Correlation of Bacterial Coinfection Versus Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloproteinase 1 Expression in Aortic Aneurysm and Atherosclerosis
Conclusions: The present work favors a role for coinfection of both M pneumoniae and C pneumoniae in the development of aortic atherosclerotic aneurysm, with increased adventitial inflammation, inhibition of TIMP-1 activity, and increased collagen degradation. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - August 31, 2013 Category: Surgery Authors: Alessandra Roggério, Nádia Vieira Sambiase, Suely A.P. Palomino, Maria Alice Pedreira de Castro, Erasmo Simão da Silva, Noedir G. Stolf, Maria de Lourdes Higuchi Tags: Basic Science Source Type: research
Antibiotic therapy in nongastrointestinal MALT lymphoma: a review of the literature
Although antibiotic therapy has been established as the standard of care in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, much less is known about the value of antibiotic therapy in nongastrointestinal (non-GI) MALT lymphomas. A computerized search (Medline) accompanied by a manual search to identify clinical reports on the topic of antibacterial therapy in patients with non-GI MALT lymphomas was performed. The majority of data were available for MALT lymphoma of the ocular adnexa (OAML) including a total of 131 patients in 4 retrospective studies, 3 prospective series (including 81 patients), an...
Source: Blood - August 22, 2013 Category: Hematology Authors: Kiesewetter, B., Raderer, M. Tags: Free Research Articles, Lymphoid Neoplasia, Review Articles, Clinical Trials and Observations Source Type: research
in silico analyses of metabolic pathway and protein interaction network for identification of next gen therapeutic targets in Chlamydophila pneumoniae.
Abstract
Chlamydophila pneumoniae, the causative agent of chronic obstructive pulmonary disease (COPD), is presently the fifth mortality causing chronic disease in the world. The understanding of disease and treatment options are limited represents a severe concern and a need for better therapeutics. With the advancements in the field of complete genome sequencing and computational approaches development have lead to metabolic pathway analysis and protein-protein interaction network which provides vital evidence to the protein function and has been appropriate to the fields such as systems biology and drug...
Source: Bioinformation - August 6, 2013 Category: Bioinformatics Authors: Ravindranath BS, Krishnamurthy V, Krishna V, Vasudevanayaka KB Tags: Bioinformation Source Type: research
In silico synteny based comparative genomics approach for identification and characterization of novel therapeutic targets in Chlamydophila pneumoniae.
Abstract
Chlamydophila pneumoniae is one of the most important and well studied gram negative bacterial strain with respect to community acquired pneumonia and other respiratory diseases like Chronic obstructive pulmonary disease (COPD), Chronic asthma, Alzheimer's disease, Atherosclerosis and Multisclerosis which have a great potential to infect humans and many other mammals. According to WHO prediction, COPD is to become the third leading cause of death by 2030. Unfortunately, the molecular mechanisms leading to chronic infections are poorly understood and the difficulty in culturing C pneumoniae in expe...
Source: Bioinformation - July 22, 2013 Category: Bioinformatics Authors: Ravindranath BS, Krishnamurthy V, Krishna V, C SK Tags: Bioinformation Source Type: research
Statistical Genetic Analysis of Serological Measures of Common, Chronic Infections in Alaska Native Participants in the GOCADAN Study
ABSTRACT
This paper describes genetic investigations of seroreactivity to five common infectious pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), herpes simplex virus 1 (HSV‐1), and herpes simplex virus 2 (HSV‐2). Seroprevalence rates indicate that infections with most of these pathogens are common (≥20% for all of them, >80% for H. pylori, CMV, a...
Source: Genetic Epidemiology - June 26, 2013 Category: Epidemiology Authors: Rohina Rubicz, Jianhui Zhu, Sandra Laston, Shelley A. Cole, V. Saroja Voruganti, Sven O. E. Ebbesson, Barbara V. Howard, Jean W. MacCluer, Michael Davidson, Jason G. Umans, Anthony G. Comuzzie, Harald H. H. Göring Tags: Research Article Source Type: research
Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage
Summary: Objectives: High acute respiratory tract infection (ARTI) rates are observed in indigenous populations. We assessed the role of viral infections and nasopharyngeal bacterial carriage in ARTIs in Eñepa Amerindians from Venezuela.Methods: In 40 children aged 0–10 years with ARTIs, healthy nearest-age sibling controls and their mothers the presence of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Moraxella catarrhalis, Mycoplasma pneumoniae, Chlamydophila pneumoniae/psittachi and 15 respiratory viruses was investigated.Results: S. pneumoniae was the most frequently detected pathogen, wit...
Source: Journal of Infection - June 24, 2013 Category: Infectious Diseases Authors: Lilly M. Verhagen, Keyla Gómez-Castellano, Eveline Snelders, Ismar Rivera-Olivero, Leonor Pocaterra, Willem J.G. Melchers, Jacobus H. de Waard, Peter W.M. Hermans Tags: Bacteria and Bacterial Diseases Source Type: research
Molecular and genomic aberrations in Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas
Abstract
The etiology and pathogenesis of ocular adnexal extranodal marginal zone lymphoma (OAEMZL) are still unknown and the association with Chlamydophila psittaci (C. psittaci) has been shown in only some geographic regions. Herein we comprehensively examined the frequency of chromosomal translocations as well as CARD11, MYD88 (L265P) and A20 mutations /deletions in 45 C. psittaci negative OAEMZLs. t(14;18)(q32;q21) IGH‐MALT1 and t(11;18)(q21;q21) API2‐MALT1 were not detected in any of the analyzed tumors while 3 tumors harbored IGH translocations to an unidentified partner. CARD11 mutations were not found in all th...
Source: American Journal of Hematology - May 29, 2013 Category: Hematology Authors: Daxing Zhu, Offiong F Ikpatt, Sander R Dubovy, Chen Lossos, Yasodha Natkunam, Jennifer R. Chapman‐Fredricks, Yao‐Shan Fan, Izidore S. Lossos Tags: Research Article Source Type: research
Epidemiology and associations with climatic conditions of Mycoplasma pneumoniae and Chlamydophila pneumoniae infections among Chinese children hospitalized with acute respiratory infections
Conclusions:
M. pneumoniae and C. pneumoniae are important infectious agents in hospitalized children with acute respiratory tract infections. M. pneumoniae infection showed a strong direct correlation with environmental temperature. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - May 25, 2013 Category: Pediatrics Authors: Zhengrong ChenWei JiYuqing WangYongdong YanHong ZhuXuejun ShaoJun Xu Source Type: research
Adult case of Stevens–Johnson syndrome possibly induced by Chlamydophila pneumoniae infection with severe involvement of bronchial epithelium resulting in constructive respiratory disorder
(Source: The Journal of Dermatology)
Source: The Journal of Dermatology - March 21, 2013 Category: Dermatology Authors: Aya Tanaka, Mayuko Nakano, Mamori Tani, Masahiro Kira, Ichiro Katayama, Junichiro Nakagawa, Kenichi Tahara, Shizuka Koh, So Goto, Ryo Takahashi Tags: Letter to the Editor Source Type: research
Selected Emerging Diseases of Amphibia
This review summarizes the most recent updates on emerging infectious diseases of amphibia. A brief summary of Batrachochytrium dendrobatidis history, epidemiology, pathogenesis, life cycle, diagnosis, treatment, and biosecurity is provided. Ambystoma tigrinum virus, common midwife toad virus, frog virus 3, Rana grylio virus, Rana catesbeiana ranavirus, Mahaffey Road virus, Rana esculenta virus, Bohle iridovirus, and tiger frog virus ranaviruses are extensively reviewed. Emerging bacterial pathogens are discussed, including Flavobacter sp, Aeromonas sp, Citrobacter freundii, Chlamydophila sp, Mycobacterium liflandii, Eliza...
Source: Veterinary Clinics of North America: Exotic Animal Practice - March 18, 2013 Category: Veterinary Research Authors: La’Toya V. Latney, Eric Klaphake Source Type: research
ABC transporter ATPase of Chlamydophila pneumoniae as a potential vaccine candidate.
Abstract
Better vaccines and new therapeutic drugs could be a successful breakthrough against intracellular bacteria. M. tuberculosis ABC transporter ATPase (Rv0986) plays a role in mycobacterial virulence by inhibiting phagosome-lysosome fusion. Thus, it could be a potential vaccine candidate. C. pneumoniae another important intracellular bacterium possesses a protein named CpB0255, which is homologous with the mycobacterial Rv0986. The aim of this study was the cloning, over-expression and purification of CpB0255 ABC transporter ATPase protein to study its biological properties. The immunogenicity and pr...
Source: Acta Microbiologica et Immunologica Hungarica - March 1, 2013 Category: Microbiology Authors: Szabó AM, Sipák Z, Miczák A, Faludi I Tags: Acta Microbiol Immunol Hung Source Type: research
Descriptive epidemiology of upper respiratory disease and associated risk factors in cats in an animal shelter in coastal western Canada.
We examined 250 cats at an animal shelter in the coastal temperate region of Canada to determine whether age, source, gender, and sterilization status influenced risk of shedding at intake, transmission of infection, and development of clinical upper respiratory disease (URD). On admission, 28% of the cats were positive for 1 or more infectious agent related to URD; 21% were carriers of Mycoplasma felis and < 3% were carriers of feline calicivirus (FCV), feline herpesvirus-1 (FHV-1) or Bordetella bronchiseptica. Chlamydophila felis and H1N1 influenza virus were not detected. Carrier status was not affected by source, ge...
Source: The Canadian Veterinary Journal - February 1, 2013 Category: Veterinary Research Authors: Gourkow N, Lawson JH, Hamon SC, Phillips CJ Tags: Can Vet J Source Type: research
Biased immunoglobulin light chain use in the chlamydophila psittaci negative ocular adnexal marginal zone lymphomas
Abstract
Ocular adnexal mucosa associated lymphoid tissue lymphomas (OAMALTL) are the most common lymphomas of the eye. The potential roles for specific antigens in these lymphomas are still controversial. Previously we examined IGHV usage and mutations IGHVin Chlamydophila (C) psittaci‐negative OAMALTL, demonstrating biased use of the IGHV4 family and IGHV4‐34 gene and evidence for antigen selection. Herein, we examined the IKGV/IGLV gene usage and mutations in 34 C. psittaci‐negative OAMALTL originating from the orbit (15), conjunctivae (14) and lacrimal gland (5). Clonal potentially functional IGKV/IGLV gene seque...
Source: American Journal of Hematology - February 1, 2013 Category: Hematology Authors: Daxing Zhu, Chen Lossos, Jennifer R. Chapman‐Fredricks, Izidore S Lossos Tags: Research Article Source Type: research
Two-step bacterial broad-range polymerase chain reaction analysis of heart valve tissue improves bacteriological diagnosis of infective endocarditis
Abstract: Positive heart valve (HV) culture is a major Duke's criterion for the diagnosis of infective endocarditis but is poorly sensitive. Two broad-range 16S rDNA polymerase chain reaction (PCR) methods were applied to 31 HV samples: first, a real-time method, then conventional end-point PCR was applied to HV samples on which the first PCR was negative. Five specific real-time PCR procedures were also used in order to identify Bartonella spp., Tropheryma whipplei, Chlamydophila pneumoniae, Mycoplasma pneumonia, and Coxiella burnetii. A strategy combining the 2-step broad-range PCR methods improved the sensitivity of the...
Source: Diagnostic Microbiology and Infectious Disease - January 14, 2013 Category: Microbiology Authors: Rémi Boussier, Sylvie Rogez, Bruno François, Eric Denes, Marie-Cécile Ploy, Fabien Garnier Tags: Bacteriology Source Type: research
