Intracellular Zn < sup > 2+ < /sup > Promotes Extracellular Matrix Remodeling in Dexamethasone-Treated Trabecular Meshwork
Am J Physiol Cell Physiol. 2024 Mar 25. doi: 10.1152/ajpcell.00725.2023. Online ahead of print.ABSTRACTGiven the widespread application of glucocorticoids in ophthalmology, the associated elevation of intraocular pressure (IOP) has long been a vexing concern for clinicians, yet the underlying mechanisms remain inconclusive. Much of the discussion focuses on the extracellular matrix (ECM) of trabecular meshwork (TM). It's widely agreed that glucocorticoids impact the expression of Matrix metalloproteinases (MMPs), leading to ECM deposition. Since Zn2+ is vital for MMPs, we explored its role in ECM alterations induced by dex...
Source: American Journal of Physiology. Cell Physiology - March 25, 2024 Category: Cytology Authors: Canying Liu Jiahui Tang Yuze Chen Qi Zhang Jicheng Lin Siting Wu Jiaxu Han Zhe Liu Caiqing Wu Yehong Zhuo Yiqing Li Source Type: research
Intracellular Zn < sup > 2+ < /sup > Promotes Extracellular Matrix Remodeling in Dexamethasone-Treated Trabecular Meshwork
Am J Physiol Cell Physiol. 2024 Mar 25. doi: 10.1152/ajpcell.00725.2023. Online ahead of print.ABSTRACTGiven the widespread application of glucocorticoids in ophthalmology, the associated elevation of intraocular pressure (IOP) has long been a vexing concern for clinicians, yet the underlying mechanisms remain inconclusive. Much of the discussion focuses on the extracellular matrix (ECM) of trabecular meshwork (TM). It's widely agreed that glucocorticoids impact the expression of Matrix metalloproteinases (MMPs), leading to ECM deposition. Since Zn2+ is vital for MMPs, we explored its role in ECM alterations induced by dex...
Source: Am J Physiol Cell Ph... - March 25, 2024 Category: Cytology Authors: Canying Liu Jiahui Tang Yuze Chen Qi Zhang Jicheng Lin Siting Wu Jiaxu Han Zhe Liu Caiqing Wu Yehong Zhuo Yiqing Li Source Type: research
Case report: unprecedented case of infantile cerebral infarction following COVID-19 and favorable outcome
We present a case of a previously healthy 7-month-old infant who developed cerebral infarction and coagulation dysfunction three days after COVID-19 onset. Clinically, the infant had weakness in the left limbs and pinpoint bleeding spots. A cranial magnetic resonance imaging showed ischemic strokes in the right basal ganglia and thalamus. Laboratory tests indicated thrombocytopenia and coagulation dysfunction. Inflammatory cytokines like interleukin-10 were elevated, with increased CD3+, CD4+, and CD8+ T lymphocytes but decreased CD3- CD16+ CD56+ natural killer cells. Treatment included mannitol, dexamethasone, oral aspiri...
Source: Frontiers in Immunology - March 25, 2024 Category: Allergy & Immunology Source Type: research
Hair cortisol and changes in cortisol dynamics in chronic kidney disease
ConclusionCortisol-after-DST and salivary cortisol rhythm present progressive alterations in CKD patients. Changes in cortisol excretion and HPA dynamics in CKD are not accompanied by significant changes in long-term exposure to cortisol evaluated by HC. The clinical significance and pathophysiological mechanisms explaining the associations between HPA parameters, body composition, and kidney damage warrant further study. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 25, 2024 Category: Endocrinology Source Type: research
Iris atrophy following intracameral dexamethasone injection: a report of two pediatric cases
(Source: Journal of AAPOS)
Source: Journal of AAPOS - March 25, 2024 Category: Opthalmology Authors: Brian M. Nguyen, Christine L. Do, Ian P. Boydstun, Palak B. Wall Tags: Short Report Source Type: research
Multi-organ developmental toxicity and its characteristics in fetal mice induced by dexamethasone at different doses, stages, and courses during pregnancy
In conclusion, this study systematically confirmed PDE-induced multi-organ developmental toxicity, elucidated its characteristics, and proposed the potential "glucocorticoid (GC)-IGF1" axis programming mechanism. This research provided an experimental foundation for a comprehensive understanding of the effect and characteristics of dexamethasone on fetal multi-organ development, thereby guiding the application of "precision medicine" during pregnancy.PMID:38522057 | DOI:10.1007/s00204-024-03707-4 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 24, 2024 Category: Toxicology Authors: Xiaoqi Zhao Hao Xiao Xiaomin Li Lu Zhu Yu Peng Huijun Chen Liaobin Chen Dan Xu Hui Wang Source Type: research
Multi-organ developmental toxicity and its characteristics in fetal mice induced by dexamethasone at different doses, stages, and courses during pregnancy
In conclusion, this study systematically confirmed PDE-induced multi-organ developmental toxicity, elucidated its characteristics, and proposed the potential "glucocorticoid (GC)-IGF1" axis programming mechanism. This research provided an experimental foundation for a comprehensive understanding of the effect and characteristics of dexamethasone on fetal multi-organ development, thereby guiding the application of "precision medicine" during pregnancy.PMID:38522057 | DOI:10.1007/s00204-024-03707-4 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 24, 2024 Category: Toxicology Authors: Xiaoqi Zhao Hao Xiao Xiaomin Li Lu Zhu Yu Peng Huijun Chen Liaobin Chen Dan Xu Hui Wang Source Type: research
Recent Developments in Convenience of Administration of the Anti-CD38 Antibody Isatuximab: Subcutaneous Delivery and Fast Intravenous Infusion in Patients With Multiple Myeloma
Clin Lymphoma Myeloma Leuk. 2024 Feb 12:S2152-2650(24)00063-6. doi: 10.1016/j.clml.2024.02.004. Online ahead of print.ABSTRACTIsatuximab-based combinations are among the accepted standard-of-care regimens for early-line treatment of patients with relapsed/refractory multiple myeloma (RRMM), based on the results of the Phase 3 ICARIA-MM and IKEMA trials. Further study findings have shown benefit with Isa-based combinations in patients with newly diagnosed MM, as reported from the randomized GMMG-HD7 and CONCEPT trials. Isa is currently approved in various countries for intravenous (IV) administration in patients with RRMM. ...
Source: Clinical Lymphoma and Myeloma - March 22, 2024 Category: Cancer & Oncology Authors: Hang Quach Gurdeep Parmar Maria-Victoria Mateos Sikander Ailawadhi Xavier Leleu Source Type: research
Recent Developments in Convenience of Administration of the Anti-CD38 Antibody Isatuximab: Subcutaneous Delivery and Fast Intravenous Infusion in Patients With Multiple Myeloma
Clin Lymphoma Myeloma Leuk. 2024 Feb 12:S2152-2650(24)00063-6. doi: 10.1016/j.clml.2024.02.004. Online ahead of print.ABSTRACTIsatuximab-based combinations are among the accepted standard-of-care regimens for early-line treatment of patients with relapsed/refractory multiple myeloma (RRMM), based on the results of the Phase 3 ICARIA-MM and IKEMA trials. Further study findings have shown benefit with Isa-based combinations in patients with newly diagnosed MM, as reported from the randomized GMMG-HD7 and CONCEPT trials. Isa is currently approved in various countries for intravenous (IV) administration in patients with RRMM. ...
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Hang Quach Gurdeep Parmar Maria-Victoria Mateos Sikander Ailawadhi Xavier Leleu Source Type: research
Recent Developments in Convenience of Administration of the Anti-CD38 Antibody Isatuximab: Subcutaneous Delivery and Fast Intravenous Infusion in Patients With Multiple Myeloma
Clin Lymphoma Myeloma Leuk. 2024 Feb 12:S2152-2650(24)00063-6. doi: 10.1016/j.clml.2024.02.004. Online ahead of print.ABSTRACTIsatuximab-based combinations are among the accepted standard-of-care regimens for early-line treatment of patients with relapsed/refractory multiple myeloma (RRMM), based on the results of the Phase 3 ICARIA-MM and IKEMA trials. Further study findings have shown benefit with Isa-based combinations in patients with newly diagnosed MM, as reported from the randomized GMMG-HD7 and CONCEPT trials. Isa is currently approved in various countries for intravenous (IV) administration in patients with RRMM. ...
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Hang Quach Gurdeep Parmar Maria-Victoria Mateos Sikander Ailawadhi Xavier Leleu Source Type: research
Recent Developments in Convenience of Administration of the Anti-CD38 Antibody Isatuximab: Subcutaneous Delivery and Fast Intravenous Infusion in Patients With Multiple Myeloma
Clin Lymphoma Myeloma Leuk. 2024 Feb 12:S2152-2650(24)00063-6. doi: 10.1016/j.clml.2024.02.004. Online ahead of print.ABSTRACTIsatuximab-based combinations are among the accepted standard-of-care regimens for early-line treatment of patients with relapsed/refractory multiple myeloma (RRMM), based on the results of the Phase 3 ICARIA-MM and IKEMA trials. Further study findings have shown benefit with Isa-based combinations in patients with newly diagnosed MM, as reported from the randomized GMMG-HD7 and CONCEPT trials. Isa is currently approved in various countries for intravenous (IV) administration in patients with RRMM. ...
Source: Clinical Lymphoma and Myeloma - March 22, 2024 Category: Cancer & Oncology Authors: Hang Quach Gurdeep Parmar Maria-Victoria Mateos Sikander Ailawadhi Xavier Leleu Source Type: research
Comparing the efficacy of glucocorticoids and anti-VEGF in treating diabetic macular edema: systematic review and comprehensive analysis
This study included randomized controlled trials up to February 2023 comparing the efficacy of corticosteroid-related therapy and anti-VEGF therapy. PubMed, the Cochrane Library, and Embase were searched, and the quality of the studies was carefully assessed. Finally, 39 studies were included.ResultsResults at 3-month followup showed that intravitreal injection of bevacizumab (IVB) + triamcinolone acetonide (TA) was the most beneficial in improving best-corrected visual acuity and reducing the thickness of macular edema in the center of the retina in patients with DME. Results at 6-month follow-up showed that intravitreal ...
Source: Frontiers in Endocrinology - March 22, 2024 Category: Endocrinology Source Type: research
Letter to the editor: Dexamethasone and overall survival and progression free survival in patients with newly diagnosed glioblastoma: a meta-analysis
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Ultrasound-guided erector spinae nerve block for relief of endometriosis pain in the emergency department
We report the case of a 23-year-old female with a past medical history of endometriosis who presented to a freestanding emergency department with a chief complaint of 10/10 pelvic pain on a numeric rating scale. She had tried non-steroidal inflammatory medications and heat with no success. The patient had medication intolerances to opioid analgesics and was given ketorolac intramuscularly with no relief of her pain. The emergency physician discussed and offered to perform an erector spinae plane nerve block (ESPB) for pain relief. Ultrasonography was utilized for visualization of landmarks with a curvilinear transducer; a ...
Source: Pain Physician - March 21, 2024 Category: Anesthesiology Authors: Robert Stenberg Kristen Septaric Erin L Simon Source Type: research
A silk-based hydrogel containing dexamethasone and lipoic acid microcrystals for local delivery to the inner ear
In this study, to endow viscous effects of hydrogels, nonspherical dexamethasone (DEX) and lipoic acid (LA) MCs were incorporated into silk fibroin (SF) hydrogels, which were subsequently administered to the tympanic cavity to investigate their pharmaceutical properties. First, we prepared DEX and LA MCs by a traditional precipitation technique followed by SF hydrogel incorporation (SF+DEX+LA). After characterization of the physicochemical features, including morphology, rheology, and dissolution, both a suspension of combined DEX and LA MCs (DEX+LA) and SF+DEX+LA were administered to guinea pigs by IT injection, after whi...
Source: Colloids and Surfaces - March 21, 2024 Category: Biotechnology Authors: Haixia Xiong Peili Zhang Dongcheng Wang Zhimin Zhou Jianjun Sun Mingfang Diao Source Type: research
