Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease
CONCLUSION: For the first time, we demonstrated that serum concentrations of GDF-15 are elevated in patients with IBD in comparison to healthy controls, and the results imply that GDF-15 might be involved in IBD pathophysiology. Yet, it remains elusive whether GDF-15 could serve as a prognostic indicator in these patients.PMID:38659482 | PMC:PMC11036493 | DOI:10.3748/wjg.v30.i13.1899 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic Piero Marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males Josko Bozic Source Type: research
Insights into treatment of complex Crohn's perianal fistulas
AbstractComplex perianal fistula is a common complication of Crohn ’s disease (CD) which leads to negative impact on patient’s quality of life. Successful management of the disease requires a multidisciplinary approach, including a gastroenterologist and a colorectal surgeon, applying combined surgical and medical therapy. One of frequently practiced surgical p rocedures is seton placement in the fistula tract, which is used to control perianal sepsis and drain the fistula, while preventing recurrent abscess formation.Darvadstrocel, a suspension of expanded, allogeneic, adipose-derived, mesenchymal stem cells, is safe ...
Source: BMC Proceedings - April 25, 2024 Category: Biomedical Science Source Type: research
Sensors, Vol. 24, Pages 2727: Faecal Volatile Organic Compound Analysis in De Novo Paediatric Inflammatory Bowel Disease by Gas Chromatography & ndash;Ion Mobility Spectrometry: A Case & ndash;Control Study
In conclusion, faecal VOC profiles of paediatric IBD patients differ significantly from those of CGIs. (Source: Sensors)
Source: Sensors - April 25, 2024 Category: Biotechnology Authors: Eva Vermeer Jasmijn Z. Jagt Trenton K. Stewart James A. Covington Eduard A. Struys Robert de Jonge Nanne K. H. de Boer Tim G. J. de Meij Tags: Article Source Type: research
The need for surgery in pediatric patients with inflammatory bowel disease treated with biologicals
ConclusionDespite initiation of biological treatment, the risk of intestinal surgery remains high in pediatric IBD patients and often the need for surgery emerges after the transition to adult IBD clinics. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research
Updates in the Management of Crohn's Disease
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786382 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Clinics in Colon and Rectal Surgery)
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Khaitov, Sergey Tags: Preface Source Type: research
Bowel Resection Margins in Crohn's Disease: Do They Matter?
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786376Many patients with Crohn's disease (CD) will ultimately require surgical intervention for refractory disease despite recognizing that surgery does not cure CD. The initial operation, primarily for ileocolic disease, is focused on resecting the offending pathology and ideally providing a reduced likelihood for subsequent operations and additional bowel loss through surgical techniques. The appropriate margin, macro- vs. microscopic, lays in balance to provide an adequate resection that minimizes bowel loss, compared to an extensive resection which ensures a thorough resectio...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Choi, Beatrix Cohen, David Schwartzberg, David M. Tags: Review Article Source Type: research
Preoperative Optimization of Crohn's Patients before Abdominopelvic Surgery
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786380In this article, we review and identify modifiable risk factors associated with postoperative complications of Crohn's disease. We highlight the importance of factors such as nutrition, corticosteroids, immunomodulators, abscesses, ideal timing of surgery, and biologic and small-molecule therapy on surgical outcomes. Herein, we discuss the strategies for attenuating these risk factors. Special consideration is given to venous thromboembolism prophylaxis in this patient population. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAA...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Moussally, Moustafa Paski, Shirley C. Cohen, Benjamin Holubar, Stefan D. Tags: Review Article Source Type: research
Stratified Patient Profiling for Vedolizumab Effectiveness in Crohn's Disease: Identifying Optimal Subgroups for Enhanced Treatment Response in the EVOLVE Study
CONCLUSIONS: Subpopulations of biologic-naive patients with CD in whom vedolizumab appeared to have a larger effect relative to anti-TNFα agents for the outcome of clinical remission were identified. Validation of the identified subpopulations and simplified rules are warranted to confirm these findings.GOV IDENTIFIER: NCT03710486. Graphical Abstract available for this article.PMID:38658485 | DOI:10.1007/s12325-024-02825-w (Source: Adv Data)
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Andres Yarur Gerassimos J Mantzaris Song Wang Shashi Adsul Pravin Kamble Erin Cook Gautam Sajeev Annie Guerin Brian Bressler Source Type: research
Long-term real-world data of ustekinumab in Crohn's disease: the Stockholm ustekinumab study
CONCLUSION: Among difficult-to-treat patients with CD, ustekinumab was effective in the majority, with high drug persistence at 12 and 24 months in combination with a favourable safety profile.PMID:38655034 | PMC:PMC11036920 | DOI:10.1177/17562848241242700 (Source: Adv Data)
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Francesca Bello Samer Muhsen Haider Sabhan Alexandra Borin Fredrik Johansson Charlotte H öög Ole Forsberg Christina Wennerstr öm Charlotte S öderman Mikael L ördal Sven Almer Source Type: research
Diagnosis of Pediatric Appendicovesical Fistula by Contrast-enhanced Ultrasound: A Case Report
We reported a pediatric case of appendicovesical fistula that remained undiagnosed by non-contrast CT, fluoroscopic voiding cystourethrography (VCUG). Although the bladder orifice was identified during cystoscopy, its connection to the fistula site could not be determined. However, the trans-vesical contrast-enhanced ultrasound clearly demonstrated the presence of fistula. (Source: Urology)
Source: Urology - April 24, 2024 Category: Urology & Nephrology Authors: Yang Xiuzhen, Xu Zheming, Yan Xiang, Ye Jingjing, Fu Junfen Source Type: research
Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence
AbstractPurpose of ReviewExposure to many synthetic chemicals has been linked to a variety of adverse human health effects, including autoimmune diseases. In this scoping review, we summarize recent evidence detailing the effects of synthetic environmental chemicals on autoimmune diseases and highlight current research gaps and recommendations for future studies.Recent FindingsWe identified 68 recent publications related to environmental chemical exposures and autoimmune diseases. Most studies evaluated exposure to persistent environmental chemicals and autoimmune conditions including rheumatoid arthritis (RA), systemic lu...
Source: Current Environmental Health Reports - April 24, 2024 Category: Environmental Health Source Type: research
Imaging and clinical predictors of surgery in stricturing ileal Crohn ’s disease: a retrospective study from a large pediatric hospital
ConclusionSurgery remains common in stricturing pediatric CD, with increasing stricture ratio and sMaRIA score associated with need for surgical management.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 24, 2024 Category: Radiology Source Type: research
Stratified Patient Profiling for Vedolizumab Effectiveness in Crohn ’s Disease: Identifying Optimal Subgroups for Enhanced Treatment Response in the EVOLVE Study
ConclusionsSubpopulations of biologic-naive patients with CD in whom vedolizumab appeared to have a larger effect relative to anti-TNF α agents for the outcome of clinical remission were identified. Validation of the identified subpopulations and simplified rules are warranted to confirm these findings.ClinicalTrials.gov IdentifierNCT03710486.Graphical Abstract available for this article.Graphical Abstract (Source: Advances in Therapy)
Source: Advances in Therapy - April 24, 2024 Category: Drugs & Pharmacology Source Type: research
Reply to comments on: "Efficacy of cx601 (darvadstrocel) for the treatment of perianal fistulizing Crohn's disease-A prospective nationwide multicenter cohort study"
Wien Klin Wochenschr. 2024 Apr 23. doi: 10.1007/s00508-024-02363-z. Online ahead of print.NO ABSTRACTPMID:38652312 | DOI:10.1007/s00508-024-02363-z (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - April 23, 2024 Category: General Medicine Authors: Stefan Riss Christopher Dawoud Source Type: research
Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients
CONCLUSION: The use of biologics or small molecules for patients with IBD who received organ transplants did not show a significant difference in safety outcomes. However, the possibility of severe infections must be considered.PMID:38653566 | DOI:10.3349/ymj.2023.0361 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Ga Hee Kim Minjun Kim Kyuwon Kim Jung-Bin Park Ji Eun Baek June Hwa Bae Seung Wook Hong Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park Source Type: research
