Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
Exp Eye Res. 2024 Mar 30:109883. doi: 10.1016/j.exer.2024.109883. Online ahead of print.ABSTRACTCorneal transplantation represents the primary therapeutic approach for managing corneal endothelial dysfunction, but corneal donors remain scarce. Anterior chamber cell injection emerges as a highly promising alternative strategy for corneal transplantation, with pluripotent stem cells (PSC) demonstrating considerable potential as an optimal cell source. Nevertheless, only a few studies have explored the differentiation of functional corneal endothelial-like cells originating from PSC. In this investigation, a chemical-defined ...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: Dulei Zou Ting Wang Wenjing Li Xin Wang Bochao Ma Xiangyue Hu Qingjun Zhou Zongyi Li Weiyun Shi Haoyun Duan Source Type: research
Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
Exp Eye Res. 2024 Mar 30:109883. doi: 10.1016/j.exer.2024.109883. Online ahead of print.ABSTRACTCorneal transplantation represents the primary therapeutic approach for managing corneal endothelial dysfunction, but corneal donors remain scarce. Anterior chamber cell injection emerges as a highly promising alternative strategy for corneal transplantation, with pluripotent stem cells (PSC) demonstrating considerable potential as an optimal cell source. Nevertheless, only a few studies have explored the differentiation of functional corneal endothelial-like cells originating from PSC. In this investigation, a chemical-defined ...
Source: Experimental Eye Research - April 1, 2024 Category: Opthalmology Authors: Dulei Zou Ting Wang Wenjing Li Xin Wang Bochao Ma Xiangyue Hu Qingjun Zhou Zongyi Li Weiyun Shi Haoyun Duan Source Type: research
Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
Exp Eye Res. 2024 Mar 30:109883. doi: 10.1016/j.exer.2024.109883. Online ahead of print.ABSTRACTCorneal transplantation represents the primary therapeutic approach for managing corneal endothelial dysfunction, but corneal donors remain scarce. Anterior chamber cell injection emerges as a highly promising alternative strategy for corneal transplantation, with pluripotent stem cells (PSC) demonstrating considerable potential as an optimal cell source. Nevertheless, only a few studies have explored the differentiation of functional corneal endothelial-like cells originating from PSC. In this investigation, a chemical-defined ...
Source: Biomed Res - April 1, 2024 Category: Research Authors: Dulei Zou Ting Wang Wenjing Li Xin Wang Bochao Ma Xiangyue Hu Qingjun Zhou Zongyi Li Weiyun Shi Haoyun Duan Source Type: research
Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
Exp Eye Res. 2024 Mar 30:109883. doi: 10.1016/j.exer.2024.109883. Online ahead of print.ABSTRACTCorneal transplantation represents the primary therapeutic approach for managing corneal endothelial dysfunction, but corneal donors remain scarce. Anterior chamber cell injection emerges as a highly promising alternative strategy for corneal transplantation, with pluripotent stem cells (PSC) demonstrating considerable potential as an optimal cell source. Nevertheless, only a few studies have explored the differentiation of functional corneal endothelial-like cells originating from PSC. In this investigation, a chemical-defined ...
Source: Experimental Eye Research - April 1, 2024 Category: Opthalmology Authors: Dulei Zou Ting Wang Wenjing Li Xin Wang Bochao Ma Xiangyue Hu Qingjun Zhou Zongyi Li Weiyun Shi Haoyun Duan Source Type: research
Views of admitted palliative care patients and their clinicians on corneal donation discussions: a qualitative content analysis of semi-structured interviews
There is a severe shortage of corneas for donation, globally, for transplantation and research purposes. One group of individuals who could potentially be donors are those who die within the inpatient palliati... (Source: BMC Palliative Care)
Source: BMC Palliative Care - April 1, 2024 Category: Palliative Care Authors: Chirag Patel, Mitchell Nicmanis, Anna Chur-Hansen and Gregory B. Crawford Tags: Research Source Type: research
Epithelial ingrowth in descemet membrane endothelial keratoplasty associated with vitreous loss
Epithelial ingrowth is a rare but potentially sight-threatening complication caused by the invasion of corneal or conjunctival epithelial cells into the eye during ocular surgeries. DMEK is emerging as a widel... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - March 26, 2024 Category: Opthalmology Authors: Anny M.S. Cheng, Anup Kubal, Shailesh K. Gupta, Anil S. Vedula, David T.Y. Yang and Aarup A. Kubal Tags: Case Report Source Type: research
Management of corneal melting after collagen cross-linking for keratoconus: a case report and a review of the literature
We describe the management of a case of severe corneal melting after corneal cross-linking (CXL) treated with a staged approach using a conjunctival flap followed by deep anterior lamellar keratoplasty (DALK). (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - March 25, 2024 Category: Opthalmology Authors: Antonio Moramarco, Natalie di Geronimo, Lorenzo Gardini, Arianna Grendele and Luigi Fontana Tags: Case Report Source Type: research
Keratoconus: exploring fundamentals and future perspectives - a comprehensive systematic review
CONCLUSION: The efficient and widespread clinical translation of machine learning models in keratoconus management is a crucial goal of potential future approaches to better visual performance in keratoconus patients.TRIAL REGISTRATION: The article has been registered through PROSPERO, an international database of prospectively registered systematic reviews, with the ID: CRD42022319338.PMID:38516169 | PMC:PMC10956165 | DOI:10.1177/25158414241232258 (Source: Adv Data)
Source: Adv Data - March 22, 2024 Category: Epidemiology Authors: Sana Niazi Zisis Gatzioufas Farideh Doroodgar Oliver Findl Alireza Baradaran-Rafii Jacob Liechty Majid Moshirfar Source Type: research
Keratoconus: exploring fundamentals and future perspectives - a comprehensive systematic review
CONCLUSION: The efficient and widespread clinical translation of machine learning models in keratoconus management is a crucial goal of potential future approaches to better visual performance in keratoconus patients.TRIAL REGISTRATION: The article has been registered through PROSPERO, an international database of prospectively registered systematic reviews, with the ID: CRD42022319338.PMID:38516169 | PMC:PMC10956165 | DOI:10.1177/25158414241232258 (Source: Adv Data)
Source: Adv Data - March 22, 2024 Category: Epidemiology Authors: Sana Niazi Zisis Gatzioufas Farideh Doroodgar Oliver Findl Alireza Baradaran-Rafii Jacob Liechty Majid Moshirfar Source Type: research
