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MALT lymphoma prognostic index
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Tags: Free Research Articles, CME article CONTINUING MEDICAL EDUCATION (CME) QUESTIONS Source Type: research

Garcia-Sanz R. WM, MYD88, and CXCR4: following the thread. Blood. 2016;128(6):746-748.
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research

Red cell fragments can mask severe thrombocytopenia
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Innes, A. J., Matthey, F. Tags: Thrombocytopenia, Free Research Articles, BloodWork, Platelets and Thrombopoiesis, Red Cells, Iron, and Erythropoiesis BLOOD WORK Source Type: research

Philadelphia chromosome-positive B-lymphoblastic lymphoma involving the genitourinary system and bone at initial diagnosis and relapse
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Zheng, L., Hu, S. Tags: Free Research Articles, BloodWork, Lymphoid Neoplasia BLOOD WORK Source Type: research

Persistence of the losing cord blood unit following double cord blood transplantation: finding the unseen
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Milano, F., Gammill, H., Oliver, D. C., Kanaan, S. B., Nelson, J. L., Delaney, C. Tags: Transplantation Letter to Blood Source Type: research

Allogeneic hematopoietic cell transplantation for high-risk CLL: 10-year follow-up of the GCLLSG CLL3X trial
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Krämer, I., Stilgenbauer, S., Dietrich, S., Böttcher, S., Zeis, M., Stadler, M., Bittenbring, J., Uharek, L., Scheid, C., Hegenbart, U., Ho, A., Hallek, M., Kneba, M., Schmitz, N., Döhner, H., Dreger, P. Tags: Transplantation, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Letter to Blood Source Type: research

Circulatory and maturation kinetics of human monocyte subsets in vivo
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Tak, T., Drylewicz, J., Conemans, L., de Boer, R. J., Koenderman, L., Borghans, J. A. M., Tesselaar, K. Tags: Immunobiology and Immunotherapy, Phagocytes, Granulocytes, and Myelopoiesis Letter to Blood Source Type: research

CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Dong, L., Zheng, H., Qu, C.-K. Tags: Hematopoiesis and Stem Cells, Myeloid Neoplasia Letter to Blood Source Type: research

Circulating and skin-derived Sezary cells: clonal but with phenotypic plasticity
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Roelens, M., Delord, M., Ram-Wolff, C., Marie-Cardine, A., Alberdi, A., Maki, G., Homyrda, L., Bensussan, A., Bagot, M., Toubert, A., Moins-Teisserenc, H. Tags: Immunobiology and Immunotherapy, Lymphoid Neoplasia Letter to Blood Source Type: research

Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations
X-linked recessive ectodermal dysplasia with immunodeficiency is a rare primary immunodeficiency caused by hypomorphic mutations of the IKBKG gene encoding the nuclear factor B essential modulator (NEMO) protein. This condition displays enormous allelic, immunological, and clinical heterogeneity, and therapeutic decisions are difficult because NEMO operates in both hematopoietic and nonhematopoietic cells. Hematopoietic stem cell transplantation (HSCT) is potentially life-saving, but the small number of case reports available suggests it has been reserved for only the most severe cases. Here, we report the health status be...
Source: Blood - September 21, 2017 Category: Hematology Authors: Miot, C., Imai, K., Imai, C., Mancini, A. J., Kucuk, Z. Y., Kawai, T., Nishikomori, R., Ito, E., Pellier, I., Dupuis Girod, S., Rosain, J., Sasaki, S., Chandrakasan, S., Pachlopnik Schmid, J., Okano, T., Colin, E., Olaya-Vargas, A., Yamazaki-Nakashimada, Tags: Transplantation Source Type: research

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function
Coagulation proteases have increasingly recognized functions beyond hemostasis and thrombosis. Disruption of activated protein C (aPC) or insulin signaling impair function of podocytes and ultimately cause dysfunction of the glomerular filtration barrier and diabetic kidney disease (DKD). We here show that insulin and aPC converge on a common spliced-X-box binding protein-1 (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis. Analogous to insulin, physiological levels of aPC maintain ER proteostasis in DKD. Accordingly, genetically impaired protein C activation exacerbates maladaptive ER response, ...
Source: Blood - September 21, 2017 Category: Hematology Authors: Madhusudhan, T., Wang, H., Ghosh, S., Dong, W., Kumar, V., Al-Dabet, M. M., Manoharan, J., Nazir, S., Elwakiel, A., Bock, F., Kohli, S., Marquardt, A., Sögüt, I., Shahzad, K., Müller, A. J., Esmon, C. T., Nawroth, P. P., Reiser, J. Tags: Thrombosis and Hemostasis Source Type: research

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism
Plasmodium vivax is the most prevalent parasite species that causes malaria in humans and exclusively infects reticulocytes. Reticulocyte infection is facilitated by P vivax Duffy binding protein (DBP), which utilizes DARC (Duffy antigen receptor for chemokines) as an entry point. However, the selective tropism of P vivax for transferrin receptor (CD71)-positive reticulocytes remained unexplained, given the constitutive expression of DARC during reticulocyte maturation. CD71/RNA double staining of reticulocytes enriched from adult peripheral blood reveals 4 distinct reticulocyte populations: CD71high/RNAhigh (~0.016%), CD7...
Source: Blood - September 21, 2017 Category: Hematology Authors: Ovchynnikova, E., Aglialoro, F., Bentlage, A. E. H., Vidarsson, G., Salinas, N. D., von Lindern, M., Tolia, N. H., van den Akker, E. Tags: Red Cells, Iron, and Erythropoiesis, Brief Reports Source Type: research

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)
Cutaneous T-cell lymphoma (CTCL) is an incurable non-Hodgkin lymphoma of the skin-homing T cell. In early-stage disease, lesions are limited to the skin, but in later-stage disease, the tumor cells can escape into the blood, the lymph nodes, and at times the visceral organs. To clarify the genomic basis of CTCL, we performed genomic analysis of 220 CTCLs. Our analyses identify 55 putative driver genes, including 17 genes not previously implicated in CTCL. These novel mutations are predicted to affect chromatin (BCOR, KDM6A, SMARCB1, TRRAP), immune surveillance (CD58, RFXAP), MAPK signaling (MAP2K1, NF1), NF-B signaling (PR...
Source: Blood - September 21, 2017 Category: Hematology Authors: Park, J., Yang, J., Wenzel, A. T., Ramachandran, A., Lee, W. J., Daniels, J. C., Kim, J., Martinez-Escala, E., Amankulor, N., Pro, B., Guitart, J., Mendillo, M. L., Savas, J. N., Boggon, T. J., Choi, J. Tags: Lymphoid Neoplasia Source Type: research

Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma
Reed-Sternberg (RS) cells of classical Hodgkin lymphoma (cHL) express multiple immunoregulatory proteins that shape the cHL microenvironment and allow tumor cells to evade immune surveillance. Expression of certain immunoregulatory proteins is modulated by prosurvival transcription factors, such as NFB and STATs. Because these factors also induce expression of the oncogenic PIM1/2/3 serine/threonine kinases, and as PIMs modulate transcriptional activity of NFB and STATs, we hypothesized that these kinases support RS cell survival and foster their immune privilege. Here, we investigated PIM1/2/3 expression in cHL and assess...
Source: Blood - September 21, 2017 Category: Hematology Authors: Szydłowski, M., Prochorec-Sobieszek, M., Szumera-Cieckiewicz, A., Derezinska, E., Hoser, G., Wasilewska, D., Szymanska-Giemza, O., Jabłonska, E., Białopiotrowicz, E., Sewastianik, T., Polak, A., Czardybon, W., Gałezowski, M., W Tags: Lymphoid Neoplasia Source Type: research

A MALT lymphoma prognostic index
This study aimed to develop and validate a specific prognostic tool to personalize and optimize treatment of patients with MALT lymphoma. A prognostic index was built by Cox regression (stepwise selection) using data from 401 patients enrolled in the international randomized International Extranodal Lymphoma Study Group 19 (IELSG-19) trial (NCT 00210353). A validation set, including 633 patients, was obtained by merging 3 independent cohorts of MALT lymphoma patients. The 3 individual features maintaining the greatest prognostic significance for event-free survival (EFS, the main endpoint of the IELSG-19 trial) were age &g...
Source: Blood - September 21, 2017 Category: Hematology Authors: Thieblemont, C., Cascione, L., Conconi, A., Kiesewetter, B., Raderer, M., Gaidano, G., Martelli, M., Laszlo, D., Coiffier, B., Lopez Guillermo, A., Torri, V., Cavalli, F., Johnson, P. W., Zucca, E. Tags: Free Research Articles, Lymphoid Neoplasia, CME article, Clinical Trials and Observations Source Type: research

How I treat pediatric venous thromboembolism
The incidence of pediatric venous thromboembolism (VTE) has been increasing significantly over the past decade in part as a result of increased recognition of this serious disorder but more so because of the increased use of central venous catheters and other technological advancements involved in the care of ill children. Management of pediatric VTE is a complex undertaking, considering that the vast majority of children who develop this complication have serious underlying medical disorders. Although the incidence is rising, in comparison with adults, this remains a relatively rare disorder, and as such, large-scale clin...
Source: Blood - September 21, 2017 Category: Hematology Authors: Young, G. Tags: Pediatric Hematology, How I Treat, Free Research Articles, Thrombosis and Hemostasis, Clinical Trials and Observations Source Type: research

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia
Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases. (Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Lilljebjörn, H., Fioretos, T. Tags: Pediatric Hematology, Lymphoid Neoplasia, Blood Spotlight, Clinical Trials and Observations Source Type: research

Are outcomes of allografts for CLL still relevant?
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Shea, T. C. Tags: Free Research Articles COMMENTS Source Type: research

Transplant for NEMO: this and much, much more
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Hickstein, D. D., Notarangelo, L. Tags: Free Research Articles COMMENTS Source Type: research

Diabetic kidney disease: as easy as aPC?
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: McFadyen, J. D., Cooper, M. E. Tags: Free Research Articles COMMENTS Source Type: research

Expanding and expounding the genomic map of CTCL
(Source: Blood)
Source: Blood - September 21, 2017 Category: Hematology Authors: Mishra, A., Porcu, P. Tags: Free Research Articles COMMENTS Source Type: research

Cyclin D1-negative mantle cell lymphoma with aberrant CD3 expression
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Malek, A., Bhagat, G. Tags: Free Research Articles, BloodWork, Lymphoid Neoplasia BLOOD WORK Source Type: research

Exuberant nodal proliferation of mature plasmacytoid dendritic cells in a patient with chronic myelomonocytic leukemia
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Wang, H.-Y., Feldman, A. L. Tags: Free Research Articles, BloodWork, Myeloid Neoplasia BLOOD WORK Source Type: research

Hematologic relapse in AL amyloidosis after high-dose melphalan and stem cell transplantation
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Browning, S., Quillen, K., Sloan, J. M., Doros, G., Sarosiek, S., Sanchorawala, V. Tags: Transplantation, Lymphoid Neoplasia, Clinical Trials and Observations Letter to Blood Source Type: research

Platelet soluble CD40-ligand level is associated with transfusion adverse reactions in a mixed threshold-and-hit model
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Cognasse, F., Sut, C., Fromont, E., Laradi, S., Hamzeh-Cognasse, H., Garraud, O. Tags: Transfusion Medicine, Platelets and Thrombopoiesis, Clinical Trials and Observations Letter to Blood Source Type: research

Targeted therapies in 54 patients with Erdheim-Chester disease, including follow-up after interruption (the LOVE study)
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Cohen Aubart, F., Emile, J.-F., Carrat, F., Charlotte, F., Benameur, N., Donadieu, J., Maksud, P., Idbaih, A., Barete, S., Hoang-Xuan, K., Amoura, Z., Haroche, J. Tags: Myeloid Neoplasia, Phagocytes, Granulocytes, and Myelopoiesis, Clinical Trials and Observations Letter to Blood Source Type: research

Five-year follow-up of brentuximab vedotin combined with ABVD or AVD for advanced-stage classical Hodgkin lymphoma
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Connors, J. M., Ansell, S. M., Fanale, M., Park, S. I., Younes, A. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Letter to Blood Source Type: research

Tissue-type plasminogen activator regulates macrophage activation and innate immunity
Tissue-type plasminogen activator (tPA) is the major intravascular activator of fibrinolysis and a ligand for receptors involved in cell signaling. In cultured macrophages, tPA inhibits the response to lipopolysaccharide (LPS) by a pathway that apparently requires low-density lipoprotein receptor-related protein-1 (LRP1). Herein, we show that the mechanism by which tPA neutralizes LPS involves rapid reversal of IBα phosphorylation. tPA independently induced transient IBα phosphorylation and extracellular signal-regulated kinase 1/2 (ERK1/2) activation in macrophages; however, these events did not trigger inflam...
Source: Blood - September 14, 2017 Category: Hematology Authors: Mantuano, E., Azmoon, P., Brifault, C., Banki, M. A., Gilder, A. S., Campana, W. M., Gonias, S. L. Tags: Immunobiology and Immunotherapy, Phagocytes, Granulocytes, and Myelopoiesis, Thrombosis and Hemostasis Source Type: research

Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi
In this study, we show that whereas P cynomolgi merozoites invade monkey red blood cells indiscriminately in vitro, in humans, they are restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy antigen/chemokine receptor (DARC or CD234). This likely contributes to the paucity of detectable zoonotic cynomolgi malaria. We further describe postinvasion morphologic and rheologic alterations in P cynomolgi–infected human reticulocytes that are strikingly similar to those observed for P vivax. These observations stress the value of P cynomolgi as a model in the development of blood sta...
Source: Blood - September 14, 2017 Category: Hematology Authors: Kosaisavee, V., Suwanarusk, R., Chua, A. C. Y., Kyle, D. E., Malleret, B., Zhang, R., Imwong, M., Imerbsin, R., Ubalee, R., Samano-Sanchez, H., Yeung, B. K. S., Ong, J. J. Y., Lombardini, E., Nosten, F., Tan, K. S. W., Bifani, P., Snounou, G., Renia, L., Tags: Red Cells, Iron, and Erythropoiesis Source Type: research

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency
Pyruvate kinase (PK) deficiency is a rare genetic disease that causes chronic hemolytic anemia. There are currently no targeted therapies for PK deficiency. Here, we describe the identification and characterization of AG-348, an allosteric activator of PK that is currently in clinical trials for the treatment of PK deficiency. We demonstrate that AG-348 can increase the activity of wild-type and mutant PK enzymes in biochemical assays and in patient red blood cells treated ex vivo. These data illustrate the potential for AG-348 to restore the glycolytic pathway activity in patients with PK deficiency and ultimately lead to...
Source: Blood - September 14, 2017 Category: Hematology Authors: Kung, C., Hixon, J., Kosinski, P. A., Cianchetta, G., Histen, G., Chen, Y., Hill, C., Gross, S., Si, Y., Johnson, K., DeLaBarre, B., Luo, Z., Gu, Z., Yao, G., Tang, H., Fang, C., Xu, Y., Lv, X., Biller, S., Su, S.-S. M., Yang, H., Popovici-Muller, J., Sal Tags: Red Cells, Iron, and Erythropoiesis Source Type: research

The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation
As a central regulator of cell polarity, the activity of CDC42 GTPase is tightly controlled in maintaining normal hematopoietic stem and progenitor cell (HSC/P) functions. We found that transformation of HSC/P to acute myeloid leukemia (AML) is associated with increased CDC42 expression and activity in leukemia cells. In a mouse model of AML, the loss of Cdc42 abrogates MLL-AF9–induced AML development. Furthermore, genetic ablation of CDC42 in both murine and human MLL-AF9 (MA9) cells decreased survival and induced differentiation of the clonogenic leukemia-initiating cells. We show that MLL-AF9 leukemia cells mainta...
Source: Blood - September 14, 2017 Category: Hematology Authors: Mizukawa, B., OBrien, E., Moreira, D. C., Wunderlich, M., Hochstetler, C. L., Duan, X., Liu, W., Orr, E., Grimes, H. L., Mulloy, J. C., Zheng, Y. Tags: Hematopoiesis and Stem Cells, Myeloid Neoplasia Source Type: research

Gene therapy for Wiskott-Aldrich syndrome in a severely affected adult
Until recently, hematopoietic stem cell transplantation was the only curative option for Wiskott-Aldrich syndrome (WAS). The first attempts at gene therapy for WAS using a -retroviral vector improved immunological parameters substantially but were complicated by acute leukemia as a result of insertional mutagenesis in a high proportion of patients. More recently, treatment of children with a state-of-the-art self-inactivating lentiviral vector (LV-w1.6 WASp) has resulted in significant clinical benefit without inducing selection of clones harboring integrations near oncogenes. Here, we describe a case of a presplenectomize...
Source: Blood - September 14, 2017 Category: Hematology Authors: Morris, E. C., Fox, T., Chakraverty, R., Tendeiro, R., Snell, K., Rivat, C., Grace, S., Gilmour, K., Workman, S., Buckland, K., Butler, K., Chee, R., Salama, A. D., Ibrahim, H., Hara, H., Duret, C., Mavilio, F., Male, F., Bushman, F. D., Galy, A., Burns, Tags: Immunobiology and Immunotherapy, Clinical Trials and Observations, Gene Therapy Source Type: research

FDG-PET-driven consolidation strategy in diffuse large B-cell lymphoma: final results of a randomized phase 2 study
Dose-dense induction and up-front consolidation with autologous stem cell transplantation (ASCT) remain controversial issues when treating patients with high-risk diffuse large B-cell lymphoma. GELA designed a randomized phase 2 trial evaluating the efficacy of either rituximab, doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone (R-ACVBP) or rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP14) induction and a positron emission tomography (PET)-driven ASCT or standard immunochemotherapy (SIC) consolidation in age-adjusted international prognosis index 2 (aaIPI2)-aaIPI3 patients. PET was ...
Source: Blood - September 14, 2017 Category: Hematology Authors: Casasnovas, R.- O., Ysebaert, L., Thieblemont, C., Bachy, E., Feugier, P., Delmer, A., Tricot, S., Gabarre, J., Andre, M., Fruchart, C., Mounier, N., Delarue, R., Meignan, M., Berriolo-Riedinger, A., Bardet, S., Emile, J.- F., Jais, J.- P., Haioun, C., Ti Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research

How I monitor long-term and late effects after blood or marrow transplantation
Blood or marrow transplantation (BMT) is used with curative intent for hematologic malignancies. Conditional on surviving the first 2 years after BMT, 5-year survival generally exceeds 70%. However, the cumulative therapeutic exposures lead to premature onset of chronic health conditions, such that the 15-year cumulative incidence of severe or life-threatening chronic health conditions exceeds 40%, resulting in premature mortality. The high burden of morbidity, coupled with a long latency between BMT and the development of chronic health conditions necessitates life-long risk-based monitoring of the BMT survivors. The issu...
Source: Blood - September 14, 2017 Category: Hematology Authors: Bhatia, S., Armenian, S. H., Landier, W. Tags: Transplantation, How I Treat, Free Research Articles, Clinical Trials and Observations Source Type: research

MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts
Acute myeloid leukemia (AML) is a deadly hematologic malignancy characterized by the uncontrolled growth of immature myeloid cells. Over the past several decades, we have learned a tremendous amount regarding the genetic aberrations that govern disease development in AML. Among these are genes that encode noncoding RNAs, including the microRNA (miRNA) family. miRNAs are evolutionarily conserved small noncoding RNAs that display important physiological effects through their posttranscriptional regulation of messenger RNA targets. Over the past decade, studies have identified miRNAs as playing a role in nearly all aspects of...
Source: Blood - September 14, 2017 Category: Hematology Authors: Wallace, J. A., OConnell, R. M. Tags: Myeloid Neoplasia, Review Articles, Clinical Trials and Observations Source Type: research

Flexibility and innovation in the FDAs novel regulatory approval strategies for hematologic drugs
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Farrell, A. T., Goldberg, K. B., Pazdur, R. Tags: Blood Forum, Clinical Trials and Observations Source Type: research

Erdheim-Chester disease: the "targeted" revolution
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Vaglio, A., Diamond, E. L. Tags: Free Research Articles COMMENTS Source Type: research

Brentuximab: is it time for a new "B" in ABVD?
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Stephens, D. M. Tags: Free Research Articles COMMENTS Source Type: research

tPA and anger management for macrophages
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Miles, L. A., Parmer, R. J. Tags: Free Research Articles COMMENTS Source Type: research

Gene therapy: WAS (not) just for kids
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Kohn, D. B. Tags: Free Research Articles COMMENTS Source Type: research

High-risk DLBCL: interim PET? Not yet
(Source: Blood)
Source: Blood - September 14, 2017 Category: Hematology Authors: Hertzberg, M. Tags: Free Research Articles COMMENTS Source Type: research

Sickle cell trait with {beta}-thalassemia, elliptocytosis, and thrombocytosis
(Source: Blood)
Source: Blood - September 7, 2017 Category: Hematology Authors: Lombardo, J. L., Lynch, D. T. Tags: Free Research Articles, BloodWork, Red Cells, Iron, and Erythropoiesis BLOOD WORK Source Type: research

The beauty and the beast: lymphoma-like morphology of myeloid blast phase in CML
(Source: Blood)
Source: Blood - September 7, 2017 Category: Hematology Authors: Asemissen, A. M., Dierlamm, J. Tags: Free Research Articles, BloodWork, Myeloid Neoplasia BLOOD WORK Source Type: research

A new tool for rapid and reliable diagnosis of HLA loss relapses after HSCT
(Source: Blood)
Source: Blood - September 7, 2017 Category: Hematology Authors: Ahci, M., Toffalori, C., Bouwmans, E., Crivello, P., Brambati, C., Pultrone, C., Stempelmann, K., Bost, D., Mazzi, B., Beelen, D. W., Ciceri, F., Mulder, W., Fleischhauer, K., Vago, L. Tags: Transplantation Letter to Blood Source Type: research

Absence of driver mutations in persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes
(Source: Blood)
Source: Blood - September 7, 2017 Category: Hematology Authors: Tesson, B., Huet, S., Grange, B., Jallades, L., Baseggio, L., Felman, P., Traverse-Glehen, A., Magaud, J.-P., Lega, J.-C., Bole-Feysot, C., Salles, G., Callet-Bauchu, E., Sujobert, P. Tags: Lymphoid Neoplasia Letter to Blood Source Type: research

Circulating dsDNA, endothelial injury, and complement activation in thrombotic microangiopathy and GVHD
Transplant-associated thrombotic microangiopathy (TA-TMA) is a common and poorly recognized complication of hematopoietic stem cell transplantation (HSCT) associated with excessive complement activation, likely triggered by endothelial injury. An important missing piece is the link between endothelial injury and complement activation. We hypothesized that neutrophil extracellular traps (NETs) mechanistically link endothelial damage with complement activation and subsequent TA-TMA. Neutrophil activation releases granule proteins together with double-stranded DNA (dsDNA) to form extracellular fibers known as NETs. NETs have ...
Source: Blood - September 7, 2017 Category: Hematology Authors: Gloude, N. J., Khandelwal, P., Luebbering, N., Lounder, D. T., Jodele, S., Alder, M. N., Lane, A., Wilkey, A., Lake, K. E., Litts, B., Davies, S. M. Tags: Transplantation Source Type: research

Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial
Bleeding remains a significant problem for many thrombocytopenic hematology/oncology patients in spite of platelet transfusions. Factors that might contribute to bleeding were analyzed for 16 320 patient-days on or after their first platelet transfusion in 1077 adult patients enrolled in the Platelet Dose (PLADO) trial. All patients had a greatly increased risk of bleeding at platelet counts of ≤5 x 109/L (odds ratio [OR], 3.1; 95% confidence interval [CI], 2.0-4.8) compared with platelet counts ≥81 x 109/L. Platelet counts between 6 x 109/L and 80 x 109/L were also associated with a somewhat elevated bleeding risk i...
Source: Blood - September 7, 2017 Category: Hematology Authors: Uhl, L., Assmann, S. F., Hamza, T. H., Harrison, R. W., Gernsheimer, T., Slichter, S. J. Tags: Transfusion Medicine, Free Research Articles, Platelets and Thrombopoiesis Source Type: research

Immunoassay for human serum erythroferrone
Erythroferrone (ERFE) is a glycoprotein hormone secreted by erythroblasts in response to stimulation by erythropoietin (EPO). We previously demonstrated that ERFE messenger RNA expression and serum protein concentration increase in mice subjected to hemorrhage or EPO therapy, that ERFE acts on hepatocytes to suppress hepcidin, and that the resulting decrease in hepcidin augments iron delivery for intensified erythropoiesis. We also showed that ERFE contributes to pathological hepcidin suppression and iron overload in mice with nontransfused β-thalassemia. We now report the development and technical validation of a rab...
Source: Blood - September 7, 2017 Category: Hematology Authors: Ganz, T., Jung, G., Naeim, A., Ginzburg, Y., Pakbaz, Z., Walter, P. B., Kautz, L., Nemeth, E. Tags: Red Cells, Iron, and Erythropoiesis, Brief Reports Source Type: research

Role of ADP receptors on platelets in the growth of ovarian cancer
We investigated the effect of platelets on ovarian cancer and the role of adenosine diphosphate (ADP) receptors (P2Y12 and P2Y1) on platelets in the growth of primary ovarian cancer tumors. We showed that in murine models of ovarian cancer, a P2Y12 inhibitor (ticagrelor) reduced tumor growth by 60% compared with aspirin and by 75% compared with placebo. In P2Y12–/– mice, the growth of syngeneic ovarian cancer tumors was reduced by>85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1–/– and WT mice. Reconstitution of hematopoiesis in irradiated P...
Source: Blood - September 7, 2017 Category: Hematology Authors: Cho, M. S., Noh, K., Haemmerle, M., Li, D., Park, H., Hu, Q., Hisamatsu, T., Mitamura, T., Mak, S. L. C., Kunapuli, S., Ma, Q., Sood, A. K., Afshar-Kharghan, V. Tags: Platelets and Thrombopoiesis Source Type: research

The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage
We report that CCRL2-deficient mice have a defect in neutrophil recruitment and are protected in 2 models of inflammatory arthritis. In vitro, CCRL2 was found to constitutively form homodimers and heterodimers with CXCR2, a main neutrophil chemotactic receptor. By heterodimerization, CCRL2 could regulate membrane expression and promote CXCR2 functions, including the activation of β2-integrins. Therefore, upregulation of CCRL2 observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation. (Source: Blood)
Source: Blood - September 7, 2017 Category: Hematology Authors: Del Prete, A., Martinez-Munoz, L., Mazzon, C., Toffali, L., Sozio, F., Za, L., Bosisio, D., Gazzurelli, L., Salvi, V., Tiberio, L., Liberati, C., Scanziani, E., Vecchi, A., Laudanna, C., Mellado, M., Mantovani, A., Sozzani, S. Tags: Immunobiology and Immunotherapy, Phagocytes, Granulocytes, and Myelopoiesis Source Type: research