Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization
CONCLUSIONS: Our integrated study identified 12 potential therapeutic targets for ADs and provided novel insights into future drug development for ADs.PMID:38515381 | DOI:10.1080/08916934.2024.2330392 (Source: Autoimmunity)
Source: Autoimmunity - March 22, 2024 Category: Allergy & Immunology Authors: Qiubai Jin Feihong Ren Ping Song Source Type: research
Leukocyte Dysfunction and reduced CTLA-4 Expression are Associated with Perianal Crohn's Disease
In conclusion, IL-6, TNF, and CTLA-4 exhibit a distinct expression pattern in CD patients with a history of PCD, regardless of disease activity. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact in the disease management.PMID:38517030 | DOI:10.1093/cei/uxae027 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Murillo Duarte-Silva Rog ério Serafim Parra Marley Ribeiro Feitosa Viviani Nardini Sandra Regina Maruyama Jos é Joaquim Ribeiro da Rocha Omar Feres Cristina Ribeiro de Barros Cardoso Source Type: research
Risk Factors for Lichen Sclerosus: A Case-Control Study of 43,000 Finnish Women
CONCLUSIONS: Certain autoimmune diseases and urinary incontinence were associated with LS.PMID:38518214 | DOI:10.1097/LGT.0000000000000796 (Source: Cancer Control)
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Pia Halonen Oskari Heikinheimo Kishor Hadkhale Mika Gissler Eero Pukkala Maija Jakobsson Source Type: research
Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization
CONCLUSIONS: Our integrated study identified 12 potential therapeutic targets for ADs and provided novel insights into future drug development for ADs.PMID:38515381 | DOI:10.1080/08916934.2024.2330392 (Source: Autoimmunity)
Source: Autoimmunity - March 22, 2024 Category: Allergy & Immunology Authors: Qiubai Jin Feihong Ren Ping Song Source Type: research
Leukocyte Dysfunction and reduced CTLA-4 Expression are Associated with Perianal Crohn's Disease
In conclusion, IL-6, TNF, and CTLA-4 exhibit a distinct expression pattern in CD patients with a history of PCD, regardless of disease activity. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact in the disease management.PMID:38517030 | DOI:10.1093/cei/uxae027 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Murillo Duarte-Silva Rog ério Serafim Parra Marley Ribeiro Feitosa Viviani Nardini Sandra Regina Maruyama Jos é Joaquim Ribeiro da Rocha Omar Feres Cristina Ribeiro de Barros Cardoso Source Type: research
Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization
CONCLUSIONS: Our integrated study identified 12 potential therapeutic targets for ADs and provided novel insights into future drug development for ADs.PMID:38515381 | DOI:10.1080/08916934.2024.2330392 (Source: Autoimmunity)
Source: Autoimmunity - March 22, 2024 Category: Allergy & Immunology Authors: Qiubai Jin Feihong Ren Ping Song Source Type: research
Leukocyte Dysfunction and reduced CTLA-4 Expression are Associated with Perianal Crohn's Disease
In conclusion, IL-6, TNF, and CTLA-4 exhibit a distinct expression pattern in CD patients with a history of PCD, regardless of disease activity. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact in the disease management.PMID:38517030 | DOI:10.1093/cei/uxae027 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Murillo Duarte-Silva Rog ério Serafim Parra Marley Ribeiro Feitosa Viviani Nardini Sandra Regina Maruyama Jos é Joaquim Ribeiro da Rocha Omar Feres Cristina Ribeiro de Barros Cardoso Source Type: research
Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization
CONCLUSIONS: Our integrated study identified 12 potential therapeutic targets for ADs and provided novel insights into future drug development for ADs.PMID:38515381 | DOI:10.1080/08916934.2024.2330392 (Source: Autoimmunity)
Source: Autoimmunity - March 22, 2024 Category: Allergy & Immunology Authors: Qiubai Jin Feihong Ren Ping Song Source Type: research
Leukocyte Dysfunction and reduced CTLA-4 Expression are Associated with Perianal Crohn's Disease
In conclusion, IL-6, TNF, and CTLA-4 exhibit a distinct expression pattern in CD patients with a history of PCD, regardless of disease activity. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact in the disease management.PMID:38517030 | DOI:10.1093/cei/uxae027 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Murillo Duarte-Silva Rog ério Serafim Parra Marley Ribeiro Feitosa Viviani Nardini Sandra Regina Maruyama Jos é Joaquim Ribeiro da Rocha Omar Feres Cristina Ribeiro de Barros Cardoso Source Type: research
Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization
CONCLUSIONS: Our integrated study identified 12 potential therapeutic targets for ADs and provided novel insights into future drug development for ADs.PMID:38515381 | DOI:10.1080/08916934.2024.2330392 (Source: Autoimmunity)
Source: Autoimmunity - March 22, 2024 Category: Allergy & Immunology Authors: Qiubai Jin Feihong Ren Ping Song Source Type: research
Leukocyte Dysfunction and reduced CTLA-4 Expression are Associated with Perianal Crohn's Disease
In conclusion, IL-6, TNF, and CTLA-4 exhibit a distinct expression pattern in CD patients with a history of PCD, regardless of disease activity. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact in the disease management.PMID:38517030 | DOI:10.1093/cei/uxae027 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Murillo Duarte-Silva Rog ério Serafim Parra Marley Ribeiro Feitosa Viviani Nardini Sandra Regina Maruyama Jos é Joaquim Ribeiro da Rocha Omar Feres Cristina Ribeiro de Barros Cardoso Source Type: research
Crosstalk between NOD2 and TLR2 suppresses the development of TLR2-mediated experimental colitis
J Clin Biochem Nutr. 2024 Mar;74(2):146-153. doi: 10.3164/jcbn.23-87. Epub 2023 Dec 15.ABSTRACTNucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for muramyl dipeptide (MDP), a degradation product of bacterial cell wall peptidoglycan (PGN). PGN stimulates cell-surface Toll-like receptor 2 (TLR2) independently of NOD2, indicating the presence of crosstalk between extracellular TLR2 and intracellular NOD2 upon exposure to PGN. NOD2-deficient mice were sensitive, while TLR2-deficient mice were resistant to experimental colitis induced by intrarectal administration of PGN. Severe colitis in NOD2-defi...
Source: Clinical Biochemistry - March 21, 2024 Category: Biochemistry Authors: Natsuki Okai Yasuhiro Masuta Yasuo Otsuka Akane Hara Sho Masaki Ken Kamata Kosuke Minaga Hajime Honjo Masatoshi Kudo Tomohiro Watanabe Source Type: research
Crosstalk between NOD2 and TLR2 suppresses the development of TLR2-mediated experimental colitis
J Clin Biochem Nutr. 2024 Mar;74(2):146-153. doi: 10.3164/jcbn.23-87. Epub 2023 Dec 15.ABSTRACTNucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for muramyl dipeptide (MDP), a degradation product of bacterial cell wall peptidoglycan (PGN). PGN stimulates cell-surface Toll-like receptor 2 (TLR2) independently of NOD2, indicating the presence of crosstalk between extracellular TLR2 and intracellular NOD2 upon exposure to PGN. NOD2-deficient mice were sensitive, while TLR2-deficient mice were resistant to experimental colitis induced by intrarectal administration of PGN. Severe colitis in NOD2-defi...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Natsuki Okai Yasuhiro Masuta Yasuo Otsuka Akane Hara Sho Masaki Ken Kamata Kosuke Minaga Hajime Honjo Masatoshi Kudo Tomohiro Watanabe Source Type: research
Upadacitinib in Crohn's disease
Expert Opin Pharmacother. 2024 Mar 21. doi: 10.1080/14656566.2024.2333964. Online ahead of print.ABSTRACTINTRODUCTION: The small molecule and oral selective and reversible Janus kinase (JAK) inhibitor upadacitinib has been approved for the treatment of moderate to severe active Crohn's disease (CD) in adult patients since April 2023 by EMA/FDA.AREAS COVERED: The approval is based on the two induction studies a maintenance study showing that upadacitinib induction and maintenance therapy was superior to placebo. The approval of upadacitinib in CD expands the therapeutic armamentarium for the management of inflammatory bowel...
Source: Expert Opinion on Pharmacotherapy - March 21, 2024 Category: Drugs & Pharmacology Authors: Axel Dignass Philip Esters Cathrin Flauaus Source Type: research
Crosstalk between NOD2 and TLR2 suppresses the development of TLR2-mediated experimental colitis
J Clin Biochem Nutr. 2024 Mar;74(2):146-153. doi: 10.3164/jcbn.23-87. Epub 2023 Dec 15.ABSTRACTNucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for muramyl dipeptide (MDP), a degradation product of bacterial cell wall peptidoglycan (PGN). PGN stimulates cell-surface Toll-like receptor 2 (TLR2) independently of NOD2, indicating the presence of crosstalk between extracellular TLR2 and intracellular NOD2 upon exposure to PGN. NOD2-deficient mice were sensitive, while TLR2-deficient mice were resistant to experimental colitis induced by intrarectal administration of PGN. Severe colitis in NOD2-defi...
Source: Clinical Biochemistry - March 21, 2024 Category: Biochemistry Authors: Natsuki Okai Yasuhiro Masuta Yasuo Otsuka Akane Hara Sho Masaki Ken Kamata Kosuke Minaga Hajime Honjo Masatoshi Kudo Tomohiro Watanabe Source Type: research
