Triterpenoids from Celastrus orbiculatus Thunb. inhibit RANKL-induced osteoclast formation and bone resorption via c-Fos signaling
AbstractFourteen triterpenes, lup-20(29)-ene-3 β,6β-diol (1), betulin (2), lupeol caffeate (3), 3 β-caffeoyloxylup-20(29)-en-6α-ol (4), betulin-3 β-yl-caffeate (5), 3 β-trans-feruloylbetulin (6), betulinaldehyde 3-caffeate (7), 3-O-trans-caffeoylbetulinic acid (8), dammarenediol II 3-caffeate (9), 12-oleanene-3 β,6α-diol (10), 11 α-hydroxy-3β-amyrin (11), nivadiol (12), 29-hydroxyfriedelin (13), and celastrusin A (14) were isolated fromCelastrus orbiculatus Thunb. and evaluated for their activity on receptor activator of nuclear factor κB ligand (RANKL)-induced ost...
Source: Journal of Natural Medicines - August 10, 2020 Category: Drugs & Pharmacology Source Type: research

Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF- κB signaling pathway activation: an in vivo and in vitro study
AbstractMonosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess anti-inflammatory property. Nevertheless, the role of dioscin in GA and the underlying mechanism have not been fully understood. In the present study, we investigated the anti-inflammatory effect of dioscin on MSU-induced GA through in vivo and in vitro experiments. Histopathological analysis showed that dioscin alleviated the severity of GA concomitant with the lowered uric acid and creatinine levels. Moreover, the increasing IL-1 β, IL-6, and TNF-α levels ...
Source: Journal of Natural Medicines - August 6, 2020 Category: Drugs & Pharmacology Source Type: research

Characterization of metabolites in Saposhnikovia divaricata root from Mongolia
AbstractSaposhnikoviae Radix (SR), derived from the dried root and rhizome ofSaposhnikovia divaricata, is a popular crude drug used in traditional Chinese and Japanese medicine. To evaluate the metabolites ofS. divaricata roots from Mongolia and to investigate their geographical variation, we developed the HPLC method, determined the contents of 9 chromones and 4 coumarins, and conducted multivariate statistical analysis. All Mongolian specimens contained prim-O-glucosylcimifugin (1) and 4 ′-O- β-d-glucosyl-5-O-methylvisamminol (3), and their total amount (5.04 –25.06 mg/g) exceeded the criterion assi...
Source: Journal of Natural Medicines - August 1, 2020 Category: Drugs & Pharmacology Source Type: research

Quality evaluation of Angelicae acutilobae radix: individual differences and localization of ( Z )-ligustilide in Angelica acutiloba root
AbstractIt has been difficult to evaluate the quality of Angelicae acutilobae Radix (Toki) because of large differences in the contents of its chemical constituents. In this research, we revealed individual differences and localization of (Z)-ligustilide in Toki cultivated and processed under the same conditions. Thirteen Toki samples (dry weight: 68.2  g–132.3 g) were divided and categorized into 13 parts and the (Z)-ligustilide content of each part was quantified. Total (Z)-ligustilide content ranged from 0.08% to 0.22% and the maximum difference between samples was approximately 2.8-fold. In addition, th...
Source: Journal of Natural Medicines - July 31, 2020 Category: Drugs & Pharmacology Source Type: research

Two new sesquiterpenes from Artemisia annua L.
AbstractInvestigation of the dried whole plants ofArtemisia annua led to the isolation of two new sesquiterpenes, artemanins A (1) and B (2), along with twenty-nine known compounds. The structures of the new compounds were elucidated by spectroscopic and chemical means. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - July 24, 2020 Category: Drugs & Pharmacology Source Type: research

Two new phenylpropanoids from the resin of Styrax tonkinensis (Pierre) Craib ex Hartw
AbstractAbstractTwo new phenylpropanoids, named stytonkinol A (1) and stytonkinol B (2), have been isolated from the resin ofStyrax tonkinensis (Pierre) Craib ex Hartw. Their structures were determined by spectroscopic analysis, including 1D and 2D NMR, and HR-ESI –MS. Two isolated compounds were assayed for cytotoxic activities against five tumor cell lines (HepG-2, A549, Hela, MCF-7, and PC-3) by Cell Counting Kit-8 (CCK-8) test in vitro. The cytotoxic effectiveness observed against Hela, and MCF-7 cell lines of compound1 were superior or similar to the positive control cisplatin (IC50 values of 40.95 and 47.36 &nb...
Source: Journal of Natural Medicines - July 21, 2020 Category: Drugs & Pharmacology Source Type: research

Sauchinone: a prospective therapeutic agent-mediated EIF4EBP1 down-regulation suppresses proliferation, invasion and migration of lung adenocarcinoma cells
AbstractLung adenocarcinoma (LUAD) is the top prevalent histological kind of lung cancer worldwide. Recent evidences have demonstrated that Sauchinone plays an anticancer role in tumor cell invasion and migration. Therefore, we performed this investigation to explain the potential role of Sauchinone in LUAD as well as the potential mechanism involved. Cell counting kit 8 (CCK-8) and transwell experiments were implemented to measure the proliferative, invasive and migratory abilities of LUAD cells. qRT-PCR and Western blot were performed to detect the transfection efficiency of si-EIF4EBP1s. Additionally, Western blot was a...
Source: Journal of Natural Medicines - July 15, 2020 Category: Drugs & Pharmacology Source Type: research

Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/ β-catenin pathway
In conclusion, Licoricidin exerted neuroprotective effect on TBI model and the effect was possibly due to its antioxidative effect and antiapoptotic effect via regulating the FoxO3/Wnt/β-catenin pathway. Licoricidin may be a candidate drug for TBI therapy. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - July 12, 2020 Category: Drugs & Pharmacology Source Type: research

Isolation and evaluation of cardenolides from Lansium domesticum as Notch inhibitors
In this study, six naturally occurring Notch inhibitors were isolated from the methanol (MeOH) extract ofLansium domesticum using our novel cell-based assay. Hongherin (2), a cardiac glycoside, demonstrated potent Notch inhibitory activity with an IC50 of 0.62  μM and was found to be cytotoxic in HPB-ALL human T cell acute lymphoblastic leukemia cells. Hongherin (2) also induced the differentiation of C17.2 neural stem cells to neurons, causing a 65% increase in differentiation compared to the control. Mechanistically, hongherin (2) reduced the amount of Notch1 (full length) and mastermind-like protein (MAML). This...
Source: Journal of Natural Medicines - July 9, 2020 Category: Drugs & Pharmacology Source Type: research

Antiangiogenic effects of AG36, a triterpenoid saponin from Ardisia gigantifolia stapf.
AbstractAG36 is a triterpenoid saponin fromArdisia gigantifolia stapf. Our recent studies proved that AG36 displayed prominent cytotoxicity against breast cancer cells both in vitro and in vivo. However, whether AG36 has antiangiogenic properties is unknown. Therefore, in the present study, we evaluated the antiangiogenic effect of AG36 and the underlying mechanism. The results indicated that AG36 could significantly inhibit the proliferation, migration and invasion of human umbilical vein endothelial cells (HUVEC). Further antiangiogenic molecular mechanism investigation showed that AG36 significantly suppressed phosphory...
Source: Journal of Natural Medicines - July 8, 2020 Category: Drugs & Pharmacology Source Type: research

The search for, and chemistry and mechanism of, neurotrophic natural products
AbstractNeurotrophic factors, now termed neurotrophins, which belong to a class of polypeptidyl agents, have been shown to potentially be beneficial for the treatment of neurodegenerative diseases such as Alzheimer ’s disease, because endogenous neurotrophic factors (NGF, BDNF, NT3, NT4) have been recognized to play critical roles in the promotion of neurogenesis, differentiation, and neuroprotection throughout the development of the central nervous system. However, high-molecular weight proteins are unable to cross the blood–brain barrier and are easily decomposed by peptidase under physiological conditions. T...
Source: Journal of Natural Medicines - July 8, 2020 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory canthin-6-one alkaloids from the roots of Thailand Eurycoma longifolia Jack
AbstractTwo new canthin-6-one alkaloids, 4,9-dimethoxy-5-hydroxycanthin-6-one (1) and 9-methoxy-(R/S)-5-(1-hydroxyethyl)-canthin-6-one (2), together with fifteen known ones were isolated from the roots of ThailandEurycoma longifolia Jack. Among the known canthin-6-one alkaloids, compounds9 and16 were isolated from theEurycoma genus for the first time. Meanwhile, the nitric oxide (NO) inhibitory activities of all isolates were examined in lipopolysaccharide (LPS)-stimulated RAW264.7 cells at 50  µM. Moreover, a dose-dependent experiment was conducted for active compounds1,2,4,6,7,10,12–17 at the concentrati...
Source: Journal of Natural Medicines - July 8, 2020 Category: Drugs & Pharmacology Source Type: research

Firmosides A and B: two new sucrose ferulates from the aerial parts of Silene firma and evaluation of radical scavenging activities
AbstractTwo new tri-ferulates of sucrose, firmosides A and B (1 and2, respectively), together with 18 known compounds (3–20), were isolated from the aerial parts ofSilene firma. The structures of the isolated compounds were elucidated by various spectroscopic methods, including 1D, 2D NMR, and high-resolution electro-spray ionization –mass spectrometry (HR-ESI–MS). All the isolated compounds were evaluated for their free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. As a result, two new compounds (1,2) and11 demonstrated significant radical scavenging activity, implying t...
Source: Journal of Natural Medicines - July 6, 2020 Category: Drugs & Pharmacology Source Type: research

Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia
AbstractArtemisia sieversiana is an annual herbaceous plant distributed throughout Central and East Eurasia and is regarded as an undesirable forage plant in Mongolia. It affects livestock, so information about its chemical composition is needed. We isolated three new sesquiterpenoids (1–3) and known compounds fromA.sieversiana and investigated their activities. The absolute configuration of1 was established using single-crystal X-ray diffraction crystallography, and its configuration differed from those of reported compounds with similar structures. Two additional new sesquiterpenoids (2 and3) with similar structure...
Source: Journal of Natural Medicines - July 3, 2020 Category: Drugs & Pharmacology Source Type: research

Magnolol inhibits myotube atrophy induced by cancer cachexia through myostatin signaling pathway in vitro
This study reveals that magnolol inhibits myotube atrophy induced by CCM by increasing protein synthesis and decreasing ubiquitin-mediated proteolysis, so that magnolol is a promising leading compound in treating muscle atrophy induced by cancer cachexia. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - June 29, 2020 Category: Drugs & Pharmacology Source Type: research

The acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract
In this study, we developed an easy protocol that can be used to collect raphides from unprocessed Pinellia Tuber and an assay protocol that can be used to evaluate the acridity of the raphides in vitro. The raphides of Pinellia Tuber were discovered to have a lipophilic character and to be collected easily by the extraction using petroleum ether. It was also found that the denaturation of the raphides could be assayed by the dispersity of them in petroleum ether layer of the water/petroleum ether partition, and the acridity of the raphides was found to be in correlation with the assayed denaturation. The raphides were den...
Source: Journal of Natural Medicines - June 26, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases
The article Biosynthesis of medicinally important plant metabolites by unusual. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - June 22, 2020 Category: Drugs & Pharmacology Source Type: research

Appetite-enhancing effects of inhaling cinnamon, clove, and fennel essential oils containing phenylpropanoid analogues
AbstractCinnamon, clove, and fennel are commonly used as spices and herbal medicines, and one of their medicinal uses is as aromatic stomachics. We investigated the effect on appetite in mice of inhaling volatile compounds contained in essential oils extracted from herbal medicines used as aromatic stomachics. The appetite-enhancing effects of cinnamon and fennel essential oils were similar to those of their main componentstrans-cinnamaldehyde andtrans-anethole, respectively. The appetite-enhancing effects of clove essential oil were observed over a wide range of doses (4.5  × 10−4 to 4.5  ...
Source: Journal of Natural Medicines - June 15, 2020 Category: Drugs & Pharmacology Source Type: research

Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells
AbstractAbstractFrom the methanolic extract of the aerial parts ofPetasites japonicus, six new eremophilane-type sesquiterpenoids, petasitesterpenes I –VI were isolated together with eight known compounds includingS-japonin and eremophilenolide. The chemical structures of the isolated new compounds were elucidated based on chemical/physicochemical evidence. For petasitesterpenes I and II, the absolute configurations were established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, petasitesterpenes I, II, VI, andS-japonin showed cytotoxic activity aga...
Source: Journal of Natural Medicines - June 13, 2020 Category: Drugs & Pharmacology Source Type: research

Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response
AbstractSoshiho-tang (SSHT) has traditionally been used to treat gastrointestinal disorders. In this experiment, we investigated the protective effect of SSHT on inflammatory liver injury in lipopolysaccharide (LPS)-sensitized mice. Male C57BL/6J mice aged 6  weeks were randomly placed in 6 groups (n = 5): normal mice (CTR), LPS-sensitized mice (LPS), LPS-sensitized mice treated with dexamethasone (DEX) and LPS-sensitized mice treated with 0.05, 0.55, and 5.55 g/kg of SSHT (SSHT 0.05, SSHT 0.55, and SSHT 5.55). Various doses of SSHT was given once a day for 7 days. After 2 h of LPS injec t...
Source: Journal of Natural Medicines - June 12, 2020 Category: Drugs & Pharmacology Source Type: research

Toosendanin relatives, trypanocidal principles from Meliae Cortex
AbstractAfrica Trypanosomiasis remains a serious health problem, but the approved drugs for this disease are so few that novel trypanocidal compounds are demanded. In search for trypanocidal principles from medicinal plants, we found MeOH extracts of Meliae Cortex with potent activity through the screening from about 300 kinds of methanolic extract. By bioassay-guided fractionation from this extract through the liquid –liquid partition and subsequent chromatographic technique using silica gel and ODS, finally we disclosed toosendanin (1) and its relatives as active principles. These active congeners showed not only p...
Source: Journal of Natural Medicines - June 11, 2020 Category: Drugs & Pharmacology Source Type: research

Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases
AbstractRecent research progress on the “second generation” type III polyketide synthases is summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA thioesters to generate various core structures of medicinally important plant secondary metabolites, including the R1–C–R2 scaffold of alkyl quinolones, curcuminoids, as well as the 8-azabicyclo[3.2.1]octane ring of tropane alkaloids. The discovery of this fascinating enzyme superfamily provides excellent opportunities for the manipulation of the enzyme reactions to expand the supply of natural and unnatural molecules for fut...
Source: Journal of Natural Medicines - June 5, 2020 Category: Drugs & Pharmacology Source Type: research

Caffeic acid and rosmarinic acid contents in genus Perilla
This study investigated the caffeic acid and rosmarinic acid contents of several pure strains in genusPerilla. Perilla plants cultivated under a certain set of conditions had different caffeic acid and rosmarinic acid contents. For example, their contents were higher inP. setoyensis ( “Setoegoma”), suggesting that the genetic background of the species greatly affects caffeic acid and rosmarinic acid contents. Several strains ofP. frutescens var.crispa were cultivated at the Experimental Station for Medicinal Plants, Graduate School of Pharmaceutical Sciences, Kyoto University and differences in their caffeic ac...
Source: Journal of Natural Medicines - June 2, 2020 Category: Drugs & Pharmacology Source Type: research

Inhibitory effect of ergosterol on bladder carcinogenesis is due to androgen signaling inhibition by brassicasterol, a metabolite of ergosterol
In this study, we analyzed the mechanism by which ergosterol inhibits bladder carcinogenesis. Rats were given an N-butyl-N-(4-hydroxybutyl) nitrosamine (BHBN) solution ad libitum, and then a promoter [saccharin sodium (SS), DL-tryptophan, or BHBN] was administered together with ergosterol or its metabolite, brassicasterol. The bladders were removed from rats, and the inhibitory effect on carcinogenesis promotion was evaluated by an agglutination assay with concanavalin A (Con A). Although the oral administration of ergosterol inhibited the promotion of bladder carcinogenesis with SS, the intraperitoneal administration of b...
Source: Journal of Natural Medicines - June 1, 2020 Category: Drugs & Pharmacology Source Type: research

Physical and chemical characteristics of soils in Ephedra gerardiana and E. pachyclada habitats of Kali Gandaki Valley in Central Nepal
AbstractIn the Kali Gandaki Valley in Central Nepal,Ephedra gerardiana andE. pachyclada show species specificity for physical and chemical characteristics of soils. Here, the relationship between soil characteristics and ephedrine and pseudoephedrine contents was examined.E. gerardiana grew in moist alpine scrub and upper alpine meadow from 3735 to 4156  m a.s.l., whileE. pachyclada grew in the lowerCaragana steppe and dry alpine scrub from 2629 to 3671  m a.s.l. The soil texture ofE. gerardiana andE. pachyclada collection sites were classified as loam or sandy loam mainly composed of sand and silt. Loss on ignit...
Source: Journal of Natural Medicines - May 8, 2020 Category: Drugs & Pharmacology Source Type: research

Resveratrol oligomer structure in Dipterocarpaceaeous plants
AbstractOligostilbenoids are a group of natural products derived from the oxidative coupling of C6–C2–C6 units found in some plant families. A structurally diverse chemical pool is produced after the successive regioselective and stereoselective oligomerization of resveratrol. This review describes the current status and knowledge of the structure of resveratrol oligomers (ROs) in Dipterocarpaceaeous plants (DPs). Beginning with the recently validated formation of ROs in DPs, each downstream conversion is described from the perspective of the resveratrol coupling mode. Particular emphasis is placed upon the reg...
Source: Journal of Natural Medicines - April 30, 2020 Category: Drugs & Pharmacology Source Type: research

Five new 2-(2-phenylethyl)chromone derivatives from agarwood
In this study, five new 2-(2-phenylethyl)chromones (2,13–16) and eleven known compounds (1,3–12) were isolated from the agarwood. The structures of the new compounds were determined by1H-,13C-, and two-dimensional NMR together with electronic circular dichroism (ECD) spectroscopy. All isolated compounds were evaluated for the phosphodiesterase (PDE) 3A and 5A1 inhibitory activity by the fluorescence polarization method. Dimeric 2-(2-phenylehyl)chromones (13,14,16) had potent inhibitory activity to PDE 5A1 with IC50 values of micro molar range (13: 4.2  μM,14: 7.9  μM,16: 4.3  μM), wherea...
Source: Journal of Natural Medicines - April 25, 2020 Category: Drugs & Pharmacology Source Type: research

Identifying the compounds that can distinguish between Saposhnikovia root and its substitute, Peucedanum ledebourielloides root, using LC-HR/MS metabolomics
AbstractPreviously, we established a1H NMR metabolomics method using reversed-phase solid-phase extraction column (RP-SPEC), and succeeded in distinguishing wild from cultivated samples of Saposhnikoviae radix (SR), and between SR and its substitute,Peucedanum ledebourielloides root (PR). Herein, we performed LC-HR/MS metabolomics using fractions obtained via RP-SPEC to identify characteristic components of SR and PR. One and three characteristic components were respectively found for SR and PR; these components were isolated with theirm/z values and retention times as a guide. The characteristic component of SR was identi...
Source: Journal of Natural Medicines - April 24, 2020 Category: Drugs & Pharmacology Source Type: research

Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities
AbstractThree new quassinoids, javanicinols A and B (1 and2) and 4-keto-(16S)-methoxyjavanicin B (3), together with three known quassinoids (4 –6) were isolated from the chloroform-soluble fraction of the methanol extract of thePicrasma javanica wood. The structures of1 –3 were determined by spectroscopic analyses, including 1D and 2D NMR, HRESIMS, and CD. The anti-HIV-1 viral protein R (Vpr) assay revealed that1 and2 exhibited potent anti-Vpr activities at 1.25  μM. Furthermore, the assay also revealed the potent anti-Vpr activities of (16R)-methoxyjavanicin B (7) and (16S)-methoxyjavanicin B (8), whic...
Source: Journal of Natural Medicines - April 23, 2020 Category: Drugs & Pharmacology Source Type: research

Quassilactones A and B, structural characterization of a new class of norquassinoids from Brucea javanica
AbstractTwo novel norquassinoids possessing a unique ketal skeleton, designated quassilactones A (1) and B (2), were isolated from the fruits ofBrucea javanica (Simaroubaceae). Their structures were established by extensive NMR and HR-ESI-MS spectroscopic analysis. The absolute configuration of1 was determined through single-crystal X-ray crystallography, and that of2 was assigned by comparing the calculated electronic and experimental circular dichroism with compound1. In addition, their cytotoxic activities against three human cancer cell lines and their antimicrobial activities were evaluated.Graphic abstract (Source: J...
Source: Journal of Natural Medicines - April 11, 2020 Category: Drugs & Pharmacology Source Type: research

Trypanocidal and leishmanicidal activity of six limonoids
AbstractSix limonoids [kotschyienone A and B (1,2), 7-deacetylgedunin (3), 7-deacetyl-7-oxogedunin (4), andirobin (5) and methyl angolensate (6)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms ofTrypanosoma brucei and promastigotes ofLeishmania major. Whereas all compounds showed anti-trypanosomal activity, only compounds1 –4 displayed anti-leishmanial activity. The 50% growth inhibition (GI50) values for the trypanocidal and leishmanicidal activity of the compounds ranged between 2.5 and 14.9  μM. Kotschyienone A (1) was found to be the most active compound wit...
Source: Journal of Natural Medicines - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula “Goshajinkigan”
The article Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula “Goshajinkigan”. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: The structure –activity relationship review of the main bioactive constituents of  Morus genus plants
The article The structure –activity relationship review of the main bioactive constituents of Morus genus plants, written by Jiejing Yan, Jingya Ruan, Peijian Huang, Fan Sun, Dandan Zheng, Yi Zhang and Tao Wang was originally published Online First without Open Access. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Cycloartane triterpenoid (23 R , 24 E )-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both β-catenin and c-Raf–MEK1–ERK signaling axis
The article Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both β-catenin. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Sesquiterpenes with new carbon skeletons from the basidiomycete Phlebia tremellosa
The article Sesquiterpenes with new carbon skeletons from the basidiomycetePhlebia tremellosa, written by Ken ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura and Makoto Inoue was originally published Online First without Open Access. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in  immunoglobulin A nephropathy model mice
The article Antiinflammatory constituents of  Atractylodes chinensis rhizome improve glomerular lesions in  immunoglobulin A nephropathy model mice, written by Toshinari Ishii, Tetsuya Okuyama, Nao Noguchi, Yuto Nishidono, Tadayoshi Okumura, Masaki Kaibori, Ken Tanaka, Susumu Terabayashi, Yukinobu Ikeya and Mikio Nishizawa was originally published Online First without Open Access. After publication in volume 74 issue 1, page 51–64 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s)...
Source: Journal of Natural Medicines - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculate seeds
The article Inhibition of melanin production by anthracenone dimer glycosides isolated from  Cassia auriculata seeds, written by Weicheng Wang, Yi Zhang, Souichi Nakashima, Seikou Nakamura, Tao Wang, Masayuki Yoshikawa and Hisashi Matsuda (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Induction of secondary metabolite production by fungal co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp.
AbstractFungal co-culture is a strategy to induce the production of secondary metabolites by activating cryptic genes. We discovered the production of a new compound, talarodone A (1), along with five known compounds2–6 in co-culture ofTalaromyces pinophilus andParaphaeosphaeria sp. isolated from soil collected in Miyazaki Prefecture, Japan. Among them, the productions of penicidones C (2) and D (3) were enhanced 27- and sixfold, respectively, by the co-culture. The structure of3 should be represented as a γ-pyridol form with the reported chemical shifts, but not as a γ-pyridone form, based on DFT calcula...
Source: Journal of Natural Medicines - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells
In conclusion, these data demonstrated that polydatin induced MG-63 cell death through inducing apoptosis, and autophagy which was mediated via the STAT3 signaling. Therefore, polydatin might be a potential clinical drug in the remedy of osteosarcoma.Graphic abstract (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 28, 2020 Category: Drugs & Pharmacology Source Type: research

Inhibitory activities of phenylpropanoids from Lycopus lucidus on amyloid aggregation related to Alzheimer ’s disease and type 2 diabetes
In this study, thioflavin-T assay and transmission electron microscopy were performed to evaluate the inhibitory effect of three phenylpropanoids isolated fromLycopus lucidus—schizotenuin A and lycopic acids A and B—on both Aβ and hIAPP fibrillization. All tested compounds exhibited similarly strong inhibitory activity toward amyloid aggregation. These results suggested that catechol moieties play important roles in the inhibition of amyloid plaque formation. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 26, 2020 Category: Drugs & Pharmacology Source Type: research

5,6-Dihydro- α-pyrones from the leaves of Cryptocarya pulchinervia (Lauraceae)
AbstractThree new 5,6-dihydro- α-pyrones derivatives, named (S)-rugulactone (1) pulchrinervialactone A (2), and pulchrinervialactone B (4), along with one known pyrone, cryptobrachytone C (3), and three known amide derivatives (5 –7) have been isolated from the leaves ofCryptocarya pulchrinervia. The structures of1 –7 were elucidated based on extensive spectroscopic data and comparison with literatures. The configurations of compounds3 and 4 were established by single crystal X-ray diffraction analysis. This is also the first report in finding (S)-rugulactone (1) as a natural product. In addition, the pre...
Source: Journal of Natural Medicines - March 23, 2020 Category: Drugs & Pharmacology Source Type: research

Arctigenin suppresses cell proliferation via autophagy inhibition in hepatocellular carcinoma cells
In this study, we explored the effect of arctigenin (ARG), a bioactive lignan in both extracts, on cell proliferation and autophagy-related proteins in HepG2 cells. ARG inhibited the proliferation of HepG2 cells. Analysis of autophagy-related proteins demonstrated that ARG might block the autophagy that leads to sequestosome 1/p62 (p62) accumulation. The stage of inhibition in autophagy by ARG differed from those by the autophagy inhibitors 3-methyladenine (3-MA) or chloroquine (CQ). ARG could also inhibit starvation-induced autophagy. Further analysis of apoptosis-related proteins indicated that ARG did not affect caspase...
Source: Journal of Natural Medicines - March 23, 2020 Category: Drugs & Pharmacology Source Type: research

Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities
AbstractThree new steroidal saponins, aspiletreins A –C (1–3), together with 2H-chromen-2-one (4), andα-tocopherol (5), were isolated from wholeAspidistra letreae plants collected in Vietnam. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR, IR, and HRESIMS, and by comparison with the reported data in the literature. Compounds1–3 exhibited moderate cytotoxicities against the LU-1, HeLa, MDA-MB-231, HepG2, and MKN-7 human cancer cell lines, with IC50 values ranging from 7.69  ± 0.40 to 20.46 ± 3.11 &mi...
Source: Journal of Natural Medicines - March 21, 2020 Category: Drugs & Pharmacology Source Type: research

The effects of inhibiting the activation of hepatic stellate cells by lignan components from the fruits of Schisandra chinensis and the mechanism of schisanhenol
In this study, we compared the inhibiting effects of the seven lignan components fromS. chinensis on HSC activation. We found that the seven lignans inhibited the activation of human HSCs (LX-2) in various degrees. Among all lignans, schisanhenol showed the best effect in inhibiting the activation of LX-2 with a dose –effect relationship. Sal also inhibited the phosphorylations of Smad1, Smad2, Smad3, extracellular regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), p38, and nuclear transcription factor-κB (NF-κB), as well as downregulated Smad4. All these findings suggested that schisanhenol m...
Source: Journal of Natural Medicines - March 19, 2020 Category: Drugs & Pharmacology Source Type: research

Enzymatic studies on aromatic prenyltransferases
AbstractAromatic prenyltransferases (PTases), including ABBA-type and dimethylallyl tryptophan synthase (DMATS)-type enzymes from bacteria and fungi, play important role for diversification of the natural products and improvement of the biological activities. For a decade, the characterization of enzymes and enzymatic synthesis of prenylated compounds by using ABBA-type and DMATS-type PTases have been demonstrated. Here, I introduce several examples of the studies on chemoenzymatic synthesis of unnatural prenylated compounds and the enzyme engineering of ABBA-type and DMATS-type PTases. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 17, 2020 Category: Drugs & Pharmacology Source Type: research

Retraction Note to: Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice
This article [1] has been retracted at the request of the corresponding author because an Investigation Committee established by Kobe Gakuin University (Kobe, Japan) has found numerous discrepancies between the raw data and the data presented in Figs.  6b, d. Statistical analysis of the raw data showed no significant difference between conditions. Authors S. Harada, K. Nakamoto, W. Fujita-Hamabe, H.-H. Chen, M.-H. Chan, and S. Tokuyama agree with this retraction. Authors M. Kishimoto and M. Kobayashi could not be reached for comment about this r etraction. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - March 3, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Two new xanthones from the roots of Cratoxylum cochinchinense and their cytotoxicity
In the original publication of the article, figure  1 was published incorrectly. The correct version of figure 1 is provided below, (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - February 6, 2020 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory activities of isopimara-8(9),15-diene diterpenoids and mode of action of kaempulchraols B –D from Kaempferia pulchra rhizomes
AbstractKaempulchraols B –D (2 –4), isopimara-8(9),15-diene diterpenoids isolated fromKaempferia pulchra rhizomes collected in Myanmar, were identified as potent NF- κB inhibitors. These compounds were also effective as NO inhibitory agents, with IC50 values of 47.69, 44.97, and 38.17  μM, respectively, without showing any cytotoxicity against LPS-induced RAW264.7 cells. Investigations of the mechanisms of action of2 –4 revealed that they inhibit the NF- κB-mediated transactivation of a luciferase reporter gene, IL-6 production, and COX-2 expression, with an effective dose of 25 &...
Source: Journal of Natural Medicines - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation
AbstractCancer cells adapted to the microenvironment in tumor such as hypoxic and nutrient-starved conditions are now paid much attention as the therapeutic target of cancer. In the course of search for selective cytotoxic substances against cancer cells adapted to nutrient starvation, xanthone derivative of secalonic acid D (1) was isolated from culture extract of marine-derivedPenicillium oxalicum. Compound1 showed cytotoxic activity on the human pancreatic carcinoma PANC-1 cells adapted to glucose-starved conditions with IC50 value of 0.6  µM, whereas IC50 value of compound1 against PANC-1 cells under general...
Source: Journal of Natural Medicines - January 30, 2020 Category: Drugs & Pharmacology Source Type: research

Accelerative effects of carbazole-type alkaloids from Murraya koenigii on neurite outgrowth and their derivative ’s in vivo study for spatial memory
AbstractMurraya koenigii is a medicinal plant that contains several carbazole-type alkaloids as its characteristic constituents. Blood –brain barrier permeable constituents ofM. koenigii accelerated neurite outgrowth in PC-12 cells. Nine compounds were isolated fromM. koenigii and their effects on neurite outgrowth were examined. Murrayamine-E (8) at 10  μM showed significant effect. Focusing on the carbazole skeleton, we synthesized derivatives to attenuate cytotoxicity. 9-Benzyl-9H-carbazol-4-ol (15) exhibited strong neurite outgrowth accelerative effect. In addition, the novel object recognition test and t...
Source: Journal of Natural Medicines - January 20, 2020 Category: Drugs & Pharmacology Source Type: research