Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin a via the cAMP/PKA/p38 MAPK/CREB signaling pathway

In conclusion, this study reveal that dexamethasone mitigateds neuropathic pain through upregulation of dynorphin A in spinal microglia, likely involving the membrane glucocorticoid receptor/cAMP/PKA/p38 MAPK/CREB signaling pathway.PMID:38555991 | DOI:10.1016/j.bbi.2024.03.047

Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Meng-Yan Deng Jing Cheng Na Gao Xin-Yan Li Hao Liu Yong-Xiang Wang Source Type: research