Pediatric keratoconus epidemiology: a systematic scoping review
ConclusionsRecent epidemiological studies with better methodologies demonstrated increased prevalence rates in comparison to the older literature. This effect may be due to better diagnostic methods and better sample selection than those in historical studies. Diagnosis remains a major challenge as the early disease is usually asymptomatic. Economic and social aspects of pediatric KC remain understudied in the pediatric literature. Global, inclusive, and proactive screening studies in schools are imperative to better understand the great impact of this disease in the young. (Source: International Ophthalmology)
Source: International Ophthalmology - February 12, 2024 Category: Opthalmology Source Type: research
Effects of injectable platelet-rich fibrin (i-PRF) on pterygium surgery with conjunctival autograft
ConclusionsThanks to its platelets-derived growth factors, i-PRF can be a safe and effective adjuvant therapy for faster healing of conjunctival autograft and in the prevention of recurrence. (Source: International Ophthalmology)
Source: International Ophthalmology - February 12, 2024 Category: Opthalmology Source Type: research
Intrastromal corneal ring segments for keratoconus patients: up to 12 years follow up
ConclusionThis study represents the largest follow up for ICRS implanted in keratoconus patients. Improvement of visual acuity following ICRS implantation can be expected in the first few years, after which, a decline occurring thereafter. (Source: International Ophthalmology)
Source: International Ophthalmology - February 9, 2024 Category: Opthalmology Source Type: research
Impact of demographic factors on corneal donor recovery
ConclusionsIn a large cohort of corneal donors, non-White race, younger age, and male gender were associated with longer DTP. (Source: International Ophthalmology)
Source: International Ophthalmology - February 7, 2024 Category: Opthalmology Source Type: research
Impact of culture media on primary human corneal endothelial cells derived from old donors
In this study, we investigated various culture media to evaluate which one is the most appropriate for stimulating the proliferation while maintaining cell morphology and function of HCEnCs derived from old donors (age >65 years). All experiments were performed on paired research-grade donor corneas, divided for the conditions under investigation in order to minimize the inter-donor variability. Cell morphology as well as expression of specific markers were assessed at both mRNA (CD166, SLC4A11, ATP1A1, COL8A1, α-SMA, CD44, COL1A1, CDKN2A, LAP2A and LAP2B) and protein (ZO-1, α-SMA, Ki67 and LAP2) levels. Results obtai...
Source: Experimental Eye Research - February 5, 2024 Category: Opthalmology Authors: Alessia Merra Eleonora Maurizi Graziella Pellegrini Source Type: research
Hitting the refractive target in corneal endothelial transplantation triple procedures: A systematic review
In phakic patients, Descemet stripping automated endothelial keratoplasty (DSAEK) or Descemet membrane endothelial keratoplasty (DMEK) are frequently combined with phacoemulsification and intraocular lens (IOL) implantation (triple procedure). This surgery might cause a refractive shift difficult to predict. Early DMEK and DSAEK results have shown a tendency toward a hyperopic shift. Myopic postoperative refraction is typically intended to correct this postoperative refractive defect and bring all eyes as close to emmetropia as possible. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 1, 2024 Category: Opthalmology Authors: Rosa Giglio, Alex Lucia Vinciguerra, Alberto Grotto, Serena Milan, Daniele Tognetto Tags: Review article Source Type: research
Donor Corneal Endothelial Cell Maturity and Its Impact on Graft Survival in Glaucoma Patients Undergoing Corneal Transplantation
To examine corneal graft survival via corneal endothelial cell density (ECD) and corneal endothelial cell loss (ECL) at 5 years post transplantation in the eyes of patients with and without a history of previously undergoing glaucoma surgery according to the maturity of the donor corneal endothelial cells. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - January 31, 2024 Category: Opthalmology Authors: KOJI KITAZAWA, MUNETOYO TODA, MORIO UENO, KOICHI WAKIMASU, YASUFUMI TOMIOKA, ASAKO UEHARA, CHIE SOTOZONO, SHIGERU KINOSHITA Tags: Original Articles Source Type: research
Endophthalmitis rates and risk factors following intraocular surgeries in the medicare population from 2016 to 2019
Conclusions
Postoperative endophthalmitis rate after intraocular surgeries was 0.09% between 2016 and 2019 for Medicare beneficiaries. Endophthalmitis rates were highest for corneal transplant surgeries followed by secondary IOL surgeries and lowest for cataract surgeries. Older age, male gender and higher comorbidity index were associated with risk of endophthalmitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Chen, A., Dun, C., Schein, O. D., Srikumaran, D., Zafar, S., Makary, M., Woreta, F. Tags: Editor's choice Intraocular infection and inflammation Source Type: research
Polyhexanide based contact lens storage fluids frequently exhibit insufficient antifungal activity against Fusarium species
CONCLUSIONS: In summary, the use of Aldox- or hydrogen peroxide-based storage fluids may reduce the risk of Fusarium keratitis, while polyhexanide-based agents largely lack efficacy against Fusarium.PMID:38280372 | DOI:10.1016/j.ijmm.2024.151602 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - January 27, 2024 Category: Microbiology Authors: Benedikt Schrenker Anna Zimmermann Thorsten Koch Grit Walther Ronny Martin Daniel Kampik Oliver Kurzai Johanna Theuersbacher Source Type: research
In vivo confocal microscopy evaluation of infiltrated immune cells in corneal stroma treated with cell therapy in advanced keratoconus
ConclusionsADASCs-rCL therapy may lead to increased IC infiltration compared to ADASCs alone, impacting cell distribution and size due to the presence of the lamina. The findings reveal intricate immune patterns shaped by the corneal microenvironment and highlight the importance of understanding immune responses for the development of future therapeutic strategies. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - January 26, 2024 Category: Opthalmology Source Type: research
Ocular Involvement in Graft-versus-Host Disease
Klin Monbl Augenheilkd. 2024 Jan 23. doi: 10.1055/a-2218-0237. Online ahead of print.ABSTRACTIn ocular graft-versus-host disease (GVHD), an inflammatory reaction occurs at the ocular surface after transplantation of allogeneic hematopoietic stem cells. Self-reactive T cells of the donor are particularly responsible for this. This can lead to a pronounced wetting disorder of the ocular surface, conjunctival hyperemia, and corneal ulceration up to perforation. The ocular GVHD is associated with a high degree of suffering, such as pain, photophobia, and reduction in visual acuity. This review provides an overview of typical o...
Source: Klinische Monatsblatter fur Augenheilkunde - January 23, 2024 Category: Opthalmology Authors: Christoph Tappeiner Arnd Heiligenhaus Tina Dietrich-Ntoukas Source Type: research
The Role of IL-6, IL-10, and TNF- α in Ocular GVHD Following Allogeneic Transplantation
CONCLUSION: Dry eye symptoms related to ocular GVHD, can be partly diagnosed and assessed using various tear cytokine level detection methods.PMID:38252122 | DOI:10.1080/09273948.2024.2302445 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - January 22, 2024 Category: Allergy & Immunology Authors: Yingjie Chen Xinyu Zhuang Lei Wang Yue Xu Zhengtai Sun Yaru Ren Feng Chen Xiao Ma Xiaowen Tang Xiaofeng Zhang Source Type: research
The role of lymphatic vessels in corneal fluid homeostasis and wound healing
AbstractThe cornea, essential for vision, is normally avascular, transparent, and immune-privileged. However, injuries or infections can break this privilege, allowing blood and lymphatic vessels to invade, potentially impairing vision and causing immune responses. This review explores the complex role of corneal lymphangiogenesis in health and diseases. Traditionally, the cornea was considered devoid of lymphatic vessels, a phenomenon known as"corneal (lymph)angiogenic privilege." Recent advances in molecular markers have enabled the discovery of lymphatic vessels in the cornea under certain conditions. Several ...
Source: Journal of Ophthalmic Inflammation and Infection - January 22, 2024 Category: Opthalmology Source Type: research
Sutureless lamellar keratoplasty with lenticule from small incision lenticule extraction for treating limbal dermoid: A case report
Exp Ther Med. 2023 Dec 8;27(2):57. doi: 10.3892/etm.2023.12345. eCollection 2024 Feb.ABSTRACTThe present study reports the case of a superficial limbal dermoid surgically treated without suture by using a new technique of lamellar keratoplasty with allogenic lenticule from small incision lenticule extraction. The limbal lesion area was circumscribed by a trephine marker and lamellae were peeled off the anterior corneal stroma and sclera. After excision of the dermoid, the liquid on the bed was dried as much as possible and an appropriate stromal lenticule was attached to the implant bed without fibrin glue or suture. A ban...
Source: Experimental and Therapeutic Medicine - January 18, 2024 Category: General Medicine Authors: Yanjun Hao Bin Zhu Tao Wu Xuming Guo Source Type: research
FIL SSF intraocular lens opacification after gas tamponade: A case series
Eur J Ophthalmol. 2024 Jan 17:11206721241226743. doi: 10.1177/11206721241226743. Online ahead of print.ABSTRACTPURPOSE: To report three cases of postoperative opacification of sutureless scleral-fixed hydrophilic intraocular lens (FIL SSF IOL, Soleko, Italy) after gas tamponade. Two cases occurred after pars plana vitrectomy and one case after Descemet membrane endothelial keratoplasty.CASE REPORT: Two diabetic patients underwent a FIL SSF IOL implantation after posterior capsular rupture during cataract surgery. Rhegmatogenous retinal detachment (RRD) was observed in one patient during the initial surgery. A second patien...
Source: European Journal of Ophthalmology - January 17, 2024 Category: Opthalmology Authors: L Sejournet S Elbany Y Serrar O Loria J Bontemps T Mathis C Burillon L Kodjikian Source Type: research
