Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Models of Corneal Wound Healing
In this study, topical application of a small-molecule inhibitor of galectin-3, GB1265, in mouse models of corneal wound healing, led to the reduction of the following in injured corneas: i) corneal angiogenesis; ii) corneal fibrosis; iii) infiltration of immune cells; and iv) expression of the proinflammatory cytokine IL-1β.
Source: American Journal of Pathology - Category: Pathology Authors: Zhiyi Cao, Abdulraouf Ramadan, Albert Tai, Fredrik Zetterberg, Noorjahan Panjwani Tags: Regular article Source Type: research