Artificial intelligence-based diagnostic imaging system with virtual enteroscopy and virtual unfolded views to evaluate small bowel lesions in Crohn's disease
Rev Esp Enferm Dig. 2024 Mar 25. doi: 10.17235/reed.2024.10405/2024. Online ahead of print.ABSTRACTSince even subtle mucosal changes may be depicted using virtual endoscopy created by the three-dimensional reconstruction of MDCT images, we developed a novel diagnostic imaging system that integrates and displays virtual enteroscopy, curved planar reconstruction, and a virtual unfolded view, the width of which changes with increases/decreases in the inner luminal diameter. The system is also equipped with artificial intelligence that superimposes and displays depressed areas, generates an automatic small bowel centerline tha...
Source: Revista Espanola de Enfermedades Digestivas - March 25, 2024 Category: Gastroenterology Authors: Kazuhiro Furukawa Masahiro Oda Osamu Watanabe Masanao Nakamura Takeshi Yamamura Keiko Maeda Kensaku Mori Hiroki Kawashima Source Type: research
Integrated 16S rRNA sequencing and metagenomics insights into microbial dysbiosis and distinct virulence factors in inflammatory bowel disease
This study aims to elucidate the gut microbiota profiles in IBD patients and compare them with healthy controls in a western city of China.MethodsWe conducted a multicenter case-control study from the end of 2020, using 16S rRNA gene sequencing (n = 36) and metagenomic sequencing (n = 12) to analyze the gut microbiota of newly diagnosed IBD patients, including those with Crohn's disease (CD) and ulcerative colitis (UC).ResultsOur results demonstrated a significant enrichment of the phylum Proteobacteria, particularly the genus Escherichia-Shigella, in CD patients. Conversely, the genus Enterococcus was markedly increased i...
Source: Frontiers in Microbiology - March 25, 2024 Category: Microbiology Source Type: research
Precise infliximab exposure and pharmacodynamic control to achieve deep remission in paediatric Crohns disease (REMODEL-CD): study protocol for a multicentre, open-label, pragmatic clinical trial in the USA
Introduction
The only biologic therapy currently approved to treat moderate to severe Crohn’s disease in children (<18 years old) are those that antagonise tumour necrosis factor-alpha (anti-TNF). Therefore, it is critically important to develop novel strategies that maximise treatment effectiveness in this population. There is growing evidence that rates of sustained corticosteroid-free clinical remission, endoscopic healing and drug durability considerably improve when patients receive early anti-TNF dose optimisations guided by reactive or proactive therapeutic drug monitoring and pharmacodynamic monitoring. In...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Minar, P. P., Colman, R. J., Zhang, N., Mizuno, T., Vinks, A. A. Tags: Open access, Gastroenterology and hepatology Source Type: research
Association between inflammatory bowel disease and cancer risk: evidence triangulation from genetic correlation, Mendelian randomization, and colocalization analyses across East Asian and European populations
Inflammatory bowel disease (IBD), which includes Crohn ’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have bee... (Source: BMC Medicine)
Source: BMC Medicine - March 25, 2024 Category: Internal Medicine Authors: Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li and Youxin Wang Tags: Research article Source Type: research
