Frequency of detection of Chlamydophila pneumoniae using bronchoalveolar lavage fluid in patients with community-onset pneumonia
Conclusions The results of the present study revealed that C. pneumoniae might be a minor causative agent of community-onset pneumonia according to an evaluation of specimens obtained from the lower respiratory tract. (Source: Respiratory Investigation)
Source: Respiratory Investigation - September 23, 2017 Category: Respiratory Medicine Source Type: research
Interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line
AbstractChlamydia trachomatis (CT) and theChlamydophila species (CS)Chlamydophila pneumoniae (CPn), andChlamydophila psittaci (CPs) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (SLE). The aim of the present study was therefore to identify cellular protein interaction partners with antisera to CT ( α-CT) or CS (α-CS) and to identify functional consequences of such interaction in vitro. As detected with a commercial first trimester human prenatal brain multiprotein array (hEXselect, Engine, Germany), the most frequent inter...
Source: Immunologic Research - September 14, 2017 Category: Allergy & Immunology Source Type: research
Atypical bacterial etiology of acute respiratory infections and clinical characterizations among Iranian children.
Authors: Halaji M, Hashempour T, Pouladfar GR, Ghasabi F, Khashei R
Abstract
Acute respiratory infections (ARIs) in children younger than 5 years of age are one of the leading causes of morbidity and mortality, particularly in developing countries. Mycoplasma pneumoniae and Chlamydophila pneumoniae are prevalent causative agents of ARIs, worldwide. We sought M. pneumoniae and C. pneumoniae in respiratory samples from Iranian children with ARIs. From November 2014 to April 2015, respiratory samples of 150 children aged 1 month to 15 years old were screened for presence of M. pneumoniae and C. pneumoniae. ...
Source: Cellular and Molecular Biology - September 9, 2017 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
The effect of infectious dose on humoral and cellular immune responses in < i > Chlamydophila caviae < /i > primary ocular infection
by Ana Filipovic, Ehsan Ghasemian, Aleksandra Inic-Kanada, Ivana Lukic, Elisabeth Stein, Emilija Marinkovic, Radmila Djokic, Dejana Kosanovic, Nadine Schuerer, Hadeel Chalabi, Sandra Belij-Rammerstorfer, Marijana Stojanovic, Talin Barisani-Asenbauer
Following infection, the balance between protective immunity and immunopathology often depends on the initial infectious load. Several studies have investigated the effect of infectious dose; however, the mechanism by which infectious dose affects disease outcomes and the development of a protecti ve immune response is not known. The aim of this study was to investigate how th...
Source: PLoS One - July 5, 2017 Category: Biomedical Science Authors: Ana Filipovic Source Type: research
Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point
Community-acquired pneumonia (CAP) treatment guidelines from the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) recommend treatment for atypical pathogens (Mycoplasma pneumoniae, Chlamydophila pneumoniae and Legionella pneumophila) with a macrolide (azithromycin, clarithromycin or erythromycin), doxycycline or a fluoroquinolone [1]. Variable reduction in mortality has been shown using empirical therapy for CAP with the addition of atypical pathogen coverage in randomized controlled trials [2 –4] and observational studies [5]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - June 6, 2017 Category: Drugs & Pharmacology Authors: Thomas M. File, Paul B. Eckburg, George H. Talbot, Lily Llorens, H. David Friedland Tags: Short Communication Source Type: research
Severe acute asthma caused by Chlamydophila pneumoniae infection
Asthma exacerbation is associated with respiratory infections, including those by viruses and atypical bacteria. We herein report a case of severe acute asthma in an adult caused by Chlamydophila pneumoniae (C. pneumoniae) infection. A 39‐year‐old woman without a history of asthma reported to the emergency department with progressive worsening of cough, shortness of breath, and wheezing with low oxygen saturation. A computed tomography (CT) scan revealed patchy ground‐glass opacity and bronchial wall thickening. She was treated with systemic corticosteroids, inhaled short‐acting β2 agonists, aminophylline, doripen...
Source: Respirology Case Reports - May 28, 2017 Category: Respiratory Medicine Authors: Yoshinari Endo, Toshihiro Shirai, Mika Saigusa, Eisuke Mochizuki Tags: Case Report Source Type: research
Testing scheme to help vets investigate ovine abortion
Ceva Animal Health has launched Assure Ewe, a subsidised blood testing scheme to help sheep vets identify the cause of abortion on-farm. The scheme is available to all flocks of 50 or more breeding ewes whether or not there has been evidence of abortion. The company describes Assure Ewe as a user-friendly, simple scheme and says it will help facilitate conversations between vets and farmers while providing useful testing information to vets. The scheme requires vets to collect blood samples from six ewes in a flock and supply their own details and those of the farm. Once the results are available, Ceva will share informati...
Source: Veterinary Record - May 26, 2017 Category: Veterinary Research Tags: Products and Services Source Type: research
European Chlamydia abortus livestock isolate genomes reveal unusual stability and limited diversity, reflected in geographical signatures
Chlamydia abortus (formerly Chlamydophila abortus) is an economically important livestock pathogen, causing ovine enzootic abortion (OEA), and can also cause zoonotic infections in hum... (Source: BMC Genomics)
Source: BMC Genomics - May 4, 2017 Category: Genetics & Stem Cells Authors: H. M. B. Seth-Smith, Leonor S ánchez Busó, M. Livingstone, M. Sait, S. R. Harris, K. D. Aitchison, Evangelia Vretou, V. I. Siarkou, K. Laroucau, K. Sachse, D. Longbottom and N. R. Thomson Source Type: research
The relationship of Chlamydophila pneumoniae with schizophrenia: The role of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in this relationship.
In conclusion, we suggest that NT-3 levels during persistent C. pneumoniae infection may play a role in this relationship.
PMID: 28256360 [PubMed - as supplied by publisher] (Source: Revista Argentina de Microbiologia)
Source: Revista Argentina de Microbiologia - March 5, 2017 Category: Microbiology Tags: Rev Argent Microbiol Source Type: research
Occurrence of Chlamydophila felis, feline herpesvirus 1 and calcivirus in domestic cats of Iran.
CONCLUSION: These results confirm the presence and show the prevalence of three major pathogens associated with upper respiratory tract disease for the first time in Iran.
PMID: 28149490 [PubMed - in process] (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - February 5, 2017 Category: Microbiology Tags: Iran J Microbiol Source Type: research
The Role of NOD-like Receptors in Pulmonary Infection.
Abstract
Pneumonia is caused by both viral and bacterial pathogens and is responsible for a significant health burden in the Unites States. The innate immune system is the human body's first line of defense against these pathogens. The recognition of invading pathogens via pattern recognition receptors (PRRs) leads to proinflammatory cytokine and chemokine production followed by recruitment and activation of effector immune cells. The nonspecific inflammatory nature of the innate immune response can result in immunopathology that is detrimental to the host. In this review, we focus on one class of PRRs, th...
Source: Am J Respir Cell Mol... - February 2, 2017 Category: Respiratory Medicine Authors: Wiese KM, Coates BM, Ridge KM Tags: Am J Respir Cell Mol Biol Source Type: research
Prevalence of Chlamydophila pneumoniae and Mycoplasma pneumoniae IgM and IgG antibodies in Tunisian patients presenting with exacerbation of chronic obstructive pulmonary disease.
CONCLUSION: C. pneumoniae is a pathogen that requires specific antimicrobial treatment. Its detection must always be performed considering its prevalence in patients presenting with acute COPD exacerbations.
PMID: 28062246 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)
Source: Medecine et Maladies Infectieuses - January 9, 2017 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Infectious Agents and Neurodegenerative Diseases: Exploring the links.
Abstract
Recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD), and Lyme disease (LD). However, it is still controversial how the infections play a role in neurological diseases progression. Infections in central nervous system may lead multiple damages in infected and neighboring cells. The infection leads to the activation of inflammatory processes and host immune responses, which acts as defense mechanism and also causes damage to the host neurona...
Source: Current Topics in Medicinal Chemistry - January 2, 2017 Category: Chemistry Authors: Alam MZ, Alam Q, Kamal MA, Jiman-Fatani AA, Azhar EI, Khan MA, Haque A Tags: Curr Top Med Chem Source Type: research
Prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with HIV
The objective of this study is to determine prospectively the etiology of community-acquired pulmonary infections in hospitalized adults living with HIV. Patients were submitted to an extended microbiological investigation that included molecular methods. The microbiological findings were evaluated according to severity of the disease and pneumococcal vaccine status. Two hundred twenty-four patients underwent the extended microbiological investigation of whom 143 (64%) had an etiology determined. Among the 143 patients with a determined etiology, Pneumocystis jirovecii was the main agent, detected in 52 (36%) cases and fol...
Source: Medicine - January 1, 2017 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Atypical Pneumonia
This article reviews the advancements in the evaluation and treatment of patients and discusses current conflicts and controversies of atypical CAP. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - December 23, 2016 Category: Respiratory Medicine Authors: Lokesh Sharma, Ashley Losier, Thomas Tolbert, Charles S. Dela Cruz, Chad R. Marion Source Type: research
