Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
A Case Report of Salmonella enterica Meningitis in an Infant: A Rare Entity not to Forget
CONCLUSION: Invasive Salmonella diseases, such as meningitis, are very uncommon in industrial countries nowadays, and the optimal management is yet not well established. Late onset of com-plications from Salmonella meningitis warrants more thorough neurodevelopmental follow-ups.PMID:38676483 | DOI:10.2174/0118715265286206240402050756 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 27, 2024 Category: Infectious Diseases Authors: Maria Palyvou Evangelia Angeli George Syrogiannopoulos Evangelia Farmaki Marianna Tzanoudaki Gabriel Dimitriou Anastasia Varvarigou Despoina Gkentzi Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
A Case Report of Salmonella enterica Meningitis in an Infant: A Rare Entity not to Forget
CONCLUSION: Invasive Salmonella diseases, such as meningitis, are very uncommon in industrial countries nowadays, and the optimal management is yet not well established. Late onset of com-plications from Salmonella meningitis warrants more thorough neurodevelopmental follow-ups.PMID:38676483 | DOI:10.2174/0118715265286206240402050756 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 27, 2024 Category: Infectious Diseases Authors: Maria Palyvou Evangelia Angeli George Syrogiannopoulos Evangelia Farmaki Marianna Tzanoudaki Gabriel Dimitriou Anastasia Varvarigou Despoina Gkentzi Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
A Case Report of Salmonella enterica Meningitis in an Infant: A Rare Entity not to Forget
CONCLUSION: Invasive Salmonella diseases, such as meningitis, are very uncommon in industrial countries nowadays, and the optimal management is yet not well established. Late onset of com-plications from Salmonella meningitis warrants more thorough neurodevelopmental follow-ups.PMID:38676483 | DOI:10.2174/0118715265286206240402050756 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 27, 2024 Category: Infectious Diseases Authors: Maria Palyvou Evangelia Angeli George Syrogiannopoulos Evangelia Farmaki Marianna Tzanoudaki Gabriel Dimitriou Anastasia Varvarigou Despoina Gkentzi Source Type: research
Cancers, Vol. 16, Pages 1706: Dissecting the Puzzling Roles of FAM46C: A Multifaceted Pan-Cancer Tumour Suppressor with Increasing Clinical Relevance
Manfrini
FAM46C is a well-established tumour suppressor with a role that is not completely defined or universally accepted. Although FAM46C expression is down-modulated in several tumours, significant mutations in the FAM46C gene are only found in multiple myeloma (MM). Consequently, its tumour suppressor activity has primarily been studied in the MM context. However, emerging evidence suggests that FAM46C is involved also in other cancer types, namely colorectal, prostate and gastric cancer and squamous cell and hepatocellular carcinoma, where FAM46C expression was found to be significantly reduced in tumoural versus...
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Giancarlo Lai Federica De Grossi Ilaria Catusi Elisa Pesce Nicola Manfrini Tags: Review Source Type: research
The addition of bortezomib to rituximab, high-dose cytarabine and dexamethasone in relapsed or refractory mantle cell lymphoma—a randomized, open-label phase III trial of the European mantle cell lymphoma network
Leukemia, Published online: 27 April 2024; doi:10.1038/s41375-024-02254-2The addition of bortezomib to rituximab, high-dose cytarabine and dexamethasone in relapsed or refractory mantle cell lymphoma—a randomized, open-label phase III trial of the European mantle cell lymphoma network (Source: Leukemia)
Source: Leukemia - April 27, 2024 Category: Hematology Authors: Luca Fischer Linmiao Jiang Jan D ürig Christian Schmidt Stephan Stilgenbauer Krimo Bouabdallah Philippe Solal-Celigny Christian W. Scholz Pierre Feugier Maike de Wit Ralf Ulrich Trappe Michael Hallek Ullrich Graeven Mathias H änel Martin Hoffmann Vincen Source Type: research
Comprehensive evaluation of genetic and acquired thrombophilia markers for an individualized prediction of clinical thrombosis in patients with lymphoma and multiple myeloma
AbstractPatients diagnosed with lymphoma or multiple myeloma are at elevated risk of venous thromboembolism (VTE). Optimum risk stratification and effective thromboprophylaxis can only be achieved through the development of a multiple-specific risk score that successfully captures all aspects of the heterogeneous prothrombotic environment existing in these patients. Our aim was to identify risk factors for thrombosis and suggest an improved tool combining clinical data, thrombo-inflammatory biomarkers and genetic (Thrombo inCode ® test) variables for predicting thrombotic risk in patients with lymphoma and multiple myelom...
Source: Journal of Thrombosis and Thrombolysis - April 27, 2024 Category: Hematology Source Type: research
Hangeshashinto Inhibits < em > Porphyromonas gingivalis < /em > Pathogen-Associated Molecular Patterns-Mediated IL-6 and IL-8 Production through Toll-Like Receptors in CAL27 Cells
This study suggests that the anti-inflammatory effects of hangeshashinto may be attributed to the inhibition of TLR signal transduction pathways including NF-κB activation, thereby suppressing NF-κB-dependent gene expression.PMID:38665937 | PMC:PMC11045287 | DOI:10.1155/2024/9866670 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 26, 2024 Category: Complementary Medicine Authors: Hourei Oh Yoshimasa Makita Kazuya Masuno Yasuhiro Imamura Source Type: research
