OCT-angiography detects longitudinal microvascular changes in glaucoma: a systematic review.
CONCLUSION: OCTA is a non-invasive technology, which shows promise in glaucoma. Measures should be taken to increase the quality and standardise the methodology of VD measures in OCTA longitudinal studies, for future meta-analyses. PMID: 33452184 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 15, 2021 Category: Opthalmology Authors: Miguel A, Silva A, Barbosa-Breda J, Azevedo L, Abdulrahman A, Hereth E, Abegão Pinto L, Lachkar Y, Stalmans I Tags: Br J Ophthalmol Source Type: research

Patients presenting with metastases: stage IV uveal melanoma, an international study.
CONCLUSIONS: Though higher AJCC T-stage was associated with risk for metastases at diagnosis, even small T1 tumours were stage IV at initial presentation. The liver was the most common site of metastases; however, frequent multiorgan involvement supports initial whole-body staging. PMID: 33452185 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 15, 2021 Category: Opthalmology Authors: Garg G, Finger PT, Kivelä TT, Simpson ER, Gallie BL, Saakyan S, Amiryan AG, Valskiy V, Chin KJ, Semenova E, Seregard S, Filì M, Wilson M, Haik B, Caminal JM, Catala-Mora J, Gutiérrez C, Pelayes DE, Folgar AM, Jager MJ, Doğrusöz M, Luyten GPM, Singh A Tags: Br J Ophthalmol Source Type: research

Refractive change and incidence of myopia among rural Chinese children: the Handan Offspring Myopia Study.
Abstract PURPOSE: To assess the refractive change and incidence of myopia, as well as their risk factors, among Chinese rural children aged 6-17 years. METHODS: Children who completed the baseline vision examination of the Handan Offspring Myopia Study were re-examined, including both cycloplegic and non-cyloplegic autorefraction, with a mean follow-up time of 42.4±1.47 months. RESULTS: A total of 601 children (68.5%) who completed both baseline and the follow-up examinations were enrolled. The cumulative refractive change and axial length change were -0.53±1.03 diopter and 0.39±0.46...
Source: The British Journal of Ophthalmology - January 13, 2021 Category: Opthalmology Authors: Lin Z, Vasudevan B, Gao T, Zhou H, Ciuffreda KJ, Liang Y Tags: Br J Ophthalmol Source Type: research

Human leucocyte antigen association of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications in Han Chinese.
CONCLUSIONS: The HLA-A*02:07 and HLA-B*46:01 alleles were significantly associated with SOCs among Han Chinese patients with CM-SJS/TEN. These findings demonstrate the genetic diversity in SJS pathogenesis among different ethnic groups. PMID: 33441319 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 13, 2021 Category: Opthalmology Authors: Ma KS, Chung WH, Hsueh YJ, Chen SY, Tokunaga K, Kinoshita S, Ma DHK, Ueta M Tags: Br J Ophthalmol Source Type: research

Validating the usefulness of sectorwise regression of visual field in the central 10 °.
CONCLUSION: Accurate prediction was achieved using the sectorwise regression, in particular when a small number of VFs were used in the prediction. The accuracy of the sectorwise regression was not hampered in longer follow-up compared with PLR. PMID: 33441320 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 13, 2021 Category: Opthalmology Authors: Omoto T, Murata H, Fujino Y, Matsuura M, Yamashita T, Miki A, Ikeda Y, Mori K, Tanito M, Asaoka R Tags: Br J Ophthalmol Source Type: research

Comparing the usefulness of a new algorithm to measure visual field using the variational Bayes linear regression in glaucoma patients, in comparison to the Swedish interactive thresholding algorithm.
CONCLUSION: VBLR-VF reduced test duration while maintaining the same accuracy as the SITA-standard. PMID: 33441321 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 13, 2021 Category: Opthalmology Authors: Murata H, Asaoka R, Fujino Y, Matsuura M, Hirasawa K, Shimada S, Shoji N Tags: Br J Ophthalmol Source Type: research

Objective quantification of lens nuclear opacities using swept-source anterior segment optical coherence tomography.
Abstract BACKGROUND/AIMS: The primary objective is to quantify the lens nuclear opacity using swept-source anterior segment optical coherence tomography (SS-ASOCT) and to evaluate its correlations with Lens Opacities Classification System III (LOCS-III) system and surgical parameters. The secondary objective is to assess the diagnostic performance for hard nuclear cataract. METHODS: This cross-sectional study included 1222 patients eligible for cataract surgery (1222 eyes). The latest SS-ASOCT (CASIA-2) was used to obtain high-resolution lens images, and the average nuclear density (AND) and maximum nuclear d...
Source: The British Journal of Ophthalmology - January 13, 2021 Category: Opthalmology Authors: Wang W, Zhang J, Gu X, Ruan X, Chen X, Tan X, Jin G, Wang L, He M, Congdon N, Liu Z, Luo L, Liu Y Tags: Br J Ophthalmol Source Type: research

Screening first-degree relatives of glaucoma patients reveals barriers to participation.
CONCLUSION: Participation in this glaucoma screening campaign was poor. The major barrier to participation was distance from the screening site and associated indirect costs. Better strategies for bringing first-degree relatives in for examinations are needed. PMID: 33419787 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 8, 2021 Category: Opthalmology Authors: Shroff S, Gu SZ, Vardhan S A, Mani I, Aziz K, P N, Datta D, Friedman DS Tags: Br J Ophthalmol Source Type: research

Randomised assessor-masked trial evaluating topical manuka honey (Optimel) in treatment of meibomian gland dysfunction.
Abstract PURPOSE: To evaluate the effects of manuka honey eye-drops in the treatment of meibomian gland dysfunction. METHODS: This is an assessor-masked (single-blind), randomised controlled trial comparing conventional treatment group with interventional group using Optimel 16% manuka honey topical eye-drops. 59 patients were recruited to the study and randomised into two groups: one given regular lubricants and the other given Optimel 16% manuka honey eye-drops. The Standard Patient Evaluation of Eye Dryness (SPEED) score was measured at baseline and on follow-up. 4 patients were lost to follow-up. Multiple...
Source: The British Journal of Ophthalmology - January 8, 2021 Category: Opthalmology Authors: Li AL, Li SL, Kam KW, Young AL Tags: Br J Ophthalmol Source Type: research

Incidence and phenotypical variation of outer retina-associated hyperreflectivity in macular telangiectasia type 2.
CONCLUSIONS: The presence of ORaH is associated with increasing photoreceptor loss and disease severity. In these more advanced cases of the present study, a variable presentation of ORaH in respect to size and form was seen, but in most cases, ORaH was in contact to the RPE. Additionally, ORaH was associated with hyperpigmentation and OR NV on OCTA. These results are consistent with the concept of ORaH representing fibrovascular OR-NV with RPE proliferation after contact with the RPE. PMID: 33414243 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 7, 2021 Category: Opthalmology Authors: Mueller S, Gunnemann F, Rothaus K, Book M, Faatz H, Bird A, Pauleikhoff D Tags: Br J Ophthalmol Source Type: research

Refractive accuracy in eyes undergoing combined cataract extraction and Descemet membrane endothelial keratoplasty.
Abstract PURPOSE: To evaluate the refractive accuracy of current intraocular lens (IOL) formulas and propose a modification in calculation of corneal power in eyes undergoing combined cataract extraction and Descemet membrane endothelial keratoplasty (DMEK). DESIGN: Retrospective cohort study. METHODS: Patients with Fuchs endothelial corneal dystrophy undergoing uncomplicated combined cataract surgery and DMEK at a single institution were included. The Hoffer Q, SRK/T, Holladay I, Barrett Universal II and Haigis formulas were compared. A modified corneal power was calculated using a thick lens equation b...
Source: The British Journal of Ophthalmology - January 7, 2021 Category: Opthalmology Authors: Campbell JA, Ladas JG, Wang K, Woreta F, Srikumaran D Tags: Br J Ophthalmol Source Type: research

Choroidal macrovessels: multimodal imaging findings and review of the literature.
CONCLUSIONS: Choroidal macrovessels can mimic other entities, leading to underdiagnosis. Appreciating relevant features on different imaging modalities will aid a correct diagnosis. PMID: 33397653 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 4, 2021 Category: Opthalmology Authors: Gallo B, de Silva SR, Mahroo OA, Saihan Z, Patel PJ, Dowler JG, Pavesio C, Keane PA, Tufail A, Sagoo MS Tags: Br J Ophthalmol Source Type: research

Macular buckling versus vitrectomy on macular hole associated macular detachment in eyes with high myopia: a randomised trial.
Abstract AIM: To compare the efficacy of macular buckling (MB) and pars plana vitrectomy (PPV) for full-thickness macular holes (FTMH) and associated macular detachment (MD) in highly myopic eyes. METHODS: Prospective interventional case series of eyes undergoing PPV or MB for FTMH and MD. MAIN OUTCOME MEASURES: Best-corrected visual acuity (BCVA) at postoperative month 24. Other measured outcomes include the initial surgical success rate, macular hole closure rate and the progression of myopic maculopathy. RESULTS: A total of 53 eyes from 53 participants were included in this study (26 participants...
Source: The British Journal of Ophthalmology - January 4, 2021 Category: Opthalmology Authors: Zhao X, Li Y, Ma W, Lian P, Yu X, Chen S, Huang X, Liu B, Lu L Tags: Br J Ophthalmol Source Type: research

The UK National Artificial Eye Questionnaire Study: comparisons between cosmetic shell and artificial eye users. Part 2: maintenance, management and quality of life.
Abstract AIMS: To compare the unique experiences related to artificial eye (AE) versus cosmetic shell (CS) wear. METHODS: In this observational, cross-sectional study, the National Artificial Eye Questionnaire was employed nationwide within the National Health Service England. This second part of the study assesses daily management and care experiences, as well as visual function and quality of life aspects. RESULTS: Overall, 951 respondents wore an AE, while 238 wore a CS. Both AE and CS respondents rated a relatively high score for a beneficial effect of prosthesis polishing, with an average score of 8...
Source: The British Journal of Ophthalmology - January 4, 2021 Category: Opthalmology Authors: Ullrich K, Worrell E, Shapira Y, Litwin A, Malhotra R Tags: Br J Ophthalmol Source Type: research

Corneal sub-basal nerve plexus microneuromas in individuals with and without dry eye.
CONCLUSION: MN frequencies did not significantly differ between individuals with and without DE symptoms. Their presence alone could not distinguish between DE subtypes, including features of NCP in our study population. PMID: 33397656 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 4, 2021 Category: Opthalmology Authors: Dermer H, Hwang J, Mittal R, Cohen A, Galor A Tags: Br J Ophthalmol Source Type: research

Short-term efficacy of latanoprostene bunod for the treatment of open-angle glaucoma and ocular hypertension: a systematic literature review and a network meta-analysis.
CONCLUSION: LBN was significantly more effective than the PGA unoprostone and most of the beta-blockers. Compared with the most widely used PGAs, LBN numerically outperformed latanoprost and travoprost and was similar to bimatoprost 0.01%. PMID: 33397657 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 4, 2021 Category: Opthalmology Authors: Harasymowycz P, Royer C, Cui AX, Barbeau M, Jobin-Gervais K, Mathurin K, Lachaine J, Beauchemin C Tags: Br J Ophthalmol Source Type: research

Quantitative OCT angiography of the retinal microvasculature and choriocapillaris in highly myopic eyes with myopic macular degeneration.
Abstract PURPOSE: To quantify retinal and choriocapillaris (CC) microvasculature in highly myopic (HM) eyes with myopic macular degeneration (MMD) using swept-source optical coherence tomography angiography (SS-OCTA). METHODS: 162 HM eyes (spherical equivalent ≤ -6.0 dioptres or axial length (AL) ≥26.5 mm) from 98 participants were enrolled, including 60 eyes (37.0%) with tessellated fundus, 54 eyes (33.3%) with peripapillary diffuse chorioretinal atrophy (PDCA), 27 eyes (16.7%) with macular diffuse chorioretinal atrophy (MDCA) and 21 eyes (13.0%) with patchy or macular atrophy. PLEX Elite 9000 S...
Source: The British Journal of Ophthalmology - January 4, 2021 Category: Opthalmology Authors: Zheng F, Chua J, Ke M, Tan B, Yu M, Hu Q, Cheung CMG, Ang M, Lee SY, Wong TY, SNEC Retina Group, Schmetterer L, Wong CW, Hoang QV Tags: Br J Ophthalmol Source Type: research

Graft detachments in endothelial keratoplasty.
Abstract Graft detachment is the most common complication of endothelial keratoplasty. With the ongoing advancements in the field of endothelial keratoplasty, our understanding of risk factors of graft detachments and its management has been evolving. Various prevention measures have been described in literature including presoaking the donor graft, anterior chamber tamponade, venting incisions, sutures to prevent dislocation of graft. Management of a detached graft involves secondary interventions such as rebubbling, suturing and regrafts. In this review, we discuss graft detachment in different types of endothel...
Source: The British Journal of Ophthalmology - January 4, 2021 Category: Opthalmology Authors: Deshmukh R, Nair S, Ting DSJ, Agarwal T, Beltz J, Vajpayee RB Tags: Br J Ophthalmol Source Type: research

Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.
CONCLUSIONS: CRER in eyes with GA declined linearly over approximately 13 years and may serve as an anatomic endpoint in future clinical trials aiming to preserve the central zone. PMID: 33361441 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 23, 2020 Category: Opthalmology Authors: Shen LL, Sun M, Ahluwalia A, Park MM, Young BK, Lad EM, Toth C, Del Priore LV Tags: Br J Ophthalmol Source Type: research

Microbiological evaluation of corneal and contact lens cultures in contact lens-associated bacterial keratitis.
CONCLUSIONS: Although there was a disagreement in the microbiological yield between contact lens and corneal cultures, contact lens cultures were useful in management of patients while achieving similar outcomes. PMID: 33361442 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 23, 2020 Category: Opthalmology Authors: Mukhtar S, Atta S, Durrani A, Perera C, Kowalski R, Jhanji V Tags: Br J Ophthalmol Source Type: research

OCTA versus dye angiography for the diagnosis and evaluation of neovascularisation in punctate inner choroidopathy.
CONCLUSIONS: In this study, we investigated the utility of OCTA in the diagnosis and evaluation of patients with CNV secondary to PIC. Compared with dye angiography, OCTA show convincing diagnosis accuracy. Although OCTA has several limitations and is not sufficient to replace dye angiography in clinical practice, it can provide clinicians with a non-invasive way to monitor patients with CNV secondary to PIC and guide treatment decisions. PMID: 33361443 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 23, 2020 Category: Opthalmology Authors: Gan Y, Zhang X, Su Y, Shen M, Peng Y, Wen F Tags: Br J Ophthalmol Source Type: research

Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR.
CONCLUSIONS: Retinal capillary closure, quantified by SS-OCTA, can identify NPDR severity progression. It is located mainly in the perifoveal retinal capillary circulation in the initial stages of NPDR, whereas the retinal midperiphery is predominantly affected in moderate-to-severe NPDR. PMID: 33355147 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 22, 2020 Category: Opthalmology Authors: Santos T, Warren LH, Santos AR, Marques IP, Kubach S, Mendes LG, Sisternes L, Madeira MH, Durbin M, Cunha-Vaz JG Tags: Br J Ophthalmol Source Type: research

Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography.
CONCLUSION: PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses. PMID: 33355172 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 22, 2020 Category: Opthalmology Authors: Gao L, Wang J, You Q, Guo Y, Flaxel CJ, Hwang TS, Huang D, Jia Y, Bailey ST Tags: Br J Ophthalmol Source Type: research

Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy.
er JB Abstract AIMS: To compare the efficacy of diabetic retinal neovascularisation (NV) detection using the widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vitreoretinal interface (VRI) Angio slab and SS-OCT VRI Structure slab. METHODS: A prospective, observational study was performed at Massachusetts Eye and Ear from January 2019 to June 2020. Patients with proliferative diabetic retinopathy (PDR), patients with non-proliferative diabetic retinopathy and patients with diabetes but without diabetic retinopathy were included. All patients were imaged with WF SS-OCTA using the 12&t...
Source: The British Journal of Ophthalmology - December 21, 2020 Category: Opthalmology Authors: Lu ES, Cui Y, Le R, Zhu Y, Wang JC, Laíns I, Katz R, Lu Y, Zeng R, Garg I, Wu DM, Eliott D, Vavvas DG, Husain D, Miller JW, Kim LA, Miller JB Tags: Br J Ophthalmol Source Type: research

Long-term visual and anatomic outcomes of patients with peripapillary pachychoroid syndrome.
CONCLUSION: Patients with PPS experienced decreased retinal oedema and decreased choroidal thickening throughout the course of disease. While some patients experienced visual decline, the overall visual outcome was relatively favourable and independent of trends in retinal or choroidal thickening. PMID: 33355149 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 21, 2020 Category: Opthalmology Authors: Xu D, Garg E, Lee K, Sakurada Y, Amphornphruet A, Phasukkijwatana N, Liakopoulos S, Pautler SE, Kreiger AE, Yzer S, Lee WK, Sadda S, Freund KB, Sarraf D Tags: Br J Ophthalmol Source Type: research

Development and validation of a deep learning system to screen vision-threatening conditions in high myopia using optical coherence tomography images.
CONCLUSIONS: We used OCT macular images for the development of CNN models to identify vision-threatening conditions in high myopia patients. Our models achieved reliable sensitivities and high specificities, comparable to those of retina specialists and may be applied for large-scale high myopia screening and patient follow-up. PMID: 33355150 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 21, 2020 Category: Opthalmology Authors: Li Y, Feng W, Zhao X, Liu B, Zhang Y, Chi W, Lu M, Lin J, Wei Y, Li J, Zhang Q, Zhu Y, Chen C, Lu L, Zhao L, Lin H Tags: Br J Ophthalmol Source Type: research

Microvascular abnormalities and long-term efficacy after stereotactic radiotherapy under continued intravitreal anti-VEGF treatment for neovascular AMD.
This study evaluated the long-term efficacy and safety of adjunct SRT to anti-VEGF injections in a treat-and-extend regimen in nAMD. METHODS: 50 consecutive patients were followed 3 years after single-session SRT, a safety analysis including standardised study imaging, and a reading centre based image analysis was performed after 2 years. RESULTS: After increase from baseline (4.24±0.66 weeks) to 12 months (7.52±3.05 weeks, p
Source: The British Journal of Ophthalmology - December 21, 2020 Category: Opthalmology Authors: Hatz K, Zimmermann F, Lazaridis E, Kardamakis D, Guichard M, Türksever C, Pruente C, Schmidt-Erfurth UM, Gerendas BS Tags: Br J Ophthalmol Source Type: research

Proton beam irradiation of uveal melanoma involving the iris, ciliary body and anterior choroid without surgical localisation (light field).
CONCLUSIONS: Patients treated with PBI using a light field set-up technique experience good outcomes after irradiation. Eye preservation and retention of good VA are seen in the majority of cases, and tumour recurrence is low. PMID: 33355171 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 21, 2020 Category: Opthalmology Authors: Oxenreiter MM, Lane AM, Aronow MB, Shih H, Trofimov AV, Kim IK, Gragoudas ES Tags: Br J Ophthalmol Source Type: research

Primary acquired melanosis/melanoma: utility of conjunctival map biopsy.
CONCLUSIONS: Map biopsy enhances overall assessment of the anatomic and pathologic extent, impacting use of adjuvant topical chemotherapy. In absence of map biopsy, it would be impossible to diagnose PAM sine pigmento. Additional corroborative work is needed to validate our observations. PMID: 33355161 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 18, 2020 Category: Opthalmology Authors: Soto H, Bowen RC, Raval V, Yeaney G, Singh A Tags: Br J Ophthalmol Source Type: research

Peripapillary sclera exhibits a v-shaped configuration that is more pronounced in glaucoma eyes.
Abstract AIMS: To compare the shape of the anterior surface of the peripapillary sclera (PPS) between glaucoma and healthy subjects. METHODS: 88 primary open angle glaucoma (POAG), 98 primary angle closure glaucoma (PACG) and 372 age-matched and gender-matched healthy controls were recruited in this study. The optic nerve head of one randomly selected eye of each subject was imaged with spectral domain optical coherence tomography. The shape of the PPS was measured through an angle defined between a line parallel to the nasal anterior PPS boundary and one parallel to the temporal side. A negative value indica...
Source: The British Journal of Ophthalmology - December 17, 2020 Category: Opthalmology Authors: Wang X, Tun TA, Nongpiur ME, Htoon HM, Tham YC, Strouthidis NG, Aung T, Cheng CY, Girard MJ Tags: Br J Ophthalmol Source Type: research

Irish National Diabetic RetinaScreen Programme: report on five rounds of retinopathy screening and screen-positive referrals. (INDEAR study report no. 1).
CONCLUSIONS: Screening programme has seen a reduced detection rate both screen-positive retinopathy referral in Ireland over five rounds of screening. Management of nondiabetic eye diseases poses a significant challenge in improving visual outcomes of people living with diabetes in Ireland. PMID: 33334818 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 17, 2020 Category: Opthalmology Authors: Pandey R, Morgan MM, Murphy C, Kavanagh H, Acheson R, Cahill M, McGettrick P, O'Toole L, Hamroush F, Mooney T, Byrne H, Fitzpatrick P, Keegan DJ Tags: Br J Ophthalmol Source Type: research

Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity.
CONCLUSION: Patients with moderate and severe SARS-CoV-2 pneumonia had decreased central retinal VD as compared with that of asymptomatic/paucisymptomatic cases or control subjects. PMID: 33328184 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 16, 2020 Category: Opthalmology Authors: Zapata MÁ, Banderas García S, Sánchez A, Falcó A, Otero-Romero S, Arcos G, Velazquez-Villoria D, García-Arumí J Tags: Br J Ophthalmol Source Type: research

Health-related quality of life in Ahmed FP7, and Baerveldt 250 and 350 patients compared with medical controls.
CONCLUSIONS: Glaucoma patients with a younger age, diplopia, lower visual acuity, worse mean deviation or a GDD had lower HRQoL. Those with B350 had lower self-perception scores, consistent with previous reports in the literature. This subscale was not diminished in FP7 or B250, so the decreased self-perception scores may be due to greater visibility or awareness of the B350. PMID: 33328185 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 16, 2020 Category: Opthalmology Authors: Kilgore KP, Wang F, Stern NC, Jamali Dogahe S, White LJ, Khanna CL Tags: Br J Ophthalmol Source Type: research

Immunocytochemistry of the ocular surface after different techniques of limbal stem cell transplantation for chronic chemical burns.
Abstract AIM: To compare the immunocytochemistry (ICC) on impression cytology of corneal surface epithelium after simple limbal epithelial transplantation (SLET) and conjunctival-limbal autograft (CLAU). METHODS: A prospective study of 20 patients above 1 year of age with chronic chemical burns, who underwent limbal stem cell transplantation (LSCT). They were divided equally in group A (SLET) and group B (CLAU). ICC was done for cytokeratin 3 (CK3) and cytokeratin 19 (CK19), preoperatively and postoperatively at 6 months. RESULTS: Four cases were excluded due to inadequate cellularity in preoperat...
Source: The British Journal of Ophthalmology - December 16, 2020 Category: Opthalmology Authors: Arora R, Saran R, Jha V, Gotmare ND, Jain P Tags: Br J Ophthalmol Source Type: research

Trabeculectomy in patients with diabetes: subconjunctival Mitomycin C with or without intravitreal bevacizumab.
Abstract BACKGROUND/AIMS: To evaluate the success of Mitomycin C (MMC) augmented trabeculectomy with or without intravitreal bevacizumab in patients with diabetes without neovascular glaucoma. METHODS: Fifty-six patients with diabetes who needed trabeculectomy were randomised to either combination of 2.5 mg intravitreal bevacizumab and subconjunctival MMC (group A, 28 eyes) or subconjunctival MMC alone (group B, 28 eyes). The main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, bleb morphology and success probability. Surgical success was defined as complete accord...
Source: The British Journal of Ophthalmology - December 16, 2020 Category: Opthalmology Authors: Nilforushan N, Es'haghi A, Miraftabi A, Abolfathzadeh N, Banifatemi M Tags: Br J Ophthalmol Source Type: research

Assessment of patient burden from dry eye disease using a combination of five visual analogue scales and a radar graph: a pilot study of the PENTASCORE.
uin C Abstract BACKGROUND/AIMS: Dry eye disease (DED) questionnaires would ideally be easy and fast to answer and explore the main aspects of disease burden and satisfaction (efficacy and tolerability) with treatment. This pilot study evaluates the Pentascore questionnaire for routinely assessing DED. METHODS: The Pentascore combines five visual analogue scales (VAS) to assess the intensity and frequency of ocular pain/discomfort, the impact of DED on daily activities and visual tasks and the efficacy and tolerability of ongoing DED treatment(s). This retrospective study compared Pentascore to the Ocular Surf...
Source: The British Journal of Ophthalmology - December 16, 2020 Category: Opthalmology Authors: Labetoulle M, Benichou J, M'nafek N, Garnier F, Rabut G, Ben Hadj Salah W, Labbé A, Rousseau A, Baudouin C Tags: Br J Ophthalmol Source Type: research

Optic nerve sheath diameter changes at high altitude and in acute mountain sickness: meta-regression analyses.
Abstract BACKGROUND/AIMS: To assess changes in optic nerve sheath diameter (ONSD) at high altitude and in acute mountain sickness (AMS). METHODS: Cochrane Library, EMBASE, Google Scholar and PubMed were searched for articles published from their inception to 31st of July 2020. Outcome measures were mean changes of ONSD at high altitude and difference in ONSD change between subjects with and without AMS. Meta-regressions were conducted to investigate the relation of ONSD change to altitude and time spent at that altitude. RESULTS: Eight studies with 248 participants comparing ONSD from sea level to high a...
Source: The British Journal of Ophthalmology - December 11, 2020 Category: Opthalmology Authors: Tsai TY, Gozari G, Su YC, Lee YK, Tu YK Tags: Br J Ophthalmol Source Type: research

Cascade screening for glaucoma in high-risk family members of African-Caribbean glaucoma patients in an urban population in London.
CONCLUSION: Cascade screening of FDR of African-Caribbean glaucoma patients in inner city London was unsuccessful. Research confidentiality guidance prohibiting research teams directly contacting family members was a barrier. Greater community engagement, community-based screening and permission to contact FDR directly might have improved uptake. PMID: 33303425 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 10, 2020 Category: Opthalmology Authors: Nagar A, Myers S, Kozareva D, Simcoe M, Hammond C Tags: Br J Ophthalmol Source Type: research

Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery.
CONCLUSIONS: Taking pregabalin during LASEK surgery may affect corneal nerve sensitivity and reduce pain. However, for up to 6 months thereafter, corneal sensitivity and nerve fibre density are not significantly different from findings in the control group, so pregabalin does not seem to affect nerve regeneration or structural changes. PMID: 33303426 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 10, 2020 Category: Opthalmology Authors: Paik DW, Lim DH, Chung TY Tags: Br J Ophthalmol Source Type: research

Multimodal imaging in subclinical best vitelliform macular dystrophy.
Abstract BACKGROUND: To analyse multimodal imaging alterations in the subclinical form of best vitelliform macular dystrophy (BVMD). METHODS: The study was designed as an observational, cross-sectional case series. Eleven eyes of 7 subclinical patients with BVMD and 12 age-matched and sex-matched controls were included. Multimodal imaging included fundus blue-light autofluorescence, near-infrared autofluorescence (NIR-AF), structural optical coherence tomography (OCT) and OCT angiography (OCTA). The quantitative analysis included the calculation of the following parameters: vessel density (VD), vessel tortuos...
Source: The British Journal of Ophthalmology - December 8, 2020 Category: Opthalmology Authors: Parodi MB, Arrigo A, Calamuneri A, Aragona E, Bandello F Tags: Br J Ophthalmol Source Type: research

Outcomes of enucleation and porous polyethylene orbital implant insertion in patients with paediatric retinoblastoma: a long-term follow-up study.
Abstract BACKGROUND/AIMS: To report the long-term outcomes of enucleation and insertion of porous polyethylene (PP) orbital implant according to the evolving surgical techniques and implant in patients with paediatric retinoblastoma . METHODS: Patients with paediatric retinoblastoma who underwent enucleation and PP implant insertion from December 1998 to December 2014 were retrospectively reviewed and divided into four groups: group A, classic enucleation +PP implant; group B, enucleation +PP implant +anterior closure of the posterior Tenon's (ACPT) capsule; group C, enucleation +PP implant +free orbital fat ...
Source: The British Journal of Ophthalmology - December 8, 2020 Category: Opthalmology Authors: Yang MK, Lee MJ, Kim N, Choung H, Khwarg SI Tags: Br J Ophthalmol Source Type: research

Comparison of the structure-function relationship between compass microperimetry and Humphrey field analyser in myopic open-angle glaucoma eyes.
Abstract BACKGROUND/AIMS: To compare the structure-function relationship between compass microperimetry (CMP; CenterVue, Padova, Italy) and Humphrey field analyser (HFA; Carl Zeiss Meditec, Dublin, California, USA) in open-angle glaucoma (OAG) eyes with myopia. METHODS: Circumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field (VF) mean sensitivity (MS) were obtained in 90 OAG subjects using the optical coherence tomography, CMP and HFA in a random order. The global and sectoral structure-function relationships between the cpRNFLT and VFMS were assessed with different VF devices (CMP vs H...
Source: The British Journal of Ophthalmology - December 8, 2020 Category: Opthalmology Authors: Shin JW, Song MK, Won HJ, Jo Y, Kook MS Tags: Br J Ophthalmol Source Type: research

Estimation of Goldmann applanation tonometer intraocular pressure (IOP) from scleral Schiotz IOP values in eyes with type-1 keratoprostheses.
CONCLUSION: Scleral Schiotz IOP values along with our predictive model can be an alternative objective method to FT IOP in assessing IOP in eyes with type-1 keratoprostheses. PMID: 33293270 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 8, 2020 Category: Opthalmology Authors: Senthil S, Chary R, Ali MH, Choudhari NS, Garudadri CS Tags: Br J Ophthalmol Source Type: research

Longitudinal analysis of microvascular perfusion and neurodegenerative changes in early type 2 diabetic retinal disease.
UM Abstract AIM: To prospectively monitor subclinical changes in capillary perfusion and retinal layer thickness in patients with type 2 diabetes and early diabetic retinal disease over 2 years. METHODS: In this longitudinal study we performed biannual retinal vascular imaging using optical coherence tomography angiography (RTVue) to analyse the foveal avascular zone (FAZ) area, perimeter, acircularity index (AI) and parafoveal superficial/deep vessel density (VD). Spectral-domain optical coherence tomography (Spectralis) was used to measure the thickness of nine macular layers and the peripapillary n...
Source: The British Journal of Ophthalmology - December 8, 2020 Category: Opthalmology Authors: Aschauer J, Pollreisz A, Karst S, Hülsmann M, Hajdu D, Datlinger F, Egner B, Kriechbaum K, Pablik E, Schmidt-Erfurth UM Tags: Br J Ophthalmol Source Type: research

Fluid-based prognostication in n-AMD: Type 3 macular neovascularisation needs an analysis in isolation.
PMID: 33293272 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 8, 2020 Category: Opthalmology Authors: Sharma A, Parachuri N, Kumar N, Bandello F, Kuppermann BD, Loewenstein A, Regillo C, Chakravarthy U Tags: Br J Ophthalmol Source Type: research

Central serous chorioretinopathy imaging biomarkers.
Abstract PURPOSE: To identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR) through 12 months. METHODS: Patients with diagnosis of CSCR, either acute or chronic, were included in this multicentric, retrospective study. Demographic factors; systemic risk factors; central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ) and interdigitation zone damage on optical coherence tomography; details of leak on fluorescein angiography and indocyanine green angiography were included as predictors of anatomi...
Source: The British Journal of Ophthalmology - December 7, 2020 Category: Opthalmology Authors: Singh SR, Iovino C, Zur D, Masarwa D, Iglicki M, Gujar R, Lupidi M, Maltsev DS, Bousquet E, Bencheqroun M, Amoroso F, Lima LH, Padhy SK, Govindahari V, Chandra K, Souied EH, Rodriguez FJ, Daza LA, Rios HA, Cagini C, Peiretti E, Behar-Cohen F, Chhablani J Tags: Br J Ophthalmol Source Type: research

Visual impairment and perceptual visual disorders in children with cerebral palsy in Nigeria.
CONCLUSION: Children with CP have a wide spectrum of ocular morbidity and visual impairment, underestimated by carers. Children with CP require visual acuity assessments with a range of tests which account for associated comorbidities and oculomotor dysfunction. Functional vision assessments for PVD is important. CVI is common. PMID: 33268343 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 2, 2020 Category: Opthalmology Authors: Duke RE, Nwachukuw J, Torty C, Okorie U, Kim MJ, Burton K, Gilbert C, Bowman R Tags: Br J Ophthalmol Source Type: research

Clinical profile and outcome of early surgery in neonatal-onset glaucoma presenting over a 5-year period.
The objective of the paper was to study the clinical profiles, surgical and visual outcomes of NOG at least 1 year following early surgery. METHODS: Prospective interventional cohort study at a tertiary care referral centre. Babies with NOG, who presented between January 2013 and December 2017, had a history suggestive of disease onset within 1 month of birth, and underwent surgery by 3 months of age, were prospectively enrolled. Those who completed a 1-year follow-up after surgery were analysed. RESULTS: 94 eyes of 53 babies were analysed. 35 (66%) had PCG. Neonatal congenital ectropion uvea...
Source: The British Journal of Ophthalmology - December 2, 2020 Category: Opthalmology Authors: Kaushik S, Dhingra D, Arora A, Singh MP, Kaur S, Joshi G, Snehi S, Gupta G, Pandav SS Tags: Br J Ophthalmol Source Type: research

Corneal Transplant Follow-up Study II: a randomised trial to determine whether HLA class II matching reduces the risk of allograft rejection in penetrating keratoplasty.
Abstract PURPOSE: A randomised trial to test the hypothesis that human leucocyte antigen (HLA) class II matching reduces the risk of allograft rejection in high-risk penetrating keratoplasty (PK). METHODS: All transplants were matched for HLA class I antigens (≤2 mismatches at the A and B loci) and corneas were allocated to patients by cohort minimisation to achieve 0, 1 or 2 HLA class II antigen mismatches. The corneal transplants (n=1133) were followed for 5 years. The primary outcome measure was time to first rejection episode. RESULTS: Cox regression analysis found no influence of HLA class II mis...
Source: The British Journal of Ophthalmology - December 2, 2020 Category: Opthalmology Authors: Armitage WJ, Winton HL, Jones MNA, Downward L, Crewe JM, Rogers CA, Tole DM, Dick AD Tags: Br J Ophthalmol Source Type: research

Hyperreflective cystoid spaces in diabetic macular oedema: prevalence and clinical implications.
CONCLUSION: Hyperreflective cystoid spaces detected by OCTA affected more than one-third of the DMO eyes. Their disappearance was not associated with any functional improvement and led to the formation of new hard exudate deposits in about one-third of the eyes. PMID: 33262106 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - December 1, 2020 Category: Opthalmology Authors: Couturier A, Mane V, Lavia CA, Tadayoni R Tags: Br J Ophthalmol Source Type: research