Classification of pachychoroid disease on ultrawide-field indocyanine green angiography using auto-machine learning platform.
CONCLUSIONS: Auto machine-learning platform can be used in the classification of pachychoroid on UWF ICGA images after careful consideration for pachychoroid definition and limitation of the platform including unstable performance on the medical image. PMID: 32620684 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 3, 2020 Category: Opthalmology Authors: Kim IK, Lee K, Park JH, Baek J, Lee WK Tags: Br J Ophthalmol Source Type: research

Is physical activity protective against myopia?
PMID: 32620685 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 3, 2020 Category: Opthalmology Authors: Foreman J, Crowston JG, Dirani M Tags: Br J Ophthalmol Source Type: research

Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion.
Abstract AIMS: To examine the choroidal change accompanying retinal vein occlusion (RVO) in detail, we measured changes in choroidal structure after intravitreal aflibercept (IVA) injections for RVO using binarisation of enhanced depth imaging optical coherence tomographic (EDI-OCT) images and assessed associations with clinical outcome. METHODS: Retrospective, observational case series. Forty treatment-naïve patients (10 central, 18 major branch and 12 macular branch RVO) were examined by EDI-OCT before and 1, 3 and 6 months after IVA injections. EDI-OCT images were binarised using ImageJ. Subfoveal cro...
Source: The British Journal of Ophthalmology - July 3, 2020 Category: Opthalmology Authors: Mitamura Y, Enkhmaa T, Sano H, Niki M, Murao F, Egawa M, Sonoda S, Sakamoto T Tags: Br J Ophthalmol Source Type: research

Thinner retinal nerve fibre layer in young adults with foetal alcohol spectrum disorders.
CONCLUSION: Significant differences in peripapillary and macular RNFL, retinal thickness and BCVA were found in this group of young adults with FASD compared with healthy controls. However, there were no differences in the size of the optic disc. PMID: 32620687 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 3, 2020 Category: Opthalmology Authors: Gyllencreutz E, Aring E, Landgren V, Landgren M, Gronlund MA Tags: Br J Ophthalmol Source Type: research

Progressive retinal nerve fibre layer thinning and choroidal microvasculature dropout at the location of disc haemorrhage in glaucoma.
Abstract BACKGROUND/AIMS: To investigate whether parapapillary choroidal microvasculature dropout (MvD) is associated with progressive retinal nerve fibre layer (RNFL) thinning in eyes with primary open-angle glaucoma (POAG) and disc haemorrhage (DH). METHODS: Parapapillary microvasculature was evaluated by swept-source optical coherence tomography (OCT) angiography (OCTA) in 50 eyes with POAG and DH, 1 year before, at the time of and 1 year after the detection of DH. MvD was defined as an area in the parapapillary deep layer of focal sectoral dropout with no visible microvascular network. Progressive changes...
Source: The British Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Authors: Kim CY, Lee EJ, Kim JA, Kim H, Kim TW Tags: Br J Ophthalmol Source Type: research

Efficacy and safety of selective laser trabeculoplasty and pattern scanning laser trabeculoplasty: a randomised clinical trial.
Abstract AIMS: To compare the intraocular pressure (IOP) lowering effect and safety profile between pattern scanning laser trabeculoplasty (PSLT) and selective laser trabeculoplasty (SLT) in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) over a 12-month follow-up. METHODS: 132 patients with POAG or OHT were consecutively enrolled and randomised (1:1) to receive PSLT (n=65) or SLT (n=67) in a single centre. IOP was measured before and then on 1 day, 1 week, 1, 3, 6, 9 and 12 months after PSLT/SLT. The primary outcome measure was the proportion of patients with ≥20% IOP reducti...
Source: The British Journal of Ophthalmology - June 30, 2020 Category: Opthalmology Authors: Wong MOM, Lai IS, Chan PP, Chan NC, Chan AY, Lai GW, Chiu VS, Leung CK Tags: Br J Ophthalmol Source Type: research

Examining the added value of microperimetry and low luminance deficit for predicting progression in age-related macular degeneration.
Abstract PURPOSE: To examine the added predictive value of microperimetric sensitivity and low luminance deficit (LLD; difference between photopic and low luminance visual acuity (VA)) to information from colour fundus photography (CFP) for progression to late age-related macular degeneration (AMD) in individuals with bilateral large drusen. METHODS: 140 participants with bilateral large drusen underwent baseline microperimetry testing, VA measurements and CFP. They were then reviewed at 6-monthly intervals to 36 months, to determine late AMD progression. Microperimetry pointwise sensitivity SD (PSD), LLD and...
Source: The British Journal of Ophthalmology - June 30, 2020 Category: Opthalmology Authors: Wu Z, Luu CD, Hodgson LA, Caruso E, Chen FK, Chakravarthy U, Arnold JJ, Heriot WJ, Runciman J, Guymer RH Tags: Br J Ophthalmol Source Type: research

Low systemic vitamin D as a potential risk factor in primary open-angle glaucoma: a review of current evidence.
Abstract Currently, intraocular pressure is the only modifiable risk factor for glaucoma; thus, identifying other modifiable determinants may have far-reaching outcomes. There has been increasing interest in vitamin D status and glaucoma pathogenesis as low vitamin D has been identified by some studies as an independent risk factor for glaucoma. Although the exact mechanism of vitamin D in glaucoma remains uncertain, there is sufficient evidence to continue research in this area. There is a potential physiological role for vitamin D as an anti-inflammatory agent in the oxidative stress-driven pathogenesis of prima...
Source: The British Journal of Ophthalmology - June 30, 2020 Category: Opthalmology Authors: Huynh B, Shah P, Sii F, Hunter D, Carnt N, White A Tags: Br J Ophthalmol Source Type: research

Prospective evaluation of an artificial intelligence-enabled algorithm for automated diabetic retinopathy screening of 30  000 patients.
CONCLUSION: The algorithm demonstrated safe levels of sensitivity for high-risk retinopathy in a real-world screening service, with specificity that could halve the workload for human graders. AI machine learning and deep learning algorithms such as this can provide clinically equivalent, rapid detection of retinopathy, particularly in settings where a trained workforce is unavailable or where large-scale and rapid results are needed. PMID: 32606081 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 30, 2020 Category: Opthalmology Authors: Heydon P, Egan C, Bolter L, Chambers R, Anderson J, Aldington S, Stratton IM, Scanlon PH, Webster L, Mann S, du Chemin A, Owen CG, Tufail A, Rudnicka AR Tags: Br J Ophthalmol Source Type: research

Deep learning model to predict visual field in central 10 ° from optical coherence tomography measurement in glaucoma.
Deep learning model to predict visual field in central 10° from optical coherence tomography measurement in glaucoma. Br J Ophthalmol. 2020 Jun 27;: Authors: Hashimoto Y, Asaoka R, Kiwaki T, Sugiura H, Asano S, Murata H, Fujino Y, Matsuura M, Miki A, Mori K, Ikeda Y, Kanamoto T, Yamagami J, Inoue K, Tanito M, Yamanishi K Abstract BACKGROUND/AIM: To train and validate the prediction performance of the deep learning (DL) model to predict visual field (VF) in central 10° from spectral domain optical coherence tomography (SD-OCT). METHODS: This multicentre, cross-sectional study included pair...
Source: The British Journal of Ophthalmology - June 27, 2020 Category: Opthalmology Authors: Hashimoto Y, Asaoka R, Kiwaki T, Sugiura H, Asano S, Murata H, Fujino Y, Matsuura M, Miki A, Mori K, Ikeda Y, Kanamoto T, Yamagami J, Inoue K, Tanito M, Yamanishi K Tags: Br J Ophthalmol Source Type: research

Long-term follow-up of cystinosis patients treated with 0.55% cysteamine hydrochloride.
CONCLUSION: This large safety cohort confirms the efficacy, safety and tolerability of Cystadrops in real-world clinical practice. PMID: 32593979 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 27, 2020 Category: Opthalmology Authors: Liang H, Labbé A, Baudouin C, Plisson C, Giordano V Tags: Br J Ophthalmol Source Type: research

Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy.
CONCLUSION: WF SS-OCTA is useful for identification of DR lesions. WF SS-OCTA plus UWF CFP may offer a less invasive alternative to FA for DR diagnosis. PMID: 32591347 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 26, 2020 Category: Opthalmology Authors: Cui Y, Zhu Y, Wang JC, Lu Y, Zeng R, Katz R, Vingopoulos F, Le R, Laíns I, Wu DM, Eliott D, Vavvas DG, Husain D, Miller JW, Kim LA, Miller JB Tags: Br J Ophthalmol Source Type: research

APEX: a phase II randomised clinical trial evaluating the safety and preliminary efficacy of oral X-82 to treat exudative age-related macular degeneration.
Abstract PURPOSE: The safety and efficacy of X-82, an orally administered inhibitor of vascular endothelial growth factor (VEGF) and platelet-derived growth factor, was investigated for treatment of wet age-related macular degeneration (AMD) in a phase II clinical trial. METHODS: This phase II, randomised, double-masked, placebo-controlled trial enrolled subjects with a prior diagnosis of exudative AMD having received at least two intravitreal injections of anti-VEGF therapy. Subjects were randomised equally into four groups that received either daily 50mg, 100mg or 200mg dosages of X-82 or a placebo tablet. ...
Source: The British Journal of Ophthalmology - June 25, 2020 Category: Opthalmology Authors: Cohen MN, O'Shaughnessy D, Fisher K, Cerami J, Awh CC, Salazar DE, Rosenfeld P, Heier JS Tags: Br J Ophthalmol Source Type: research

Evolving consensus for immunomodulatory therapy in non-infectious uveitis during the COVID-19 pandemic.
CONCLUSION: Consensus guidelines were proposed based on global expert opinion and practical experience to bridge the gap between clinical needs and the absence of medical evidence, to guide the treatment of patients with NIU during the COVID-19 pandemic. PMID: 32586933 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 25, 2020 Category: Opthalmology Authors: Agrawal R, Testi I, Lee CS, Tsui E, Blazes M, Thorne JE, Okada AA, Smith JR, McCluskey PJ, Kempen JH, Christoph T, Agarwal M, Bodaghi B, Nguyen QD, Gupta V, De Smet MD, Zierhut M, Pavesio C, COVID-19 IMT Study Group Tags: Br J Ophthalmol Source Type: research

Effect of baseline test selection on glaucoma progression detection by optical coherence tomography-guided progression analysis.
Abstract PURPOSE: To evaluate the effect of baseline test selection on progression detection of circumpapillary retinal nerve fibre layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) in glaucomatous eyes by optical coherence tomography (OCT)-guided progression analysis (GPA). METHODS: A total of 53 eyes with either RNFL or GCIPL progression determined using OCT-GPA were included. Three different baseline conditions were created by dividing eight serial OCT tests from each eye into three sets. Specifically, these sets presented baseline tests at exams 1-2 (1st set), 2-3 (2nd set) and 3-4 (3rd...
Source: The British Journal of Ophthalmology - June 25, 2020 Category: Opthalmology Authors: Kang DH, Hwang YH Tags: Br J Ophthalmol Source Type: research

Training in the year of the eye: the impact of the COVID-19 pandemic on ophthalmic education.
PMID: 32586935 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 25, 2020 Category: Opthalmology Authors: Bakshi SK, Ho AC, Chodosh J, Fung AT, Chan RVP, Ting DSW Tags: Br J Ophthalmol Source Type: research

OCT changes in peri-tumour normal retina following ruthenium-106 and proton beam radiotherapy for uveal melanoma.
Abstract INTRODUCTION: Uveal melanoma is most commonly treated with radiotherapy, destroying the tumour cells with adequate safety margins and limiting collateral damage to surrounding structures to preserve maximal vision. We used optical coherence tomography (OCT) to study the effects of radiotherapy on the retina. METHODS: Patients with posteriorly located choroidal melanoma treated with proton beam radiotherapy (PBR) and ruthenium-106 brachytherapy between January 2010 and June 2014 underwent spectral domain OCT. RESULTS: Images of 32 patients following ruthenium-106 brachytherapy and 44 patients fol...
Source: The British Journal of Ophthalmology - June 25, 2020 Category: Opthalmology Authors: Hussain R, Heussen FM, Heimann H Tags: Br J Ophthalmol Source Type: research

12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study.
Abstract BACKGROUND/AIMS: To examine the incidence, causative microorganisms and in vitro antimicrobial susceptibility and resistance profiles of infectious keratitis (IK) in Nottingham, UK. METHODS: A retrospective study of all patients who were diagnosed with IK and underwent corneal scraping between July 2007 and October 2019 (a 12-year period) at a UK tertiary referral centre. Relevant data, including demographic factors, microbiological profiles and in vitro antibiotic susceptibility of IK, were analysed. RESULTS: The estimated incidence of IK was 34.7 per 100 000 people/year. Of the 1333 cor...
Source: The British Journal of Ophthalmology - June 24, 2020 Category: Opthalmology Authors: Ting DSJ, Ho CS, Cairns J, Elsahn A, Al-Aqaba M, Boswell T, Said DG, Dua HS Tags: Br J Ophthalmol Source Type: research

Reduced vessel density in deep capillary plexus correlates with retinal layer thickness in choroideremia.
CONCLUSIONS: Our study showed severe alterations in both outer and inner retinal layers of patients with CHM. The extended retinal involvement might be the consequence of neuronal and vascular trophic factor reduction produced by the primarily altered RPE and/or secondary Müller glial cell reaction. PMID: 32580956 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 24, 2020 Category: Opthalmology Authors: Arrigo A, Romano F, Parodi MB, Charbel Issa P, Birtel J, Bandello F, Maclaren RE Tags: Br J Ophthalmol Source Type: research

Impact of myopia on the association of long-term intraocular pressure fluctuation with the rate of progression in normal-tension glaucoma.
Abstract BACKGROUND/AIMS: To investigate whether the association of long-term intraocular pressure (IOP) fluctuation with the rate of progression of normal-tension glaucoma (NTG) differs between myopia and non-myopia. METHODS: The medical records of 65 myopic NTG (axial length (AL) > 24.0 mm) and 64 non-myopic NTG eyes (AL 
Source: The British Journal of Ophthalmology - June 24, 2020 Category: Opthalmology Authors: Lee J, Ahn EJ, Kim YW, Ha A, Kim YK, Jeoung JW, Park KH Tags: Br J Ophthalmol Source Type: research

Late-term topical tacrolimus for subepithelial infiltrates resistant to topical steroids and ciclosporin secondary to adenoviral keratoconjunctivitis.
CONCLUSION: Topical 0.03% tacrolimus might show efficacy against the SEIs persisting at least 2 years despite corticosteroid and/or CSA treatment without any prominent side effect. While at least a period of 3 months was necessary for a significant improvement in the BCVA, SEIs and Schirmer results, a period of 6 months was necessary for a decrease in Oxford score. PMID: 32563992 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 20, 2020 Category: Opthalmology Authors: Arici C, Mergen B Tags: Br J Ophthalmol Source Type: research

Myopia in school-aged children with preterm birth: the roles of time spent outdoors and serum vitamin D.
CONCLUSIONS: Among preterm children with or without ROP, more time spent outdoors was associated with lower odds of myopia. The serum 25(OH)D concentration was not associated with myopia, but a high proportion of the participants had insufficient levels. PMID: 32561534 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 19, 2020 Category: Opthalmology Authors: Chou HD, Yao TC, Huang YS, Huang CY, Yang ML, Sun MH, Chen HC, Liu CH, Chu SM, Hsu JF, Chen KJ, Hwang YS, Lai CC, Wu WC Tags: Br J Ophthalmol Source Type: research

Comparison of outcomes between Aurolab aqueous drainage implant placed in the superotemporal versus inferonasal quadrant.
CONCLUSIONS: Inferonasal AADI placement appears to be an equally safe and effective surgical option compared with superotemporal AADI placement and may be helpful in certain clinical situations. PMID: 32554442 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 17, 2020 Category: Opthalmology Authors: Puthuran GV, Palmberg PF, Wijesinghe HK, Shreya TS, Krishnadas SR, Gedde SJ, Robin AL Tags: Br J Ophthalmol Source Type: research

Outcomes of the Boston type 1 and the Aurolab keratoprosthesis in eyes with limbal stem cell deficiency.
CONCLUSION: Keratoprosthesis is an effective treatment option for patients with corneal blindness secondary to LSCD. In a setting where LSCD is a common cause of corneal blindness, the AuroKpro, when available can be considered an alternative to the Boston Kpro to achieve anatomical and functional success in patients who otherwise would not have access to this device. PMID: 32554443 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 17, 2020 Category: Opthalmology Authors: Shanbhag SS, Senthil S, Mohamed A, Basu S Tags: Br J Ophthalmol Source Type: research

Four-year observation of the changes in corneal endothelium cell density and the correlated factors after Implantable Collamer Lens V4c implantation.
CONCLUSIONS: ICL V4c implantation is safe and effective for myopia correction. Anterior segment biometric parameters including the vault, ACA and C-ICL may influence changes in ECD; specifically, the vault plays a major role. PMID: 32546550 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 16, 2020 Category: Opthalmology Authors: Yang W, Zhao J, Sun L, Zhao J, Niu L, Wang X, Zhou X Tags: Br J Ophthalmol Source Type: research

Epidemiology of visual impairment, sight-threatening or treatment-requiring diabetic eye disease in children and young people in the UK: findings from DECS.
CONCLUSIONS: Secondary prevention of visual disability due to retinopathy is currently the sole purpose of national eye screening programmes globally. However, the rarity of treatment-requiring retinopathy in children/young people living with diabetes, alongside growing concerns about suboptimal screening uptake, merit new consideration of the utility of screening for primary prevention of diabetes-related morbidity by using the screening event and findings as a catalyst for better diabetes self-management. PMID: 32536608 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 14, 2020 Category: Opthalmology Authors: Ibanez-Bruron MC, Solebo AL, Cumberland P, Rahi JS Tags: Br J Ophthalmol Source Type: research

Real world evidence on 5661 patients treated for macular oedema secondary to branch retinal vein occlusion with intravitreal anti-vascular endothelial growth factor, intravitreal dexamethasone or macular laser.
CONCLUSIONS: Visual acuity improvements were higher and more sustained with anti-VEGF. Higher treatment burden occurred with anti-VEGF but this reduced over 36 months. Patients with better vision at baseline than those in the clinical trials maintained high levels of vision with both anti-VEGF and dexamethasone. PMID: 32532760 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 12, 2020 Category: Opthalmology Authors: Gale R, Pikoula M, Lee AY, Denaxas S, Egan C, Tufail A, Taylor P, UK EMR Users Group Tags: Br J Ophthalmol Source Type: research

Analysis of choriocapillaris perfusion and choroidal layer changes in patients with chronic central serous chorioretinopathy randomised to micropulse laser or photodynamic therapy.
CONCLUSION: The flow deficit areas identified in the choriocapillaris layer may suggest possible relative choroidal ischaemia. With measurement of choroidal volume reduction and faster rates of flow deficit area change, PDT has a stronger effect than MLT in promoting choriocapillaris recovery. PMID: 32532761 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 12, 2020 Category: Opthalmology Authors: Ho M, Lai FHP, Ng DSC, Iu LPL, Chen LJ, Mak ACY, Yip Y, Cheung C, Young AL, Brelen M Tags: Br J Ophthalmol Source Type: research

Artificial intelligence for anterior segment diseases: Emerging applications in ophthalmology.
Abstract With the advancement of computational power, refinement of learning algorithms and architectures, and availability of big data, artificial intelligence (AI) technology, particularly with machine learning and deep learning, is paving the way for 'intelligent' healthcare systems. AI-related research in ophthalmology previously focused on the screening and diagnosis of posterior segment diseases, particularly diabetic retinopathy, age-related macular degeneration and glaucoma. There is now emerging evidence demonstrating the application of AI to the diagnosis and management of a variety of anterior segment c...
Source: The British Journal of Ophthalmology - June 12, 2020 Category: Opthalmology Authors: Ting DSJ, Foo VH, Yang LWY, Sia JT, Ang M, Lin H, Chodosh J, Mehta J, Ting DSW Tags: Br J Ophthalmol Source Type: research

Uveitis and cystoid macular oedema secondary to topical prostaglandin analogue use in ocular hypertension and open angle glaucoma.
CONCLUSIONS: Cases of uveitis or CME revealed a confounding effect of ocular surgery, aphakia or subluxed intraocular lens. PGAs may be used in non-surgical patients without concern of causing CME or uveitis. The incidences of PGA-associated CME and uveitis are rare with limited prospective studies on the cause-effect relationship. PMID: 32532763 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 12, 2020 Category: Opthalmology Authors: Hu J, Vu JT, Hong B, Gottlieb C Tags: Br J Ophthalmol Source Type: research

COVID-19 and immunosuppression: a review of current clinical experiences and implications for ophthalmology patients taking immunosuppressive drugs.
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in Wuhan city, Hubei province, China. This is the third and largest coronavirus outbreak since the new millennium after SARS in 2002 and Middle East respiratory syndrome (MERS) in 2012. Over 3 million people have been infected and the COVID-19 has caused more than 217 000 deaths. A concern exists regarding the vulnerability of patients who have been treated with immunosuppressive drugs prior or during this pandemic. Would they be more susceptible to infection by the SARS-CoV-2 and how would their clinical cour...
Source: The British Journal of Ophthalmology - June 12, 2020 Category: Opthalmology Authors: Thng ZX, De Smet MD, Lee CS, Gupta V, Smith JR, McCluskey PJ, Thorne JE, Kempen JH, Zierhut M, Nguyen QD, Pavesio C, Agrawal R Tags: Br J Ophthalmol Source Type: research

Microaneurysms visualisation using five different optical coherence tomography angiography devices compared to fluorescein angiography.
Abstract BACKGROUND: To compare fluorescein angiography (FA) and five different optical coherence tomography angiography (OCTA) devices and to test their reproducibility in the evaluation of retinal microaneurysms (MAs) secondary to diabetic retinopathy (DR). METHODS: On the same day, patients with DR were imaged with FA and five OCTA devices: prototype Spectralis OCTA, prototype PlexElite, RTVue XR Avanti, AngioPlex and DRI OCT Triton. For all OCTA devices, a 3×3 volume scan pattern was performed. MAs were evaluated for the superficial capillary plexus (SCP) and deep capillary plexus (DCP). RESULT...
Source: The British Journal of Ophthalmology - June 11, 2020 Category: Opthalmology Authors: Parrulli S, Corvi F, Cozzi M, Monteduro D, Zicarelli F, Staurenghi G Tags: Br J Ophthalmol Source Type: research

Comparison of 13 formulas for IOL power calculation with measurements from partial coherence interferometry.
o CE Abstract BACKGROUND/AIMS: To compare the accuracy of 13 formulas for intraocular lens (IOL) power calculation in cataract surgery. METHODS: In this retrospective interventional case series, optical biometry measurements were entered into these formulas: Barrett Universal II (BUII) with and without anterior chamber depth (ACD) as a predictor, EVO 2.0 with and without ACD as a predictor, Haigis, Hoffer Q, Holladay 1, Holladay 2AL, Kane, Næser 2, Pearl-DGS, RBF 2.0, SRK/T, T2 and VRF. The mean prediction error (PE), median absolute error (MedAE), mean absolute error and percentage of eyes with a PE wi...
Source: The British Journal of Ophthalmology - June 10, 2020 Category: Opthalmology Authors: Savini G, Di Maita M, Hoffer KJ, Næser K, Schiano-Lomoriello D, Vagge A, Di Cello L, Traverso CE Tags: Br J Ophthalmol Source Type: research

Ten-year incidence and assessment of safe screening intervals for diabetic retinopathy: the OPHDIAT study.
CONCLUSIONS: These data suggest that in Paris area, a 2-year, 3-year and 4-year screening interval was considered safe for type 1 DM, type 2 DM and for low-risk patients with type 2 DM, respectively, without DR at the first examination. While these data might be used to support the consideration of extending screening intervals, a randomised clinical trial would be suitable to confirm the safety for patients with DM. PMID: 32522790 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 10, 2020 Category: Opthalmology Authors: Chamard C, Daien V, Erginay A, Gautier JF, Villain M, Tadayoni R, Carriere I, Massin P Tags: Br J Ophthalmol Source Type: research

Nuclear expression of BAP-1 in transvitreal incisional biopsies and subsequent enucleation of eyes with posterior choroidal melanoma.
CONCLUSION: Loss of nuclear BAP-1 expression occurred in a large proportion of the small tumours included in this study. BAP-1 immunoreactivity in transvitreal incisional biopsies of choroidal melanoma is substantially concordant with immunoreactivity in enucleated specimens and identifies patients with poor metastasis-free survival. PMID: 32522791 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 10, 2020 Category: Opthalmology Authors: Herrspiegel C, Kvanta A, Lardner E, Ramsköld Cabaca L, Wells J, Bartuma K, Seregard S, Stålhammar G Tags: Br J Ophthalmol Source Type: research

Cardiovascular risk in patients receiving ranibizumab for exudative age-related macular degeneration: a nationwide self-controlled case-series study.
CONCLUSIONS: Ranibizumab intravitreal injections did not increase the overall risk of stroke or AMI. Although the cardiovascular risk in patient receiving ranibizumab seems to be low, continuous monthly use of ranibizumab for high-risk patients should be judged carefully. PMID: 32522792 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 10, 2020 Category: Opthalmology Authors: Jeon HL, Byun SJ, Pratt NL, Sultana J, Park SJ, Shin JY Tags: Br J Ophthalmol Source Type: research

Presentation, surgery and 1-year outcomes of childhood cataract surgery in Tanzania.
CONCLUSION: Three-quarters of children were blind preoperatively whereas over half had good vision 1-year postoperatively. Preoperative blindness, nystagmus/strabismus and aphakia predicted poor visual outcome, suggesting that cataract density determines density of amblyopia. PMID: 32522793 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 10, 2020 Category: Opthalmology Authors: Mndeme FG, Mmbaga BT, Msina M, Mwende J, Vaitha SJ, Kim MJ, Macleod D, Burton MJ, Gilbert CE, Bowman R Tags: Br J Ophthalmol Source Type: research

Corneal endothelium in paediatric patients with uveitis: a prospective longitudinal study.
Abstract PURPOSE: To study the longitudinal effect of anterior chamber inflammation on the corneal endothelium in children. METHODS: In this prospective longitudinal observational study, children (aged
Source: The British Journal of Ophthalmology - June 10, 2020 Category: Opthalmology Authors: Fung SSM, El Hamouly A, Sami H, Jiandani D, Williams S, Tehrani N, Mireskandari K, Ali A Tags: Br J Ophthalmol Source Type: research

Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2.
CONCLUSIONS: The results indicate that OCT-A represents a useful imaging modality for monitoring NV-progression and treatment effects in MacTel. We demonstrate its advantages over conventional B-scan OCT imaging, including an earlier detection of NV-progression, and propose an adjustment of the current OCT-controlled PRN treatment regime in order to prevent NV-progression and subsequent functional loss in neovascular MacTel. PMID: 32513667 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 8, 2020 Category: Opthalmology Authors: Tzaridis S, Hess K, Friedlander M, Holz FG Tags: Br J Ophthalmol Source Type: research

Progression of retinopathy and incidence of cardiovascular disease: findings from the Chronic Renal Insufficiency Cohort Study.
Abstract PURPOSE: Chronic kidney disease (CKD) patients often develop cardiovascular disease (CVD) and retinopathy. The purpose of this study was to assess the association between progression of retinopathy and concurrent incidence of CVD events in participants with CKD. DESIGN: We assessed 1051 out of 1936 participants in the Chronic Renal Insufficiency Cohort Study that were invited to have fundus photographs obtained at two timepoints separated by 3.5 years, on average. METHODS: Using standard protocols, presence and severity of retinopathy (diabetic, hypertensive or other) and vessel diameter calibre...
Source: The British Journal of Ophthalmology - June 5, 2020 Category: Opthalmology Authors: Grunwald JE, Pistilli M, Ying GS, Maguire MG, Daniel E, Whittock-Martin R, Parker-Ostroff C, Jacoby D, Go AS, Townsend RR, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, CRIC Study investigators Tags: Br J Ophthalmol Source Type: research

Weekly and seasonal changes of intraocular pressure measured with an implanted intraocular telemetry sensor.
oup Abstract BACKGROUND/AIMS: To better understand seasonal and weekday intraocular pressure (IOP) variations, long-term daily IOP measurements were assessed in patients with glaucoma using an intraocular telemetric sensor. METHODS: This prospective, open-label, multicentre observational study analysed the IOP variation patterns in 22 eyes of 22 patients with primary open-angle glaucoma (67.8±6.8 years, 36.4% female) who had undergone placement of an intraocular telemetric sensor at the time of cataract surgery. The telemetric system combines an implantable IOP sensor with a hand-held reading device. P...
Source: The British Journal of Ophthalmology - June 4, 2020 Category: Opthalmology Authors: Mansouri K, Gillmann K, Rao HL, Weinreb RN, ARGOS–2 Study Group Tags: Br J Ophthalmol Source Type: research

Automated diagnoses of age-related macular degeneration and polypoidal choroidal vasculopathy using bi-modal deep convolutional neural networks.
CONCLUSION: A bi-modal DCNN for automated classification of AMD and PCV is accurate and promising in the realm of public health. PMID: 32499330 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 4, 2020 Category: Opthalmology Authors: Xu Z, Wang W, Yang J, Zhao J, Ding D, He F, Chen D, Yang Z, Li X, Yu W, Chen Y Tags: Br J Ophthalmol Source Type: research

SD-OCT peripapillary nerve fibre layer and ganglion cell complex parameters in glaucoma: principal component analysis.
CONCLUSIONS: PCA identified a diffuse representation of the papillary and macular SD-OCT parameters as the most important PC to summarise structural data in healthy and glaucomatous eyes. PCs and pRNFL parameters showed the greatest discriminative ability between healthy and glaucoma cases. PMID: 32493759 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 3, 2020 Category: Opthalmology Authors: Pazos M, Biarnés M, Blasco-Alberto A, Dyrda A, Luque-Fernández MÁ, Gómez A, Mora C, Milla E, Muniesa M, Antón A, Díaz-Alemán VT Tags: Br J Ophthalmol Source Type: research

Accuracy of optical coherence tomography for diagnosing glaucoma: an overview of systematic reviews.
CONCLUSIONS: The quality of published DTA reviews on OCT for diagnosing glaucoma was mixed. Two reliable SRs found moderate sensitivity at high specificity for average RNFL thickness in diagnosing manifest glaucoma. Our overview suggests that the methodological quality of both primary and secondary DTA research on glaucoma is in need of improvement. PMID: 32493760 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 3, 2020 Category: Opthalmology Authors: Michelessi M, Li T, Miele A, Azuara-Blanco A, Qureshi R, Virgili G Tags: Br J Ophthalmol Source Type: research

Choroidal luminal and stromal areas and choriocapillaris perfusion are characterised by a non-linear quadratic relation in healthy eyes.
CONCLUSION: Based on our models, changes in the luminal and stromal areas in the choroid lead to an initial increase in CC perfusion. Subsequently, further increases in LA and SA amounts are accompanied by a progressive increment in CC FD%. PMID: 32493761 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - June 3, 2020 Category: Opthalmology Authors: Borrelli E, Gabela MC, Sacconi R, Querques L, Vella G, Zuccaro B, Gelormini F, Bandello F, Querques G Tags: Br J Ophthalmol Source Type: research

Long-term natural history of visual acuity in eyes with choroideremia: a systematic review and meta-analysis of data from 1004 individual eyes.
CONCLUSION: BCVA in eyes with CHM follows a 2-phase linear decline with a transition age of approximately 39 years. Future trials enrolling young patients may not be able to use BCVA as a primary or sole endpoint, but rather, may need to employ additional disease biomarkers that change before age 39. BCVA may still have utility as a primary endpoint for patients older than 39 years who have measurable BCVA decline rates. PMID: 32471821 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - May 29, 2020 Category: Opthalmology Authors: Shen LL, Ahluwalia A, Sun M, Young BK, Grossetta Nardini HK, Del Priore LV Tags: Br J Ophthalmol Source Type: research

Two-year interim safety results of the 0.2 µg/day fluocinolone acetonide intravitreal implant for the treatment of diabetic macular oedema: the observational PALADIN study.
Two-year interim safety results of the 0.2 µg/day fluocinolone acetonide intravitreal implant for the treatment of diabetic macular oedema: the observational PALADIN study. Br J Ophthalmol. 2020 May 27;: Authors: Mansour SE, Kiernan DF, Roth DB, Eichenbaum D, Holekamp NM, Kaba S, Werts E Abstract BACKGROUND: The 0.2 µg/day fluocinolone acetonide (FAc) implant delivers continuous, low-dose, intravitreal corticosteroid for the treatment of diabetic macular oedema (DMO). This ongoing, 3-year, observational clinical trial provides long-term, 'real-world' safety results for the FAc implant in D...
Source: The British Journal of Ophthalmology - May 27, 2020 Category: Opthalmology Authors: Mansour SE, Kiernan DF, Roth DB, Eichenbaum D, Holekamp NM, Kaba S, Werts E Tags: Br J Ophthalmol Source Type: research

Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope.
Abstract BACKGROUND/IMS: To compare the retinal vessel diameter measurements obtained from the swept-source optical coherence tomography angiography (OCTA; Plex Elite 9000, Carl Zeiss Meditec, USA) and adaptive optics ophthalmoscope (AOO; RTX1, Imagine Eyes, France). METHODS: Fifteen healthy subjects, 67% women, mean age (SD) 30.87 (6.19) years, were imaged using OCTA and AOO by a single experienced operator on the same day. Each eye was scanned using two OCTA protocols (3×3 mm2 and 9×9 mm2) and two to five AOO scans (1.2×1.2 mm2). The OCTA and AOO scans were scaled to t...
Source: The British Journal of Ophthalmology - May 27, 2020 Category: Opthalmology Authors: Yao X, Ke M, Ho Y, Lin E, Wong DWK, Tan B, Schmetterer L, Chua J Tags: Br J Ophthalmol Source Type: research

Characteristics of myopic traction maculopathy in myopic Singaporean adults.
Abstract PURPOSE: To investigate the characteristics, risk factors and visual impact of myopic traction maculopathy (MTM) among adults with myopia in Singapore. METHODS: We analysed 3316 myopic eyes of adults aged over 40 years who participated in the Singapore Epidemiology of Eye Diseases-2 study. Detailed questionnaires and ophthalmic examinations were conducted. A total of 2913 myopic eyes of 1639 subjects were graded for MTM by spectral-domain optical coherence tomography. MTM is defined as the presence of retinoschisis, lamellar or full-thickness macula hole and foveal retinal detachment. Fundus photogra...
Source: The British Journal of Ophthalmology - May 23, 2020 Category: Opthalmology Authors: Matsumura S, Sabanayagam C, Wong CW, Tan CS, Kuo A, Wong YL, Ohno-Matsui K, Wong TY, Cheng CY, Hoang QV, Saw SM Tags: Br J Ophthalmol Source Type: research

Association of alcohol intake with incidence and progression of diabetic retinopathy.
CONCLUSIONS AND RELEVANCE: In our longitudinal population of Singapore Indians, baseline alcohol intake, particularly infrequent consumption, was associated with lower risk of developing DR, compared with non-drinkers, in line with previous cross-sectional findings. PMID: 32447326 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - May 23, 2020 Category: Opthalmology Authors: Gupta P, Fenwick EK, Sabanayagam C, Gan ATL, Tham YC, Thakur S, Man REK, Mitchell P, Wong TY, Cheng CY, Lamoureux EL Tags: Br J Ophthalmol Source Type: research