Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family.
CONCLUSION: SLC4A11 mutations are the usual cause of CHED in Iranians. The 10 novel mutations observed contribute significantly to the approximately 85 mutations reported since discovery of the role of the gene in CHED pathogenesis more than 10 years ago. MPDZ mutations may be a cause of CHED and even FECD in a minority of patients. Proposed functions of MPDZ with respect to tight junctions and maintenance of the corneal endothelial barrier are in accordance with a role in corneal endothelial pathobiology. PMID: 31420327 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - August 16, 2019 Category: Opthalmology Authors: Moazzeni H, Javadi MA, Asgari D, Khani M, Emami M, Moghadam A, Panahi-Bazaz MR, Hosseini Tehrani M, Karimian F, Hosseini B, Nekuie Moghadam T, Hassanpour H, Akbari MT, Elahi E Tags: Br J Ophthalmol Source Type: research

Foveal microvasculature, refractive errors, optical biometry and their correlations in school-aged children with retinopathy of prematurity after intravitreal antivascular endothelial growth factors or laser photocoagulation.
CONCLUSION: In school-aged children with history of type 1 ROP, despite similar visual acuity outcome, those who underwent anti-VEGF injection had favourable developmental outcomes compared with laser photocoagulation. Significant correlations exist between fovea microvasculature and optical biometric components. PMID: 31420328 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - August 16, 2019 Category: Opthalmology Authors: Chen YC, Chen SN Tags: Br J Ophthalmol Source Type: research

Practice patterns to decrease myopia progression differ among paediatric ophthalmologists around the world.
In this study, we compared between different geographical areas worldwide the practice patterns used by paediatric ophthalmologists to decrease the progression of myopia. METHODS: Global responses to a questionnaire were analysed (n=794) for demographic variations. Pharmacological, optical and behavioural categories were defined as effective or ineffective based on the current scientific peer reviewed literature. RESULTS: Treatment rates varied significantly between geographical regions (mean 57%, range 39%-89%, p
Source: The British Journal of Ophthalmology - August 13, 2019 Category: Opthalmology Authors: Leshno A, Farzavandi SK, Gomez-de-Liaño R, Sprunger DT, Wygnanski-Jaffe T, Mezer E Tags: Br J Ophthalmol Source Type: research

Longitudinal changes in axial length in high myopia: a 4-year prospective study.
Abstract AIM: To determine the longitudinal changes in the axial length (AL) in patients with high myopia without any other ophthalmic disease METHODS: Participants were divided into two groups: a high myopia group (60 eyes) without myopic degeneration, such as chorioretinal atrophy or posterior staphyloma, and a control group (60 eyes). Both groups were further divided into subgroups according to the AL: subgroup 1 (≥27.5 mm), subgroup 2 (26.0-27.5 mm), subgroup 3 (24.5-26.0 mm) and subgroup 4 (
Source: The British Journal of Ophthalmology - August 13, 2019 Category: Opthalmology Authors: Lee MW, Lee SE, Lim HB, Kim JY Tags: Br J Ophthalmol Source Type: research

Local therapy for cancer therapy-associated uveitis: a case series and review of the literature.
CONCLUSION: Based on our series as well as the existing literature demonstrating the use of local therapy for irAEs, we propose an approach to local therapy for cancer therapy-associated uveitis starting with topical steroids and initiating injectable steroids in cases of recalcitrant panuveitis or posterior uveitis. Subclinical inflammation on posterior segment imaging responds robustly to difluprednate or intravitreal steroid therapy, and patients with posterior segment involvement may require more aggressive management and long-term maintenance. PMID: 31409649 [PubMed - as supplied by publisher] (Source: The Britis...
Source: The British Journal of Ophthalmology - August 13, 2019 Category: Opthalmology Authors: Venkat AG, Arepalli S, Sharma S, Karthik N, Lowder C, Ehlers JP, Singh A, Goshe J, Srivastava S Tags: Br J Ophthalmol Source Type: research

Nomogram for visual acuity outcome after iodine-125 plaque radiotherapy and prophylactic intravitreal bevacizumab for uveal melanoma in 1131 patients.
CONCLUSIONS: A nomogram using clinical or treatment risk factors can predict visual acuity outcome following plaque radiotherapy and prophylactic intravitreal bevacizumab for uveal melanoma and is available online at https://fighteyecancer.com/nomograms/. PMID: 31409650 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - August 13, 2019 Category: Opthalmology Authors: Dalvin LA, Zhang Q, Hamershock RA, Chang M, Yu MD, Mashayekhi A, Shields CL Tags: Br J Ophthalmol Source Type: research

Singapore Chinese Eye Study: key findings from baseline examination and the rationale, methodology of the 6-year follow-up series.
Abstract BACKGROUND/AIMS: In order to address the eye care needs of the increasing numbers of elderly Chinese globally, there is a need for comprehensive understanding on the longitudinal trends of age-related eye diseases among Chinese. We herein report the key findings from the baseline Singapore Chinese Eye Study (SCES-1), and describe the rationale and methodology of the 6-year follow-up study (SCES-2). METHODS: 3353 Chinese adults who participated in the baseline SCES-1 (2009-2011) were invited for the 6-year follow-up SCES-2 (2015-2017). Examination procedures for SCES-2 included standardised ocular, sy...
Source: The British Journal of Ophthalmology - August 10, 2019 Category: Opthalmology Authors: Majithia S, Tham YC, Chee ML, Teo CL, Chee ML, Dai W, Kumari N, Lamoureux EL, Sabanayagam C, Wong TY, Cheng CY Tags: Br J Ophthalmol Source Type: research

One-year outcomes of anti-vascular endothelial growth factor therapy in peripapillary choroidal neovascularisation.
ani J Abstract PURPOSE: To report the visual and anatomical outcomes in eyes with peripapillary choroidal neovascularisation (CNV) through 12 months. METHODS: This was a multicentre, retrospective, interventional case series which included treatment-naïve cases of peripapillary choroidal neovascular membrane (CNVM) with a minimum follow-up of 12 months. Multimodal imaging which comprised optical coherence tomography (OCT), fluorescein angiography and/or indocyanine green angiography was performed at baseline and follow-up visits. OCT parameters included central macular thickness (CMT), subfoveal choroida...
Source: The British Journal of Ophthalmology - August 10, 2019 Category: Opthalmology Authors: Singh SR, Fung AT, Fraser-Bell S, Lupidi M, Mohan S, Gabrielle PH, Zur D, Iglicki M, M López-Corell P, Gallego-Pinazo R, Farinha C, Lima LH, Mansour AM, Casella AM, Wu L, Silva R, Uwaydat SH, Govindahari V, Arevalo JF, Chhablani J Tags: Br J Ophthalmol Source Type: research

Cornea verticillata in Fabry disease: a comparative study between slit-lamp examination and in vivo corneal confocal microscopy.
CONCLUSIONS: The slit-lamp examination has a limited diagnostic power in the detection of epithelial deposits in patients with FD when compared with the IVCM. In fact, the slit-lamp examination suffers from a high number of false negative results and, consequently, from a low negative predictive value (16%). IVCM allows the detection of corneal microstructural changes in patients with FD and may represent a reliable tool for the early diagnosis and follow-up of the disease. PMID: 31401555 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - August 10, 2019 Category: Opthalmology Authors: Leonardi A, Carraro G, Modugno RL, Rossomando V, Scalora T, Lazzarini D, Calò L Tags: Br J Ophthalmol Source Type: research

Acanthamoeba keratitis therapy: time to cure and visual outcome analysis for different antiamoebic therapies in 227 cases.
CONCLUSION: PHMB 0.02% monotherapy for the initial treatment of AK is as effective as biguanide+diamidine combination therapy. Chlorhexidine monotherapy was too infrequent for comparison. The outcome data are the most detailed available. PMID: 31401556 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - August 10, 2019 Category: Opthalmology Authors: Papa V, Rama P, Radford C, Minassian DC, Dart JKG Tags: Br J Ophthalmol Source Type: research

Longitudinal changes in the ganglion cell-inner plexiform layer thickness in high myopia: a prospective observational study.
Abstract AIM: To determine longitudinal changes of the ganglion cell-inner plexiform layer (GC-IPL) thickness in patients with high myopia. METHODS: The subjects were divided into two groups: a high myopia group (axial length ≥26.0 mm) and a normal control group. Both groups were divided into subgroups based on age (decade): 20s, 30s, 40s and 50s. Twenty eyes were included in each subgroup. After the initial visit, GC-IPL thicknesses were measured three more times with at least a 1-year interval between examinations using spectral domain optical coherence tomography. The average GC-IPL thickness was...
Source: The British Journal of Ophthalmology - August 10, 2019 Category: Opthalmology Authors: Lee MW, Nam KY, Park HJ, Lim HB, Kim JY Tags: Br J Ophthalmol Source Type: research

Rate of three-dimensional neuroretinal rim thinning in glaucomatous eyes with optic disc haemorrhage.
Abstract BACKGROUND: To investigate the thinning rate of three-dimensional neuroretinal rim thickness (3D-NRT) in glaucoma eyes with optic disc haemorrhage (DH) and its relationship to retinal nerve fibre layer thickness (RNFLT) progression. METHODS: Ninety-five (95) eyes of 95 glaucoma patients with initial DH in the inferotemporal (n=69) and superotemporal (n=26) regions and 48 eyes of 48 glaucoma patients without DH were retrospectively reviewed. The rates of change for 3D-NRT and RNFLT were compared by linear mixed-effect model. For the direct comparison between 3D-NRT and RNFLT, dynamic-range-based norma...
Source: The British Journal of Ophthalmology - August 8, 2019 Category: Opthalmology Authors: Kim YW, Lee WJ, Seol BR, Kim YK, Jeoung JW, Park KH Tags: Br J Ophthalmol Source Type: research

Outer retinal hyperreflective deposits (ORYD): a new OCT feature in na ïve diabetic macular oedema after PPV with ILM peeling.
Outer retinal hyperreflective deposits (ORYD): a new OCT feature in naïve diabetic macular oedema after PPV with ILM peeling. Br J Ophthalmol. 2019 Aug 07;: Authors: Iglicki M, Loewenstein A, Barak A, Schwartz S, Zur D Abstract AIMS: We aimed to investigate a novel optical coherence tomography (OCT) finding of outer retinal hyperreflective deposits (ORYDs) in patients with naïve diabetic macular oedema (DMO) seen after small gauge pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling. Furthermore, we evaluated the predictive value of ORYD for visual outcome over 24 months...
Source: The British Journal of Ophthalmology - August 7, 2019 Category: Opthalmology Authors: Iglicki M, Loewenstein A, Barak A, Schwartz S, Zur D Tags: Br J Ophthalmol Source Type: research

Intraocular pressure control and visual field changes in primary angle closure disease: the CUHK PACG Longitudinal (CUPAL) study.
Abstract PURPOSE: To determine the relationship of intraocular pressure (IOP) control with subsequent visual field (VF) deterioration in patients with primary angle closure disease (PACD). METHODS: 419 PACD eyes from 240 Chinese patients were included. Mean IOP and IOP fluctuation were calculated as the average and SD divided by mean IOP, respectively, of all the IOP measured in the initial 18 months for assessment of IOP control. The relationship between IOP control and subsequent VF parameters over time was examined using linear mixed models. VF deterioration was defined as IOP control associated with decre...
Source: The British Journal of Ophthalmology - August 7, 2019 Category: Opthalmology Authors: Cheung CY, Li SL, Chan PPM, Chan NCY, Tan S, Man X, Tham CC Tags: Br J Ophthalmol Source Type: research

Tear neuromediators in eyes on chronic topical antiglaucoma therapy with and without BAK preservatives.
Abstract PURPOSE: To evaluate tear neuropeptides (NPs) (vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), substance P (SP), nerve growth factor (NGF)) in chronic ocular topical hypotensive therapy with and without benzalkonium chloride (BAK) preservative. METHODS: A comparative, open label, cross-sectional study of patients using antiglaucoma medications for>6 months with BAK (group I), without BAK (group II) and controls was done. Tear NPs (ELISA), ocular surface evaluation tests (tear breakup time (TBUT), Schirmer's test, corneal and conjunctival staining ...
Source: The British Journal of Ophthalmology - August 5, 2019 Category: Opthalmology Authors: Murugesan V, Dwivedi R, Saini M, Gupta V, Dada T, Vivekanandhan S Tags: Br J Ophthalmol Source Type: research

Anatomical and functional outcomes following switching from aflibercept to ranibizumab in neovascular age-related macular degeneration in Europe: SAFARI study.
, Igwe F, Ayan F Abstract BACKGROUND/AIMS: Prospective data on switching anti-vascular endothelial growth factors in patients with neovascular age-related macular degeneration (nAMD) who have previously shown no/partial response are limited. This prospective study assessed the effect of switching from aflibercept to ranibizumab on anatomical and functional outcomes in patients with persistent/recurrent disease activity. METHODS: SAFARI (NCT02161575) was a 6-month, prospective, single-arm study conducted in the UK and Germany. Patients, meeting strict eligibility criteria for one of two subgroups (primary trea...
Source: The British Journal of Ophthalmology - August 5, 2019 Category: Opthalmology Authors: Gale RP, Pearce I, Eter N, Ghanchi F, Holz FG, Schmitz-Valckenberg S, Balaskas K, Burton BJL, Downes SM, Eleftheriadis H, George S, Gilmour D, Hamilton R, Lotery AJ, Patel N, Prakash P, Santiago C, Thomas S, Varma D, Walters G, Williams M, Wolf A, Zakri R Tags: Br J Ophthalmol Source Type: research

A prospective trial of adjuvant therapy for high-risk uveal melanoma: assessing 5-year survival outcomes.
CONCLUSIONS: When adjusted for differences in age, tumour size and initial treatment, survival between treated and observed patients was no longer significant (p=0.56 MFS and p=0.92 OS). Differences in baseline tumour characteristics between treated and observed patients can influence interpretation of results. TRIAL REGISTRATION NUMBER: NCT01100528. PMID: 31371315 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - August 1, 2019 Category: Opthalmology Authors: Binkley E, Triozzi PL, Rybicki L, Achberger S, Aldrich W, Singh A Tags: Br J Ophthalmol Source Type: research

Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis.
Abstract AIMS: Corvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT) and corneal hysteresis (CH), in comparison with IOP measured with Goldmann applanation tonometry (GAT) and the ocular response analyzer (ORA). METHODS: A total of 141 eyes from 141 subjects (35 healthy eyes and 106 glaucomatous eyes) unde...
Source: The British Journal of Ophthalmology - July 30, 2019 Category: Opthalmology Authors: Matsuura M, Murata H, Fujino Y, Yanagisawa M, Nakao Y, Tokumo K, Nakakura S, Kiuchi Y, Asaoka R Tags: Br J Ophthalmol Source Type: research

Indocyanine green angiography for identifying telangiectatic capillaries in diabetic macular oedema.
CONCLUSION: Late ICG staining revealing large microvascular abnormalities is commonly observed during DME. Because of their specific angiographic and OCT features relative to microaneurysms, we propose to name them telangiectatic capillaries (TelCaps). PMID: 31358497 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 29, 2019 Category: Opthalmology Authors: Castro Farías D, Matsui Serrano R, Bianchi Gancharov J, de Dios Cuadras U, Sahel J, Graue Wiechers F, Dupas B, Paques M Tags: Br J Ophthalmol Source Type: research

Altered ellipsoid zone reflectivity and deep capillary plexus rarefaction correlate with progression in Best disease.
Abstract AIMS: To evaluate the effects of neurovascular damage in patients with the typical vitelliform lesion of Best vitelliform macular dystrophy (BVMD) in the attempt to identify different progression patterns. METHODS: Prospective, observational case series. Patients in the vitelliform stage of BVMD and healthy controls underwent complete ophthalmological examination on a yearly basis, including best-corrected visual acuity (BCVA), biomicroscopy, optical coherence tomography (OCT) and OCT angiography (OCT-A). 4.5×4.5 mm OCT-A slabs were imported into ImageJ software and their vessel density ...
Source: The British Journal of Ophthalmology - July 29, 2019 Category: Opthalmology Authors: Romano F, Arrigo A, Leone PP, Saladino A, Bandello F, Battaglia Parodi M Tags: Br J Ophthalmol Source Type: research

Foveal avascular zone morphology and parafoveal capillary perfusion in sickle cell retinopathy.
CONCLUSIONS: Abnormal FAZ morphology and altered parafoveal capillary perfusion were found in patients with SCR. Our customised OCT-A image analysis method uniquely highlights significant quantitative alterations in perfusion density mapping in a qualitative display, with minimal obscuration of OCT-A image detail. PMID: 31337609 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 23, 2019 Category: Opthalmology Authors: Lynch G, Scott AW, Linz MO, Han I, Andrade Romo JS, Linderman RE, Carroll J, Rosen RB, Chui TY Tags: Br J Ophthalmol Source Type: research

The role of M üller cells in tractional macular disorders: an optical coherence tomography study and physical model of mechanical force transmission.
The role of Müller cells in tractional macular disorders: an optical coherence tomography study and physical model of mechanical force transmission. Br J Ophthalmol. 2019 Jul 20;: Authors: Govetto A, Hubschman JP, Sarraf D, Figueroa MS, Bottoni F, dell'Omo R, Curcio CA, Seidenari P, Delledonne G, Gunzenhauser R, Ferrara M, Au A, Virgili G, Scialdone A, Repetto R, Romano MR Abstract BACKGROUND: To explore the role of foveal and parafoveal Müller cells in the morphology and pathophysiology of tractional macular disorders with a mathematical model of mechanical force transmission. METHODS:...
Source: The British Journal of Ophthalmology - July 20, 2019 Category: Opthalmology Authors: Govetto A, Hubschman JP, Sarraf D, Figueroa MS, Bottoni F, dell'Omo R, Curcio CA, Seidenari P, Delledonne G, Gunzenhauser R, Ferrara M, Au A, Virgili G, Scialdone A, Repetto R, Romano MR Tags: Br J Ophthalmol Source Type: research

Ophthalmic statistics note 13: method agreement studies in ophthalmology-please don't carry on correlating ….
Ophthalmic statistics note 13: method agreement studies in ophthalmology-please don't carry on correlating…. Br J Ophthalmol. 2019 Jul 18;: Authors: Bunce C, Stratton IM, Elders A, Czanner G, Doré C, Freemantle N, Ophthalmic Statistics Group PMID: 31320382 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 18, 2019 Category: Opthalmology Authors: Bunce C, Stratton IM, Elders A, Czanner G, Doré C, Freemantle N, Ophthalmic Statistics Group Tags: Br J Ophthalmol Source Type: research

Implementation of a cloud-based referral platform in ophthalmology: making telemedicine services a reality in eye care.
CONCLUSION: After implementation more than half of the HES referrals have been avoided. This platform offers a digital-first solution that enables rapid-access eye care for patients in community optometrists, facilitates communication between healthcare providers and may serve as a foundation for implementation of artificial intelligence. PMID: 31320383 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 18, 2019 Category: Opthalmology Authors: Kern C, Fu DJ, Kortuem K, Huemer J, Barker D, Davis A, Balaskas K, Keane PA, McKinnon T, Sim DA Tags: Br J Ophthalmol Source Type: research

Repeatability of automated leakage quantification and microaneurysm identification utilising an analysis platform for ultra-widefield fluorescein angiography.
The objective quantification of UWFA features is a labour-intensive manual process, limiting its utility. The present study assesses the consistency/repeatability of an automated assessment platform for the characterisation of retinal vascular features, quantification of microaneurysms (MA) and leakage foci in UWFA images. METHODS: An Institutional Review Board-approved retrospective image analysis study was performed on UWFA images. For each eye, two arteriovenous-phase images and two late-phase images were selected. Automated assessment was performed for retinal vascular features, MA identification and leakage segme...
Source: The British Journal of Ophthalmology - July 18, 2019 Category: Opthalmology Authors: Jiang A, Srivastava S, Figueiredo N, Babiuch A, Hu M, Reese J, Ehlers JP Tags: Br J Ophthalmol Source Type: research

Understanding biosimilars and its regulatory aspects across the globe: an ophthalmology perspective.
CONCLUSION: This review discusses the biosimilars, their regulation globally and their difference from generics from ophthalmic perspective. PMID: 31315829 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 17, 2019 Category: Opthalmology Authors: Sharma A, Kumar N, Kuppermann BD, Bandello F, Loewenstein A Tags: Br J Ophthalmol Source Type: research

Factors associated with extended remission in neovascular age-related macular degeneration on pro re nata treatment protocol.
CONCLUSION: ER is achievable in 9.2% of patients under PRN therapy for nAMD. At presentation with nAMD, anatomical features on retinal imaging may predict the likelihood of achieving ER and a shorter time to achieve ER. PMID: 31302628 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 13, 2019 Category: Opthalmology Authors: Lin T, Dans KC, Muftuoglu IK, Meshi A, Amador-Patarroyo MJ, Cheng L, Freeman WR Tags: Br J Ophthalmol Source Type: research

Automated identification of malignancy in whole-slide pathological images: identification of eyelid malignant melanoma in gigapixel pathological slides using deep learning.
CONCLUSION: Our DLS, which uses artificial intelligence, can automatically detect MM in histopathological slides and highlight the lesion area on WSIs using a probabilistic heatmap. In addition, our approach has the potential to be applied to the histopathological sections of other tumour types. PMID: 31302629 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 13, 2019 Category: Opthalmology Authors: Wang L, Ding L, Liu Z, Sun L, Chen L, Jia R, Dai X, Cao J, Ye J Tags: Br J Ophthalmol Source Type: research

Visual function is reduced in young adults formerly born prematurely: a population-based study.
;m G, Larsson E Abstract AIMS: To assess visual function in young adults born preterm and compare with full-term individuals of the same age. METHODS: Young adults, born preterm (birth weight ≤1500 g) in 1988-1990, previously included in a population-based study on the incidence of retinopathy of prematurity (ROP) in Stockholm County, Sweden were included. A control group of participants born at term, in the same area during the same time period, was used for comparison. Best-corrected visual acuities were assessed at distance and near with logMAR charts. Distance visual acuity was also measured with singl...
Source: The British Journal of Ophthalmology - July 13, 2019 Category: Opthalmology Authors: Pétursdóttir D, Holmström G, Larsson E Tags: Br J Ophthalmol Source Type: research

Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant.
CONCLUSION: We show that familial MED can arise from a TUBB3 variant and could be considered a limited form of CFEOM. Neurological features such as mild facial palsy and cortical malformations can be present in patients with MED. Thus, in individuals with congenital MED, consideration may be made for TUBB3 mutation screening. PMID: 31302631 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 13, 2019 Category: Opthalmology Authors: Thomas MG, Maconachie GDE, Constantinescu CS, Chan WM, Barry B, Hisaund M, Sheth V, Kuht HJ, Dineen RA, Harieaswar S, Engle EC, Gottlob I Tags: Br J Ophthalmol Source Type: research

Hypotony and the Argus II retinal prosthesis: causes, prevention and management.
ovic L, Iezzi R, Gaucher D, Arevalo JF, Gregori NZ, Wiedemann P, Özmert E, Lim JI, Rezende FA, Huang SS, Merlini F, Patel U, Greenberg RJ, Justus S, Bacherini D, Cinelli L, Humayun MS PMID: 31300454 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 12, 2019 Category: Opthalmology Authors: Rizzo S, Barale PO, Ayello-Scheer S, Devenyi RG, Delyfer MN, Korobelnik JF, Rachitskaya A, Yuan A, Jayasundera KT, Zacks DN, Handa JT, Montezuma SR, Koozekanani D, Stanga P, da Cruz L, Walter P, Augustin AJ, Olmos de Koo LC, Ho AC, Kirchhof B, Hahn P, Vaj Tags: Br J Ophthalmol Source Type: research

Association of the ZC3H11B, ZFHX1B and SNTB1 genes with myopia of different severities.
CONCLUSIONS: We confirmed ZC3H11B as a susceptibility gene for high and extreme myopia, and ZFHX1B and SNTB for extreme myopia in Chinese populations. Instead of myopia onset, these three genes were more likely to impose risks of progressing to high and extreme myopia. PMID: 31300455 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 12, 2019 Category: Opthalmology Authors: Tang SM, Li FF, Lu SY, Kam KW, Tam POS, Tham CC, Pang CP, Yam JCS, Chen LJ Tags: Br J Ophthalmol Source Type: research

Measuring dynamic levels of self-perceived anxiety and concern during simulated mobility tasks in people with non-neovascular age-related macular degeneration.
Abstract BACKGROUND/AIMS: To assess response to real-world mobility scenarios in people with dry age-related macular degeneration (AMD) using a computer-based test. METHODS: Participants were shown 18 point-of-view computer-based movies simulating walking through real-world scenarios, and pressed a button during scenes which would cause them self-perceived anxiety or concern in their day-to-day life. Button pressure was recorded throughout. Pressure traces were generated, which aligned with each movie time point. Group averages based on AMD severity were generated. Bootstrapped confidence intervals (CIs) for ...
Source: The British Journal of Ophthalmology - July 9, 2019 Category: Opthalmology Authors: Taylor DJ, Smith ND, Jones PR, Binns AM, Crabb DP Tags: Br J Ophthalmol Source Type: research

Outcome of peripheral iridotomy in subjects with uveitis.
Abstract BACKGROUND/AIMS: Peripheral iridotomy (PI) may be required in subjects with uveitis to manage iris bombe, seclusio pupillae and primary angle closure glaucoma. The aim of this study was to identify risk factors for failure of both laser and surgical PIs in patients with uveitis and determine survival durations. METHODS: Retrospective study of subjects with a history of uveitis undergoing yttrium-aluminium-garnet (YAG) laser or surgical PI at Auckland District Health Board over an 11-year period. Failure of PI was defined as loss of patency or recurrence of iris bombe. A mixed effects shared frailty m...
Source: The British Journal of Ophthalmology - July 9, 2019 Category: Opthalmology Authors: Betts TD, Sims JL, Bennett SL, Niederer RL Tags: Br J Ophthalmol Source Type: research

The estimated healthcare cost of diabetic retinopathy in Indonesia and its projection for 2025.
CONCLUSIONS: The estimated healthcare cost of DR in Indonesia in 2017 was considerably high, nearly 2% of the 2017 national state budget, and projected to increase significantly to more than threefold in 2025. The highest cost may incur for DR requiring both laser and IVT injection. Therefore, public health intervention to delay or prevent severe DR may substantially reduce the healthcare cost of DR in Indonesia. PMID: 31285276 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 8, 2019 Category: Opthalmology Authors: Sasongko MB, Wardhana FS, Febryanto GA, Agni AN, Supanji S, Indrayanti SR, Widayanti TW, Widyaputri F, Widhasari IA, Lestari YD, Adriono GA, Sovani I, Kartasasmita AS Tags: Br J Ophthalmol Source Type: research

Simulating vascular leakage on optical coherence tomography angiography using an overlay technique with corresponding thickness maps.
CONCLUSION: OCTA as a whole can be used to simulate leakage, but currently, sensitivity of the technique is low. Further understanding of the OCTA technology may yield novel means of detecting retinal pathology. PMID: 31278146 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 5, 2019 Category: Opthalmology Authors: de Carlo TE, Zahid S, Bohm KJ, Chan RVP, Lim JI, Mieler WF Tags: Br J Ophthalmol Source Type: research

Sutureless superficial anterior lamellar keratoplasty for recurrent corneal haze after repeat excimer laser surface ablation.
CONCLUSIONS: Sutureless SALK provides a useful treatment option in patients with recurrent haze after excimer laser treatment. It can eliminate haze recurrence for at least a period of 5 years and can improve BSCVA, although there may be significant SIA. PMID: 31278147 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 5, 2019 Category: Opthalmology Authors: Myerscough J, Bovone C, Thomas PBM, Mimouni M, Aljassar F, Padroni S, Busin M Tags: Br J Ophthalmol Source Type: research

Identifying the factors for improving quality of oral fluorescein angiography.
an WR Abstract AIM: To evaluate the quality of oral fluorescein angiography (FA) in relation to food intake. METHODS: This is an observational, case-crossover study. We collected information from patients undergoing routine oral FA for retinal disease at the Shiley Eye Institute. Eighty patients (160 eyes) were analysed. Fasting and non-fasting images of the same patient were recorded, compared and analysed for different image quality parameters and clinical relevance by experienced retina specialists. RESULTS: When analysing the images, intergrader agreement was moderate to good with a Kappa averaging 0...
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Amador-Patarroyo MJ, Lin T, Meshi A, Dans KC, Chen K, Borooah S, Molano-Gonzalez N, Díaz-Rojas JA, Freeman WR Tags: Br J Ophthalmol Source Type: research

Validating the efficacy of the binomial pointwise linear regression method to detect glaucoma progression with multicentral database.
Abstract BACKGROUND/AIM: We previously reported the benefit of applying binomial pointwise linear regression (PLR: binomial PLR) to detect 10-2 glaucomatous visual field (VF) progression. The purpose of the current study was to validate the usefulness of the binomial PLR to detect glaucomatous VF progression in the central 24°. METHODS: Series of 15 VFs (Humphrey Field Analyzer 24-2 SITA-standard) from 341 eyes of 233 patients, obtained over 7.9±2.1 years (mean±SD), were investigated. PLR was performed by regressing the total deviation of all test points. VF progression was determined from t...
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Asano S, Murata H, Matsuura M, Fujino Y, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N, Zangwill LM, Asaoka R Tags: Br J Ophthalmol Source Type: research

Binocular game versus part-time patching for treatment of anisometropic amblyopia in Chinese children: a randomised clinical trial.
Abstract AIMS: To compare amblyopic-eye visual acuity (VA) and binocularity improvement of a binocular game with part-time patching in the treatment of Chinese children with anisometropic amblyopia. METHODS: 103 Chinese children aged 3-13 years with anisometropic amblyopia were recruited in a randomised clinical trial. Eligible participants were randomly assigned to the binocular, patching and combined groups. Primary outcome was amblyopic-eye VA improvement at 3 months. Secondary outcomes included reduction of suppression and change of stereoacuity. RESULTS: Of 85 completed participants, 44 (52%) were w...
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Yao J, Moon HW, Qu X Tags: Br J Ophthalmol Source Type: research

Association of toll-like receptor 10 polymorphisms with paediatric idiopathic uveitis in Han Chinese.
CONCLUSION: TLR10 gene polymorphisms (rs2101521, rs10004195, rs11725309 and rs6841698) confer susceptibility to PIU in Han Chinese. In a stratified analysis, rs2101521 and rs6841698 are associated with PIU with BK, and rs6841698 correlates with PIU with cataract. PMID: 31272954 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Lv M, Tan H, Deng J, Du L, Su G, Wang Q, Zhong Z, Tan X, Cao Q, Kijlstra A, Yang P Tags: Br J Ophthalmol Source Type: research

Long-term outcome of low-cost glaucoma drainage device (Aurolab aqueous drainage implant) compared with Ahmed glaucoma valve.
CONCLUSION: Both AADI and AGV implant had comparable mean IOP at 3 years with lesser requirement of AGM in the AADI group. Both procedures appear to be safe with slight preponderance of hypotony-related complications in AADI group. PMID: 31272955 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Pandav SS, Seth NG, Thattaruthody F, Kaur M, Akella M, Vats A, Kaushik S, Raj S Tags: Br J Ophthalmol Source Type: research

An update on the modern management of paediatric uveitis.
This article highlights the evidence-based practice for the contemporary management of paediatric uveitis to readers in different specialities who may come across this condition. It raises awareness of early systemic treatment aiming to achieve early and complete disease inactivity thereby improving the chances of a long-term positive outcome. PMID: 31272956 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Choi J, Hawley DP, Ashworth J, Edelsten C, Bossuyt ASAM Tags: Br J Ophthalmol Source Type: research

Long-term outcomes of ocular adnexal lesions in IgG4-related ophthalmic disease.
Abstract AIMS: To determine the long-term outcomes of ocular adnexal lesions in immunoglobulin G4-related ophthalmic disease (IgG4-ROD). METHODS: This retrospective, non-randomised exploratory study included 82 patients with ocular adnexal lesions. We evaluated the long-term outcomes in 71 patients during the median follow-up period of 30 months, who underwent either watchful waiting (n=20; range 12-90 months) or systemic corticosteroid treatment, delivered according to consensus guidelines (n=51; range 9- 115 months). We also analysed factors that might contribute to recalcitrance to treatment. RESULTS:...
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Kubota T, Katayama M, Nishimura R, Moritani S Tags: Br J Ophthalmol Source Type: research

Treatment strategies for Graves' ophthalmopathy: a network meta-analysis.
CONCLUSION: A robust recommendation regarding the best treatment cannot be made, because most evidence was rated as low or very low quality according to the Grading of Recommendations, Assessment, Development and Evaluations framework. Large RCTs and individual participant data meta-analyses are necessary to confirm these results and explore potential moderators. PROPERO TRIAL REGISTRATION NUMBER: CRD42018103029. PMID: 31272958 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Zhou X, Zhou D, Wang J, Chen G Tags: Br J Ophthalmol Source Type: research

Systemic medications and cortical cataract: the Singapore Epidemiology of Eye Diseases Study.
CONCLUSION: ACE inhibitors, fibrates and AGIs were associated with increased prevalence of cortical cataract in this Asian population, independent of the presence of hypertension, hyperlipidaemia and diabetes, respectively. Whether they contribute to the risk of cortical cataract needs confirmation in longitudinal studies. PMID: 31272959 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 4, 2019 Category: Opthalmology Authors: Dai W, Tham YC, Chee ML, Majithia S, Poh S, Tan AG, Tao Y, Wang JJ, Cheng CY Tags: Br J Ophthalmol Source Type: research

Estimated number of ophthalmologists worldwide (International Council of Ophthalmology update): will we meet the needs?
CONCLUSIONS: Although the estimated global ophthalmologist workforce appears to be growing, the appropriate distribution of the eye care workforce and the development of comprehensive eye care delivery systems are needed to ensure that eye care needs are universally met. PMID: 31266774 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 2, 2019 Category: Opthalmology Authors: Resnikoff S, Lansingh VC, Washburn L, Felch W, Gauthier TM, Taylor HR, Eckert K, Parke D, Wiedemann P Tags: Br J Ophthalmol Source Type: research

Characterisation of microvascular abnormalities using OCT angiography in patients with biallelic variants in USH2A and MYO7A.
Abstract AIMS: Using optical coherence tomography angiography (OCTA) to characterise microvascular changes in the retinal plexuses and choriocapillaris (CC) of patients with MYO7A and USH2A mutations and correlate with genotype, retinal structure and function. METHODS: Twenty-seven patients with molecularly confirmed USH2A (n=21) and MYO7A (n=6) mutations underwent macular 6×6 mm OCTA using the AngioVue. Heidelberg spectral-domain OCT scans and MAIA microperimetry were also performed, the preserved ellipsoid zone (EZ) band width and mean macular sensitivity (MS) were recorded. OCTA of the inner retina, ...
Source: The British Journal of Ophthalmology - July 2, 2019 Category: Opthalmology Authors: Hagag AM, Mitsios A, Gill JS, Nunez Do Rio JM, Theofylaktopoulos V, Houston S, Webster AR, Dubis AM, Moosajee M Tags: Br J Ophthalmol Source Type: research

Non-invasive Intraocular pressure monitoring with contact lens.
CONCLUSION: The described inexpensive and non-invasive sensor is able to reliably monitor the IOP changes based on porcine eye model. PMID: 31266776 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - July 2, 2019 Category: Opthalmology Authors: Campigotto A, Leahy S, Zhao G, Campbell RJ, Lai Y Tags: Br J Ophthalmol Source Type: research

Rapid Assessment of Avoidable Blindness: looking back, looking forward.
Abstract The Rapid Assessment of Avoidable Blindness, or RAAB, is a relatively simple and low-cost survey methodology to provide data on the prevalence and causes of visual loss. The aim of this article is to reflect on the achievements and challenges of RAAB, and to describe the future developments that are needed to ensure that it remains a relevant and widely used tool. To date, at least 331 RAABs have been undertaken in 79 countries, and these surveys provide an important source of information on visual loss at both the local and global level. A RAAB repository has been developed which includes the site and da...
Source: The British Journal of Ophthalmology - July 2, 2019 Category: Opthalmology Authors: Mactaggart I, Limburg H, Bastawrous A, Burton MJ, Kuper H Tags: Br J Ophthalmol Source Type: research