Outcome of acute kidney injury: how to make a difference?
Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. In addition to the well-known immediate complications (hydroelectrolytic disorders, hypervole... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - April 15, 2021 Category: Intensive Care Authors: Matthieu Jamme, Matthieu Legrand and Guillaume Geri Tags: Review Source Type: research

Perioperative hemodynamic optimization: from guidelines to implementation —an experts’ opinion paper
Despite a large body of evidence, the implementation of guidelines on hemodynamic optimization and goal-directed therapy remains limited in daily routine practice. To facilitate/accelerate this implementation,... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - April 14, 2021 Category: Intensive Care Authors: Jean-Luc Fellahi, Emmanuel Futier, Camille Vaisse, Olivier Collange, Olivier Huet, Jer ôme Loriau, Etienne Gayat, Benoit Tavernier, Matthieu Biais, Karim Asehnoune, Bernard Cholley and Dan Longrois Tags: Review Source Type: research

Monitoring skin blood flow to rapidly identify alterations in tissue perfusion during fluid removal using continuous veno-venous hemofiltration in patients with circulatory shock
Continuous veno-venous hemofiltration (CVVH) can be used to reduce fluid overload and tissue edema, but excessive fluid removal may impair tissue perfusion. Skin blood flow (SBF) alters rapidly in shock, so it... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - April 14, 2021 Category: Intensive Care Authors: Wasineenart Mongkolpun, P éter Bakos, Jean-Louis Vincent and Jacques Creteur Tags: Research Source Type: research

Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial
Vascular access for renal replacement therapy (RRT) is routine question in the intensive care unit. Randomized trials comparing jugular and femoral sites have shown similar rate of nosocomial events and cathet... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - April 8, 2021 Category: Intensive Care Authors: Nicolas Benichou, Sa ïd Lebbah, David Hajage, Laurent Martin-Lefèvre, Bertrand Pons, Eric Boulet, Alexandre Boyer, Guillaume Chevrel, Nicolas Lerolle, Dorothée Carpentier, Nicolas de Prost, Alexandre Lautrette, Anne Bretagnol, Julien Mayaux, Saad Nseir Tags: Research Source Type: research

Effects of remote ischemic conditioning on microcirculatory alterations in patients with sepsis: a single-arm clinical trial
Remote ischemic conditioning (RIC) is a promising technique that may protect organs and tissues from the effects of additional ischemic episodes. However, the therapeutic efficacy of RIC in humans with sepsis ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - April 7, 2021 Category: Intensive Care Authors: Inga Kiudulaite, Egle Belousoviene, Astra Vitkauskiene and Andrius Pranskunas Tags: Research Source Type: research

Efficacy and safety of human soluble thrombomodulin (ART-123) for treatment of patients in France with sepsis-associated coagulopathy: post hoc analysis of SCARLET
The phase 3 multinational SCARLET study evaluated the efficacy and safety of a recombinant human soluble thrombomodulin (ART-123) for treatment of sepsis-associated coagulopathy (SAC), which correlates with in... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 31, 2021 Category: Intensive Care Authors: Bruno Fran çois, Maud Fiancette, Julie Helms, Emmanuelle Mercier, Jean-Baptiste Lascarrou, Toshihiko Kayanoki, Kosuke Tanaka, David Fineberg, Jean-Louis Vincent and Xavier Wittebole Tags: Research Source Type: research

Inter-hospital transport of critically ill patients to manage the intensive care unit surge during the COVID-19 pandemic in France
The COVID-19 pandemic led authorities to evacuate via various travel modalities critically ill ventilated patients into less crowded units. However, it is not known if interhospital transport impacts COVID-19 ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 31, 2021 Category: Intensive Care Authors: Benoit Painvin, H élène Messet, Maeva Rodriguez, Thomas Lebouvier, Delphine Chatellier, Louis Soulat, Stephane Ehrmann, Arnaud W. Thille, Arnaud Gacouin and Jean-Marc Tadie Tags: Research Source Type: research

Left ventricular longitudinal wall fractional shortening accurately predicts longitudinal strain in critically ill patients with septic shock
Left ventricular longitudinal strain (LVLS) may be a sensitive indicator of left ventricular (LV) systolic function in patients with sepsis, but is dependent on high image quality and analysis software. Mitral... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 30, 2021 Category: Intensive Care Authors: Patrik Johansson Blixt, Michelle S. Chew, Rasmus Åhman, Lina de Geer, Lill Blomqwist, Meriam Åström Aneq, Jan Engvall and Henrik Andersson Tags: Research Source Type: research

Clinical performance of lung ultrasound in predicting ARDS morphology
To assess diagnostic performance of lung ultrasound (LUS) in identifying ARDS morphology (focal vs non-focal), compared with the gold standard computed tomography. (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 29, 2021 Category: Intensive Care Authors: Andrea Costamagna, Emanuele Pivetta, Alberto Goffi, Irene Steinberg, Pietro Arina, Anna Teresa Mazzeo, Lorenzo Del Sorbo, Simona Veglia, Ottavio Davini, Luca Brazzi, V. Marco Ranieri and Vito Fanelli Tags: Research Source Type: research

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortality
COVID-19 pneumonia and subsequent respiratory failure is causing an immense strain on intensive care units globally. Early prediction of severe disease enables clinicians to avoid acute respiratory distress sy... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 22, 2021 Category: Intensive Care Authors: Adeline Lim, Aleksandar Radujkovic, Markus A. Weigand and Uta Merle Tags: Research Source Type: research

An international survey on aminoglycoside practices in critically ill patients: the AMINO III study
While aminoglycosides (AG) have been used for decades, debate remains on their optimal dosing strategy. We investigated the international practices of AG usage specifically regarding dosing and therapeutic dru... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 19, 2021 Category: Intensive Care Authors: Claire Roger, Benjamin Louart, Loubna Elotmani, Greg Barton, Leslie Escobar, Despoina Koulenti, Jeffrey Lipman, Marc Leone, Laurent Muller, Caroline Boutin, Julien Amour, Iouri Banakh, Joel Cousson, Jeremy Bourenne, Jean-Michel Constantin, Jacques Albanes Tags: Research Source Type: research

Pain and dyspnea control during awake fiberoptic bronchoscopy in critically ill patients: safety and efficacy of remifentanil target-controlled infusion
Flexible fiberoptic bronchoscopy is frequently used in intensive care unit, but is a source of discomfort, dyspnea and anxiety for patients. Our objective was to assess the feasibility and tolerance of a sedat... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 16, 2021 Category: Intensive Care Authors: Margot Caron, Antoine Parrot, Alexandre Elabbadi, Sophie Dupeyrat, Matthieu Turpin, Thomas Baury, Sacha Rozencwajg, Clarisse Blayau, Jean-Pierre Fulgencio, Aude Gibelin, Pierre-Yves Blanchard, S éverine Rodriguez, Daisy Daigné, Marie-Cécile Allain, Mur Tags: Research Source Type: research

Cerebrovascular autoregulation and arterial carbon dioxide in patients with acute respiratory distress syndrome: a prospective observational cohort study
Early hypercapnia is common in patients with acute respiratory distress syndrome (ARDS) and is associated with increased mortality. Fluctuations of carbon dioxide have been associated with adverse neurological... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 16, 2021 Category: Intensive Care Authors: Ursula Kahl, Yuanyuan Yu, Axel Nierhaus, Daniel Frings, Barbara Sensen, Anne Daubmann, Stefan Kluge and Marlene Fischer Tags: Research Source Type: research

Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunctio... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 15, 2021 Category: Intensive Care Authors: Kevin Roedl, Dominik Jarczak, Andreas Drolz, Dominic Wichmann, Olaf Boenisch, Geraldine de Heer, Christoph Burdelski, Daniel Frings, Barbara Sensen, Axel Nierhaus, Marc L ütgehetmann, Stefan Kluge and Valentin Fuhrmann Tags: Research Source Type: research

High levels of plasma biomarkers at 24 h were found to be strong predictors of 90-day mortality: beware of some potential confounders!
(Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 15, 2021 Category: Intensive Care Authors: Patrick M. Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter to the Editor Source Type: research

Reply to: High levels of plasma biomarkers at 24 h were found to be strong predictors of 90-day mortality: beware of some potential confounders!
(Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 15, 2021 Category: Intensive Care Authors: Toni J äntti, Veli-Pekka Harjola, Mikko Haapio and Johan Lassus Tags: Letter to the Editor Source Type: research

The use of extracorporeal CO2 removal in acute respiratory failure
Chronic obstructive pulmonary disease (COPD) exacerbation and protective mechanical ventilation of acute respiratory distress syndrome (ARDS) patients induce hypercapnic respiratory acidosis. (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 11, 2021 Category: Intensive Care Authors: Rapha ël Giraud, Carlo Banfi, Benjamin Assouline, Amandine De Charrière, Maurizio Cecconi and Karim Bendjelid Tags: Review Source Type: research

Early combination of albumin with crystalloids administration might be beneficial for the survival of septic patients: a retrospective analysis from MIMIC-IV database
Fluid therapy is a cornerstone in the treatment of sepsis. Recently, the guidelines have recommended the combined administration that using crystalloids plus albumin for septic patients, but the optimal timing fo... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 10, 2021 Category: Intensive Care Authors: Shiyu Zhou, Zhenhua Zeng, Hongxia Wei, Tong Sha and Shengli An Tags: Research Source Type: research

New clinical algorithm including fungal biomarkers to better diagnose probable invasive pulmonary aspergillosis in ICU
The classification of invasive pulmonary aspergillosis (IPA) issued by the European Organization for the Research and Treatment of Cancer/Mycoses Study Group Education and Research Consortium (EORTC/MSGERC) is... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 8, 2021 Category: Intensive Care Authors: Joffrey Hamam, Jean-Christophe Navellou, Anne-Pauline Bellanger, St éphane Bretagne, Hadrien Winiszewski, Emeline Scherer, Gael Piton and Laurence Millon Tags: Research Source Type: research

Ability of procalcitonin to distinguish between bacterial and nonbacterial infection in severe acute exacerbation of chronic obstructive pulmonary syndrome in the ICU
To assess the ability of procalcitonin (PCT) to distinguish between bacterial and nonbacterial causes of patients with severe acute exacerbation of COPD (AECOPD) admitted to the ICU, we conducted a retrospecti... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 6, 2021 Category: Intensive Care Authors: C édric Daubin, François Fournel, Fabrice Thiollière, Fabrice Daviaud, Michel Ramakers, Andréa Polito, Bernard Flocard, Xavier Valette, Damien Du Cheyron, Nicolas Terzi, Muriel Fartoukh, Stephane Allouche and Jean-Jacques Parienti Tags: Research Source Type: research

Serum melatonin concentration in critically ill patients randomized to sedation or non-sedation
Abolished circadian rhythm is associated with altered cognitive function, delirium, and as a result increased mortality in critically ill patients, especially in those who are mechanically ventilated. The caus... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 6, 2021 Category: Intensive Care Authors: Jakob Oxlund, Torben Knudsen, Thomas Str øm, Jørgen T. Lauridsen, Poul J. Jennum and Palle Toft Tags: Research Source Type: research

Continuous positive airway pressure for respiratory support during COVID-19 pandemic: a frugal approach from bench to bedside
We describe a frugal approach (focusing on needs, performance, and costs) to manage a massive influx of COVID-19 patients with acute hypoxemic respiratory failure (AHRF) using the Boussignac valve protected by... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 2, 2021 Category: Intensive Care Authors: Guillaume Carteaux, Manuella Pons, Fran çois Morin, Samuel Tuffet, Arnaud Lesimple, Bilal Badat, Anne-Fleur Haudebourg, François Perier, Yvon Deplante, Constance Guillaud, Frédéric Schlemmer, Elena Fois, Nicolas Mongardon, Mehdi Khellaf, Karim Jaffal, Tags: Research Source Type: research

High flow nasal oxygen therapy to avoid invasive mechanical ventilation in SARS-CoV-2 pneumonia: a retrospective study
The efficacy of high flow nasal canula oxygen therapy (HFNO) to prevent invasive mechanical ventilation (IMV) is not well established in severe coronavirus disease 2019 (COVID-19). The aim of this study was to... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 27, 2021 Category: Intensive Care Authors: Nicolas Bonnet, Olivier Martin, Marouane Boubaya, Vincent Levy, Nathan Ebstein, Philippe Karoubi, Yacine Tandjaoui-Lambiotte, Guillaume Van Der Meersch, Johanna Oziel, Marie Soulie, Mohamed Ghalayini, Anais Winchenne, Jean Ralph Zahar, Passem Ahmed, St é Tags: Research Source Type: research

Intensive care management of patients with COVID-19: a practical approach
SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the early twentieth century. Since there is no ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 18, 2021 Category: Intensive Care Authors: Ludhmila Abrah ão Hajjar, Isabela Bispo Santos da Silva Costa, Stephanie Itala Rizk, Bruno Biselli, Brenno Rizerio Gomes, Cristina Salvadori Bittar, Gisele Queiroz de Oliveira, Juliano Pinheiro de Almeida, Mariana Vieira de Oliveira Bello, Cibele Garzill Tags: Review Source Type: research

Determinants of hospital and one-year mortality among older patients admitted to intensive care units: results from the multicentric SENIOREA cohort
This study aimed at determining which geriatric and ICU parameters were associated with in-hospital and long-... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 17, 2021 Category: Intensive Care Authors: Julien Demiselle, Guillaume Duval, Jean-Fran çois Hamel, Anne Renault, Laetitia Bodet-Contentin, Laurent Martin-Lefèvre, Dominique Vivier, Daniel Villers, Montaine Lefèvre, René Robert, Philippe Markowicz, Sylvain Lavoué, Anne Courte, Eddy Lebas, St Tags: Research Source Type: research

Predicting fluid responsiveness in non-intubated COVID-19 patients: two methods are better than one
(Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 15, 2021 Category: Intensive Care Authors: Morgan Caplan, Michael Howsam, Raphael Favory and Sebastien Preau Tags: Letter to the Editor Source Type: research

Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation
The effect of cytomegalovirus (CMV) reactivation on the length of mechanical ventilation and mortality in immunocompetent ICU patients requiring invasive mechanical ventilation remains controversial. The main ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 11, 2021 Category: Intensive Care Authors: Laurent Papazian, Samir Jaber, Sami Hraiech, Karine Baumstarck, Sophie Cayot-Constantin, Nadia Aissaoui, Boris Jung, Marc Leone, Bertrand Souweine, Carole Schwebel, J érémy Bourenne, Jérôme Allardet-Servent, Toufik Kamel, Qin Lu, Christine Zandotti, A Tags: Research Source Type: research

Poor outcome associated with mucormycosis in critically ill hematological patients: results of a multicenter study
Mucormycosis is an emerging fungal infection that may lead to multi-organ failure, especially in patients with hematological malignancies (HM). We performed a retrospective, cohort study, in five intensive car... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 10, 2021 Category: Intensive Care Authors: Matthieu Jestin, Elie Azoulay, Fr édéric Pène, Fabrice Bruneel, Julien Mayaux, Martin Murgier, Michael Darmon and Sandrine Valade Tags: Research Source Type: research

Validation of the pediatric refractory septic shock definition: post hoc analysis of a controlled trial
The European Society of Pediatric and Neonatal Intensive Care (ESPNIC) developed and validated a definition of pediatric refractory septic shock (RSS), based on two septic shock scores (SSS). Both bedside SSS ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 10, 2021 Category: Intensive Care Authors: Luc Morin, Karthik Narayanan Ramaswamy, Muralidharan Jayashree, Arun Bansal, Karthi Nallasamy, Pierre Tissieres and Sunit Singhi Tags: Research Source Type: research

Outcomes of severe systemic rheumatic disease patients requiring extracorporeal membrane oxygenation
Systemic rheumatic diseases (SRDs) are a group of inflammatory disorders that can require intensive care unit (ICU) admission because of multiorgan involvement with end-organ failure(s). Critically ill SRD pat... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 9, 2021 Category: Intensive Care Authors: Pierre Bay, Guillaume Lebreton, Alexis Mathian, Pierre Demondion, Cyrielle Desnos, Juliette Chommeloux, Guillaume H ékimian, Nicolas Bréchot, Ania Nieszkowska, Matthieu Schmidt, Fleur Cohen-Aubart, Pascal Leprince, Charles-Edouard Luyt, Zahir Amoura, Al Tags: Research Source Type: research

Non-invasive ventilation alternating with high-flow nasal oxygen versus high-flow nasal oxygen alone after extubation in COPD patients: a post hoc analysis of a randomized controlled trial
Several randomized clinical trials have shown that non-invasive ventilation (NIV) applied immediately after extubation may prevent reintubation in patients at high-risk of extubation failure. However, most of ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 9, 2021 Category: Intensive Care Authors: Arnaud W. Thille, R émi Coudroy, Mai-Anh Nay, Arnaud Gacouin, Maxens Decavèle, Romain Sonneville, François Beloncle, Christophe Girault, Laurence Dangers, Alexandre Lautrette, Quentin Levrat, Anahita Rouzé, Emmanuel Vivier, Jean-Baptiste Lascarrou, Je Tags: Research Source Type: research

Non-invasive method to detect high respiratory effort and transpulmonary driving pressures in COVID-19 patients during mechanical ventilation
High respiratory drive in mechanically ventilated patients with spontaneous breathing effort may cause excessive lung stress and strain and muscle loading. Therefore, it is important to have a reliable estimat... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 8, 2021 Category: Intensive Care Authors: Lisanne Roesthuis, Maarten van den Berg and Hans van der Hoeven Tags: Research Source Type: research

Levosimendan use in patients with acute heart failure and reduced ejection fraction with or without severe renal dysfunction in critical cardiac care units: a multi-institution database study
Acute heart failure is a life-threatening clinical condition. Levosimendan is an effective inotropic agent used to maintain cardiac output, but its usage is limited by the lack of evidence in patients with sev... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 8, 2021 Category: Intensive Care Authors: Cze-Ci Chan, Kuang-Tso Lee, Wan-Jing Ho, Yi-Hsin Chan and Pao-Hsien Chu Tags: Research Source Type: research

Predictors of fluid responsiveness in critically ill patients mechanically ventilated at low tidal volumes: systematic review and meta-analysis
Dynamic predictors of fluid responsiveness have shown good performance in mechanically ventilated patients at tidal volumes (Vt)  > 8 mL kg−1. Nevertheless, most critically ill conditions demand lower Vt. We sough... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 8, 2021 Category: Intensive Care Authors: Jorge Iv án Alvarado Sánchez, Juan Daniel Caicedo Ruiz, Juan José Diaztagle Fernández, William Fernando Amaya Zuñiga, Gustavo Adolfo Ospina-Tascón and Luis Eduardo Cruz Martínez Tags: Review Source Type: research

Integrity at end of life in the intensive care unit: a qualitative study of nurses ’ views
Integrity is a core value for delivering ethical health care. However, there is a lack of precision in defining what integrity is and how nurses understand it. In the setting of nurses caring for critically il... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 5, 2021 Category: Intensive Care Authors: Lena Palmryd, Åsa Rejnö and Tove E. Godskesen Tags: Research Source Type: research

Sympathetic stimulation increases serum lactate concentrations in patients admitted with sepsis: implications for resuscitation strategies
Diametrically opposed positions exist regarding the deleterious effects of elevated lactate. There are data suggesting that it is a detrimental proxy for tissue hypoperfusion and anaerobic metabolism in sepsis... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 5, 2021 Category: Intensive Care Authors: Nikhil Jagan, Lee E. Morrow, Ryan W. Walters, Robert W. Plambeck, Tej M. Patel, Douglas R. Moore and Mark A. Malesker Tags: Research Source Type: research

Predictive value of plasma proenkephalin and neutrophil gelatinase-associated lipocalin in acute kidney injury and mortality in cardiogenic shock
Acute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. However, data on AKI markers such as plasma proenkephalin (P-PENK) and neutrophil gelatinase-associated lipocalin (P-NGAL) in ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 5, 2021 Category: Intensive Care Authors: Toni J äntti, Tuukka Tarvasmäki, Veli-Pekka Harjola, Kari Pulkki, Heidi Turkia, Tuija Sabell, Heli Tolppanen, Raija Jurkko, Mari Hongisto, Anu Kataja, Alessandro Sionis, Jose Silva-Cardoso, Marek Banaszewski, Salvatore DiSomma, Alexandre Mebazaa, Mikko Tags: Research Source Type: research

Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study
Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments deve... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 3, 2021 Category: Intensive Care Authors: Hans Flaatten, Bertrand Guidet, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Ariane Boumendil, Muhammed Elhadi, Jesper Fj ølner, Michael Joannidis, Christian Jung, Susannah Leaver, Brian Marsh, Rui Moreno, Sandra Oeyen, Yuriy Nalapko, Joerg C. Sc Tags: Research Source Type: research

Increased susceptibility to intensive care unit-acquired pneumonia in severe COVID-19 patients: a multicentre retrospective cohort study
The aim of this study is to determine whether severe COVID-19 patients harbour a higher risk of ICU-acquired pneumonia. (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 29, 2021 Category: Intensive Care Authors: Jean-Fran çois Llitjos, Swann Bredin, Jean-Baptiste Lascarrou, Thibaud Soumagne, Mariana Cojocaru, Maxime Leclerc, Arnaud Lepetit, Albin Gouhier, Julien Charpentier, Gaël Piton, Matthieu Faron, Annabelle Stoclin and Frédéric Pène Tags: Research Source Type: research

Current use of inotropes in circulatory shock
Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope thera... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 29, 2021 Category: Intensive Care Authors: Thomas W. L. Scheeren, Jan Bakker, Thomas Kaufmann, Djillali Annane, Pierre Asfar, E. Christiaan Boerma, Maurizio Cecconi, Michelle S. Chew, Bernard Cholley, Maria Cronhjort, Daniel De Backer, Arnaldo Dubin, Martin W. D ünser, Jacques Duranteau, Anthony Tags: Research Source Type: research

Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure
Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 27, 2021 Category: Intensive Care Authors: Virginie Lemiale, Guillaume Dumas, Alexandre Demoule, Frederic P ène, Achille Kouatchet, Magali Bisbal, Saad Nseir, Laurent Argaud, Loay Kontar, Kada Klouche, Francois Barbier, Amelie Seguin, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Floren Tags: Research Source Type: research

Triage policy of severe Covid-19 patients: what to do now?
(Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 27, 2021 Category: Intensive Care Authors: Pieter Depuydt and Bertrand Guidet Tags: Letter to the Editor Source Type: research

Predicting fluid responsiveness in non-intubated COVID-19 patients
(Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 27, 2021 Category: Intensive Care Authors: Frederic Michard Tags: Letter to the Editor Source Type: research

Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial
The detrimental effects of inotropes are well-known, and in many fields they are only used within a goal-directed therapy approach. Nevertheless, standard management in many centers includes administering inot... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 26, 2021 Category: Intensive Care Authors: Rafael Alves Franco, Juliano Pinheiro de Almeida, Giovanni Landoni, Thomas W. L. Scheeren, Filomena Regina Barbosa Gomes Galas, Julia Tizue Fukushima, Suely Zefferino, Pasquale Nardelli, Marilde de Albuquerque Piccioni, Elisandra Cristina Trevisan Calvo A Tags: Research Source Type: research

Trendelenburg maneuver predicts fluid responsiveness in patients on veno-arterial extracorporeal membrane oxygenation
Evaluation of fluid responsiveness during veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support is crucial. The aim of this study was to investigate whether changes in left ventricular outflow tr... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 26, 2021 Category: Intensive Care Authors: Jing-chao Luo, Ying Su, Li-li Dong, Jun-yi Hou, Xin Li, Ying Zhang, Guo-guang Ma, Ji-li Zheng, Guang-wei Hao, Huan Wang, Yi-jie Zhang, Zhe Luo and Guo-wei Tu Tags: Research Source Type: research

Higher anticoagulation targets and risk of thrombotic events in severe COVID-19 patients: bi-center cohort study
Thromboprophylaxis of COVID-19 patients is a highly debated issue. We aimed to compare the occurrence of thrombotic/ischemic events in COVID-19 patients with acute respiratory distress syndrome (ARDS) treated ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 25, 2021 Category: Intensive Care Authors: Julie Helms, Fran çois Severac, Hamid Merdji, Maleka Schenck, Raphaël Clere-Jehl, Mathieu Baldacini, Mickaël Ohana, Lélia Grunebaum, Vincent Castelain, Eduardo Anglés-Cano, Laurent Sattler and Ferhat Meziani Tags: Research Source Type: research

Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study
Regional citrate anticoagulation (RCA) is the gold standard of anticoagulation for continuous renal replacement therapy but is rarely used for intermittent hemodialysis (IHD) in ICU. Few studies assessed the s... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 22, 2021 Category: Intensive Care Authors: Christophe Leroy, Bruno Pereira, Edouard Soum, Claire Bachelier, Elisabeth Coupez, Laure Calvet, Konstantinos Bachoumas, Claire Dupuis, Bertrand Souweine and Alexandre Lautrette Tags: Research Source Type: research

Insulin sensitivity in critically ill patients: are women more insulin resistant?
Glycaemic control (GC) in intensive care unit is challenging due to significant inter- and intra-patient variability, leading to increased risk of hypoglycaemia. Recent work showed higher insulin resistance in... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 21, 2021 Category: Intensive Care Authors: Vincent Uyttendaele, J. Geoffrey Chase, Jennifer L. Knopp, Rebecca Gottlieb, Geoffrey M. Shaw and Thomas Desaive Tags: Research Source Type: research

Relationship between lipoprotein concentrations and short-term and 1-year mortality in intensive care unit septic patients: results from the HIGHSEPS study
High-density lipoproteins (HDLs), particles characterized by their reverse cholesterol transport function, display pleiotropic properties, including anti-inflammatory and antioxidant functions. Moreover, all l... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 19, 2021 Category: Intensive Care Authors: S ébastien Tanaka, Jules Stern, Donia Bouzid, Tiphaine Robert, Monique Dehoux, Aurélie Snauwaert, Nathalie Zappella, Maxime Cournot, Brice Lortat-Jacob, Pascal Augustin, Enora Atchade, Alexy Tran-Dinh, Olivier Meilhac and Philippe Montravers Tags: Research Source Type: research

Uncertainty in the impact of liver support systems in acute-on-chronic liver failure: a systematic review and network meta-analysis
The role of artificial and bioartificial liver support systems in acute-on-chronic liver failure (ACLF) is still controversial. We aimed to perform the first network meta-analysis comparing and ranking differe... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 18, 2021 Category: Intensive Care Authors: Klementina Ocskay, Anna Kanjo, No émi Gede, Zsolt Szakács, Gabriella Pár, Bálint Erőss, Jan Stange, Steffen Mitzner, Péter Hegyi and Zsolt Molnár Tags: Review Source Type: research