Leukocyte Dysfunction and reduced CTLA-4 Expression are Associated with Perianal Crohn's Disease

In conclusion, IL-6, TNF, and CTLA-4 exhibit a distinct expression pattern in CD patients with a history of PCD, regardless of disease activity. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact in the disease management.PMID:38517030 | DOI:10.1093/cei/uxae027

Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Murillo Duarte-Silva Rog ério Serafim Parra Marley Ribeiro Feitosa Viviani Nardini Sandra Regina Maruyama Jos é Joaquim Ribeiro da Rocha Omar Feres Cristina Ribeiro de Barros Cardoso Source Type: research