Cancers, Vol. 16, Pages 1393: Dexamethasone in Patients with Glioblastoma: A Systematic Review and Meta-Analysis
Conclusion: Despite the widespread use of dexamethasone in glioblastoma patients, its use is correlated with worse long-term outcomes. Consequently, Dexamethasone administration should be restricted to selected symptomatic patients. Future prospective studies are crucial to confirm these findings. (Source: Cancers)
Source: Cancers - April 1, 2024 Category: Cancer & Oncology Authors: Pierre Scheffler Christian Fung Shahan Momjian Dominik Koessinger Levin H äni Nicolas Neidert Jakob Straehle Florian Volz Oliver Schnell J ürgen Beck Amir El Rahal Tags: Systematic Review Source Type: research
Heart and Lung Transplant in a Patient with Relapsed AL Amyloidosis
Introduction: AL amyloidosis is a systemic disease of abnormal light chain production and pathologic amyloid fibrils that infiltrate tissue and lead to organ dysfunction. Solid organ transplantation historically has played a small role in management due to concerns of multi-organ involvement and risk of relapse. Standard of care previously included cyclophosphamide, bortezomib, and dexamethasone (CyBorD). For relapsed disease, treatment options often included immunomodulatory drugs that are associated with an increased risk of transplant rejection or autologous bone marrow transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Urey, E. Adler, V. Pretorius, M. Kearns, E. Golts, A. Kao, G. Yung, A. Kafi, C. Lin, C. Costello, K. Afshar Source Type: research
Dexamethasone/mercaptopurine/methotrexate
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin a via the cAMP/PKA/p38 MAPK/CREB signaling pathway
In conclusion, this study reveal that dexamethasone mitigateds neuropathic pain through upregulation of dynorphin A in spinal microglia, likely involving the membrane glucocorticoid receptor/cAMP/PKA/p38 MAPK/CREB signaling pathway.PMID:38555991 | DOI:10.1016/j.bbi.2024.03.047 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Meng-Yan Deng Jing Cheng Na Gao Xin-Yan Li Hao Liu Yong-Xiang Wang Source Type: research
GSK4716 enhances 5-HT1AR expression by glucocorticoid receptor signaling in hippocampal HT22 cells
CONCLUSION: The results could provide insight into the potential applications of small molecules, such as GSK4716, in the regulation of 5-HT1AR expression, which plays a role in serotonergic neurotransmission.PMID:38555524 | DOI:10.1080/01616412.2024.2322180 (Source: Neurological Research)
Source: Neurological Research - March 31, 2024 Category: Neurology Authors: Juhee Lim Jiyeon Park Wonwoong Lee Hyun Jin Choi Source Type: research
Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin a via the cAMP/PKA/p38 MAPK/CREB signaling pathway
In conclusion, this study reveal that dexamethasone mitigateds neuropathic pain through upregulation of dynorphin A in spinal microglia, likely involving the membrane glucocorticoid receptor/cAMP/PKA/p38 MAPK/CREB signaling pathway.PMID:38555991 | DOI:10.1016/j.bbi.2024.03.047 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Meng-Yan Deng Jing Cheng Na Gao Xin-Yan Li Hao Liu Yong-Xiang Wang Source Type: research
GSK4716 enhances 5-HT1AR expression by glucocorticoid receptor signaling in hippocampal HT22 cells
CONCLUSION: The results could provide insight into the potential applications of small molecules, such as GSK4716, in the regulation of 5-HT1AR expression, which plays a role in serotonergic neurotransmission.PMID:38555524 | DOI:10.1080/01616412.2024.2322180 (Source: Neurological Research)
Source: Neurological Research - March 31, 2024 Category: Neurology Authors: Juhee Lim Jiyeon Park Wonwoong Lee Hyun Jin Choi Source Type: research
Multifunctional hyaluronic acid/gelatin methacryloyl core-shell microneedle for comprehensively treating oral mucosal ulcers
Int J Biol Macromol. 2024 Mar 28:131221. doi: 10.1016/j.ijbiomac.2024.131221. Online ahead of print.ABSTRACTOral ulceration is the most common oral mucosal disease. Oral mucosal ulcers are extremely painful, may interfere with eating and speaking, and potentially complicate systemic symptoms in severe cases. The humid and highly dynamic environment of the oral cavity makes local drug administration for treating oral mucosal ulcers challenging. To overcome these challenges, we designed and prepared a novel dissolving microneedle (MN) patch containing multiple drugs in a core-shell to promote oral ulcer healing. The MNs cont...
Source: International Journal of Biological Macromolecules - March 30, 2024 Category: Biochemistry Authors: Yi Yu Yijun Gao Yiyu Zeng Wenhui Ge Chengxuan Tang Xiaoyan Xie Liangle Liu Source Type: research
Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells
CONCLUSIONS: Mifepristone alone is capable of inducing adipocyte differentiation in 3T3-L1 cells and adipogenesis in vivo. PPARγ plays a critical role in the mifepristone-induced adipocyte differentiation. Mifepristone-induced adipocytes are closer to the in situ adipocytes than those induced by the conventional protocol. The present study proposes a single treatment with mifepristone as a novel protocol to induce more physiologically relevant adipocytes in 3T3-L1 cells than the conventional protocol.PMID:38553665 | PMC:PMC10981365 | DOI:10.1186/s11658-024-00559-9 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 30, 2024 Category: Molecular Biology Authors: Takeshi Hashimoto Katsuya Hirano Source Type: research
PANoptosis, an indicator of COVID-19 severity and outcomes
This study conducted a bioinformatics analysis of online single-cell RNA sequence (scRNA-seq) and bulk RNA-seq datasets to explore the potential of PANoptosis as an indicator of COVID-19 severity. The degree of PANoptosis in bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) indicated the severity of COVID-19. Single-cell transcriptomics identified pro-inflammatory monocytes as one of the primary sites of PANoptosis in COVID-19. The study subsequently demonstrated the immune and metabolic characteristics of this group of pro-inflammatory monocytes. In addition, the analysis illustrated that d...
Source: Briefings in Bioinformatics - March 30, 2024 Category: Bioinformatics Authors: Qingyuan Yang Wanmei Song Hanizaier Reheman Dan Wang Jieming Qu Yanan Li Source Type: research
Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells
CONCLUSIONS: Mifepristone alone is capable of inducing adipocyte differentiation in 3T3-L1 cells and adipogenesis in vivo. PPARγ plays a critical role in the mifepristone-induced adipocyte differentiation. Mifepristone-induced adipocytes are closer to the in situ adipocytes than those induced by the conventional protocol. The present study proposes a single treatment with mifepristone as a novel protocol to induce more physiologically relevant adipocytes in 3T3-L1 cells than the conventional protocol.PMID:38553665 | PMC:PMC10981365 | DOI:10.1186/s11658-024-00559-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 30, 2024 Category: Biochemistry Authors: Takeshi Hashimoto Katsuya Hirano Source Type: research
Myelomatous pleural effusion in multiple myeloma- A rare presentation
J Cancer Res Ther. 2024 Jan 1;20(1):476-478. doi: 10.4103/jcrt.jcrt_1772_22. Epub 2023 May 2.ABSTRACTMultiple myeloma is a malignant plasma cell condition that mostly affects the skeletal system and bone marrow. Pleural effusions are uncommon and typically result from other conditions coexisting with multiple myeloma. Malignant myelomatous pleural effusions are rare complications of multiple myeloma, occurring in less than 1% of patients and are associated with poor prognosis having mean survival of less than 4 months. The present case report is a 41-year-old multiple myeloma patient who developed bilateral pleural effusio...
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Ingale Yaminy Pradeep R Kulkarni Mayuri S Patil Sourabh M Patel Nirali Source Type: research
Multifunctional hyaluronic acid/gelatin methacryloyl core-shell microneedle for comprehensively treating oral mucosal ulcers
Int J Biol Macromol. 2024 Mar 28:131221. doi: 10.1016/j.ijbiomac.2024.131221. Online ahead of print.ABSTRACTOral ulceration is the most common oral mucosal disease. Oral mucosal ulcers are extremely painful, may interfere with eating and speaking, and potentially complicate systemic symptoms in severe cases. The humid and highly dynamic environment of the oral cavity makes local drug administration for treating oral mucosal ulcers challenging. To overcome these challenges, we designed and prepared a novel dissolving microneedle (MN) patch containing multiple drugs in a core-shell to promote oral ulcer healing. The MNs cont...
Source: International Journal of Biological Macromolecules - March 30, 2024 Category: Biochemistry Authors: Yi Yu Yijun Gao Yiyu Zeng Wenhui Ge Chengxuan Tang Xiaoyan Xie Liangle Liu Source Type: research
Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells
CONCLUSIONS: Mifepristone alone is capable of inducing adipocyte differentiation in 3T3-L1 cells and adipogenesis in vivo. PPARγ plays a critical role in the mifepristone-induced adipocyte differentiation. Mifepristone-induced adipocytes are closer to the in situ adipocytes than those induced by the conventional protocol. The present study proposes a single treatment with mifepristone as a novel protocol to induce more physiologically relevant adipocytes in 3T3-L1 cells than the conventional protocol.PMID:38553665 | PMC:PMC10981365 | DOI:10.1186/s11658-024-00559-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 30, 2024 Category: Biochemistry Authors: Takeshi Hashimoto Katsuya Hirano Source Type: research
PANoptosis, an indicator of COVID-19 severity and outcomes
This study conducted a bioinformatics analysis of online single-cell RNA sequence (scRNA-seq) and bulk RNA-seq datasets to explore the potential of PANoptosis as an indicator of COVID-19 severity. The degree of PANoptosis in bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) indicated the severity of COVID-19. Single-cell transcriptomics identified pro-inflammatory monocytes as one of the primary sites of PANoptosis in COVID-19. The study subsequently demonstrated the immune and metabolic characteristics of this group of pro-inflammatory monocytes. In addition, the analysis illustrated that d...
Source: Briefings in Bioinformatics - March 30, 2024 Category: Bioinformatics Authors: Qingyuan Yang Wanmei Song Hanizaier Reheman Dan Wang Jieming Qu Yanan Li Source Type: research
