Lefamulin (Xenleta) for Community-Acquired Bacterial Pneumonia
Date: September 23, 2019
Issue #:
1581Summary:
Lefamulin (Xenleta– Nabriva), a semisynthetic
pleuromutilin antibiotic, has been approved by the
FDA for IV and oral treatment of community-acquired
bacterial pneumonia (CABP) in adults. It is the first
systemic pleuromutilin antibiotic to be approved in the
US; retapamulin(Altabax), a 1% topical ointment for
treatment of impetigo, was approved in 2007. (Source: The Medical Letter)
Source: The Medical Letter - August 20, 2019 Category: Drugs & Pharmacology Authors: admin Tags: Amoxicillin Ampicillin/sulbactam Avelox Azithromycin Cefotaxime Cefpodoxime ceftaroline Ceftriaxone Chlamydophila pneumoniae Doxycycline Fluoroquinolones Haemophilus influenzae lefamulin Levaquin Levofloxacin Linezolid meth Source Type: research
High Seroprevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae among Scrub Typhus Patients in South Korea.
Abstract
Scrub typhus is an acute febrile illness caused by the obligate intracellular organism Orientia tsutsugamushi, endemic to South Korea. The course of scrub typhus can range from a self-limiting disease to a fatal illness. Serological cross-reactivity has been reported with other intracellular organisms, including Rickettsia species, Chlamydophila species, and Mycoplasma pneumoniae. We conducted a retrospective study to assess the current seroprevalence of M. pneumoniae IgM and Chlamydia pneumoniae IgM in scrub typhus patients in South Korea. We enrolled 150 patients with suspected rickettsial disea...
Source: The American Journal of Tropical Medicine and Hygiene - August 18, 2019 Category: Tropical Medicine Authors: Hwang JH, Jeon M, Kim CH, Lee CS Tags: Am J Trop Med Hyg Source Type: research
Viruses, Vol. 11, Pages 744: Isolation and Full-Length Sequence Analysis of a Pestivirus from Aborted Lamb Fetuses in Italy
ni
Ana Moreno
Pestiviruses are distributed worldwide and are responsible for a variety of economically important diseases. They are not very host-specific, and thus sheep can be infected by well-known pestiviruses like bovine viral diarrhea virus (BVDV) and border disease virus (BDV), as well as by other recently discovered pestivirus species. The aim of this study is to describe the isolation and characterization of four pestivirus strains detected in aborted lamb fetuses from a single farm in the Brescia province (Northern Italy). A total of twelve aborted fetuses were collected and examined. After necropsy, organs...
Source: Viruses - August 12, 2019 Category: Virology Authors: Enrica Sozzi Antonio Lavazza Alessandra Gaffuri Fabio Carlo Bencetti Alice Prosperi Davide Lelli Chiara Chiapponi Ana Moreno Tags: Article Source Type: research
Streptococcus pneumoniae and Haemophilus influenzae nasopharyngeal molecular detection in children with acute respiratory tract infection in SANADOR Hospital, Romania.
CONCLUSION: A definitive laboratory diagnosis of these micro-organisms can be made for invasive disease, but there are difficulties in establishing the aetiology for mucosal infection. Molecular detection tests could complement culture-based tests by strengthening their surveillance.
PMID: 31389781 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - August 6, 2019 Category: Microbiology Authors: Giucă MC, Cîlcic C, Mihăescu G, Gavrilă A, Dinescu M, Gătej RI Tags: J Med Microbiol Source Type: research
Head-to-head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease.
CONCLUSIONS: It is not clear from the evidence included in this review whether there is a difference in efficacy or safety between different classes or regimens of prophylactic antibiotic, given for 12 to 13 weeks to people with COPD. Whilst no head-to-head comparisons of antibiotic resistance were identified, concerns about this continue. The sample size in this review is small and both included studies are of short duration. Thus, there is considerable uncertainty in effects observed and the effects of different prophylactic antibiotics requires further research.
PMID: 31125127 [PubMed - as supplied by publisher]...
Source: Cochrane Database of Systematic Reviews - May 23, 2019 Category: General Medicine Authors: Threapleton CJ, Janjua S, Fortescue R, Baker EH Tags: Cochrane Database Syst Rev Source Type: research
Environmental and Other Extrinsic Risk Factors Contributing to the Pathogenesis of Cutaneous T Cell Lymphoma (CTCL)
Conclusions
Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - April 17, 2019 Category: Cancer & Oncology Source Type: research
[Human Psittacosis: A Case Report].
We describe a case of a 42-year-old woman, with known exposure to birds, who presented to the emergency department with one-week evolution of myalgia, polyarthritis, and respiratory symptoms. At admission, she had fever, respiratory failure, raised inflammatory markers and bilateral interstitial infiltrates at chest radiography. Considering the clinical findings and epidemiological background, we raised the hypothesis of a Chlamydophila psittaci atypical pneumonia that was serologically confirmed. Tetracyclines are the mainstay of treatment and the macrolides are an effective alternative. We highlight the importance of the...
Source: Acta Medica Portuguesa - March 22, 2019 Category: General Medicine Tags: Acta Med Port Source Type: research
Distribution of the atypical pathogens of community-acquired pneumonia to disease severity.
Conclusions: Although these 11 atypical pathogens were the common causes of CAP (including SCAP) among Chinese, they were not observed to increase risks for SCAP or death in Hospital.
PMID: 30622770 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 11, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
[Features distinguishing ornithosis from avian acute hypersensitivity pneumonitis - a retrospective analysis].
CONCLUSIONS: Our results suggest that patients with ornithosis and HP have important differences in their clinical, biological, and radiological presentation.
PMID: 30473450 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - November 28, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Neck vein obstruction: Diagnosis and the role of chronic persistent Chlamydophila pneumoniae infection.
CONCLUSION: Further research to validate this diagnostic protocol is required.
PMID: 30360684 [PubMed - as supplied by publisher] (Source: Phlebology)
Source: Phlebology - October 25, 2018 Category: Internal Medicine Authors: Thibault PK Tags: Phlebology Source Type: research
Chlamydophila psittaci pneumonia associated to exposure to fulmar birds (Fulmaris glacialis) in the Faroe Islands
. (Source: Infectious Diseases)
Source: Infectious Diseases - September 22, 2018 Category: Infectious Diseases Authors: Marian Elsubeth Foss ádal Mansour Grand Shahin Gaini Source Type: research
Laboratory investigation of trends in bacterial pneumonia in Cheonan, Korea from January 2008 to September 2017.
CONCLUSION: The prevalence of bacterial pneumonia in Cheonan, along with the proportion of co-infections among patients increased over the 10-year study period. The findings will aid the development of treatment and prevention guidelines.
PMID: 30178647 [PubMed - as supplied by publisher] (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - August 24, 2018 Category: Biotechnology Authors: Yook YS, Jeon JS, Park JO, Kim JK Tags: J Microbiol Biotechnol Source Type: research
Role of vasodilator-stimulated phosphoprotein in human cytomegalovirus-induced hyperpermeability of human endothelial cells.
Authors: Tian Y, He Y, Zhang L, Zhang J, Xu L, Ma Y, Xu X, Wei L
Abstract
Atherosclerosis (AS) is a common chronic vascular disease and epidemiological evidence demonstrates that infection is closely associated with the occurrence of AS, including infection by human cytomegalovirus (HCMV) and Chlamydophila pneumoniae. The aim of the present study was to investigate the effect of HCMV AD169 infection on the barrier function of human umbilical vein endothelial cells (HUVECs) and to understand the role of vasodilator-stimulated phosphoprotein (VASP) during this process. In cultured HUVEC-CRL-1730 cells, knock...
Source: Experimental and Therapeutic Medicine - August 18, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research
Severe atypical pneumonia in critically ill patients: a retrospective multicenter study
Chlamydophila pneumoniae (CP) and Mycoplasma pneumoniae (MP) patients could require intensive care unit (ICU) admission for acute respiratory failure. (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 13, 2018 Category: Intensive Care Authors: S. Valade, L. Biard, V. Lemiale, L. Argaud, F. P ène, L. Papazian, F. Bruneel, A. Seguin, A. Kouatchet, J. Oziel, S. Rouleau, N. Bele, K. Razazi, O. Lesieur, F. Boissier, B. Megarbane & hellip; Tags: Research Source Type: research
