Strain and host-cell dependent role of type-1 fimbriae in the adherence phenotype of super-shed Escherichia coli O157:H7
Int J Med Microbiol. 2021 May 5;311(4):151511. doi: 10.1016/j.ijmm.2021.151511. Online ahead of print.ABSTRACTSuper-shed (SS) Escherichia coli O157 (E. coli O157) demonstrate a strong, aggregative, locus of enterocyte effacement (LEE)-independent adherence phenotype on bovine recto-anal junction squamous epithelial (RSE) cells, and harbor polymorphisms in non-LEE-adherence-related loci, including in the type 1 fimbriae operon. To elucidate the role of type 1 fimbriae in strain- and host-specific adherence, we evaluated the entire Fim operon (FimB-H) and its adhesion (FimH) deletion mutants in four E. coli O157 strains, SS1...
Source: International Journal of Medical Microbiology - May 11, 2021 Category: Microbiology Authors: Robab Katani Indira T Kudva Sreenidhi Srinivasan Judith B Stasko Megan Schilling Lingling Li Rebecca Cote Chitrita DebRoy Terrance M Arthur Evgeni V Sokurenko Vivek Kapur Source Type: research

Strain and host-cell dependent role of type-1 fimbriae in the adherence phenotype of super-shed Escherichia coli O157:H7
Int J Med Microbiol. 2021 May 5;311(4):151511. doi: 10.1016/j.ijmm.2021.151511. Online ahead of print.ABSTRACTSuper-shed (SS) Escherichia coli O157 (E. coli O157) demonstrate a strong, aggregative, locus of enterocyte effacement (LEE)-independent adherence phenotype on bovine recto-anal junction squamous epithelial (RSE) cells, and harbor polymorphisms in non-LEE-adherence-related loci, including in the type 1 fimbriae operon. To elucidate the role of type 1 fimbriae in strain- and host-specific adherence, we evaluated the entire Fim operon (FimB-H) and its adhesion (FimH) deletion mutants in four E. coli O157 strains, SS1...
Source: International Journal of Medical Microbiology - May 11, 2021 Category: Microbiology Authors: Robab Katani Indira T Kudva Sreenidhi Srinivasan Judith B Stasko Megan Schilling Lingling Li Rebecca Cote Chitrita DebRoy Terrance M Arthur Evgeni V Sokurenko Vivek Kapur Source Type: research

Strain and host-cell dependent role of type-1 fimbriae in the adherence phenotype of super-shed Escherichia coli O157:H7
Int J Med Microbiol. 2021 May 5;311(4):151511. doi: 10.1016/j.ijmm.2021.151511. Online ahead of print.ABSTRACTSuper-shed (SS) Escherichia coli O157 (E. coli O157) demonstrate a strong, aggregative, locus of enterocyte effacement (LEE)-independent adherence phenotype on bovine recto-anal junction squamous epithelial (RSE) cells, and harbor polymorphisms in non-LEE-adherence-related loci, including in the type 1 fimbriae operon. To elucidate the role of type 1 fimbriae in strain- and host-specific adherence, we evaluated the entire Fim operon (FimB-H) and its adhesion (FimH) deletion mutants in four E. coli O157 strains, SS1...
Source: International Journal of Medical Microbiology - May 11, 2021 Category: Microbiology Authors: Robab Katani Indira T Kudva Sreenidhi Srinivasan Judith B Stasko Megan Schilling Lingling Li Rebecca Cote Chitrita DebRoy Terrance M Arthur Evgeni V Sokurenko Vivek Kapur Source Type: research

Discovery of myricetin as an inhibitor against Streptococcus mutans and an anti-adhesion approach to biofilm formation
Int J Med Microbiol. 2021 May 5;311(4):151512. doi: 10.1016/j.ijmm.2021.151512. Online ahead of print.ABSTRACTStreptococcus mutans (S. mutans) are cariogenic microorganisms. Sortase A (SrtA) is a transpeptidase that attaches Pac to the cell surface. The biofilm formation of S. mutans is promoted by SrtA regulated Pac. Myricetin (Myr) has a variety of pharmacological properties, including inhibiting SrtA activity of Staphylococcus aureus. The purpose of this research was to investigate the inhibitory effect of Myr on SrtA of S. mutans and its subsequent influence on the biofilm formation. Here, Myr was discovered as a poten...
Source: International Journal of Medical Microbiology - May 10, 2021 Category: Microbiology Authors: Ping Hu Bibo Lv Kongxi Yang Zimin Lu Jingzhi Ma Source Type: research

Discovery of myricetin as an inhibitor against Streptococcus mutans and an anti-adhesion approach to biofilm formation
Int J Med Microbiol. 2021 May 5;311(4):151512. doi: 10.1016/j.ijmm.2021.151512. Online ahead of print.ABSTRACTStreptococcus mutans (S. mutans) are cariogenic microorganisms. Sortase A (SrtA) is a transpeptidase that attaches Pac to the cell surface. The biofilm formation of S. mutans is promoted by SrtA regulated Pac. Myricetin (Myr) has a variety of pharmacological properties, including inhibiting SrtA activity of Staphylococcus aureus. The purpose of this research was to investigate the inhibitory effect of Myr on SrtA of S. mutans and its subsequent influence on the biofilm formation. Here, Myr was discovered as a poten...
Source: International Journal of Medical Microbiology - May 10, 2021 Category: Microbiology Authors: Ping Hu Bibo Lv Kongxi Yang Zimin Lu Jingzhi Ma Source Type: research

Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing
CONCLUSIONS: Our data demonstrates the potential of amplicon nanopore sequencing using aqueous humor to enable rapid, sensitive and less invasive microbial diagnosis of endophthalmitis.PMID:33930723 | DOI:10.1016/j.ijmm.2021.151505 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 30, 2021 Category: Microbiology Authors: Kang Il Jun Baek-Lok Oh Narae Kim Joo Young Shin Jangsup Moon Source Type: research

Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing
CONCLUSIONS: Our data demonstrates the potential of amplicon nanopore sequencing using aqueous humor to enable rapid, sensitive and less invasive microbial diagnosis of endophthalmitis.PMID:33930723 | DOI:10.1016/j.ijmm.2021.151505 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 30, 2021 Category: Microbiology Authors: Kang Il Jun Baek-Lok Oh Narae Kim Joo Young Shin Jangsup Moon Source Type: research

Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing
CONCLUSIONS: Our data demonstrates the potential of amplicon nanopore sequencing using aqueous humor to enable rapid, sensitive and less invasive microbial diagnosis of endophthalmitis.PMID:33930723 | DOI:10.1016/j.ijmm.2021.151505 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 30, 2021 Category: Microbiology Authors: Kang Il Jun Baek-Lok Oh Narae Kim Joo Young Shin Jangsup Moon Source Type: research

Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing
CONCLUSIONS: Our data demonstrates the potential of amplicon nanopore sequencing using aqueous humor to enable rapid, sensitive and less invasive microbial diagnosis of endophthalmitis.PMID:33930723 | DOI:10.1016/j.ijmm.2021.151505 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 30, 2021 Category: Microbiology Authors: Kang Il Jun Baek-Lok Oh Narae Kim Joo Young Shin Jangsup Moon Source Type: research

Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing
CONCLUSIONS: Our data demonstrates the potential of amplicon nanopore sequencing using aqueous humor to enable rapid, sensitive and less invasive microbial diagnosis of endophthalmitis.PMID:33930723 | DOI:10.1016/j.ijmm.2021.151505 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 30, 2021 Category: Microbiology Authors: Kang Il Jun Baek-Lok Oh Narae Kim Joo Young Shin Jangsup Moon Source Type: research

Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing
CONCLUSIONS: Our data demonstrates the potential of amplicon nanopore sequencing using aqueous humor to enable rapid, sensitive and less invasive microbial diagnosis of endophthalmitis.PMID:33930723 | DOI:10.1016/j.ijmm.2021.151505 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 30, 2021 Category: Microbiology Authors: Kang Il Jun Baek-Lok Oh Narae Kim Joo Young Shin Jangsup Moon Source Type: research

Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing
CONCLUSIONS: Our data demonstrates the potential of amplicon nanopore sequencing using aqueous humor to enable rapid, sensitive and less invasive microbial diagnosis of endophthalmitis.PMID:33930723 | DOI:10.1016/j.ijmm.2021.151505 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 30, 2021 Category: Microbiology Authors: Kang Il Jun Baek-Lok Oh Narae Kim Joo Young Shin Jangsup Moon Source Type: research

Microbial diagnosis of endophthalmitis using nanopore amplicon sequencing
CONCLUSIONS: Our data demonstrates the potential of amplicon nanopore sequencing using aqueous humor to enable rapid, sensitive and less invasive microbial diagnosis of endophthalmitis.PMID:33930723 | DOI:10.1016/j.ijmm.2021.151505 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 30, 2021 Category: Microbiology Authors: Kang Il Jun Baek-Lok Oh Narae Kim Joo Young Shin Jangsup Moon Source Type: research

Molecular epidemiology and antimicrobial resistance of Clostridioides difficile in Germany, 2014-2019
In conclusion these data demonstrate that RT027 is a driver for rifampicin and metronidazole resistance, underlining the importance of continuous surveillance efforts.PMID:33915347 | DOI:10.1016/j.ijmm.2021.151507 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 29, 2021 Category: Microbiology Authors: Ahmed Mohamed Mostafa Abdrabou Zia Ul Habib Bajwa Alexander Halfmann Alexander Mellmann Anna Nimmesgern Lena Margardt Markus Bischoff Lutz von M üller Barbara G ärtner Fabian K Berger Source Type: research

Molecular epidemiology and antimicrobial resistance of Clostridioides difficile in Germany, 2014-2019
In conclusion these data demonstrate that RT027 is a driver for rifampicin and metronidazole resistance, underlining the importance of continuous surveillance efforts.PMID:33915347 | DOI:10.1016/j.ijmm.2021.151507 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 29, 2021 Category: Microbiology Authors: Ahmed Mohamed Mostafa Abdrabou Zia Ul Habib Bajwa Alexander Halfmann Alexander Mellmann Anna Nimmesgern Lena Margardt Markus Bischoff Lutz von M üller Barbara G ärtner Fabian K Berger Source Type: research

First description of the katG gene deletion in a Mycobacterium tuberculosis clinical isolate and its impact on the mycobacterial fitness
Int J Med Microbiol. 2021 Apr 19;311(4):151506. doi: 10.1016/j.ijmm.2021.151506. Online ahead of print.ABSTRACTIsoniazid (INH) is the cornerstone of the anti-tuberculosis regimens and emergence of Mycobacterium tuberculosis (Mtb) resistant strains is a major threat to our ability to control tuberculosis (TB) at global level. Mutations in the gene coding the catalase KatG confer resistance to high level of INH. In this paper, we describe for the first time a complete deletion of the genomic region containing the katG gene in an Mtb clinical strain isolated in Italy in a patient with HIV infection that previously completed I...
Source: International Journal of Medical Microbiology - April 27, 2021 Category: Microbiology Authors: Flavio De Maio Antonella Cingolani Delia Mercedes Bianco Alessandro Salustri Ivana Palucci Maurizio Sanguinetti Giovanni Delogu Michela Sali Source Type: research

Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii
Int J Med Microbiol. 2021 Apr 19;311(4):151504. doi: 10.1016/j.ijmm.2021.151504. Online ahead of print.ABSTRACTThe metabolism of Legionella pneumophila strain Paris was elucidated during different time intervals of growth within its natural host Acanthamoeba castellanii. For this purpose, the amoebae were supplied after bacterial infection (t =0 h) with 11 mM [U-13C6]glucose or 3 mM [U-13C3]serine, respectively, during 0-17 h, 17-25 h, or 25-27 h of incubation. At the end of these time intervals, bacterial and amoebal fractions were separated. Each of these fractions was hydrolyzed under acidic conditions. 13C-Enrichments ...
Source: International Journal of Medical Microbiology - April 27, 2021 Category: Microbiology Authors: Mareike Kunze Thomas Steiner Fan Chen Claudia Huber Kerstin Rydzewski Maren St ämmler Klaus Heuner Wolfgang Eisenreich Source Type: research

First description of the katG gene deletion in a Mycobacterium tuberculosis clinical isolate and its impact on the mycobacterial fitness
Int J Med Microbiol. 2021 Apr 19;311(4):151506. doi: 10.1016/j.ijmm.2021.151506. Online ahead of print.ABSTRACTIsoniazid (INH) is the cornerstone of the anti-tuberculosis regimens and emergence of Mycobacterium tuberculosis (Mtb) resistant strains is a major threat to our ability to control tuberculosis (TB) at global level. Mutations in the gene coding the catalase KatG confer resistance to high level of INH. In this paper, we describe for the first time a complete deletion of the genomic region containing the katG gene in an Mtb clinical strain isolated in Italy in a patient with HIV infection that previously completed I...
Source: International Journal of Medical Microbiology - April 27, 2021 Category: Microbiology Authors: Flavio De Maio Antonella Cingolani Delia Mercedes Bianco Alessandro Salustri Ivana Palucci Maurizio Sanguinetti Giovanni Delogu Michela Sali Source Type: research

Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii
Int J Med Microbiol. 2021 Apr 19;311(4):151504. doi: 10.1016/j.ijmm.2021.151504. Online ahead of print.ABSTRACTThe metabolism of Legionella pneumophila strain Paris was elucidated during different time intervals of growth within its natural host Acanthamoeba castellanii. For this purpose, the amoebae were supplied after bacterial infection (t =0 h) with 11 mM [U-13C6]glucose or 3 mM [U-13C3]serine, respectively, during 0-17 h, 17-25 h, or 25-27 h of incubation. At the end of these time intervals, bacterial and amoebal fractions were separated. Each of these fractions was hydrolyzed under acidic conditions. 13C-Enrichments ...
Source: International Journal of Medical Microbiology - April 27, 2021 Category: Microbiology Authors: Mareike Kunze Thomas Steiner Fan Chen Claudia Huber Kerstin Rydzewski Maren St ämmler Klaus Heuner Wolfgang Eisenreich Source Type: research

Prevalence, genomic characteristics, and transmission dynamics of mcr-1-positive Salmonella enterica Typhimurium from patients with infectious diarrhea
CONCLUSIONS: The prevalence of mcr-1-positive Salmonella among different sources was low. Clonal transmission could not be the main reason for the expansion of mcr-1-positive Salmonella, but be attributed to the horizontal transfer of IncHI2-pST3 plasmid. Continuous surveillance on Salmonella should be performed to investigate the response of colistin banning in food-producing animals by mcr-1-positive Salmonella populations.PMID:33866091 | DOI:10.1016/j.ijmm.2021.151501 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 18, 2021 Category: Microbiology Authors: Cong Shen Furong Ma Suiyan Deng Lan-Lan Zhong Mohamed Abd El-Gawad El-Sayed Ahmed Guili Zhang Bin Yan Min Dai Fan Yang Yong Xia Guo-Bao Tian Source Type: research

Prevalence, genomic characteristics, and transmission dynamics of mcr-1-positive Salmonella enterica Typhimurium from patients with infectious diarrhea
CONCLUSIONS: The prevalence of mcr-1-positive Salmonella among different sources was low. Clonal transmission could not be the main reason for the expansion of mcr-1-positive Salmonella, but be attributed to the horizontal transfer of IncHI2-pST3 plasmid. Continuous surveillance on Salmonella should be performed to investigate the response of colistin banning in food-producing animals by mcr-1-positive Salmonella populations.PMID:33866091 | DOI:10.1016/j.ijmm.2021.151501 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 18, 2021 Category: Microbiology Authors: Cong Shen Furong Ma Suiyan Deng Lan-Lan Zhong Mohamed Abd El-Gawad El-Sayed Ahmed Guili Zhang Bin Yan Min Dai Fan Yang Yong Xia Guo-Bao Tian Source Type: research

Prevalence, genomic characteristics, and transmission dynamics of mcr-1-positive Salmonella enterica Typhimurium from patients with infectious diarrhea
CONCLUSIONS: The prevalence of mcr-1-positive Salmonella among different sources was low. Clonal transmission could not be the main reason for the expansion of mcr-1-positive Salmonella, but be attributed to the horizontal transfer of IncHI2-pST3 plasmid. Continuous surveillance on Salmonella should be performed to investigate the response of colistin banning in food-producing animals by mcr-1-positive Salmonella populations.PMID:33866091 | DOI:10.1016/j.ijmm.2021.151501 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 18, 2021 Category: Microbiology Authors: Cong Shen Furong Ma Suiyan Deng Lan-Lan Zhong Mohamed Abd El-Gawad El-Sayed Ahmed Guili Zhang Bin Yan Min Dai Fan Yang Yong Xia Guo-Bao Tian Source Type: research

Prevalence, genomic characteristics, and transmission dynamics of mcr-1-positive Salmonella enterica Typhimurium from patients with infectious diarrhea
CONCLUSIONS: The prevalence of mcr-1-positive Salmonella among different sources was low. Clonal transmission could not be the main reason for the expansion of mcr-1-positive Salmonella, but be attributed to the horizontal transfer of IncHI2-pST3 plasmid. Continuous surveillance on Salmonella should be performed to investigate the response of colistin banning in food-producing animals by mcr-1-positive Salmonella populations.PMID:33866091 | DOI:10.1016/j.ijmm.2021.151501 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 18, 2021 Category: Microbiology Authors: Cong Shen Furong Ma Suiyan Deng Lan-Lan Zhong Mohamed Abd El-Gawad El-Sayed Ahmed Guili Zhang Bin Yan Min Dai Fan Yang Yong Xia Guo-Bao Tian Source Type: research

Prevalence, genomic characteristics, and transmission dynamics of mcr-1-positive Salmonella enterica Typhimurium from patients with infectious diarrhea
CONCLUSIONS: The prevalence of mcr-1-positive Salmonella among different sources was low. Clonal transmission could not be the main reason for the expansion of mcr-1-positive Salmonella, but be attributed to the horizontal transfer of IncHI2-pST3 plasmid. Continuous surveillance on Salmonella should be performed to investigate the response of colistin banning in food-producing animals by mcr-1-positive Salmonella populations.PMID:33866091 | DOI:10.1016/j.ijmm.2021.151501 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 18, 2021 Category: Microbiology Authors: Cong Shen Furong Ma Suiyan Deng Lan-Lan Zhong Mohamed Abd El-Gawad El-Sayed Ahmed Guili Zhang Bin Yan Min Dai Fan Yang Yong Xia Guo-Bao Tian Source Type: research

Prevalence, genomic characteristics, and transmission dynamics of mcr-1-positive Salmonella enterica Typhimurium from patients with infectious diarrhea
CONCLUSIONS: The prevalence of mcr-1-positive Salmonella among different sources was low. Clonal transmission could not be the main reason for the expansion of mcr-1-positive Salmonella, but be attributed to the horizontal transfer of IncHI2-pST3 plasmid. Continuous surveillance on Salmonella should be performed to investigate the response of colistin banning in food-producing animals by mcr-1-positive Salmonella populations.PMID:33866091 | DOI:10.1016/j.ijmm.2021.151501 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 18, 2021 Category: Microbiology Authors: Cong Shen Furong Ma Suiyan Deng Lan-Lan Zhong Mohamed Abd El-Gawad El-Sayed Ahmed Guili Zhang Bin Yan Min Dai Fan Yang Yong Xia Guo-Bao Tian Source Type: research

Prevalence, genomic characteristics, and transmission dynamics of mcr-1-positive Salmonella enterica Typhimurium from patients with infectious diarrhea
CONCLUSIONS: The prevalence of mcr-1-positive Salmonella among different sources was low. Clonal transmission could not be the main reason for the expansion of mcr-1-positive Salmonella, but be attributed to the horizontal transfer of IncHI2-pST3 plasmid. Continuous surveillance on Salmonella should be performed to investigate the response of colistin banning in food-producing animals by mcr-1-positive Salmonella populations.PMID:33866091 | DOI:10.1016/j.ijmm.2021.151501 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 18, 2021 Category: Microbiology Authors: Cong Shen Furong Ma Suiyan Deng Lan-Lan Zhong Mohamed Abd El-Gawad El-Sayed Ahmed Guili Zhang Bin Yan Min Dai Fan Yang Yong Xia Guo-Bao Tian Source Type: research

Regulation of the gut barrier by carbohydrates from diet - Underlying mechanisms and possible clinical implications
Int J Med Microbiol. 2021 Mar 26;311(4):151499. doi: 10.1016/j.ijmm.2021.151499. Online ahead of print.ABSTRACTThe gut barrier has been recognized as being of relevance in the pathogenesis of multiple different diseases ranging from inflammatory bowel disease, irritable bowel syndrome, inflammatory joint disease, fatty liver disease, and cardiometabolic disorders. The regulation of the gut barrier is, however, poorly understood. Especially, the role of food components such as sugars and complex carbohydrates has been discussed controversially in this respect. More recently, the intestinal microbiota has been proposed as an...
Source: International Journal of Medical Microbiology - April 17, 2021 Category: Microbiology Authors: Stephan C Bischoff Valentina Kaden-Volynets Louisa Filipe Rosa Daria Guseva Benjamin Seethaler Source Type: research

Regulation of the gut barrier by carbohydrates from diet - Underlying mechanisms and possible clinical implications
Int J Med Microbiol. 2021 Mar 26;311(4):151499. doi: 10.1016/j.ijmm.2021.151499. Online ahead of print.ABSTRACTThe gut barrier has been recognized as being of relevance in the pathogenesis of multiple different diseases ranging from inflammatory bowel disease, irritable bowel syndrome, inflammatory joint disease, fatty liver disease, and cardiometabolic disorders. The regulation of the gut barrier is, however, poorly understood. Especially, the role of food components such as sugars and complex carbohydrates has been discussed controversially in this respect. More recently, the intestinal microbiota has been proposed as an...
Source: International Journal of Medical Microbiology - April 17, 2021 Category: Microbiology Authors: Stephan C Bischoff Valentina Kaden-Volynets Louisa Filipe Rosa Daria Guseva Benjamin Seethaler Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Microbiota profiling in aging-associated inflammation and liver degeneration
CONCLUSION: Despite no consistent and robust changes of microbiota composition in small and/or large intestine of mice of different age were observed, our data suggest that alterations of markers of intestinal barrier function in small intestine are associated with an induction of several Tlrs and beginning hepatic inflammation in older mice and increase with age.PMID:33813306 | DOI:10.1016/j.ijmm.2021.151500 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 4, 2021 Category: Microbiology Authors: Anja Baumann Ang élica Hernández-Arriaga Annette Brandt Victor S ánchez Anika Nier Finn Jung Richard Kehm Annika H öhn Tilman Grune Christiane Frahm Otto Wilhelm Witte Am élia Camarinha-Silva Ina Bergheim Source Type: research

Early life host regulation of the mammalian enteric microbiota composition
Int J Med Microbiol. 2021 Mar 19;311(3):151498. doi: 10.1016/j.ijmm.2021.151498. Online ahead of print.ABSTRACTThe enteric microbiota exerts a major influence on the host. It promotes food degradation, nutrient absorption, immune maturation and protects from infection with pathogenic microorganisms. However, certain compositional alterations also enhance the risk to develop metabolic, inflammatory and immune-mediated diseases. This suggests that the enteric microbiota is subject to strong evolutionary pressure. Here, we hypothesize that endogenous, genetically determined mechanisms exist that shape and optimize the enteric...
Source: International Journal of Medical Microbiology - March 28, 2021 Category: Microbiology Authors: Niels van Best Mathias W Hornef Source Type: research

Early life host regulation of the mammalian enteric microbiota composition
Int J Med Microbiol. 2021 Mar 19;311(3):151498. doi: 10.1016/j.ijmm.2021.151498. Online ahead of print.ABSTRACTThe enteric microbiota exerts a major influence on the host. It promotes food degradation, nutrient absorption, immune maturation and protects from infection with pathogenic microorganisms. However, certain compositional alterations also enhance the risk to develop metabolic, inflammatory and immune-mediated diseases. This suggests that the enteric microbiota is subject to strong evolutionary pressure. Here, we hypothesize that endogenous, genetically determined mechanisms exist that shape and optimize the enteric...
Source: International Journal of Medical Microbiology - March 28, 2021 Category: Microbiology Authors: Niels van Best Mathias W Hornef Source Type: research

Early life host regulation of the mammalian enteric microbiota composition
Int J Med Microbiol. 2021 Mar 19;311(3):151498. doi: 10.1016/j.ijmm.2021.151498. Online ahead of print.ABSTRACTThe enteric microbiota exerts a major influence on the host. It promotes food degradation, nutrient absorption, immune maturation and protects from infection with pathogenic microorganisms. However, certain compositional alterations also enhance the risk to develop metabolic, inflammatory and immune-mediated diseases. This suggests that the enteric microbiota is subject to strong evolutionary pressure. Here, we hypothesize that endogenous, genetically determined mechanisms exist that shape and optimize the enteric...
Source: International Journal of Medical Microbiology - March 28, 2021 Category: Microbiology Authors: Niels van Best Mathias W Hornef Source Type: research

Early life host regulation of the mammalian enteric microbiota composition
Int J Med Microbiol. 2021 Mar 19;311(3):151498. doi: 10.1016/j.ijmm.2021.151498. Online ahead of print.ABSTRACTThe enteric microbiota exerts a major influence on the host. It promotes food degradation, nutrient absorption, immune maturation and protects from infection with pathogenic microorganisms. However, certain compositional alterations also enhance the risk to develop metabolic, inflammatory and immune-mediated diseases. This suggests that the enteric microbiota is subject to strong evolutionary pressure. Here, we hypothesize that endogenous, genetically determined mechanisms exist that shape and optimize the enteric...
Source: International Journal of Medical Microbiology - March 28, 2021 Category: Microbiology Authors: Niels van Best Mathias W Hornef Source Type: research

Early life host regulation of the mammalian enteric microbiota composition
Int J Med Microbiol. 2021 Mar 19;311(3):151498. doi: 10.1016/j.ijmm.2021.151498. Online ahead of print.ABSTRACTThe enteric microbiota exerts a major influence on the host. It promotes food degradation, nutrient absorption, immune maturation and protects from infection with pathogenic microorganisms. However, certain compositional alterations also enhance the risk to develop metabolic, inflammatory and immune-mediated diseases. This suggests that the enteric microbiota is subject to strong evolutionary pressure. Here, we hypothesize that endogenous, genetically determined mechanisms exist that shape and optimize the enteric...
Source: International Journal of Medical Microbiology - March 28, 2021 Category: Microbiology Authors: Niels van Best Mathias W Hornef Source Type: research

Early life host regulation of the mammalian enteric microbiota composition
Int J Med Microbiol. 2021 Mar 19;311(3):151498. doi: 10.1016/j.ijmm.2021.151498. Online ahead of print.ABSTRACTThe enteric microbiota exerts a major influence on the host. It promotes food degradation, nutrient absorption, immune maturation and protects from infection with pathogenic microorganisms. However, certain compositional alterations also enhance the risk to develop metabolic, inflammatory and immune-mediated diseases. This suggests that the enteric microbiota is subject to strong evolutionary pressure. Here, we hypothesize that endogenous, genetically determined mechanisms exist that shape and optimize the enteric...
Source: International Journal of Medical Microbiology - March 28, 2021 Category: Microbiology Authors: Niels van Best Mathias W Hornef Source Type: research

CD101 as an indicator molecule for pathological changes at the interface of host-microbiota interactions
Int J Med Microbiol. 2021 Mar 20;311(4):151497. doi: 10.1016/j.ijmm.2021.151497. Online ahead of print.ABSTRACTIntestinal microbiota signal to local and distant tissues in the body. Thus, they also regulate biochemical, metabolic and immunological processes in the gut and in the pancreas. Vice versa, eating habits or the immune system of the host shape the intraluminal microbiota. Disruptions of these versatile host-microbiota interactions underlie the pathogenesis of complex immune-mediated disorders such as inflammatory bowel disease (IBD) or type 1 diabetes (T1D). Consequently, dysbiosis and increased intestinal permeab...
Source: International Journal of Medical Microbiology - March 27, 2021 Category: Microbiology Authors: Marius Wrage Johanna Kaltwasser Sonja Menge Jochen Mattner Source Type: research

CD101 as an indicator molecule for pathological changes at the interface of host-microbiota interactions
Int J Med Microbiol. 2021 Mar 20;311(4):151497. doi: 10.1016/j.ijmm.2021.151497. Online ahead of print.ABSTRACTIntestinal microbiota signal to local and distant tissues in the body. Thus, they also regulate biochemical, metabolic and immunological processes in the gut and in the pancreas. Vice versa, eating habits or the immune system of the host shape the intraluminal microbiota. Disruptions of these versatile host-microbiota interactions underlie the pathogenesis of complex immune-mediated disorders such as inflammatory bowel disease (IBD) or type 1 diabetes (T1D). Consequently, dysbiosis and increased intestinal permeab...
Source: International Journal of Medical Microbiology - March 27, 2021 Category: Microbiology Authors: Marius Wrage Johanna Kaltwasser Sonja Menge Jochen Mattner Source Type: research

Establishing causality in Salmonella-microbiota-host interaction: The use of gnotobiotic mouse models and synthetic microbial communities
Int J Med Microbiol. 2021 Mar 2;311(3):151484. doi: 10.1016/j.ijmm.2021.151484. Online ahead of print.ABSTRACTColonization resistance (CR), the ability to block infections by potentially harmful microbes, is a fundamental function of host-associated microbial communities and highly conserved between animals and humans. Environmental factors such as antibiotics and diet can disturb microbial community composition and thereby predispose to opportunistic infections. The most prominent is Clostridioides difficile, the causative agent of diarrhea and pseudomembranous colitis. In addition, the risk to succumb to infections with ...
Source: International Journal of Medical Microbiology - March 23, 2021 Category: Microbiology Authors: B ärbel Stecher Source Type: research

Molecular characterization and antimicrobial resistance of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2013 to 2018
In this study, we genotyped the cell-surface M virulence protein gene (emm) from 621 GAS isolates obtained from patients with STSS in Japan in 2013-2018 and performed antimicrobial susceptibility testing using the broth microdilution method. The predominant emm type was found to be 1, followed by 89, 12, and 3, which were identified in more than 70 % of STSS isolates. The proportions of emm3 and emm89 increased from 2.4 % and 12.0 %, respectively, during 2010-2012 to 5.6 % and 23.3 % during 2013-2018. In contrast, the proportion of emm1 decreased from 60.6 % to 39.3 % during the same two periods. Some emm types showed incr...
Source: International Journal of Medical Microbiology - March 23, 2021 Category: Microbiology Authors: Tadayoshi Ikebe Rumi Okuno Yoshiko Kanda Mari Sasaki Takahiro Yamaguchi Hitoshi Otsuka Yu Kazawa Miyuki Suzuki Hitomi Ohya Kaoru Uchida Makoto Ohnishi Working Group for Beta-Hemolytic Streptococci in Japan Source Type: research

Establishing causality in Salmonella-microbiota-host interaction: The use of gnotobiotic mouse models and synthetic microbial communities
Int J Med Microbiol. 2021 Mar 2;311(3):151484. doi: 10.1016/j.ijmm.2021.151484. Online ahead of print.ABSTRACTColonization resistance (CR), the ability to block infections by potentially harmful microbes, is a fundamental function of host-associated microbial communities and highly conserved between animals and humans. Environmental factors such as antibiotics and diet can disturb microbial community composition and thereby predispose to opportunistic infections. The most prominent is Clostridioides difficile, the causative agent of diarrhea and pseudomembranous colitis. In addition, the risk to succumb to infections with ...
Source: International Journal of Medical Microbiology - March 23, 2021 Category: Microbiology Authors: B ärbel Stecher Source Type: research

Molecular characterization and antimicrobial resistance of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2013 to 2018
In this study, we genotyped the cell-surface M virulence protein gene (emm) from 621 GAS isolates obtained from patients with STSS in Japan in 2013-2018 and performed antimicrobial susceptibility testing using the broth microdilution method. The predominant emm type was found to be 1, followed by 89, 12, and 3, which were identified in more than 70 % of STSS isolates. The proportions of emm3 and emm89 increased from 2.4 % and 12.0 %, respectively, during 2010-2012 to 5.6 % and 23.3 % during 2013-2018. In contrast, the proportion of emm1 decreased from 60.6 % to 39.3 % during the same two periods. Some emm types showed incr...
Source: International Journal of Medical Microbiology - March 23, 2021 Category: Microbiology Authors: Tadayoshi Ikebe Rumi Okuno Yoshiko Kanda Mari Sasaki Takahiro Yamaguchi Hitoshi Otsuka Yu Kazawa Miyuki Suzuki Hitomi Ohya Kaoru Uchida Makoto Ohnishi Working Group for Beta-Hemolytic Streptococci in Japan Source Type: research