Heat shock protein 70 is involved in polaprezinc driven cell protection against Helicobacter pylori-induced injury
The objective of this study was to determine the protective effects of PZ on human gastric epithelial cells (GES-1) against H. pylori-induced damage, while also examining heat shock protein 70 (HSP70) as a potential underlying factor in this protection. Our findings revealed that PZ exerted bactericidal effects against H. pylori strains. We also observed that PZ mitigated the H. pylori-induced damage to GES-1 cells by increasing cell viability, reducing LDH release, and decreasing the secretion of pro-inflammatory factors such as MCP-1 and IL-6. Co-culturing PZ with GES-1 cells significantly up-regulated the GES-1 HSP70 ex...
Source: International Journal of Medical Microbiology - June 7, 2023 Category: Microbiology Authors: Fansen Meng Siying Zhu Meiliang Gong Hongjin Tao Weihua Wang Gangshi Wang Source Type: research

Heat shock protein 70 is involved in polaprezinc driven cell protection against Helicobacter pylori-induced injury
The objective of this study was to determine the protective effects of PZ on human gastric epithelial cells (GES-1) against H. pylori-induced damage, while also examining heat shock protein 70 (HSP70) as a potential underlying factor in this protection. Our findings revealed that PZ exerted bactericidal effects against H. pylori strains. We also observed that PZ mitigated the H. pylori-induced damage to GES-1 cells by increasing cell viability, reducing LDH release, and decreasing the secretion of pro-inflammatory factors such as MCP-1 and IL-6. Co-culturing PZ with GES-1 cells significantly up-regulated the GES-1 HSP70 ex...
Source: International Journal of Medical Microbiology - June 7, 2023 Category: Microbiology Authors: Fansen Meng Siying Zhu Meiliang Gong Hongjin Tao Weihua Wang Gangshi Wang Source Type: research

Heat shock protein 70 is involved in polaprezinc driven cell protection against Helicobacter pylori-induced injury
The objective of this study was to determine the protective effects of PZ on human gastric epithelial cells (GES-1) against H. pylori-induced damage, while also examining heat shock protein 70 (HSP70) as a potential underlying factor in this protection. Our findings revealed that PZ exerted bactericidal effects against H. pylori strains. We also observed that PZ mitigated the H. pylori-induced damage to GES-1 cells by increasing cell viability, reducing LDH release, and decreasing the secretion of pro-inflammatory factors such as MCP-1 and IL-6. Co-culturing PZ with GES-1 cells significantly up-regulated the GES-1 HSP70 ex...
Source: International Journal of Medical Microbiology - June 7, 2023 Category: Microbiology Authors: Fansen Meng Siying Zhu Meiliang Gong Hongjin Tao Weihua Wang Gangshi Wang Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research

Preclinical evaluation of 2-[ < sup > 18 < /sup > F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection
Int J Med Microbiol. 2023 May 16;313(3):151581. doi: 10.1016/j.ijmm.2023.151581. Online ahead of print.ABSTRACTFluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study wa...
Source: International Journal of Medical Microbiology - May 20, 2023 Category: Microbiology Authors: Lisanne M Braams J ürgen W A Sijbesma Hendrikus H Boersma Jan Maarten van Dijl Philip H Elsinga Andor W J M Glaudemans Riemer H J A Slart Marleen van Oosten Source Type: research