Decreased risk of treatment failure with vedolizumab and thiopurines combined compared with vedolizumab monotherapy in Crohns disease
Conclusion Using validated methodologies, combination therapy with vedolizumab and thiopurines was associated with lower treatment failure compared with vedolizumab monotherapy in CD but not UC across the USA and France. (Source: Gut)
Source: Gut - August 11, 2022 Category: Gastroenterology Authors: Kirchgesner, J., Desai, R. J., Schneeweiss, M. C., Beaugerie, L., Schneeweiss, S., Kim, S. C. Tags: Gut Inflammatory bowel disease Source Type: research

Risk of adverse events and reported clinical relapse after COVID-19 vaccination in patients with IBD
We have read with interest the recent papers of Kennedy et al1 2 regarding the attenuated anti-SARS-CoV-2 antibody response in patients with IBD and the crucial role of the COVID-19 vaccine in this cohort. The COVID-19 vaccine has been recommended especially for the vulnerable population, including immune-mediated inflammatory diseases.3–5 Therefore, we explored the rate of adverse events (AEs) and the onset of GI symptoms after vaccination with different COVID-19 vaccines in a large cohort of patients with IBD. In this prospective study, we collected data (demographic and clinical variables, COVID-19 vaccine type, l...
Source: Gut - August 11, 2022 Category: Gastroenterology Authors: Cannatelli, R., Ferretti, F., Carmagnola, S., Bergna, I. M. B., Monico, M. C., Maconi, G., Ardizzone, S. Tags: Gut, COVID-19 PostScript Source Type: research

Response to: 'Case of postpartum axial spondyloarthritis by Furuhashi et al
We were pleased to read the correspondence of Furuhashi et al1 who highlighted the importance of considering coexisting risk factors when diagnosing axial spondyloArthritis (ax-SpA) in early postpartum women. The authors correctly pointed out that patients with inflammatory bowel disease are more likely to develop ax-SpA due to common pathogenic mechanisms.2 In fact, the presence of Crohn’s disease or ulcerative colitis is part of the Assessment of SpondyloArthritis international Society criteria for the diagnosis of ax-SpA.3 In our study, on the prevalence of bone marrow oedema (BME) at the sacroiliac joint (SIJ) in...
Source: Annals of the Rheumatic Diseases - August 11, 2022 Category: Rheumatology Authors: Hoballah, A., Lukas, C., Leplat, C., Taourel, P., Pialat, J.-B., Sans, N., Ramos-Pascual, S., Saffarini, M., Cyteval, C. Tags: ARD Correspondence response Source Type: research

A Comparative Analysis of Drug Therapy, Disease Phenotype, and Health Care Outcomes for Men and Women with Inflammatory Bowel Disease
ConclusionsThese findings highlight differences in disease course and treatment approaches between men and women with IBD and support the consideration of sex and gender when researching disease outcomes. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - August 10, 2022 Category: Gastroenterology Source Type: research

Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24
J Cell Mol Med. 2022 Aug 9. doi: 10.1111/jcmm.17498. Online ahead of print.ABSTRACTThe pathophysiology of inflammatory bowel diseases (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members (REG Iα, REG Iβ and REG IV) are expressed in Crohn's disease (CD) and ulcerative colitis (UC) and involved as proliferative mucosal factors in IBD. We revealed that REG Iα and REG Iβ were induced in cell culture system by IL-6/IL-22. Although REG IV was upregulated in IBD biopsy samples, the upregulation of REG IV was not at all induced in cell culture by autoimmune-rela...
Source: J Cell Mol Med - August 10, 2022 Category: Molecular Biology Authors: Shin Takasawa Chikatsugu Tsuchida Sumiyo Sakuramoto-Tsuchida Tomoko Uchiyama Mai Makino Akiyo Yamauchi Asako Itaya-Hironaka Source Type: research

Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24
J Cell Mol Med. 2022 Aug 9. doi: 10.1111/jcmm.17498. Online ahead of print.ABSTRACTThe pathophysiology of inflammatory bowel diseases (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members (REG Iα, REG Iβ and REG IV) are expressed in Crohn's disease (CD) and ulcerative colitis (UC) and involved as proliferative mucosal factors in IBD. We revealed that REG Iα and REG Iβ were induced in cell culture system by IL-6/IL-22. Although REG IV was upregulated in IBD biopsy samples, the upregulation of REG IV was not at all induced in cell culture by autoimmune-rela...
Source: Molecular Medicine - August 10, 2022 Category: Molecular Biology Authors: Shin Takasawa Chikatsugu Tsuchida Sumiyo Sakuramoto-Tsuchida Tomoko Uchiyama Mai Makino Akiyo Yamauchi Asako Itaya-Hironaka Source Type: research

Use of Vedolizumab in Inflammatory Bowel Disease: A Single-Center Experience
CONCLUSION: Vedolizumab therapy is effective in both induction and maintenance of remission in inflammatory bowel disease patients who are resistant to anti-tumor necrosis factor or who can not receive anti-tumor necrosis factor therapy due to side effects. No signifi- cant side effect was observed in the patients during follow-up.PMID:35946879 | DOI:10.5152/tjg.2022.21684 (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - August 10, 2022 Category: Gastroenterology Authors: Çağdaş Erdoğan Bayram Ye şil Ferhat Bacaks ız Derya Ar ı Volkan G ökbulut Mahmut Y üksel Yasemin Özderin Özin Ertu ğrul Kayaçetin Source Type: research

Beliefs About Medicines and Adherence to Treatment in Turkish Patients with Inflammatory Bowel Disease
CONCLUSION: The negative perception of treatment in inflammatory bowel disease affects adherence to the treatment. Considering some social factors that affect adherence to the treatment and taking measures to enhance the adherence to treatment will increase the success of treatment.PMID:35946875 | DOI:10.5152/tjg.2022.21355 (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - August 10, 2022 Category: Gastroenterology Authors: G üray Can Ahmet Yozgat Ahmet Tezel G ülbin Ünsal Ali R ıza Soylu Source Type: research

Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24
J Cell Mol Med. 2022 Aug 9. doi: 10.1111/jcmm.17498. Online ahead of print.ABSTRACTThe pathophysiology of inflammatory bowel diseases (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members (REG Iα, REG Iβ and REG IV) are expressed in Crohn's disease (CD) and ulcerative colitis (UC) and involved as proliferative mucosal factors in IBD. We revealed that REG Iα and REG Iβ were induced in cell culture system by IL-6/IL-22. Although REG IV was upregulated in IBD biopsy samples, the upregulation of REG IV was not at all induced in cell culture by autoimmune-rela...
Source: J Cell Mol Med - August 10, 2022 Category: Molecular Biology Authors: Shin Takasawa Chikatsugu Tsuchida Sumiyo Sakuramoto-Tsuchida Tomoko Uchiyama Mai Makino Akiyo Yamauchi Asako Itaya-Hironaka Source Type: research

Prospective and challenges of live bacterial therapeutics from a superhero < em > Escherichia coli < /em > Nissle 1917
Crit Rev Microbiol. 2022 Aug 10:1-17. doi: 10.1080/1040841X.2022.2109405. Online ahead of print.ABSTRACTEscherichia coli Nissle 1917 (EcN), the active component of Mutaflor(R), is a notable probiotic from Gram-negative to treat Crohn's disease and irritable bowel syndrome. Therefore, a comprehensive genomic database maximizes the systemic probiotic assessment to discover EcN's role in human health. Recently, advanced synthetic and genetic tools have opened up a rich area to execute EcN as "living medicines" with controllable functions. Incorporating unique biomarkers allows the engineered EcN to switch genes on and off in ...
Source: Critical Reviews in Microbiology - August 10, 2022 Category: Microbiology Authors: Sefli Sri Wahyu Effendi I-Son Ng Source Type: research

Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24
J Cell Mol Med. 2022 Aug 9. doi: 10.1111/jcmm.17498. Online ahead of print.ABSTRACTThe pathophysiology of inflammatory bowel diseases (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members (REG Iα, REG Iβ and REG IV) are expressed in Crohn's disease (CD) and ulcerative colitis (UC) and involved as proliferative mucosal factors in IBD. We revealed that REG Iα and REG Iβ were induced in cell culture system by IL-6/IL-22. Although REG IV was upregulated in IBD biopsy samples, the upregulation of REG IV was not at all induced in cell culture by autoimmune-rela...
Source: Molecular Medicine - August 10, 2022 Category: Molecular Biology Authors: Shin Takasawa Chikatsugu Tsuchida Sumiyo Sakuramoto-Tsuchida Tomoko Uchiyama Mai Makino Akiyo Yamauchi Asako Itaya-Hironaka Source Type: research

Use of Vedolizumab in Inflammatory Bowel Disease: A Single-Center Experience
CONCLUSION: Vedolizumab therapy is effective in both induction and maintenance of remission in inflammatory bowel disease patients who are resistant to anti-tumor necrosis factor or who can not receive anti-tumor necrosis factor therapy due to side effects. No signifi- cant side effect was observed in the patients during follow-up.PMID:35946879 | DOI:10.5152/tjg.2022.21684 (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - August 10, 2022 Category: Gastroenterology Authors: Çağdaş Erdoğan Bayram Ye şil Ferhat Bacaks ız Derya Ar ı Volkan G ökbulut Mahmut Y üksel Yasemin Özderin Özin Ertu ğrul Kayaçetin Source Type: research

Beliefs About Medicines and Adherence to Treatment in Turkish Patients with Inflammatory Bowel Disease
CONCLUSION: The negative perception of treatment in inflammatory bowel disease affects adherence to the treatment. Considering some social factors that affect adherence to the treatment and taking measures to enhance the adherence to treatment will increase the success of treatment.PMID:35946875 | DOI:10.5152/tjg.2022.21355 (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - August 10, 2022 Category: Gastroenterology Authors: G üray Can Ahmet Yozgat Ahmet Tezel G ülbin Ünsal Ali R ıza Soylu Source Type: research

Reduced diversity of intestinal T-cell receptor repertoire in patients with Crohn ’s disease
ConclusionsThe diversity of the TCR repertoire is reduced in inflamed mucosa of CD patients, which might contribute to intestinal inflammation. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - August 10, 2022 Category: Microbiology Source Type: research

Transanal ileal pouch-anal anastomosis for ulcerative colitis: a single-center comparative study
ConclusionsThe ta-IPAA approach for UC is a safe procedure and offers acceptable short-time outcomes. (Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - August 10, 2022 Category: Surgery Source Type: research