Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
CONCLUSION: The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.PMID:38577186 | PMC:PMC10989502 | DOI:10.3748/wjg.v30.i9.1154 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Source Type: research
Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
CONCLUSION: MC3R and MC5R are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.PMID:38577176 | PMC:PMC10989484 | DOI:10.3748/wjg.v30.i9.1132 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Source Type: research
Simulated cost ‐effectiveness of a novel precision‐guided dosing strategy in adult patients with Crohn's disease initiating infliximab maintenance therapy
ConclusionsPGD provides clinical and QoL benefits by maintaining remission and avoiding IFX failure; it is the most cost-effective under conservative assumptions. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 5, 2024 Category: Drugs & Pharmacology Authors: Elmar R. Alizadeh,
Thierry Dervieux,
Severine Vermeire,
Marla Dubinsky,
Geert D'Haens,
David Laharie,
Andrew Shim,
Byron P. Vaughn Tags: RESEARCH ARTICLE Source Type: research
Fibrosis in IBD: from pathogenesis to therapeutic targets
Background
Intestinal fibrosis resulting in stricture formation and obstruction in Crohn’s disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest unmet needs in inflammatory bowel disease (IBD). Fibrosis is caused by a multifactorial and complex process involving immune and non-immune cells, their soluble mediators and exposure to luminal contents, such as microbiota and environmental factors. To date, no antifibrotic therapy is available. Some progress has been made in creating consensus definitions and measurements to quantify stricture morphology for clinical ...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Rieder, F., Mukherjee, P. K., Massey, W. J., Wang, Y., Fiocchi, C. Tags: GUT Recent advances in clinical practice, Gut Source Type: research
Defining gene-lifestyle interactions in inflammatory bowel disease: progress towards understanding disease pathogenesis
Recently, Lopes et al quantified the effect of modifiable lifestyle factors in inflammatory bowel disease (IBD) prevention using population attributable risk, and reported that 42.9% of Crohn’s disease (CD) cases and 44.4% of ulcerative colitis (UC) cases could have been prevented by lifestyle interventions. This interesting result was based on 6 prospective cohorts including 3 US cohorts with 208 070 participants and 3 large European cohorts that were used for validation.1 Undoubtedly, this well-performed study illustrates the possible merits of lifestyle modification as a prevention strategy for IBD. However, we wo...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Zhao, J., Chen, J., Sun, Y., Yuan, S., Wellens, J., Kalla, R., Theodoratou, E., Li, X., Satsangi, J. Tags: Gut PostScript Source Type: research
Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn ’s Disease and Ulcerative Colitis
ConclusionPROs correlate with CRP and FCP; however, disease location and phenotype impact their ability to distinguish symptom severity. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Rapid Endoscopic Diagnosis of Benign Ulcerative Colorectal Diseases with an Artificial Intelligence Contextual Framework
Benign ulcerative colorectal diseases (UCDs) such as ulcerative colitis (UC), Crohn ’s disease (CD), ischemic colitis (IC) and intestinal tuberculosis (ITB) share similar phenotypes with different etiologies and treatment strategies. To accurately diagnose closely-related diseases like UCDs, we hypothesize that contextual learning is critical in enhancing the ability of the artif icial intelligence models to differentiate the subtle differences in lesions amidst the vastly divergent spatial contexts. (Source: Gastroenterology)
Source: Gastroenterology - April 4, 2024 Category: Gastroenterology Authors: Xiaobei Luo, Jiahao Wang, Chuanchuan Tan, Qi Dou, Zelong Han, Zhenjiang Wang, Farah Tasnim, Xiyu Wang, Qiang Zhan, Xiang Li, Qunyan Zhou, Jianbin Cheng, Fabiao Liao, Hon Chi Yip, Jiayi Jiang, Robby T. Tan, Side Liu, Hanry Yu Tags: Clinical - Alimentary Tract Source Type: research
Myeloid Cells and Sphingosine-1-Phosphate Are Required for TCR αβ Intraepithelial Lymphocyte Recruitment to the Colon Epithelium
J Immunol. 2024 Apr 3:ji2200556. doi: 10.4049/jimmunol.2200556. Online ahead of print.ABSTRACTIntraepithelial lymphocytes (IELs) are T cells important for the maintenance of barrier integrity in the intestine. Colon IELs are significantly reduced in both MyD88-deficient mice and those lacking an intact microbiota, suggesting that MyD88-mediated detection of bacterial products is important for the recruitment and/or retention of these cells. Here, using conditionally deficient MyD88 mice, we show that myeloid cells are the key mediators of TCRαβ+ IEL recruitment to the colon. Upon exposure to luminal bacteria, myeloid cel...
Source: Journal of Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Sarah Mann Danielson Adam R Lefferts Eric Norman Emilie H Regner Hanna M Schulz Danielle Sansone-Poe David J Orlicky Kristine A Kuhn Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial
CONCLUSIONS: Parenteral n-3 polyunsaturated fatty acids supplementation promotes postoperative recovery in patients with Crohn's disease following bowel resection, with fewer complications and reduced inflammatory cytokines. This trial was registered at clinicaltrials.gov as NCT03901937 at https://classic.CLINICALTRIALS: gov/ct2/show/NCT03901937?term=NCT03901937&cond=Crohn+Disease&draw=2&rank=1.PMID:38569774 | DOI:10.1016/j.ajcnut.2023.12.022 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Xiaolong Ge Huaying Liu Yan Wu Wei Liu Weilin Qi Linna Ye Qian Cao Haifeng Lian Rongpan Bai Wei Zhou Source Type: research
Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease
CONCLUSIONS: We identify microbial signals and diet-related metabolites in feces, which could comprise targets for pretreatment optimization and personalized nutritional therapy in pediatric CD.PMID:38569785 | DOI:10.1016/j.ajcnut.2023.12.027 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Ben Nichols Anny Briola Michael Logan Jaroslav Havlik Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K Russell Richard Hansen Konstantinos Gerasimidis Source Type: research
Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial
CONCLUSIONS: Parenteral n-3 polyunsaturated fatty acids supplementation promotes postoperative recovery in patients with Crohn's disease following bowel resection, with fewer complications and reduced inflammatory cytokines. This trial was registered at clinicaltrials.gov as NCT03901937 at https://classic.CLINICALTRIALS: gov/ct2/show/NCT03901937?term=NCT03901937&cond=Crohn+Disease&draw=2&rank=1.PMID:38569774 | DOI:10.1016/j.ajcnut.2023.12.022 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 3, 2024 Category: Nutrition Authors: Xiaolong Ge Huaying Liu Yan Wu Wei Liu Weilin Qi Linna Ye Qian Cao Haifeng Lian Rongpan Bai Wei Zhou Source Type: research
Beyond diagnosis: investigating hospital referral impact on biological treatment initiation, hospital admission, and surgery patterns in inflammatory bowel disease - a Danish population based study
CONCLUSIONS: Based on the findings of this population-based study, we found no evidence that the referral area had a significant impact on the duration from diagnosis to the initiation of biological treatment, hospital admissions, or surgery. However, the data suggested that fewer patients with luminal Crohn's disease were referred to biologics from Non-Academic Hospitals.PMID:38567864 | DOI:10.1080/00365521.2024.2337829 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 3, 2024 Category: Gastroenterology Authors: Lone Larsen Anne Estrup Olesen Alev B üyükuslu Nayeb Simon Gr øntved Anne Lund Krarup Source Type: research
Myeloid Cells and Sphingosine-1-Phosphate Are Required for TCR αβ Intraepithelial Lymphocyte Recruitment to the Colon Epithelium
J Immunol. 2024 Apr 3:ji2200556. doi: 10.4049/jimmunol.2200556. Online ahead of print.ABSTRACTIntraepithelial lymphocytes (IELs) are T cells important for the maintenance of barrier integrity in the intestine. Colon IELs are significantly reduced in both MyD88-deficient mice and those lacking an intact microbiota, suggesting that MyD88-mediated detection of bacterial products is important for the recruitment and/or retention of these cells. Here, using conditionally deficient MyD88 mice, we show that myeloid cells are the key mediators of TCRαβ+ IEL recruitment to the colon. Upon exposure to luminal bacteria, myeloid cel...
Source: Journal of Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Sarah Mann Danielson Adam R Lefferts Eric Norman Emilie H Regner Hanna M Schulz Danielle Sansone-Poe David J Orlicky Kristine A Kuhn Source Type: research
