Rejection and Graft Vasculopathy Secondary to Effects of Crohn ’s Disease in a Heart-Transplanted Child

Introduction: Coronary allograft vasculopathy (CAV) results from a complex interplay between immune and non immune factors, with early onset CAV more likely associated with new donor specific antibodies (DSA) and evidence of rejection. Tacrolimus is absorbed both in small bowel and colon and is metabolized by CYP3a in intestinal wall and liver. Thus, inflammatory bowel disease impacting small or large bowel absorption could impact tacrolimus pharmacokinetics.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research