Crohn's Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ozanimod Differentially Impacts Circulating Lymphocyte Subsets in Patients with Moderately to Severely Active Crohn ’s Disease
ConclusionsOzanimod reduced circulating levels of all B-cell and most T-cell subsets but not monocytes or natural killer cells. Key subsets relevant to immune surveillance were not reduced, supporting the low risk of infection and malignancy with ozanimod in chronic inflammatory diseases. Levels of nonswitched memory B cells were associated with efficacy, providing a potential marker for ozanimod response.Trial Registration ClinicalTrials.gov: NCT02531113, EudraCT: 2015 –002025–19Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 3, 2024 Category: Gastroenterology Source Type: research

Influential factors on disease activity in Crohn ’s disease and their Roc curve evaluation: a cross-sectional study
This study aims to investigate the factors influencing disease activity in patients with Crohn ’s disease (CD) and provide insights and references for the management and prevention of CD. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 3, 2024 Category: Gastroenterology Authors: Jing Wang, Shuping Tong and Bingqing Lu Tags: Research Source Type: research

Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis
CONCLUSIONS: We confirmed a shared genetic basis, pleiotropic loci/genes, and causal relationship between SCZ and IBD, providing novel insights into the biological mechanism and therapeutic targets underlying these two disorders.PMID:38563283 | DOI:10.1017/S0033291724000771 (Source: Psychological Medicine)
Source: Psychological Medicine - April 2, 2024 Category: Psychiatry Authors: Jing Wang Guang-Yu Luo Tian Tian Yu-Qiang Zhao Shi-Yin Meng Jun-Hua Wu Wen-Xiu Han Bin Deng Jing Ni Source Type: research

Robotic-assisted reoperative ileal pouch –anal anastomosis: robotic pouch excision and pouch revision
ConclusionRobotic reoperative pouch surgery in highly selected patients is technically feasible with acceptable outcomes. (Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - April 1, 2024 Category: Surgery Source Type: research

Rejection and Graft Vasculopathy Secondary to Effects of Crohn ’s Disease in a Heart-Transplanted Child
Introduction: Coronary allograft vasculopathy (CAV) results from a complex interplay between immune and non immune factors, with early onset CAV more likely associated with new donor specific antibodies (DSA) and evidence of rejection. Tacrolimus is absorbed both in small bowel and colon and is metabolized by CYP3a in intestinal wall and liver. Thus, inflammatory bowel disease impacting small or large bowel absorption could impact tacrolimus pharmacokinetics. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Conway, D. Freed, H. Huynh, M. Khoury, C. Kluthe, L. West, S. Urschel Source Type: research

A Partial Toll-like Receptor 4 Agonist Attenuates Pain While Maintaining Immunosufficiency
Activation of Toll-like Receptor 4 (TLR4) from infection or tissue damage/stress is a contributing factor to many diseases including chronic pain. Many of these pain conditions are associated with chronically elevated inflammatory cytokine expression or autoimmune dysregulation (e.g., rheumatoid arthritis, Crohn ’s disease). Current treatment includes biologics that target signaling pathways downstream of TLR4. These drugs reduce pain by reducing cytokine detection and function; many target TNF-alpha. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Richard J. Traub, Ohannes Melemedjian, Shelby Hanson, Robert K. Ernst, Alison J. Scott Source Type: research

GSE192819 A "living biobank" of Crohn's Disease
Contributors : Debashis Sahoo ; Soumita Das ; Pradipta GhoshSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatient-derived organoids (PDOs) from the colons of patients with Crohn's Disease (or healthy controls) were subjected to in-depth genotype, transcriptome and phenotype assessment. These studies revealed that CD may be classified broadly into two molecular subtypes, each with its unique profile of dysregulated celluar processes. We further show that these phenotypes can be rectified with matched therapeutics, hence making such intervention personalized. Findings show that CD-...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
CONCLUSIONS: Prescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures.PMID:38554238 | DOI:10.1007/s12325-023-02766-w (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Rose J Hart Fareen Hassan Sarah Alulis Karl W Patterson Jennifer Norma Barthelmes Jennifer H Boer Dawn Lee Source Type: research

Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research