Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre
CONCLUSION: Compared with non-East Asians, Chinese LHON patients had higher proportions of m.11778G>A and m.3635G>A and lower m.3460G>A mutations. A novel progression grade derived from optic disc category was proposed. The prognostic matrix indicated that lower grade and younger-onset age are the most favourable prognostic factors.PMID:38346855 | DOI:10.1136/bjo-2023-323557 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 12, 2024 Category: Opthalmology Authors: Yuxi Zheng Yingwei Wang Yi Jiang Junwen Wang Shiqiang Li Xueshan Xiao Wenmin Sun Panfeng Wang Qingjiong Zhang Xiaoyun Jia Source Type: research

Conversion to faricimab after prior anti-vascular endothelial growth factor therapy for persistent diabetic macular oedema
CONCLUSIONS: Intravitreal faricimab can improve anatomic outcomes while maintaining visual acuity in eyes with pDME previously treated with anti-VEGF therapy.PMID:38346854 | DOI:10.1136/bjo-2023-324394 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 12, 2024 Category: Opthalmology Authors: Asad Farooq Durrani Bita Momenaei Taku Wakabayashi Sudheshna Vemula Saagar A Pandit Jason Hsu Allen C Ho Marc J Spirn Michael A Klufas Sunir J Garg James F Vander Carl D Regillo Allen Chiang Ajay E Kuriyan Yoshihiro Yonekawa Source Type: research

Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre
CONCLUSION: Compared with non-East Asians, Chinese LHON patients had higher proportions of m.11778G>A and m.3635G>A and lower m.3460G>A mutations. A novel progression grade derived from optic disc category was proposed. The prognostic matrix indicated that lower grade and younger-onset age are the most favourable prognostic factors.PMID:38346855 | DOI:10.1136/bjo-2023-323557 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 12, 2024 Category: Opthalmology Authors: Yuxi Zheng Yingwei Wang Yi Jiang Junwen Wang Shiqiang Li Xueshan Xiao Wenmin Sun Panfeng Wang Qingjiong Zhang Xiaoyun Jia Source Type: research

Is primary trabeculectomy cost-effective for patients with advanced primary open angle glaucoma? Results from the Treatment of Advanced Glaucoma Study economic model
CONCLUSION: In patients presenting with advanced POAG, trabeculectomy has a higher probability of being cost-effective over a patient's lifetime compared with medical treatment.PMID:38336459 | DOI:10.1136/bjo-2023-323390 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 9, 2024 Category: Opthalmology Authors: Hosein Shabaninejad Tara Homer Ashleigh Kernohan Anthony J King Jennifer Burr Augusto Azuara-Blanco Luke Vale Source Type: research

Risk factors for development of hyper-reflective foci overlying drusen in eyes with intermediate age-related macular degeneration
CONCLUSIONS: The presence of overlying EZ disruption and a greater drusen height substantially increased the risk for IHRF development, whereas drusen further from the fovea indicated reduced risk. Given the importance of IHRF as a biomarker for AMD progression, these findings may be of value in defining patient populations for future early intervention trials.PMID:38325906 | DOI:10.1136/bjo-2023-324098 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 7, 2024 Category: Opthalmology Authors: Alireza Mahmoudi Navid Manafi Giulia Corradetti Muneeswar Gupta Nittala Mehdi Emamverdi Stephanie Trejo Corona Charles C Wykoff David Sarraf SriniVas R Sadda Source Type: research

Pan-Indian multicentre retrospective study of 0.01% atropine for myopia control
Br J Ophthalmol. 2024 Feb 6:bjo-2024-325182. doi: 10.1136/bjo-2024-325182. Online ahead of print.NO ABSTRACTPMID:38320846 | DOI:10.1136/bjo-2024-325182 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 6, 2024 Category: Opthalmology Authors: Jason C Yam Yuzhou Zhang Source Type: research

Prediction of retinopathy progression using deep learning on retinal images within the Scottish screening programme
CONCLUSIONS: We showed that, compared with using the current retinopathy grade, DL of fundus images significantly improves the prediction of incident referable retinopathy before the next screening episode. This can impact screening recall interval policy positively, for example, by reducing the expected time with referable disease for a fixed workload-which we show as an exemplar. Additionally, it could be used to optimise workload for a fixed sojourn time.PMID:38316534 | DOI:10.1136/bjo-2023-323400 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - February 5, 2024 Category: Opthalmology Authors: Joseph Mellor Wenhua Jiang Alan Fleming Stuart J McGurnaghan Luke A K Blackbourn Caroline Styles Amos Storkey Paul M McKeigue Helen M Colhoun Source Type: research

Functional vision disorder: a review of diagnosis, management and costs
Br J Ophthalmol. 2024 Feb 2:bjo-2023-324856. doi: 10.1136/bjo-2023-324856. Online ahead of print.ABSTRACTFunctional vision disorder (FVD) is a relatively common diagnosis in ophthalmic practice which can be difficult to make because of clinician's apprehension to miss organic pathology. We review the diagnostic approach to patients with FVD, organic mimics of FVD, its diagnostic and management strategies and associated cost burden. Patients with FVD typically present with visual acuity and/or field loss. Diagnostic work-up should include patient observation, detailed history, pupillary examination, dilated ophthalmoscopy, ...
Source: The British Journal of Ophthalmology - February 2, 2024 Category: Opthalmology Authors: Brendan Ka-Lok Tao Jim Shenchu Xie Edward Margolin Source Type: research

Heterogeneity in disease activity, frequency of treatments, and visual outcomes among patients with retinal vein occlusion: relationship between injection need and vision with as-needed ranibizumab
CONCLUSION: The BRVO/CRVO population is heterogenous with a varied response to ranibizumab treatment.PMID:38290802 | DOI:10.1136/bjo-2022-323120 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Robert B Bhisitkul Peter A Campochiaro Steven Blotner Carlos Quezada-Ruiz Mimi Liu Zdenka Haskova Source Type: research

Two-year outcomes of different subretinal fluid drainage techniques during vitrectomy for fovea-off rhegmatogenous retinal detachments: ELLIPSOID-2 Study
CONCLUSIONS: Visual acuity was worse and discontinuity of the IDZ and CMO was greater in eyes with PFCL-assisted drainage compared with PRB or PR. Drainage technique may impact long-term visual acuity and photoreceptor integrity.PMID:38290803 | DOI:10.1136/bjo-2023-323879 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Bryon R McKay Aditya Bansal Michael Kryshtalskyj David T Wong Alan R Berger Rajeev H Muni Source Type: research

Imaging geographic atrophy: integrating structure and function to better understand the effects of new treatments
Br J Ophthalmol. 2024 Jan 30:bjo-2023-324246. doi: 10.1136/bjo-2023-324246. Online ahead of print.ABSTRACTGeographic atrophy (GA) is an advanced and irreversible form of age-related macular degeneration (AMD). Chronic low grade inflammation is thought to act as an initiator of this degenerative process, resulting in loss of photoreceptors (PRs), retinal pigment epithelium (RPE) and the underlying choriocapillaris. This review examined the challenges of clinical trials to date which have sought to treat GA, with particular reference to the successful outcome of C3 complement inhibition. Currently, optical coherence tomograp...
Source: The British Journal of Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Stela Vujosevic Anat Loewenstein Louise O'Toole Ursula Margarethe Schmidt-Erfurth Dinah Zur Usha Chakravarthy Source Type: research

Low-dose atropine 0.01% for the treatment of childhood myopia: a pan-India multicentric retrospective study
CONCLUSION: Low-dose atropine (0.01%) effectively reduces myopia progression over 2 years in Indian children.PMID:38290805 | DOI:10.1136/bjo-2023-324450 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Rohit Saxena Vinay Gupta Rebika Dhiman Elizabeth Joseph Sumita Agarkar R Neena Damaris Magdalene Jitendra Jethani Sandra C Ganesh Minal Patil Pooja Gogri Shailesh Gadaginamath Pradhnya Sen Jaspreet Sukhija Deepak Mishra Jyoti H Matalia Anupam Sahu Smita K Source Type: research

High-risk factors for zonular complications during cataract surgery in eyes with pseudoexfoliation syndrome
CONCLUSION: In eyes with PXF, high-risk factors for zonular complications during cataract surgery due to pre-existing severe zonular dehiscence were poor mydriasis, shallow anterior chamber and large lens decentration, suggesting the importance of evaluating these conditions preoperatively.PMID:38290806 | DOI:10.1136/bjo-2023-324832 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Ken Hayashi Motoaki Yoshida Shin-Ichi Manabe Akira Hirata Source Type: research

Predictors of 24-month onset of macular fibrosis in type 3 macular neovascularisation
CONCLUSION: Our study identifies SHRM and multilaminae as relevant predictors of 24-month onset of MF in patients with T3 MNV. These findings enrich our understanding of the development of MF in T3 MNV and can guide improved risk prognostication. Future research should consider larger samples and prospective designs to validate these predictors.PMID:38290807 | DOI:10.1136/bjo-2023-324713 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Paolo Forte Vincenzo Fontana Julia Muzio Luca Di Cello Paolo Corazza Raffaella Rosa Donatella Musetti Aldo Vagge Carlo Enrico Traverso Massimo Nicol ò Source Type: research

Lacrimal sac massage for congenital nasolacrimal duct obstruction: a multicentre randomised controlled trial
CONCLUSIONS: There was no increase in the resolution rate after 1 month of lacrimal sac massage in patients 3-11 months old with unilateral CNLDO. However, in protocol-compliant younger age groups, Crigler massage may be effective.TRIAL REGISTRATION NUMBER: UMIN Clinical Trial Registry (UMIN000032840; www.umin.ac.jp/).PMID:38242699 | DOI:10.1136/bjo-2023-324595 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - January 19, 2024 Category: Opthalmology Authors: Mizuki Asano Masaki Takeuchi Tomoko Ohno Jutaro Nakamura Nobuhisa Mizuki Nozomi Matsumura Source Type: research