Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Animal Models of Corneal Wound Healing
In this study, using mouse models of corneal wound healing, we demonstrate that topical application of a small molecule inhibitor of galectin-3, GB1265: reduces (i) corneal angiogenesis, (ii) corneal fibrosis, (iii) infiltration of immune cells and (iv) expression of proinflammatory cytokine, IL-1β, in injured corneas. Four independent techniques (RNA-seq, NanoString, RT-qPCR, and Western blot analyses) all demonstrated that decrease in corneal opacity in the galectin-3 inhibitor-treated corneas is associated with a decrease in a number of genes and signaling pathways that are known to promote fibrosis. These findings all...
Source: Am J Pathol - December 30, 2023 Category: Pathology Authors: Zhiyi Cao Abdulraouf Ramadan Albert Tai Fredrik Zetterberg Noorjahan Panjwani Source Type: research
Corneal transplant rejection and alopecia areata universalis in a patient with severe atopic dermatitis on dupilumab
Actas Dermosifiliogr. 2023 Dec 28:S0001-7310(23)01003-7. doi: 10.1016/j.ad.2023.02.039. Online ahead of print.NO ABSTRACTPMID:38159837 | DOI:10.1016/j.ad.2023.02.039 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: T Lopez-Bernala M Mazaira Fern ándeza I Vargas-Machuca Salidoa B Araneguia Source Type: research
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Animal Models of Corneal Wound Healing
In this study, using mouse models of corneal wound healing, we demonstrate that topical application of a small molecule inhibitor of galectin-3, GB1265: reduces (i) corneal angiogenesis, (ii) corneal fibrosis, (iii) infiltration of immune cells and (iv) expression of proinflammatory cytokine, IL-1β, in injured corneas. Four independent techniques (RNA-seq, NanoString, RT-qPCR, and Western blot analyses) all demonstrated that decrease in corneal opacity in the galectin-3 inhibitor-treated corneas is associated with a decrease in a number of genes and signaling pathways that are known to promote fibrosis. These findings all...
Source: The American Journal of Pathology - December 30, 2023 Category: Pathology Authors: Zhiyi Cao Abdulraouf Ramadan Albert Tai Fredrik Zetterberg Noorjahan Panjwani Source Type: research
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Animal Models of Corneal Wound Healing
In this study, using mouse models of corneal wound healing, we demonstrate that topical application of a small molecule inhibitor of galectin-3, GB1265: reduces (i) corneal angiogenesis, (ii) corneal fibrosis, (iii) infiltration of immune cells and (iv) expression of proinflammatory cytokine, IL-1β, in injured corneas. Four independent techniques (RNA-seq, NanoString, RT-qPCR, and Western blot analyses) all demonstrated that decrease in corneal opacity in the galectin-3 inhibitor-treated corneas is associated with a decrease in a number of genes and signaling pathways that are known to promote fibrosis. These findings all...
Source: Am J Pathol - December 30, 2023 Category: Pathology Authors: Zhiyi Cao Abdulraouf Ramadan Albert Tai Fredrik Zetterberg Noorjahan Panjwani Source Type: research
Corneal transplant rejection and alopecia areata universalis in a patient with severe atopic dermatitis on dupilumab
Actas Dermosifiliogr. 2023 Dec 28:S0001-7310(23)01003-7. doi: 10.1016/j.ad.2023.02.039. Online ahead of print.NO ABSTRACTPMID:38159837 | DOI:10.1016/j.ad.2023.02.039 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: T Lopez-Bernala M Mazaira Fern ándeza I Vargas-Machuca Salidoa B Araneguia Source Type: research
Corneal transplant rejection and alopecia areata universalis in a patient with severe atopic dermatitis on dupilumab
Actas Dermosifiliogr. 2023 Dec 28:S0001-7310(23)01003-7. doi: 10.1016/j.ad.2023.02.039. Online ahead of print.NO ABSTRACTPMID:38159837 | DOI:10.1016/j.ad.2023.02.039 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: T Lopez-Bernala M Mazaira Fern ándeza I Vargas-Machuca Salidoa B Araneguia Source Type: research
Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency
CONCLUSION: ASCs are a feasible and conservative therapy for treating bilateral LSCD. The therapeutic effect differs between etiologies and diminishes over time.PMID:38152876 | DOI:10.1080/02713683.2023.2297342 (Source: Cell Research)
Source: Cell Research - December 28, 2023 Category: Cytology Authors: Ana Boto de Los Bueis Cristina Vidal Arranz Almudena Del Hierro-Zarzuelo David D íaz Valle Rosal ía Méndez Fernández Mar ía Isabel Gabarrón Hermosilla Jos é Manuel Benítez Del Castillo Mariano Garc ía-Arranz Source Type: research
Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency
CONCLUSION: ASCs are a feasible and conservative therapy for treating bilateral LSCD. The therapeutic effect differs between etiologies and diminishes over time.PMID:38152876 | DOI:10.1080/02713683.2023.2297342 (Source: Current Eye Research)
Source: Current Eye Research - December 28, 2023 Category: Opthalmology Authors: Ana Boto de Los Bueis Cristina Vidal Arranz Almudena Del Hierro-Zarzuelo David D íaz Valle Rosal ía Méndez Fernández Mar ía Isabel Gabarrón Hermosilla Jos é Manuel Benítez Del Castillo Mariano Garc ía-Arranz Source Type: research
Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency
CONCLUSION: ASCs are a feasible and conservative therapy for treating bilateral LSCD. The therapeutic effect differs between etiologies and diminishes over time.PMID:38152876 | DOI:10.1080/02713683.2023.2297342 (Source: Cell Research)
Source: Cell Research - December 28, 2023 Category: Cytology Authors: Ana Boto de Los Bueis Cristina Vidal Arranz Almudena Del Hierro-Zarzuelo David D íaz Valle Rosal ía Méndez Fernández Mar ía Isabel Gabarrón Hermosilla Jos é Manuel Benítez Del Castillo Mariano Garc ía-Arranz Source Type: research
Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency
CONCLUSION: ASCs are a feasible and conservative therapy for treating bilateral LSCD. The therapeutic effect differs between etiologies and diminishes over time.PMID:38152876 | DOI:10.1080/02713683.2023.2297342 (Source: Current Eye Research)
Source: Current Eye Research - December 28, 2023 Category: Opthalmology Authors: Ana Boto de Los Bueis Cristina Vidal Arranz Almudena Del Hierro-Zarzuelo David D íaz Valle Rosal ía Méndez Fernández Mar ía Isabel Gabarrón Hermosilla Jos é Manuel Benítez Del Castillo Mariano Garc ía-Arranz Source Type: research
Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency
CONCLUSION: ASCs are a feasible and conservative therapy for treating bilateral LSCD. The therapeutic effect differs between etiologies and diminishes over time.PMID:38152876 | DOI:10.1080/02713683.2023.2297342 (Source: Current Eye Research)
Source: Current Eye Research - December 28, 2023 Category: Opthalmology Authors: Ana Boto de Los Bueis Cristina Vidal Arranz Almudena Del Hierro-Zarzuelo David D íaz Valle Rosal ía Méndez Fernández Mar ía Isabel Gabarrón Hermosilla Jos é Manuel Benítez Del Castillo Mariano Garc ía-Arranz Source Type: research
Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency
CONCLUSION: ASCs are a feasible and conservative therapy for treating bilateral LSCD. The therapeutic effect differs between etiologies and diminishes over time.PMID:38152876 | DOI:10.1080/02713683.2023.2297342 (Source: Current Eye Research)
Source: Current Eye Research - December 28, 2023 Category: Opthalmology Authors: Ana Boto de Los Bueis Cristina Vidal Arranz Almudena Del Hierro-Zarzuelo David D íaz Valle Rosal ía Méndez Fernández Mar ía Isabel Gabarrón Hermosilla Jos é Manuel Benítez Del Castillo Mariano Garc ía-Arranz Source Type: research
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Animal Models of Corneal Wound Healing
In this study, using mouse models of corneal wound healing, we demonstrate that topical application of a small molecule inhibitor of galectin-3, GB1265: reduces (i) corneal angiogenesis, (ii) corneal fibrosis, (iii) infiltration of immune cells and (iv) expression of proinflammatory cytokine, IL-1 β, in injured corneas. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 28, 2023 Category: Pathology Authors: Zhiyi Cao, Abdulraouf Ramadan, Albert Tai, Fredrik Zetterberg, Noorjahan Panjwani Tags: Regular Article Source Type: research
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Models of Corneal Wound Healing
In this study, topical application of a small-molecule inhibitor of galectin-3, GB1265, in mouse models of corneal wound healing, led to the reduction of the following in injured corneas: i) corneal angiogenesis; ii) corneal fibrosis; iii) infiltration of immune cells; and iv) expression of the proinflammatory cytokine IL-1β. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 28, 2023 Category: Pathology Authors: Zhiyi Cao, Abdulraouf Ramadan, Albert Tai, Fredrik Zetterberg, Noorjahan Panjwani Tags: Regular article Source Type: research
Characterization of cornea donors at a tissue center in the city of Medellin, Colombia
AbstractThe cornea transplant is considered the most frequently performed type of transplant in the world, with a demand that has been increasing in recent years. An observational descriptive study was conducted, focusing on the ocular tissue extracted from cadaveric donors from January 2019 to December 2021 at the Red Cross Eye Bank in Medellin, Colombia. This is the first epidemiological characterization of corneal donor tissues within the eye banks of our city, where high rates of violence-related deaths explain that tissue donors are mostly young individuals. This, in turn, results in excellent counts of endothelial ce...
Source: Cell and Tissue Banking - December 23, 2023 Category: Stem Cells Source Type: research
