Pharmacokinetics, efficacy and tolerance of cefoxitin in the treatment of cefoxitin-susceptible extended-spectrum beta-lactamase producing Enterobacterales infections in critically ill patients: a retrospective single-center study
Cefoxitin is active against some extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE), but has not been evaluated so far in the intensive care unit (ICU) settings. Data upon its pharmacokinetics ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - September 30, 2022 Category: Intensive Care Authors: Paul Chabert, Judith Provoost, Sabine Cohen, C éline Dupieux-Chabert, Laurent Bitker, Tristan Ferry, Sylvain Goutelle and Jean-Christophe Richard Tags: Research Source Type: research

Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences —a retrospective observational study
The objective of this study is to provide a full description of ARC in ICU including prevalence, evolution profile, risk factors and outcomes. (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - September 26, 2022 Category: Intensive Care Authors: Alexandre Egea, Claire Dupuis, Etienne de Montmollin, Paul-Henry Wicky, Juliette Patrier, Pierre Jaquet, Lucie Lef èvre, Fabrice Sinnah, Mehdi Marzouk, Romain Sonneville, Lila Bouadma, Bertrand Souweine and Jean-François Timsit Tags: Research Source Type: research

Validation of the flow index to detect low inspiratory effort during pressure support ventilation
Bedside assessment of low levels of inspiratory effort, which are probably insufficient to prevent muscle atrophy, is challenging. The flow index, which is derived from the analysis of the inspiratory portion ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - September 26, 2022 Category: Intensive Care Authors: Ming-Yue Miao, Wei Chen, Yi-Min Zhou, Ran Gao, De-Jing Song, Shu-Peng Wang, Yan-Lin Yang, Linlin Zhang and Jian-Xin Zhou Tags: Research Source Type: research

Early antibiotic therapy is associated with a lower probability of successful liberation from mechanical ventilation in patients with severe acute exacerbation of chronic obstructive pulmonary disease
While antibiotic therapy is advocated to improve outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) whenever mechanical ventilation is required, the evidence relies on small studi... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - September 24, 2022 Category: Intensive Care Authors: G. Deniel, M. Cour, L. Argaud, J. C. Richard and L. Bitker Tags: Research Source Type: research

Herpesviridae lung reactivation and infection in patients with severe COVID-19 or influenza virus pneumonia: a comparative study
Lung reactivations of Herpesviridae, herpes simplex virus (HSV) and cytomegalovirus (CMV) have been reported in COVID-19 patients. Whether or not those viral reactivations are more frequent than in other patients... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - September 24, 2022 Category: Intensive Care Authors: Charles-Edouard Luyt, Sonia Burrel, David Mokrani, Marc Pineton de Chambrun, Domitille Luyt, Juliette Chommeloux, Vincent Guiraud, Nicolas Br échot, Matthieu Schmidt, Guillaume Hekimian, Alain Combes and David Boutolleau Tags: Research Source Type: research

Jordi Mancebo, in memoriam (August 06 2022)
(Source: Annals of Intensive Care)
Source: Annals of Intensive Care - September 14, 2022 Category: Intensive Care Authors: Laurent Brochard and Alain Mercat Tags: Letter to the Editor Source Type: research

Multiple-site decontamination regimen decreases acquired infection incidence in mechanically ventilated COVID-19 patients
Among strategies that aimed to prevent acquired infections (AIs), selective decontamination regimens have been poorly studied in the COVID-19 setting. We assessed the impact of a multiple-site decontamination ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - September 2, 2022 Category: Intensive Care Authors: Nicolas Massart, Florian Reizine, Pierre Fillatre, Philippe Seguin, B éatrice La Combe, Aurélien Frerou, Pierre-Yves Egreteau, Baptiste Hourmant, Pierre Kergoat, Julien Lorber, Jerome Souchard, Emmanuel Canet, Guillaume Rieul, Yannick Fedun, Agathe Delb Tags: Research Source Type: research

Definition and evolution of right ventricular dysfunction in critically ill COVID-19 patients
(Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 30, 2022 Category: Intensive Care Authors: Minesh Chotalia, Mansoor N. Bangash, Jaimin M. Patel and Dhruv Parekh Tags: Letter to the Editor Source Type: research

Definition and evolution of right ventricular dysfunction in critically ill COVID-19 patients. Author ’s reply
(Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 30, 2022 Category: Intensive Care Authors: Michelle S. Chew, Saga Jansson, Meriam Åström Aneq and Jan Engvall Tags: Letter to the Editor Source Type: research

Use of dexmedetomidine in patients with sepsis: a systematic review and meta-analysis of randomized-controlled trials
The objective of this study was to summarize all randomized controlled trials (RCTs) examin... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 27, 2022 Category: Intensive Care Authors: Ting Zhang, Qimin Mei, Shabai Dai, Yecheng Liu and Huadong Zhu Tags: Review Source Type: research

Anakinra in pediatric acute fulminant myocarditis
Acute fulminant myocarditis in children is associated with elevated mortality and morbidity with few advances in its medical management. Here we report a preliminary experience of children treated with IL-1 re... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 26, 2022 Category: Intensive Care Authors: Louise Maunier, Ramy Charbel, Virginie Lambert and Pierre Tissi ères Tags: Research Source Type: research

Whole pulmonary assessment 1 year after paediatric acute respiratory distress syndrome: prospective multicentre study
Long-term pulmonary sequelae, including 1-year thoracic computed tomography (CT) sequelae of paediatric acute respiratory distress syndrome (ARDS) remain unknown. The purpose of the study was to determine pulm... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 20, 2022 Category: Intensive Care Authors: V éronique Nève, Ahmed Sadik, Laurent Petyt, Stéphane Dauger, Ahmed Kheniche, André Denjean, Pierre-Louis Léger, François Chalard, Michèle Boulé, Etienne Javouhey, Philippe Reix, Isabelle Canterino, Valérie Deken, Régis Matran, Stéphane Leteurt Tags: Research Source Type: research

Effects of mean arterial pressure target on mottling and arterial lactate normalization in patients with septic shock: a post hoc analysis of the SEPSISPAM randomized trial
In patients with septic shock, the impact of the mean arterial pressure (MAP) target on the course of mottling remains uncertain. In this post hoc analysis of the SEPSISPAM trial, we investigated whether a low... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 19, 2022 Category: Intensive Care Authors: Nicolas Fage, Julien Demiselle, Val érie Seegers, Hamid Merdji, Fabien Grelon, Bruno Mégarbane, Nadia Anguel, Jean-Paul Mira, Pierre-François Dequin, Soizic Gergaud, Nicolas Weiss, François Legay, Yves Le Tulzo, Marie Conrad, Remi Coudroy, Frédéric Tags: Research Source Type: research

Comparison of different clinical risk scores to predict long-term survival and neurological outcome in adults after cardiac arrest: results from a prospective cohort study
Several scoring systems have been used to predict short-term outcome in patients with out-of-hospital cardiac arrest (OHCA), including the disease-specific OHCA and CAHP (Cardiac Arrest Hospital Prognosis) sco... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 17, 2022 Category: Intensive Care Authors: Ren é Blatter, Simon A. Amacher, Chantal Bohren, Christoph Becker, Katharina Beck, Sebastian Gross, Kai Tisljar, Raoul Sutter, Stephan Marsch and Sabina Hunziker Tags: Research Source Type: research

The use of ICU resources in CAR-T cell recipients: a hospital-wide study
CAR-T cell (chimeric antigen receptor T) therapy has emerged as an effective treatment of refractory hematological malignancies. Intensive care management is intrinsic to CAR-T cell therapy. We aim to describe... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - August 17, 2022 Category: Intensive Care Authors: Sandrine Valade, Michael Darmon, Lara Zafrani, Eric Mariotte, Virginie Lemiale, Swann Bredin, Guillaume Dumas, Nicolas Boissel, Florence Rabian, Andr é Baruchel, Isabelle Madelaine, Jérôme Larghero, Anne Brignier, Etienne Lengliné, Stéphanie Harel, B Tags: Research Source Type: research