Familial primary calcific band-shaped keratopathy with late onset systemic disease: a case series and review of the literature
ConclusionConsidering the late onset of systemic disease in one of the siblings diagnosed with familial calcific band-shaped keratopathy (BSK), it is crucial to emphasize the necessity of long-term follow-up for these patients and their families. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 10, 2024 Category: General Medicine Source Type: research
Amniotic membrane transplantation for neurotrophic corneal ulcers
CONCLUSION: Cryopreserved amniotic membrane transplantation can be considered a good alternative for treating refractory neurotrophic corneal ulcers, as it resulted in significant improvement in pain (66%) and complete epithelial closure (60%) in many patients at 1 month postoperatively. Notably, the high failure rate highlights the need for further studies to identify patientand ulcer-related factors that may influence the outcomes of this procedure.PMID:38451687 | DOI:10.5935/0004-2749.2023-2022-0341 (Source: Herpes)
Source: Herpes - March 7, 2024 Category: Infectious Diseases Authors: Anna Carolina Badotti Linhares Ana Caroline Martinelli Mariela Regina Dalmarco Ghem Paula Basso Dias Daniel Wasilewski Source Type: research
Amniotic membrane transplantation for neurotrophic corneal ulcers
CONCLUSION: Cryopreserved amniotic membrane transplantation can be considered a good alternative for treating refractory neurotrophic corneal ulcers, as it resulted in significant improvement in pain (66%) and complete epithelial closure (60%) in many patients at 1 month postoperatively. Notably, the high failure rate highlights the need for further studies to identify patientand ulcer-related factors that may influence the outcomes of this procedure.PMID:38451687 | DOI:10.5935/0004-2749.2023-2022-0341 (Source: Herpes)
Source: Herpes - March 7, 2024 Category: Infectious Diseases Authors: Anna Carolina Badotti Linhares Ana Caroline Martinelli Mariela Regina Dalmarco Ghem Paula Basso Dias Daniel Wasilewski Source Type: research
Herpetic Keratouveitis: Missed Diagnosis Leading to Corneal Perforation
We report a case of a 70-year-old female who presented with redness and painless blurry vision in her right eye and was treated with topical corticosteroid drops for presumed idiopathic anterior uveitis. Despite initial symptomatic improvement, she reattended with a significant deterioration in vision and was found to have a large corneal infiltrate and associated perforation. The perforation was sealed with corneal gluing, and she was treated for presumed herpetic anterior uveitis with oral acyclovir. Corneal polymerase chain reaction (PCR) specimen was positive for herpes simplex virus DNA. The perforation started to lea...
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Kirupakaran Arun Panagiotis Georgoudis Source Type: research
Use of discarded corneo-scleral rims to create cornea-like tissue
CONCLUSIONS: The approach effectively helps to shorten the gap between demand and supply of CLMs/CLTs for transplantation. We are exploring the surgical transplantation of this CLT into animal eyes, as keratoprostheses, as a precursor to future applications involving human eyes. It is possible to use either the CLM or CLT, for patients with varying corneal blinding diseases.PMID:38446253 | DOI:10.1007/s11033-024-09321-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 6, 2024 Category: Molecular Biology Authors: Maryada Sharma Subhpreet Kaur Nimisha A Mavlankar Alokananda Chanda Parul Chawla Gupta Uma Nahar Saikia Jagat Ram Asish Pal Sanjay Mandal Purnananda Guptasarma Manni Luthra-Guptasarma Source Type: research
Herpetic Keratouveitis: Missed Diagnosis Leading to Corneal Perforation
We report a case of a 70-year-old female who presented with redness and painless blurry vision in her right eye and was treated with topical corticosteroid drops for presumed idiopathic anterior uveitis. Despite initial symptomatic improvement, she reattended with a significant deterioration in vision and was found to have a large corneal infiltrate and associated perforation. The perforation was sealed with corneal gluing, and she was treated for presumed herpetic anterior uveitis with oral acyclovir. Corneal polymerase chain reaction (PCR) specimen was positive for herpes simplex virus DNA. The perforation started to lea...
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Kirupakaran Arun Panagiotis Georgoudis Source Type: research
Use of discarded corneo-scleral rims to create cornea-like tissue
CONCLUSIONS: The approach effectively helps to shorten the gap between demand and supply of CLMs/CLTs for transplantation. We are exploring the surgical transplantation of this CLT into animal eyes, as keratoprostheses, as a precursor to future applications involving human eyes. It is possible to use either the CLM or CLT, for patients with varying corneal blinding diseases.PMID:38446253 | DOI:10.1007/s11033-024-09321-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 6, 2024 Category: Molecular Biology Authors: Maryada Sharma Subhpreet Kaur Nimisha A Mavlankar Alokananda Chanda Parul Chawla Gupta Uma Nahar Saikia Jagat Ram Asish Pal Sanjay Mandal Purnananda Guptasarma Manni Luthra-Guptasarma Source Type: research
UV light-mediated corneal crosslinking as (lymph)angioregressive pretreatment to promote graft survival after subsequent high-risk corneal transplantation (CrossCornealVision): protocol for a multicenter, randomized controlled trial
Good vision highly depends on the transparency of the cornea, which is the “windscreen” of the eye. In fact, corneal blindness due to transparency loss is the second most common cause of blindness worldwide, a... (Source: Trials)
Source: Trials - March 6, 2024 Category: General Medicine Authors: Johanna Wiedemann, Deniz Hos, Endrik Limburg, Ulrike Zettelmeyer, Petra Schiller, Jeremy Franklin, Bj örn Bachmann, Daniel Böhringer, Tina Dietrich-Ntoukas, Thomas A. Fuchsluger, Gerd Geerling, Stefan J. Lang, Wolfgang Johann Mayer, Siegfried Priglinger Tags: Study protocol Source Type: research
< em > Abiotrophia defectiva < /em > Endophthalmitis Post-Keratoplasty - A Case Report and Literature Review
CONCLUSION: We emphasize aggressive treatment of external disease prior to intraocular surgery. In cases of A. defectiva endophthalmitis, we advocate judicious use of steroids.PMID:38436925 | DOI:10.1080/09273948.2024.2324142 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 4, 2024 Category: Allergy & Immunology Authors: Konstantin Gushansky Source Type: research
Comparison of therapeutic effects between big-bubble deep anterior lamellar keratoplasty and penetrating keratoplasty for medically unresponsive Acanthamoeba keratitis
To compare the outcomes of big-bubble deep anterior lamellar keratoplasty (BB-DALK) and penetrating keratoplasty (PKP) in the management of medically unresponsive Acanthamoeba keratitis (AK). (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 4, 2024 Category: Infectious Diseases Authors: Xiaolin Qi, Huilin Mao, Jinhui Liu, Yanling Dong, Man Du, Ting Liu, Ting Zhang, Xiuhai Lu and Hua Gao Tags: Research Source Type: research
3D bioprinted photo crosslinkable GelMA/methylcellulose hydrogel mimicking native corneal model with enhanced in vitro cytocompatibility and sustained keratocyte phenotype for stromal regeneration
Int J Biol Macromol. 2024 Feb 28:130472. doi: 10.1016/j.ijbiomac.2024.130472. Online ahead of print.ABSTRACTCorneal transplantation serves as the standard clinical therapy for serious corneal disorders. However, rejection of grafts, significant expenditures, and most crucially, the global donor shortage, may affect the outcome. Recently, 3D bioprinting using biodegradable polymeric materials has become a suitable method for creating tissue replicas with identical architecture. One such most renowned material is GelMA, for its scaffold's three-dimensional structure, biocompatibility, robust mechanics, and favourable optical...
Source: International Journal of Biological Macromolecules - March 1, 2024 Category: Biochemistry Authors: Renuka Vijayaraghavan Sravanthi Loganathan Ravi Babu Valapa Source Type: research
3D bioprinted photo crosslinkable GelMA/methylcellulose hydrogel mimicking native corneal model with enhanced in vitro cytocompatibility and sustained keratocyte phenotype for stromal regeneration
Int J Biol Macromol. 2024 Feb 28:130472. doi: 10.1016/j.ijbiomac.2024.130472. Online ahead of print.ABSTRACTCorneal transplantation serves as the standard clinical therapy for serious corneal disorders. However, rejection of grafts, significant expenditures, and most crucially, the global donor shortage, may affect the outcome. Recently, 3D bioprinting using biodegradable polymeric materials has become a suitable method for creating tissue replicas with identical architecture. One such most renowned material is GelMA, for its scaffold's three-dimensional structure, biocompatibility, robust mechanics, and favourable optical...
Source: Cell Research - March 1, 2024 Category: Cytology Authors: Renuka Vijayaraghavan Sravanthi Loganathan Ravi Babu Valapa Source Type: research
Clinical outcomes of traumatic globe rupture in corneal graft patients
ConclusionsThis study represents the first published series from England for this type of patient cohort. Overall visual outcomes were poor with a bimodal relationship of age and mechanism of trauma. Worse prognostic factors included lens and posterior segment complications. Re-grafting in these select group of patients may prove valuable. (Source: International Ophthalmology)
Source: International Ophthalmology - February 29, 2024 Category: Opthalmology Source Type: research
Cytomegalovirus Corneal Endotheliitis: A Comprehensive Review
Ocul Immunol Inflamm. 2024 Feb 28:1-10. doi: 10.1080/09273948.2024.2320704. Online ahead of print.ABSTRACTCytomegalovirus (CMV) anterior uveitis and corneal endotheliitis are the most common ocular diseases caused by CMV infections in immunocompetent patients. The incidence of CMV corneal endotheliitis is relatively high in middle-aged men. CMV corneal endotheliitis presents with mild anterior chamber inflammation, corneal edema, keratic precipitates, and elevated intraocular pressure. It resembles Posner-Schlossman syndrome and Fuchs uveitis because of the elevated intraocular pressure. Without proper diagnosis and treatm...
Source: Ocular Immunology and Inflammation - February 28, 2024 Category: Allergy & Immunology Authors: Woong-Sun Yoo Lee-Ha Kwon Youngsub Eom Zheng Xian Thng Christopher Or Quan Dong Nguyen Seong-Jae Kim Source Type: research
Relationship of posterior peripheral corneal layers and the trabecular meshwork: an immunohistological and anatomical study
CONCLUSION: The TZ between DM, PDL and TM shows a unique histological structure at the periphery. The collagen and elastin fibres of the TM are continuous with the PDL. The structures are firmly attached to each other. These findings provide structural information that is relevant to the preparation of DMEK donor tissue.PMID:38418206 | DOI:10.1136/bjo-2023-324844 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 28, 2024 Category: Opthalmology Authors: Bur çin Kepez Yildiz Rui Freitas Perla Filippini Fatima Habroosh Dalia G Said Harminder Singh Dua Prity Sahay Source Type: research
