Environmental and Other Extrinsic Risk Factors Contributing to the Pathogenesis of Cutaneous T Cell Lymphoma (CTCL)

Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of this malignancy. Hopefully, such knowledge of potential triggers and perpetuating factors for this cancer would enable us at some point to significantly decrease CTCL incidence. Therefore, it is important to take into consideration the effects of hydrochlorothiazide diuretics and immunosuppressive medications in patients with definite or suspected diagnosis of CTCL (e.g., recalcitrant eczematous patches/plaques that appear in a bathing-suit distribution) (89). Patients living near heavy industrial factories may consider an air filtration system, if feasible, to decrease their risk of developing a malignancy. Minimizing daily exposure to pesticides/herbicides containing chemicals that are listed as probable or possible (Groups 1-2B) carcinogens on the International Agency for Research on Cancer (IARC) database, such as glyphosate, is also important. Any trauma...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Re: Yang CJ, Kumar A, Gulack BC, Mulvihill MS, Hartwig MG, Wang X, et  al. Long-term outcomes after lobectomy for non–small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis. J Thoracic Cardiovasc Surg. 2016;151:1380-8.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Notice of Correction Source Type: research
President Trump signed an Executive Order on June 14, 2019, directing federal agencies to terminate a large number of current federal advisory committees that advise agencies on everything ranging from research priorities to public health, environmental, security, and economic policy. The Executive Order on Evaluating and Improving the Utility of Federal Advisory Committees instructs agencies and departments to “evaluate the need” for each of their current advisory committees, whether established by a congressional statute, by the President, or by the head of the agency under the Federal Advisory Committee Act...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
On June 19, 2019, the United States House of Representative voted 226-203 to pass a spending package for fiscal year (FY) 2020. The “minibus” combines four appropriations bills, including Defense, Energy and Water, Labor-Health and Human Services-Education, and State-Foreign Operations. The National Institutes of Health, the largest funder of medical research, would receive $41.1 billion in FY 2020, an increase of $2 billion over the FY 2019 enacted level. The Department of Energy’s Office of Science would receive $ 6.87 billion, an increase of $285 million or 4.3 percent above the FY 2019 level and $1.3...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
Agriculture Secretary Sonny Perdue announced on June 13, 2019, that the U.S. Department of Agriculture (USDA) will relocate its research agencies — the National Institute of Food and Agriculture (NIFA) and the Economic Research Service (ERS) — from Washington, DC, to the Kansas City Region, six weeks after announcing its top three choices for the move. The specific location of the offices is yet to be identified. “Following a rigorous site selection process, the Kansas City Region provides a win-win - maximizing our mission function by putting taxpayer savings into programmatic outputs and providing affo...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
The National Park Service (NPS) is planning for the 10th annual celebration of National Fossil Day, which will take place on October 16, 2019. National Fossil Day is a nationwide celebration that will include paleontology activities planned by partner organizations across the United States. AIBS has partnered with the National Park Service to promote the event. NPS and National Fossil Day partners are sponsoring an art contest as a part of the celebration. The contest theme is “Extinct Giants and Survivors of the Last Ice Age.” For details about participating, go to: https://www.nps.gov/subjects/fossilday/art-...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
The National Science Foundation (NSF) is inviting Principal Investigators, Co-Principal Investigators, or Sponsored Project Offices (SPO), who recently submitted a proposal to NSF, to provide feedback on existing FastLane and Research.gov business functionalities. This survey is a part of the NSF's multi-year initiative to help PIs/co-PIs and SPOs more efficiently and effectively prepare and submit NSF proposals, manage NSF awards, and conduct business with NSF. The anonymous survey should take about 10 minutes to complete and will close on July 1, 2019. Complete the survey by visiting: https://www.surveymonkey.com/r/2019_...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
[Premium Times] The Nigerian government has hosted 16 Nigerians recently honoured by the United States President's Emergency Plan for AIDS Relief (PEPFAR) for their contributions to the control of the HIV epidemic in Nigeria.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Solid organ transplantation from hepatitis C virus–positive (HCV-positive) deceased donors into HCV-negative recipients is a recent approach aimed to expand the donor organ pool in the setting of severe shortage. Good short-term outcomes have been reported with this approach in combination with direct-acting antivirals. In this issue of the JCI, Zahid and colleagues have characterized early viral kinetics and the genetic landscape of donor-to-recipient HCV transmission using single-genome sequencing. In seven HCV-negative recipients of four HCV-positive donor organs, productive infection with a highly diverse viral p...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Highly effective direct-acting antivirals against hepatitis C virus (HCV) have created an opportunity to transplant organs from HCV-positive individuals into HCV-negative recipients, since de novo infection can be routinely cured. As this procedure is performed more widely, it becomes increasingly important to understand the biological underpinnings of virus transmission, especially the multiplicity of infection. Here, we used single genome sequencing of plasma virus in 4 genotype 1a HCV-positive organ donors and their 7 organ recipients to assess the genetic bottleneck associated with HCV transmission following renal and ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ01211G, Papermaryam monajati, Ali Tamaddon, Gholamhossein Yousefi, Samira Abolmaali, Rassoul Dinarvand Recently, numerous bioconjugation procedures were developed to promote the pharmacokinetic and immunological properties of L-asparaginase (ASNase), anti-leukemic enzyme. Here, compared with PEGylation, the influence of the protein conjugation with poly(HPMA)... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
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