source: Haematologica)
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Jyoti Kumar Natasha E Lewis Sarina Sherpa Dory Londono Xiaotian Sun Qi Gao Maria E Arcila Mikhail Roshal Yanming Zhang Wenbin Xiao Alexander Chan Source Type: research

Prognostic relevance of tumor-infiltrating CD4 + cells and total metabolic tumor volume-based risk stratification in diffuse large B-cell lymphoma
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285038. Online ahead of print.ABSTRACTTo elucidate the relationship between pre-treatment radiomic parameters and the proportions of various tumour-infiltrating (TI) cells, we retrospectively analysed the association of total metabolic tumour volume (TMTV) and TI cells on biopsied tumour lesions in 171 patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). The surface markers of TI cells were analysed by multicolour flow cytometry using a dissected single-cell suspension. In examining the correlation between TI cells and PET-derived parameters (SUVmax, TMT...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Daisuke Ikeda Mitsuaki Oura Atsushi Uehara Rikako Tabata Kentaro Narita Masami Takeuchi Youichi Machida Kosei Matsue Source Type: research

Dexamethasone treatment for COVID-19 is related to increased mortality in hematologic malignancy patients: results from the EPICOVIDEHA Registry
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284678. Online ahead of print.ABSTRACTNot available.PMID:38572549 | DOI:10.3324/haematol.2023.284678 (Source: Haematologica)
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Tommaso Francesco Aiello Jon Salmanton-Garcia Francesco Marchesi Barbora Weinbergerova Andreas Glenthoj Jens Van Praet Francesca Farina Julio Davila-Valls Sonia Martin-Perez Shaimaa El-Ashwah Martin Schonlein Iker Falces-Romero Jorge Labrador Uluhan Sili Source Type: research

Rethinking paraneoplastic eosinophilia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285081. Online ahead of print.ABSTRACTNot available.PMID:38572550 | DOI:10.3324/haematol.2024.285081 (Source: Haematologica)
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Kathrin M Bernt Source Type: research

Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284474. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases the microvascular network and oxidative enzymes activity including one involved in lipid oxidation, ET might improve the slope coefficient of the V_O2 vs. W curve and the metabolic flexibility of SCD patients. ET may also contribute to improve patient post-exercise cardiopulmonary and m...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Lo ïs Mougin Manon Riccetti Ang èle N Merlet Pablo Bartolucci Barnabas Gellen L éo Blervaque Thomas D'Humi ères Fr édéric Galactéros Chi-An W Emhoff L éonard Féasson Laurent A Messonnier Source Type: research

CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research

Sotatercept for anemia of myelofibrosis: a phase II investigator-initiated study
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284078. Online ahead of print.NO ABSTRACTPMID:38572554 | DOI:10.3324/haematol.2023.284078 (Source: Haematologica)
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Prithviraj Bose Lucia Masarova Naveen Pemmaraju Sharon D Bledsoe Naval G Daver Elias J Jabbour Tapan M Kadia Zeev Estrov Steven M Kornblau Michael Andreeff Nitin Jain Jorge E Cortes Gautam Borthakur Yesid Alvarado Mary Ann Richie Mackenzie H Dobbins Selen Source Type: research

Hematopoiesis post anti-CD117 monoclonal antibody treatment in wild-type and Fanconi anemia settings
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.284275. Online ahead of print.ABSTRACTAnti-CD117 monoclonal antibody (mAb) agents have emerged as exciting alternative conditioning strategies to traditional genotoxic irradiation or chemotherapy conditioning for both allogeneic and autologous gene-modified hematopoietic stem cell transplantation. Further, these agents are concurrently being explored in the treatment of mast cell disorders. Despite promising results in animal models and more recently in patients, the short-term and long-term effects of these treatments have not been fully explored. We conducted rigorous...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Morgane Denis Leah Swartzrock Hana Willner Quenton R Bubb Ethan Haslett Yan Yi Chan Anzhi Chen Mark R Krampf Agnieszka D Czechowicz Source Type: research