Corneal confocal microscopy identifies corneal nerve fibre loss and increased dendritic cells in patients with long COVID
CONCLUSION: Corneal confocal microscopy identifies corneal small nerve fibre loss and increased DCs in patients with long COVID, especially those with neurological symptoms. CCM could be used to objectively identify patients with long COVID.PMID:34312122 | DOI:10.1136/bjophthalmol-2021-319450 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 27, 2021 Category: Opthalmology Authors: Gulfidan Bitirgen Celalettin Korkmaz Adil Zamani Ahmet Ozkagnici Nazmi Zengin Georgios Ponirakis Rayaz A Malik Source Type: research

Wide-field optical coherence tomography deviation map for early glaucoma detection
This study aimed to establish a wide-field optical coherence tomography (OCT) deviation map obtained from swept-source OCT (SS-OCT) scans. Moreover, it also aimed to compare the diagnostic ability of this wide-field deviation map with that of the peripapillary and macular deviation maps currently being used for the detection of early glaucoma (EG).METHODS: Four hundred eyes, including 200 healthy eyes and 200 eyes with EG were enrolled in this retrospective observational study. Patients underwent a comprehensive ocular examination, including wide-field SS-OCT (DRI-OCT Triton; Topcon, Tokyo, Japan). The individual wide-fiel...
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Hyungjun Kim Hae Min Park Hyo Chan Jeong So Yeon Moon Hyunsoo Cho Han Woong Lim Mincheol Seong Junhong Park Won June Lee Source Type: research

Factors predictive of cystoid macular oedema following endothelial keratoplasty: a single-centre review of 2233 cases
Br J Ophthalmol. 2021 Jul 22:bjophthalmol-2020-318076. doi: 10.1136/bjophthalmol-2020-318076. Online ahead of print.ABSTRACTAIMS: To describe the incidence of postoperative cystoid macular oedema (CMO) after endothelial keratoplasty (EK) and to identify its contributory risk factors.METHODS: 2233 patients undergoing EK at Ospedali Privati Forlì 'Villa Igea', between January 2005 to October 2018 for Descemet stripping automated endothelial keratoplasty (DSAEK) and June 2014 to August 2018 for Descemet membrane endothelial keratoplasty (DMEK) with a minimum follow-up of 18 months were evaluated. Univariate and multiva...
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: James Myerscough Harry William Roberts Angeli Christy Yu Michael Mimouni Luca Furiosi Matteo Mandrioli Giuseppe Giannaccare Massimo Busin Source Type: research

Foveal structure and visual function in nanophthalmos and posterior microphthalmos
CONCLUSION: This study demonstrates that choroidal effusion, age, refractive error, axial length and retinal layer thickness are responsible for the majority of interindividual variability of BCVA as well as the morphological foveal heterogeneity in patients with nanophthalmos or posterior microphthalmos. This might give further insights into the physiology of foveal development and the process of emmetropisation, and support clinicians in the assessment of these disease entities.PMID:34301612 | DOI:10.1136/bjophthalmol-2020-318717 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Philipp L M üller Tim Treis Abdulrahman Alsaedi Andrew R Webster Peng Khaw Michel Michaelides Louisa Wickham Dilani Siriwardena Paul Foster Mariya Moosajee Carlos Pavesio Adnan Tufail Catherine Egan Source Type: research

Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK
CONCLUSION: In Japanese eyes with PCV, brolucizumab q12w/q8w monotherapy resulted in robust and consistent BCVA gains that were comparable to q8w aflibercept dosing. Anatomical outcomes favoured brolucizumab over aflibercept, with 76% of brolucizumab participants maintained on q12w dosing after loading to week 48.PMID:34301613 | DOI:10.1136/bjophthalmol-2021-319090 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Yuichiro Ogura Glenn J Jaffe Chui Ming Gemmy Cheung Gregg T Kokame Tomohiro Iida Kanji Takahashi Won Ki Lee Andrew A Chang Jordi Mon és Divya D'Souza Georges Weissgerber Kinfemichael Gedif Adrian Koh Source Type: research

Wide-field optical coherence tomography deviation map for early glaucoma detection
This study aimed to establish a wide-field optical coherence tomography (OCT) deviation map obtained from swept-source OCT (SS-OCT) scans. Moreover, it also aimed to compare the diagnostic ability of this wide-field deviation map with that of the peripapillary and macular deviation maps currently being used for the detection of early glaucoma (EG).METHODS: Four hundred eyes, including 200 healthy eyes and 200 eyes with EG were enrolled in this retrospective observational study. Patients underwent a comprehensive ocular examination, including wide-field SS-OCT (DRI-OCT Triton; Topcon, Tokyo, Japan). The individual wide-fiel...
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Hyungjun Kim Hae Min Park Hyo Chan Jeong So Yeon Moon Hyunsoo Cho Han Woong Lim Mincheol Seong Junhong Park Won June Lee Source Type: research

Factors predictive of cystoid macular oedema following endothelial keratoplasty: a single-centre review of 2233 cases
Br J Ophthalmol. 2021 Jul 22:bjophthalmol-2020-318076. doi: 10.1136/bjophthalmol-2020-318076. Online ahead of print.ABSTRACTAIMS: To describe the incidence of postoperative cystoid macular oedema (CMO) after endothelial keratoplasty (EK) and to identify its contributory risk factors.METHODS: 2233 patients undergoing EK at Ospedali Privati Forlì 'Villa Igea', between January 2005 to October 2018 for Descemet stripping automated endothelial keratoplasty (DSAEK) and June 2014 to August 2018 for Descemet membrane endothelial keratoplasty (DMEK) with a minimum follow-up of 18 months were evaluated. Univariate and multiva...
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: James Myerscough Harry William Roberts Angeli Christy Yu Michael Mimouni Luca Furiosi Matteo Mandrioli Giuseppe Giannaccare Massimo Busin Source Type: research

Foveal structure and visual function in nanophthalmos and posterior microphthalmos
CONCLUSION: This study demonstrates that choroidal effusion, age, refractive error, axial length and retinal layer thickness are responsible for the majority of interindividual variability of BCVA as well as the morphological foveal heterogeneity in patients with nanophthalmos or posterior microphthalmos. This might give further insights into the physiology of foveal development and the process of emmetropisation, and support clinicians in the assessment of these disease entities.PMID:34301612 | DOI:10.1136/bjophthalmol-2020-318717 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Philipp L M üller Tim Treis Abdulrahman Alsaedi Andrew R Webster Peng Khaw Michel Michaelides Louisa Wickham Dilani Siriwardena Paul Foster Mariya Moosajee Carlos Pavesio Adnan Tufail Catherine Egan Source Type: research

Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK
CONCLUSION: In Japanese eyes with PCV, brolucizumab q12w/q8w monotherapy resulted in robust and consistent BCVA gains that were comparable to q8w aflibercept dosing. Anatomical outcomes favoured brolucizumab over aflibercept, with 76% of brolucizumab participants maintained on q12w dosing after loading to week 48.PMID:34301613 | DOI:10.1136/bjophthalmol-2021-319090 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Yuichiro Ogura Glenn J Jaffe Chui Ming Gemmy Cheung Gregg T Kokame Tomohiro Iida Kanji Takahashi Won Ki Lee Andrew A Chang Jordi Mon és Divya D'Souza Georges Weissgerber Kinfemichael Gedif Adrian Koh Source Type: research

Wide-field optical coherence tomography deviation map for early glaucoma detection
This study aimed to establish a wide-field optical coherence tomography (OCT) deviation map obtained from swept-source OCT (SS-OCT) scans. Moreover, it also aimed to compare the diagnostic ability of this wide-field deviation map with that of the peripapillary and macular deviation maps currently being used for the detection of early glaucoma (EG).METHODS: Four hundred eyes, including 200 healthy eyes and 200 eyes with EG were enrolled in this retrospective observational study. Patients underwent a comprehensive ocular examination, including wide-field SS-OCT (DRI-OCT Triton; Topcon, Tokyo, Japan). The individual wide-fiel...
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Hyungjun Kim Hae Min Park Hyo Chan Jeong So Yeon Moon Hyunsoo Cho Han Woong Lim Mincheol Seong Junhong Park Won June Lee Source Type: research

Factors predictive of cystoid macular oedema following endothelial keratoplasty: a single-centre review of 2233 cases
Br J Ophthalmol. 2021 Jul 22:bjophthalmol-2020-318076. doi: 10.1136/bjophthalmol-2020-318076. Online ahead of print.ABSTRACTAIMS: To describe the incidence of postoperative cystoid macular oedema (CMO) after endothelial keratoplasty (EK) and to identify its contributory risk factors.METHODS: 2233 patients undergoing EK at Ospedali Privati Forlì 'Villa Igea', between January 2005 to October 2018 for Descemet stripping automated endothelial keratoplasty (DSAEK) and June 2014 to August 2018 for Descemet membrane endothelial keratoplasty (DMEK) with a minimum follow-up of 18 months were evaluated. Univariate and multiva...
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: James Myerscough Harry William Roberts Angeli Christy Yu Michael Mimouni Luca Furiosi Matteo Mandrioli Giuseppe Giannaccare Massimo Busin Source Type: research

Foveal structure and visual function in nanophthalmos and posterior microphthalmos
CONCLUSION: This study demonstrates that choroidal effusion, age, refractive error, axial length and retinal layer thickness are responsible for the majority of interindividual variability of BCVA as well as the morphological foveal heterogeneity in patients with nanophthalmos or posterior microphthalmos. This might give further insights into the physiology of foveal development and the process of emmetropisation, and support clinicians in the assessment of these disease entities.PMID:34301612 | DOI:10.1136/bjophthalmol-2020-318717 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Philipp L M üller Tim Treis Abdulrahman Alsaedi Andrew R Webster Peng Khaw Michel Michaelides Louisa Wickham Dilani Siriwardena Paul Foster Mariya Moosajee Carlos Pavesio Adnan Tufail Catherine Egan Source Type: research

Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK
CONCLUSION: In Japanese eyes with PCV, brolucizumab q12w/q8w monotherapy resulted in robust and consistent BCVA gains that were comparable to q8w aflibercept dosing. Anatomical outcomes favoured brolucizumab over aflibercept, with 76% of brolucizumab participants maintained on q12w dosing after loading to week 48.PMID:34301613 | DOI:10.1136/bjophthalmol-2021-319090 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 24, 2021 Category: Opthalmology Authors: Yuichiro Ogura Glenn J Jaffe Chui Ming Gemmy Cheung Gregg T Kokame Tomohiro Iida Kanji Takahashi Won Ki Lee Andrew A Chang Jordi Mon és Divya D'Souza Georges Weissgerber Kinfemichael Gedif Adrian Koh Source Type: research

Laser goniopuncture after deep sclerectomy: incidence, long-term outcomes and risk factors for failure
Br J Ophthalmol. 2021 Jul 20:bjophthalmol-2021-319314. doi: 10.1136/bjophthalmol-2021-319314. Online ahead of print.ABSTRACTAIMS: To report the incidence, risk factors and long-term outcomes of laser goniopuncture (LGP) in patients with previous deep sclerectomy (DS).METHODS: Retrospective cohort study of 1765 eyes (1385 patients) undergoing DS with or without cataract surgery between 2001 and 2020 in two UK institutions. Kaplan-Meier was used to estimate LGP incidence. DS success after LGP was calculated for criteria A, B, and C defined as intraocular pressure (IOP) of ≤18, ≤15 and ≤12 mm Hg with 20%, 25% and 30%...
Source: The British Journal of Ophthalmology - July 21, 2021 Category: Opthalmology Authors: Alessandro Rabiolo Duncan Leadbetter Jonathan Kirk Nitin Anand Source Type: research

Laser goniopuncture after deep sclerectomy: incidence, long-term outcomes and risk factors for failure
Br J Ophthalmol. 2021 Jul 20:bjophthalmol-2021-319314. doi: 10.1136/bjophthalmol-2021-319314. Online ahead of print.ABSTRACTAIMS: To report the incidence, risk factors and long-term outcomes of laser goniopuncture (LGP) in patients with previous deep sclerectomy (DS).METHODS: Retrospective cohort study of 1765 eyes (1385 patients) undergoing DS with or without cataract surgery between 2001 and 2020 in two UK institutions. Kaplan-Meier was used to estimate LGP incidence. DS success after LGP was calculated for criteria A, B, and C defined as intraocular pressure (IOP) of ≤18, ≤15 and ≤12 mm Hg with 20%, 25% and 30%...
Source: The British Journal of Ophthalmology - July 21, 2021 Category: Opthalmology Authors: Alessandro Rabiolo Duncan Leadbetter Jonathan Kirk Nitin Anand Source Type: research

Laser goniopuncture after deep sclerectomy: incidence, long-term outcomes and risk factors for failure
Br J Ophthalmol. 2021 Jul 20:bjophthalmol-2021-319314. doi: 10.1136/bjophthalmol-2021-319314. Online ahead of print.ABSTRACTAIMS: To report the incidence, risk factors and long-term outcomes of laser goniopuncture (LGP) in patients with previous deep sclerectomy (DS).METHODS: Retrospective cohort study of 1765 eyes (1385 patients) undergoing DS with or without cataract surgery between 2001 and 2020 in two UK institutions. Kaplan-Meier was used to estimate LGP incidence. DS success after LGP was calculated for criteria A, B, and C defined as intraocular pressure (IOP) of ≤18, ≤15 and ≤12 mm Hg with 20%, 25% and 30%...
Source: The British Journal of Ophthalmology - July 21, 2021 Category: Opthalmology Authors: Alessandro Rabiolo Duncan Leadbetter Jonathan Kirk Nitin Anand Source Type: research

Psychosocial and mental health disorders among a population-based, case-control cohort of patients with congenital upper eyelid ptosis
Br J Ophthalmol. 2021 Jul 19:bjophthalmol-2021-319276. doi: 10.1136/bjophthalmol-2021-319276. Online ahead of print.ABSTRACTBACKGROUND/AIM: Recent studies have demonstrated adverse psychosocial and mental health disorders among children with ocular disorders. The mental health burden of children with simple congenital ptosis, however, is unknown. The purpose of this study was to compare the psychosocial and mental health findings of children with simple congenital ptosis with controls.METHODS: The medical records of all children (
Source: The British Journal of Ophthalmology - July 20, 2021 Category: Opthalmology Authors: Tina M Hendricks Gregory J Griepentrog David O Hodge Brian G Mohney Source Type: research

< em > Fibrillin-1 < /em > gene mutations in a Chinese cohort with congenital ectopia lentis: spectrum and genotype-phenotype analysis
CONCLUSIONS: This study extended the knowledge of the FBN1 mutation spectrum and provided novel insights into its clinical correlation regarding EL and MSP in the Chinese population.PMID:34281902 | DOI:10.1136/bjophthalmol-2021-319084 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 20, 2021 Category: Opthalmology Authors: Zexu Chen Tianhui Chen Min Zhang Jiahui Chen Michael Deng Jialei Zheng Li-Na Lan Yongxiang Jiang Source Type: research

MRI signs helpful in the differentiation of patients with anterior ischaemic optic neuropathy and optic neuritis
CONCLUSION: In patients with an inconclusive clinical diagnosis, optic nerve enhancement pattern and distribution of white matter lesions can aid in the diagnosis and differentiation between AION and ON. Diffusion-weighted imaging did not add significant information to the diagnosis or help to differentiate between the two conditions.PMID:34281903 | DOI:10.1136/bjophthalmol-2021-319537 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 20, 2021 Category: Opthalmology Authors: Valentina Daphne Petroulia Dominik Br ügger Robert Hoepner Rino Vicini Anna Winklehner Mathias Abegg Franca Wagner Source Type: research

Psychosocial and mental health disorders among a population-based, case-control cohort of patients with congenital upper eyelid ptosis
Br J Ophthalmol. 2021 Jul 19:bjophthalmol-2021-319276. doi: 10.1136/bjophthalmol-2021-319276. Online ahead of print.ABSTRACTBACKGROUND/AIM: Recent studies have demonstrated adverse psychosocial and mental health disorders among children with ocular disorders. The mental health burden of children with simple congenital ptosis, however, is unknown. The purpose of this study was to compare the psychosocial and mental health findings of children with simple congenital ptosis with controls.METHODS: The medical records of all children (
Source: The British Journal of Ophthalmology - July 20, 2021 Category: Opthalmology Authors: Tina M Hendricks Gregory J Griepentrog David O Hodge Brian G Mohney Source Type: research

< em > Fibrillin-1 < /em > gene mutations in a Chinese cohort with congenital ectopia lentis: spectrum and genotype-phenotype analysis
CONCLUSIONS: This study extended the knowledge of the FBN1 mutation spectrum and provided novel insights into its clinical correlation regarding EL and MSP in the Chinese population.PMID:34281902 | DOI:10.1136/bjophthalmol-2021-319084 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 20, 2021 Category: Opthalmology Authors: Zexu Chen Tianhui Chen Min Zhang Jiahui Chen Michael Deng Jialei Zheng Li-Na Lan Yongxiang Jiang Source Type: research

MRI signs helpful in the differentiation of patients with anterior ischaemic optic neuropathy and optic neuritis
CONCLUSION: In patients with an inconclusive clinical diagnosis, optic nerve enhancement pattern and distribution of white matter lesions can aid in the diagnosis and differentiation between AION and ON. Diffusion-weighted imaging did not add significant information to the diagnosis or help to differentiate between the two conditions.PMID:34281903 | DOI:10.1136/bjophthalmol-2021-319537 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 20, 2021 Category: Opthalmology Authors: Valentina Daphne Petroulia Dominik Br ügger Robert Hoepner Rino Vicini Anna Winklehner Mathias Abegg Franca Wagner Source Type: research

Effect of valproic acid on functional bleb morphology in a rabbit model of minimally invasive surgery
CONCLUSIONS: The results support the application of VPA to enhance bleb morphology associated with good bleb function in MIGS with no apparent cytotoxicity.PMID:34266858 | DOI:10.1136/bjophthalmol-2020-318691 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 16, 2021 Category: Opthalmology Authors: Zhu Li Yap Li-Fong Seet Stephanie Wl Chu Li Zhen Toh Farah Ilyana Ibrahim Tina T Wong Source Type: research

Effect of valproic acid on functional bleb morphology in a rabbit model of minimally invasive surgery
CONCLUSIONS: The results support the application of VPA to enhance bleb morphology associated with good bleb function in MIGS with no apparent cytotoxicity.PMID:34266858 | DOI:10.1136/bjophthalmol-2020-318691 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 16, 2021 Category: Opthalmology Authors: Zhu Li Yap Li-Fong Seet Stephanie Wl Chu Li Zhen Toh Farah Ilyana Ibrahim Tina T Wong Source Type: research

Effect of valproic acid on functional bleb morphology in a rabbit model of minimally invasive surgery
CONCLUSIONS: The results support the application of VPA to enhance bleb morphology associated with good bleb function in MIGS with no apparent cytotoxicity.PMID:34266858 | DOI:10.1136/bjophthalmol-2020-318691 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 16, 2021 Category: Opthalmology Authors: Zhu Li Yap Li-Fong Seet Stephanie Wl Chu Li Zhen Toh Farah Ilyana Ibrahim Tina T Wong Source Type: research

Effect of valproic acid on functional bleb morphology in a rabbit model of minimally invasive surgery
CONCLUSIONS: The results support the application of VPA to enhance bleb morphology associated with good bleb function in MIGS with no apparent cytotoxicity.PMID:34266858 | DOI:10.1136/bjophthalmol-2020-318691 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 16, 2021 Category: Opthalmology Authors: Zhu Li Yap Li-Fong Seet Stephanie Wl Chu Li Zhen Toh Farah Ilyana Ibrahim Tina T Wong Source Type: research

Metagenomics of the lacrimal sac in primary acquired nasolacrimal duct obstruction: the Lacriome paper 1
CONCLUSION: This is the first whole metagenome sequencing of the lacrimal sac contents from PANDO patients. Lacrimal sacs harbour diverse microbial communities, including bacteria, viruses, and archaea. Further Lacriome studies may provide clues for a better understanding of the disease aetiopathogenesis.PMID:34261660 | DOI:10.1136/bjophthalmol-2021-319677 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 15, 2021 Category: Opthalmology Authors: Mohammad Javed Ali Source Type: research

Intravitreal application of epidermal growth factor in non-exudative age-related macular degeneration
CONCLUSIONS: Except for one eye with temporary, self-resolving cystoid macular oedema, single and repeated intravitreal applications of EGF (0.75 µg) in patients with GA did not lead to intraocular inflammations or any observed intraocular side effect.TRIAL REGISTRATION NUMBER: ISRCTN12733334.PMID:34261661 | DOI:10.1136/bjophthalmol-2021-319582 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 15, 2021 Category: Opthalmology Authors: Mukharram M Bikbov Timur A Khalimov Songhomitra Panda-Jonas Jost B Jonas Source Type: research

Incidence of central serous chorioretinopathy (2011-2018): a nationwide population-based cohort study of Japan
CONCLUSIONS: The current study provides the nationwide population-based evidence to clarify the detailed epidemiology of CSC. These results could help to understand the pathogenesis and mechanisms of CSC in the future.PMID:34261662 | DOI:10.1136/bjophthalmol-2021-319403 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 15, 2021 Category: Opthalmology Authors: Ai Kido Masahiro Miyake Hiroshi Tamura Shusuke Hiragi Takeshi Kimura Shosuke Ohtera Ayako Takahashi Sotaro Ooto Koji Kawakami Tomohiro Kuroda Akitaka Tsujikawa Source Type: research

Deep learning-assisted (automatic) diagnosis of glaucoma using a smartphone
Br J Ophthalmol. 2021 Jul 14:bjophthalmol-2020-318107. doi: 10.1136/bjophthalmol-2020-318107. Online ahead of print.ABSTRACTBACKGROUND/AIMS: To validate a deep learning algorithm to diagnose glaucoma from fundus photography obtained with a smartphone.METHODS: A training dataset consisting of 1364 colour fundus photographs with glaucomatous indications and 1768 colour fundus photographs without glaucomatous features was obtained using an ordinary fundus camera. The testing dataset consisted of 73 eyes of 73 patients with glaucoma and 89 eyes of 89 normative subjects. In the testing dataset, fundus photographs were acquired ...
Source: The British Journal of Ophthalmology - July 15, 2021 Category: Opthalmology Authors: Kenichi Nakahara Ryo Asaoka Masaki Tanito Naoto Shibata Keita Mitsuhashi Yuri Fujino Masato Matsuura Tatsuya Inoue Keiko Azuma Ryo Obata Hiroshi Murata Source Type: research

Metagenomics of the lacrimal sac in primary acquired nasolacrimal duct obstruction: the Lacriome paper 1
CONCLUSION: This is the first whole metagenome sequencing of the lacrimal sac contents from PANDO patients. Lacrimal sacs harbour diverse microbial communities, including bacteria, viruses, and archaea. Further Lacriome studies may provide clues for a better understanding of the disease aetiopathogenesis.PMID:34261660 | DOI:10.1136/bjophthalmol-2021-319677 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 15, 2021 Category: Opthalmology Authors: Mohammad Javed Ali Source Type: research

Intravitreal application of epidermal growth factor in non-exudative age-related macular degeneration
CONCLUSIONS: Except for one eye with temporary, self-resolving cystoid macular oedema, single and repeated intravitreal applications of EGF (0.75 µg) in patients with GA did not lead to intraocular inflammations or any observed intraocular side effect.TRIAL REGISTRATION NUMBER: ISRCTN12733334.PMID:34261661 | DOI:10.1136/bjophthalmol-2021-319582 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 15, 2021 Category: Opthalmology Authors: Mukharram M Bikbov Timur A Khalimov Songhomitra Panda-Jonas Jost B Jonas Source Type: research

Incidence of central serous chorioretinopathy (2011-2018): a nationwide population-based cohort study of Japan
CONCLUSIONS: The current study provides the nationwide population-based evidence to clarify the detailed epidemiology of CSC. These results could help to understand the pathogenesis and mechanisms of CSC in the future.PMID:34261662 | DOI:10.1136/bjophthalmol-2021-319403 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 15, 2021 Category: Opthalmology Authors: Ai Kido Masahiro Miyake Hiroshi Tamura Shusuke Hiragi Takeshi Kimura Shosuke Ohtera Ayako Takahashi Sotaro Ooto Koji Kawakami Tomohiro Kuroda Akitaka Tsujikawa Source Type: research

Deep learning-assisted (automatic) diagnosis of glaucoma using a smartphone
Br J Ophthalmol. 2021 Jul 14:bjophthalmol-2020-318107. doi: 10.1136/bjophthalmol-2020-318107. Online ahead of print.ABSTRACTBACKGROUND/AIMS: To validate a deep learning algorithm to diagnose glaucoma from fundus photography obtained with a smartphone.METHODS: A training dataset consisting of 1364 colour fundus photographs with glaucomatous indications and 1768 colour fundus photographs without glaucomatous features was obtained using an ordinary fundus camera. The testing dataset consisted of 73 eyes of 73 patients with glaucoma and 89 eyes of 89 normative subjects. In the testing dataset, fundus photographs were acquired ...
Source: The British Journal of Ophthalmology - July 15, 2021 Category: Opthalmology Authors: Kenichi Nakahara Ryo Asaoka Masaki Tanito Naoto Shibata Keita Mitsuhashi Yuri Fujino Masato Matsuura Tatsuya Inoue Keiko Azuma Ryo Obata Hiroshi Murata Source Type: research

Deep learning algorithms for automatic detection of pterygium using anterior segment photographs from slit-lamp and hand-held cameras
CONCLUSION: DL algorithms based on ASPs can detect presence of and referable-level pterygium with optimal sensitivity and specificity. These algorithms, particularly if used with a handheld camera, may potentially be used as a simple screening tool for detection of referable pterygium. Further validation in community setting is warranted.SYNOPSIS/PRECIS: DL algorithms based on ASPs can detect presence of and referable-level pterygium optimally, and may be used as a simple screening tool for the detection of referable pterygium in community screenings.PMID:34244208 | DOI:10.1136/bjophthalmol-2021-318866 (Source: The British...
Source: The British Journal of Ophthalmology - July 10, 2021 Category: Opthalmology Authors: Xiaoling Fang Mihir Deshmukh Miao Li Chee Zhi-Da Soh Zhen Ling Teo Sahil Thakur Jocelyn Hui Lin Goh Yu-Chi Liu Rahat Husain Jodhbir Mehta Tien Yin Wong Ching-Yu Cheng Tyler Hyungtaek Rim Yih-Chung Tham Source Type: research

Correction: Thirty-five-year trend in the prevalence of refractive error in Austrian conscripts based on 1.5 million participants
Br J Ophthalmol. 2021 Jul 8:bjophthalmol-2019-315024corr1. doi: 10.1136/bjophthalmol-2019-315024corr1. Online ahead of print.NO ABSTRACTPMID:34244209 | DOI:10.1136/bjophthalmol-2019-315024corr1 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 10, 2021 Category: Opthalmology Source Type: research

Deep learning algorithms for automatic detection of pterygium using anterior segment photographs from slit-lamp and hand-held cameras
CONCLUSION: DL algorithms based on ASPs can detect presence of and referable-level pterygium with optimal sensitivity and specificity. These algorithms, particularly if used with a handheld camera, may potentially be used as a simple screening tool for detection of referable pterygium. Further validation in community setting is warranted.SYNOPSIS/PRECIS: DL algorithms based on ASPs can detect presence of and referable-level pterygium optimally, and may be used as a simple screening tool for the detection of referable pterygium in community screenings.PMID:34244208 | DOI:10.1136/bjophthalmol-2021-318866 (Source: The British...
Source: The British Journal of Ophthalmology - July 10, 2021 Category: Opthalmology Authors: Xiaoling Fang Mihir Deshmukh Miao Li Chee Zhi-Da Soh Zhen Ling Teo Sahil Thakur Jocelyn Hui Lin Goh Yu-Chi Liu Rahat Husain Jodhbir Mehta Tien Yin Wong Ching-Yu Cheng Tyler Hyungtaek Rim Yih-Chung Tham Source Type: research

Correction: Thirty-five-year trend in the prevalence of refractive error in Austrian conscripts based on 1.5 million participants
Br J Ophthalmol. 2021 Jul 8:bjophthalmol-2019-315024corr1. doi: 10.1136/bjophthalmol-2019-315024corr1. Online ahead of print.NO ABSTRACTPMID:34244209 | DOI:10.1136/bjophthalmol-2019-315024corr1 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 10, 2021 Category: Opthalmology Source Type: research

Deep learning algorithms for automatic detection of pterygium using anterior segment photographs from slit-lamp and hand-held cameras
CONCLUSION: DL algorithms based on ASPs can detect presence of and referable-level pterygium with optimal sensitivity and specificity. These algorithms, particularly if used with a handheld camera, may potentially be used as a simple screening tool for detection of referable pterygium. Further validation in community setting is warranted.SYNOPSIS/PRECIS: DL algorithms based on ASPs can detect presence of and referable-level pterygium optimally, and may be used as a simple screening tool for the detection of referable pterygium in community screenings.PMID:34244208 | DOI:10.1136/bjophthalmol-2021-318866 (Source: The British...
Source: The British Journal of Ophthalmology - July 10, 2021 Category: Opthalmology Authors: Xiaoling Fang Mihir Deshmukh Miao Li Chee Zhi-Da Soh Zhen Ling Teo Sahil Thakur Jocelyn Hui Lin Goh Yu-Chi Liu Rahat Husain Jodhbir Mehta Tien Yin Wong Ching-Yu Cheng Tyler Hyungtaek Rim Yih-Chung Tham Source Type: research

Correction: Thirty-five-year trend in the prevalence of refractive error in Austrian conscripts based on 1.5 million participants
Br J Ophthalmol. 2021 Jul 8:bjophthalmol-2019-315024corr1. doi: 10.1136/bjophthalmol-2019-315024corr1. Online ahead of print.NO ABSTRACTPMID:34244209 | DOI:10.1136/bjophthalmol-2019-315024corr1 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 10, 2021 Category: Opthalmology Source Type: research

Deep learning algorithms for automatic detection of pterygium using anterior segment photographs from slit-lamp and hand-held cameras
CONCLUSION: DL algorithms based on ASPs can detect presence of and referable-level pterygium with optimal sensitivity and specificity. These algorithms, particularly if used with a handheld camera, may potentially be used as a simple screening tool for detection of referable pterygium. Further validation in community setting is warranted.SYNOPSIS/PRECIS: DL algorithms based on ASPs can detect presence of and referable-level pterygium optimally, and may be used as a simple screening tool for the detection of referable pterygium in community screenings.PMID:34244208 | DOI:10.1136/bjophthalmol-2021-318866 (Source: The British...
Source: The British Journal of Ophthalmology - July 10, 2021 Category: Opthalmology Authors: Xiaoling Fang Mihir Deshmukh Miao Li Chee Zhi-Da Soh Zhen Ling Teo Sahil Thakur Jocelyn Hui Lin Goh Yu-Chi Liu Rahat Husain Jodhbir Mehta Tien Yin Wong Ching-Yu Cheng Tyler Hyungtaek Rim Yih-Chung Tham Source Type: research

Correction: Thirty-five-year trend in the prevalence of refractive error in Austrian conscripts based on 1.5 million participants
Br J Ophthalmol. 2021 Jul 8:bjophthalmol-2019-315024corr1. doi: 10.1136/bjophthalmol-2019-315024corr1. Online ahead of print.NO ABSTRACTPMID:34244209 | DOI:10.1136/bjophthalmol-2019-315024corr1 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 10, 2021 Category: Opthalmology Source Type: research

Combined structure-function analysis in glaucoma screening
CONCLUSION: SAP performs slightly better than OCT in glaucoma screening of middle-aged population. However, the diagnostic capability can be improved by S-F analysis.PMID:34230023 | DOI:10.1136/bjophthalmol-2021-319178 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 7, 2021 Category: Opthalmology Authors: Elina Karvonen Katri Stoor Marja Luodonp ää Pasi H ägg Ilmari Leivisk ä Johanna Liinamaa Anja Tuulonen Ville Saarela Source Type: research

Combined structure-function analysis in glaucoma screening
CONCLUSION: SAP performs slightly better than OCT in glaucoma screening of middle-aged population. However, the diagnostic capability can be improved by S-F analysis.PMID:34230023 | DOI:10.1136/bjophthalmol-2021-319178 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 7, 2021 Category: Opthalmology Authors: Elina Karvonen Katri Stoor Marja Luodonp ää Pasi H ägg Ilmari Leivisk ä Johanna Liinamaa Anja Tuulonen Ville Saarela Source Type: research

Combined structure-function analysis in glaucoma screening
CONCLUSION: SAP performs slightly better than OCT in glaucoma screening of middle-aged population. However, the diagnostic capability can be improved by S-F analysis.PMID:34230023 | DOI:10.1136/bjophthalmol-2021-319178 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 7, 2021 Category: Opthalmology Authors: Elina Karvonen Katri Stoor Marja Luodonp ää Pasi H ägg Ilmari Leivisk ä Johanna Liinamaa Anja Tuulonen Ville Saarela Source Type: research

Factors affecting the resolution of acute non-infectious anterior scleritis
CONCLUSION: Patient characteristics including a lupus diagnosis and Hispanic race were associated with faster times to symptom resolution and steroid sparing resolution, as were treatments including systemic NSAIDs and TNF-⍺ inhibitors. Due to limitations in the available data, this analysis did not account for disease severity. Future prospective studies will further elucidate the relationship between these factors and patient outcomes.PMID:34210671 | DOI:10.1136/bjophthalmol-2021-318808 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 2, 2021 Category: Opthalmology Authors: Ahmad Abdel-Aty Ninani Kombo Source Type: research

Factors affecting the resolution of acute non-infectious anterior scleritis
CONCLUSION: Patient characteristics including a lupus diagnosis and Hispanic race were associated with faster times to symptom resolution and steroid sparing resolution, as were treatments including systemic NSAIDs and TNF-⍺ inhibitors. Due to limitations in the available data, this analysis did not account for disease severity. Future prospective studies will further elucidate the relationship between these factors and patient outcomes.PMID:34210671 | DOI:10.1136/bjophthalmol-2021-318808 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 2, 2021 Category: Opthalmology Authors: Ahmad Abdel-Aty Ninani Kombo Source Type: research

Factors affecting the resolution of acute non-infectious anterior scleritis
CONCLUSION: Patient characteristics including a lupus diagnosis and Hispanic race were associated with faster times to symptom resolution and steroid sparing resolution, as were treatments including systemic NSAIDs and TNF-⍺ inhibitors. Due to limitations in the available data, this analysis did not account for disease severity. Future prospective studies will further elucidate the relationship between these factors and patient outcomes.PMID:34210671 | DOI:10.1136/bjophthalmol-2021-318808 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 2, 2021 Category: Opthalmology Authors: Ahmad Abdel-Aty Ninani Kombo Source Type: research

Factors affecting the resolution of acute non-infectious anterior scleritis
CONCLUSION: Patient characteristics including a lupus diagnosis and Hispanic race were associated with faster times to symptom resolution and steroid sparing resolution, as were treatments including systemic NSAIDs and TNF-⍺ inhibitors. Due to limitations in the available data, this analysis did not account for disease severity. Future prospective studies will further elucidate the relationship between these factors and patient outcomes.PMID:34210671 | DOI:10.1136/bjophthalmol-2021-318808 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 2, 2021 Category: Opthalmology Authors: Ahmad Abdel-Aty Ninani Kombo Source Type: research

Factors affecting the resolution of acute non-infectious anterior scleritis
CONCLUSION: Patient characteristics including a lupus diagnosis and Hispanic race were associated with faster times to symptom resolution and steroid sparing resolution, as were treatments including systemic NSAIDs and TNF-⍺ inhibitors. Due to limitations in the available data, this analysis did not account for disease severity. Future prospective studies will further elucidate the relationship between these factors and patient outcomes.PMID:34210671 | DOI:10.1136/bjophthalmol-2021-318808 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 2, 2021 Category: Opthalmology Authors: Ahmad Abdel-Aty Ninani Kombo Source Type: research