Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial
CONCLUSIONS: Parenteral n-3 polyunsaturated fatty acids supplementation promotes postoperative recovery in patients with Crohn's disease following bowel resection, with fewer complications and reduced inflammatory cytokines. This trial was registered at clinicaltrials.gov as NCT03901937 at https://classic.CLINICALTRIALS: gov/ct2/show/NCT03901937?term=NCT03901937&cond=Crohn+Disease&draw=2&rank=1.PMID:38569774 | DOI:10.1016/j.ajcnut.2023.12.022 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Xiaolong Ge Huaying Liu Yan Wu Wei Liu Weilin Qi Linna Ye Qian Cao Haifeng Lian Rongpan Bai Wei Zhou Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial
CONCLUSIONS: Parenteral n-3 polyunsaturated fatty acids supplementation promotes postoperative recovery in patients with Crohn's disease following bowel resection, with fewer complications and reduced inflammatory cytokines. This trial was registered at clinicaltrials.gov as NCT03901937 at https://classic.CLINICALTRIALS: gov/ct2/show/NCT03901937?term=NCT03901937&cond=Crohn+Disease&draw=2&rank=1.PMID:38569774 | DOI:10.1016/j.ajcnut.2023.12.022 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Xiaolong Ge Huaying Liu Yan Wu Wei Liu Weilin Qi Linna Ye Qian Cao Haifeng Lian Rongpan Bai Wei Zhou Source Type: research
Beyond diagnosis: investigating hospital referral impact on biological treatment initiation, hospital admission, and surgery patterns in inflammatory bowel disease - a Danish population based study
CONCLUSIONS: Based on the findings of this population-based study, we found no evidence that the referral area had a significant impact on the duration from diagnosis to the initiation of biological treatment, hospital admissions, or surgery. However, the data suggested that fewer patients with luminal Crohn's disease were referred to biologics from Non-Academic Hospitals.PMID:38567864 | DOI:10.1080/00365521.2024.2337829 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 3, 2024 Category: Gastroenterology Authors: Lone Larsen Anne Estrup Olesen Alev B üyükuslu Nayeb Simon Gr øntved Anne Lund Krarup Source Type: research
Myeloid Cells and Sphingosine-1-Phosphate Are Required for TCR αβ Intraepithelial Lymphocyte Recruitment to the Colon Epithelium
J Immunol. 2024 Apr 3:ji2200556. doi: 10.4049/jimmunol.2200556. Online ahead of print.ABSTRACTIntraepithelial lymphocytes (IELs) are T cells important for the maintenance of barrier integrity in the intestine. Colon IELs are significantly reduced in both MyD88-deficient mice and those lacking an intact microbiota, suggesting that MyD88-mediated detection of bacterial products is important for the recruitment and/or retention of these cells. Here, using conditionally deficient MyD88 mice, we show that myeloid cells are the key mediators of TCRαβ+ IEL recruitment to the colon. Upon exposure to luminal bacteria, myeloid cel...
Source: Journal of Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Sarah Mann Danielson Adam R Lefferts Eric Norman Emilie H Regner Hanna M Schulz Danielle Sansone-Poe David J Orlicky Kristine A Kuhn Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial
CONCLUSIONS: Parenteral n-3 polyunsaturated fatty acids supplementation promotes postoperative recovery in patients with Crohn's disease following bowel resection, with fewer complications and reduced inflammatory cytokines. This trial was registered at clinicaltrials.gov as NCT03901937 at https://classic.CLINICALTRIALS: gov/ct2/show/NCT03901937?term=NCT03901937&cond=Crohn+Disease&draw=2&rank=1.PMID:38569774 | DOI:10.1016/j.ajcnut.2023.12.022 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Xiaolong Ge Huaying Liu Yan Wu Wei Liu Weilin Qi Linna Ye Qian Cao Haifeng Lian Rongpan Bai Wei Zhou Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial
CONCLUSIONS: Parenteral n-3 polyunsaturated fatty acids supplementation promotes postoperative recovery in patients with Crohn's disease following bowel resection, with fewer complications and reduced inflammatory cytokines. This trial was registered at clinicaltrials.gov as NCT03901937 at https://classic.CLINICALTRIALS: gov/ct2/show/NCT03901937?term=NCT03901937&cond=Crohn+Disease&draw=2&rank=1.PMID:38569774 | DOI:10.1016/j.ajcnut.2023.12.022 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Xiaolong Ge Huaying Liu Yan Wu Wei Liu Weilin Qi Linna Ye Qian Cao Haifeng Lian Rongpan Bai Wei Zhou Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial
CONCLUSIONS: Parenteral n-3 polyunsaturated fatty acids supplementation promotes postoperative recovery in patients with Crohn's disease following bowel resection, with fewer complications and reduced inflammatory cytokines. This trial was registered at clinicaltrials.gov as NCT03901937 at https://classic.CLINICALTRIALS: gov/ct2/show/NCT03901937?term=NCT03901937&cond=Crohn+Disease&draw=2&rank=1.PMID:38569774 | DOI:10.1016/j.ajcnut.2023.12.022 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Xiaolong Ge Huaying Liu Yan Wu Wei Liu Weilin Qi Linna Ye Qian Cao Haifeng Lian Rongpan Bai Wei Zhou Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial
CONCLUSIONS: Parenteral n-3 polyunsaturated fatty acids supplementation promotes postoperative recovery in patients with Crohn's disease following bowel resection, with fewer complications and reduced inflammatory cytokines. This trial was registered at clinicaltrials.gov as NCT03901937 at https://classic.CLINICALTRIALS: gov/ct2/show/NCT03901937?term=NCT03901937&cond=Crohn+Disease&draw=2&rank=1.PMID:38569774 | DOI:10.1016/j.ajcnut.2023.12.022 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Xiaolong Ge Huaying Liu Yan Wu Wei Liu Weilin Qi Linna Ye Qian Cao Haifeng Lian Rongpan Bai Wei Zhou Source Type: research
Ozanimod Differentially Impacts Circulating Lymphocyte Subsets in Patients with Moderately to Severely Active Crohn ’s Disease
ConclusionsOzanimod reduced circulating levels of all B-cell and most T-cell subsets but not monocytes or natural killer cells. Key subsets relevant to immune surveillance were not reduced, supporting the low risk of infection and malignancy with ozanimod in chronic inflammatory diseases. Levels of nonswitched memory B cells were associated with efficacy, providing a potential marker for ozanimod response.Trial Registration ClinicalTrials.gov: NCT02531113, EudraCT: 2015 –002025–19Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 3, 2024 Category: Gastroenterology Source Type: research
