Increased Anti-Inflammatory Therapeutic Potential and Progenitor Marker Expression of Corneal Mesenchymal Stem Cells Cultured in an Optimized Propagation Medium
Cell Transplant. 2024 Jan-Dec;33:9636897241241992. doi: 10.1177/09636897241241992.ABSTRACTThere is a huge unmet need for new treatment modalities for ocular surface inflammatory disorders (OSIDs) such as dry eye disease and meibomian gland dysfunction. Mesenchymal stem cell therapies may hold the answer due to their potent immunomodulatory properties, low immunogenicity, and ability to modulate both the innate and adaptive immune response. MSC-like cells that can be isolated from the corneal stroma (C-MSCs) offer a potential new treatment strategy; however, an optimized culture medium needs to be developed to produce the i...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrew Hopkinson Maria Notara Claus Cursiefen Laura E Sidney Source Type: research
Unaddressed Factors and Their Role in DMEK Outcomes: Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft
Korean J Ophthalmol. 2024 Apr 8. doi: 10.3341/kjo.2023.0103. Online ahead of print.NO ABSTRACTPMID:38584443 | DOI:10.3341/kjo.2023.0103 (Source: Korean Journal of Ophthalmology : KJO)
Source: Korean Journal of Ophthalmology : KJO - April 8, 2024 Category: Opthalmology Authors: Alexander Wallace Mohit Parekh Vito Romano Source Type: research
An untargeted metabolomics approach to study changes of the medium during human cornea culture
ConclusionThe results revealed a valuable untargeted metabolomics approach which can be applied in organ culture metabolomics. (Source: Metabolomics)
Source: Metabolomics - April 6, 2024 Category: Biology Source Type: research
Qualit ätskontrolle in der Hornhautbank mit KI: Vergleich des neuen Deep-Learning-basierten Ansatzes mit der konventionellen Endothelzelldichtenbestimmung durch das Rhine-Tec System
This study aims to compare this new method with the conventional Rhine-Tec system. 9,375 archived phase-contrast microscopic images of consecutive grafts from the Lions Eye Bank were evaluated with the deep learning method and compared with the corresponding archived analyses of the Rhine-Tec system. Specifically, comparisons of means, Bland-Altman and correlation analyses were performed. Comparable results were obtained for both methods. The mean difference between the Rhine-Tec system and the deep learning method was only -23 cells/mm2 (95% confidence interval -29 to -17). There was a statistically significant positive c...
Source: Klinische Monatsblatter fur Augenheilkunde - April 4, 2024 Category: Opthalmology Authors: Michelle Dreesbach Daniel B öhringer Paola Kammrath Betancor Mateusz Glegola Philip Christian Maier Thomas Reinhard Sonja Heinzelmann Source Type: research
Descemet Membrane Endothelial Keratoplasty (DMEK) Anesthesia Analysis
CONCLUSION: DMEK under topical anesthesia is feasible and shows comparable final visual outcomes but should be limited to selected cooperative patients and performed by experienced surgeons due to the potential for increased intraoperative challenges.PMID:38574678 | DOI:10.1055/a-2268-9295 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 4, 2024 Category: Opthalmology Authors: Christoph Andres Andr é Maurice Trouvain Peter Szurman Berthold Seitz Fabian Norbert Fries Annekatrin Rickmann Source Type: research
Qualit ätskontrolle in der Hornhautbank mit KI: Vergleich des neuen Deep-Learning-basierten Ansatzes mit der konventionellen Endothelzelldichtenbestimmung durch das Rhine-Tec System
This study aims to compare this new method with the conventional Rhine-Tec system. 9,375 archived phase-contrast microscopic images of consecutive grafts from the Lions Eye Bank were evaluated with the deep learning method and compared with the corresponding archived analyses of the Rhine-Tec system. Specifically, comparisons of means, Bland-Altman and correlation analyses were performed. Comparable results were obtained for both methods. The mean difference between the Rhine-Tec system and the deep learning method was only -23 cells/mm2 (95% confidence interval -29 to -17). There was a statistically significant positive c...
Source: Klinische Monatsblatter fur Augenheilkunde - April 4, 2024 Category: Opthalmology Authors: Michelle Dreesbach Daniel B öhringer Paola Kammrath Betancor Mateusz Glegola Philip Christian Maier Thomas Reinhard Sonja Heinzelmann Source Type: research
Descemet Membrane Endothelial Keratoplasty (DMEK) Anesthesia Analysis
CONCLUSION: DMEK under topical anesthesia is feasible and shows comparable final visual outcomes but should be limited to selected cooperative patients and performed by experienced surgeons due to the potential for increased intraoperative challenges.PMID:38574678 | DOI:10.1055/a-2268-9295 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 4, 2024 Category: Opthalmology Authors: Christoph Andres Andr é Maurice Trouvain Peter Szurman Berthold Seitz Fabian Norbert Fries Annekatrin Rickmann Source Type: research
Qualit ätskontrolle in der Hornhautbank mit KI: Vergleich des neuen Deep-Learning-basierten Ansatzes mit der konventionellen Endothelzelldichtenbestimmung durch das Rhine-Tec System
This study aims to compare this new method with the conventional Rhine-Tec system. 9,375 archived phase-contrast microscopic images of consecutive grafts from the Lions Eye Bank were evaluated with the deep learning method and compared with the corresponding archived analyses of the Rhine-Tec system. Specifically, comparisons of means, Bland-Altman and correlation analyses were performed. Comparable results were obtained for both methods. The mean difference between the Rhine-Tec system and the deep learning method was only -23 cells/mm2 (95% confidence interval -29 to -17). There was a statistically significant positive c...
Source: Klinische Monatsblatter fur Augenheilkunde - April 4, 2024 Category: Opthalmology Authors: Michelle Dreesbach Daniel B öhringer Paola Kammrath Betancor Mateusz Glegola Philip Christian Maier Thomas Reinhard Sonja Heinzelmann Source Type: research
Descemet Membrane Endothelial Keratoplasty (DMEK) Anesthesia Analysis
CONCLUSION: DMEK under topical anesthesia is feasible and shows comparable final visual outcomes but should be limited to selected cooperative patients and performed by experienced surgeons due to the potential for increased intraoperative challenges.PMID:38574678 | DOI:10.1055/a-2268-9295 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 4, 2024 Category: Opthalmology Authors: Christoph Andres Andr é Maurice Trouvain Peter Szurman Berthold Seitz Fabian Norbert Fries Annekatrin Rickmann Source Type: research
