Cordua S, Kjaer L, Skov V, Pallisgaard N, Hasselbalch HC, Ellervik C. Prevalence and phenotypes of JAK2 V617F and calreticulin mutations in a Danish general population. Blood. 2019;134(5):469-479.
(Source: Blood)
Source: Blood - October 3, 2019 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research

Lymphocytes in Sanfilippo syndrome display characteristic Alder-Reilly anomaly
(Source: Blood)
Source: Blood - October 3, 2019 Category: Hematology Authors: Do, L., Pasalic, L. Tags: Free Research Articles, BloodWork BLOOD WORK Source Type: research

A method for noninvasive prenatal diagnosis of monogenic autosomal recessive disorders
(Source: Blood)
Source: Blood - October 3, 2019 Category: Hematology Authors: Cutts, A., Vavoulis, D. V., Petrou, M., Smith, F., Clark, B., Henderson, S., Schuh, A. Tags: Sickle Cell Disease, Red Cells, Iron, and Erythropoiesis Letter to Blood Source Type: research

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
Dysregulation of polycomb repressive complex 2 (PRC2) promotes oncogenesis partly through its enzymatic function for inducing trimethylation of histone H3 lysine 27 (H3K27me3). However, it remains to be determined how PRC2 activity is regulated in normal and diseased settings. We here report a PRC2-associated cofactor, PHD finger protein 19 (PHF19; also known as polycomb-like 3), as a crucial mediator of tumorigenicity in multiple myeloma (MM). Overexpression and/or genomic amplification of PHF19 is found associated with malignant progression of MM and plasma cell leukemia, correlating to worse treatment outcomes. Using va...
Source: Blood - October 3, 2019 Category: Hematology Authors: Ren, Z., Ahn, J. H., Liu, H., Tsai, Y.-H., Bhanu, N. V., Koss, B., Allison, D. F., Ma, A., Storey, A. J., Wang, P., Mackintosh, S. G., Edmondson, R. D., Groen, R. W. J., Martens, A. C., Garcia, B. A., Tackett, A. J., Jin, J., Cai, L., Zheng, D., Wang, G. Tags: Multiple Myeloma, Lymphoid Neoplasia Source Type: research

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis
Hematopoietic transcription factor LIM domain only 2 (LMO2), a member of the TAL1 transcriptional complex, plays an essential role during early hematopoiesis and is frequently activated in T-cell acute lymphoblastic leukemia (T-ALL) patients. Here, we demonstrate that LMO2 is activated by deacetylation on lysine 74 and 78 via the nicotinamide phosphoribosyltransferase (NAMPT)/sirtuin 2 (SIRT2) pathway. LMO2 deacetylation enables LMO2 to interact with LIM domain binding 1 and activate the TAL1 complex. NAMPT/SIRT2-mediated activation of LMO2 by deacetylation appears to be important for hematopoietic differentiation of induc...
Source: Blood - October 3, 2019 Category: Hematology Authors: Morishima, T., Krahl, A.-C., Nasri, M., Xu, Y., Aghaallaei, N., Findik, B., Klimiankou, M., Ritter, M., Hartmann, M. D., Gloeckner, C. J., Stefanczyk, S., Lindner, C., Oswald, B., Bernhard, R., Hähnel, K., Hermanutz-Klein, U., Ebinger, M., Handgre Tags: Lymphoid Neoplasia Source Type: research

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential side effects of continuous inhibition of these enzymes. Utilizing conditional Kdm4a/Kdm4b/Kdm4c triple-knockout mice, we show that KDM4 activity is required for hematopoietic stem cell (HSC) maintenance in vivo. The knockout of the KDM4 demethylases leads to accumulation of H3K9me3 on transcription start sites and the correspondin...
Source: Blood - October 3, 2019 Category: Hematology Authors: Agger, K., Nishimura, K., Miyagi, S., Messling, J.-E., Rasmussen, K. D., Helin, K. Tags: Hematopoiesis and Stem Cells, Myeloid Neoplasia, Brief Reports Source Type: research

Pembrolizumab in relapsed or refractory Hodgkin lymphoma: 2-year follow-up of KEYNOTE-087
We present the 2-year follow-up of the phase 2 KEYNOTE-087 study of pembrolizumab in 210 patients, based on HL progression after autologous stem cell transplantation (ASCT) and subsequent brentuximab vedotin (BV; cohort 1); salvage chemotherapy and BV, with ineligibility for SCT owing to chemorefractory disease (cohort 2); and progression after SCT without BV (cohort 3). With a median follow-up of 27.6 months, the objective response rate (ORR) by blinded independent central review was 71.9% (95% CI, 65.3-77.9), the complete response rate (CRR) was 27.6%, and the partial response (PR) rate was 44.3%. Median duration of resp...
Source: Blood - October 3, 2019 Category: Hematology Authors: Chen, R., Zinzani, P. L., Lee, H. J., Armand, P., Johnson, N. A., Brice, P., Radford, J., Ribrag, V., Molin, D., Vassilakopoulos, T. P., Tomita, A., von Tresckow, B., Shipp, M. A., Lin, J., Kim, E., Nahar, A., Balakumaran, A., Moskowitz, C. H. Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research

Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia
T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell neoplasm with a heterogeneous clinical course. With the advent of novel treatment options that will potentially change the management of patients with T-PLL, it has become necessary to produce consensus guidelines for the design and conduct of clinical trials. The T-PLL International Study group (TPLL-ISG) set out to define standardized criteria for diagnosis, treatment indication, and evaluation of response. These criteria will facilitate comparison of results from clinical trials in T-PLL, and will thus support clinical decision making, as well as the approv...
Source: Blood - October 3, 2019 Category: Hematology Authors: Staber, P. B., Herling, M., Bellido, M., Jacobsen, E. D., Davids, M. S., Kadia, T. M., Shustov, A., Tournilhac, O., Bachy, E., Zaja, F., Porkka, K., Hoermann, G., Simonitsch-Klupp, I., Haferlach, C., Kubicek, S., Mayerhoefer, M. E., Hopfinger, G., Jaeger, Tags: Special Reports, Free Research Articles, Lymphoid Neoplasia Source Type: research

Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis
Antiphospholipid antibodies (aPLs) with complex lipid and/or protein reactivities cause complement-dependent thrombosis and pregnancy complications. Although cross-reactivities with coagulation regulatory proteins contribute to the risk for developing thrombosis in patients with antiphospholipid syndrome, the majority of pathogenic aPLs retain reactivity with membrane lipid components and rapidly induce reactive oxygen species-dependent proinflammatory signaling and tissue factor (TF) procoagulant activation. Here, we show that lipid-reactive aPLs activate a common species-conserved TF signaling pathway. aPLs dissociate an...
Source: Blood - October 3, 2019 Category: Hematology Authors: Müller-Calleja, N., Hollerbach, A., Ritter, S., Pedrosa, D. G., Strand, D., Graf, C., Reinhardt, C., Strand, S., Poncelet, P., Griffin, J. H., Lackner, K. J., Ruf, W. Tags: Plenary Papers, Thrombosis and Hemostasis Source Type: research

Myelomas sound of silencing
(Source: Blood)
Source: Blood - October 3, 2019 Category: Hematology Authors: Boise, L. H. Tags: Free Research Articles COMMENTS Source Type: research

Pembrolizumab: living up to expectations
(Source: Blood)
Source: Blood - October 3, 2019 Category: Hematology Authors: Ansell, S. M. Tags: Free Research Articles COMMENTS Source Type: research

T-PLL: harmonizing criteria for research
(Source: Blood)
Source: Blood - October 3, 2019 Category: Hematology Authors: Risitano, A. M. Tags: Free Research Articles COMMENTS Source Type: research

Willemze R, Cerroni L, Kempf W, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133(16):1703-1714.
(Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Tags: Free Research Articles ERRATA Source Type: research

Stock W, Luger SM, Advani AS, et al. A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403. Blood. 2019;133(14):1548-1559.
(Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Tags: Free Research Articles ERRATA Source Type: research

B-lymphoblastic leukemia/lymphoma with an unusual appendiceal involvement
(Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Sukswai, N., Thirabanjasak, D. Tags: Free Research Articles, BloodWork, Lymphoid Neoplasia BLOOD WORK Source Type: research

Adjuvant low-dose rituximab and plasma exchange for acquired TTP
(Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Zwicker, J. I., Muia, J., Dolatshahi, L., Westfield, L. A., Nieters, P., Rodrigues, A., Hamdan, A., Antun, A. G., Metjian, A., Sadler, J. E., on behalf of the ART Investigators Tags: Thrombocytopenia, Platelets and Thrombopoiesis, Clinical Trials and Observations Letter to Blood Source Type: research

Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy
Severe deficiency of plasma ADAMTS13 activity is the primary cause of thrombotic thrombocytopenic purpura (TTP) whereas overwhelming activation of complement via an alternative pathway results in atypical hemolytic uremic syndrome (aHUS), the prototypes of thrombotic microangiopathy (TMA). However, clinical and pathogenic distinctions between TTP and aHUS are often quite challenging. Clinical reports have suggested that complement activation may play a role in the development of TTP, which is caused by severe deficiency of plasma ADAMTS13 activity. However, the experimental evidence to support this hypothesis is still lack...
Source: Blood - September 26, 2019 Category: Hematology Authors: Zheng, L., Zhang, D., Cao, W., Song, W.-C., Zheng, X. L. Tags: Thrombocytopenia, Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research

Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-{kappa}B to repress autocrine STAT3 activation in chronic lymphocytic leukemia
Coculture of nurse-like cells (NLCs) with chronic lymphocytic leukemia (CLL) cells induced leukemia cell phosphorylation of STAT3 (pSTAT3), which could be blocked by anti-Wnt5a antibodies or the anti-ROR1 monoclonal antibody, cirmtuzumab. Time-course studies revealed Wnt5a could induce activation of NF-B within 30 minutes, but required more than 3 hours to induce pSTAT3. Culture of isolated CLL cells for 24 hours revealed Wnt5a-induced expression of interleukin 6 (IL-6), IL-8, CCL2, CCL3, CCL4, and CXCL1, which in turn could induce pSTAT3 in unstimulated CLL cells within 30 minutes. We found that Wnt5a could induce CLL cel...
Source: Blood - September 26, 2019 Category: Hematology Authors: Chen, Y., Chen, L., Yu, J., Ghia, E. M., Choi, M. Y., Zhang, L., Zhang, S., Sanchez-Lopez, E., Widhopf, G. F., Messer, K., Rassenti, L. Z., Jamieson, C., Kipps, T. J. Tags: Lymphoid Neoplasia Source Type: research

Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma
In conclusion, this study provides novel evidence suggesting that aggressive antibiotic treatment inhibits malignant T cells in lesional skin. Thus, we provide a novel rationale for treatment of SA in advanced CTCL. (Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Lindahl, L. M., Willerslev-Olsen, A., Gjerdrum, L. M. R., Nielsen, P. R., Blümel, E., Rittig, A. H., Celis, P., Herpers, B., Becker, J. C., Stausbol-Gron, B., Wasik, M. A., Gluud, M., Fredholm, S., Buus, T. B., Johansen, C., Nastasi, C., Peiffer, Tags: Lymphoid Neoplasia Source Type: research

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs
We report the presence in fetal tissues of 2 distinct CD19+ B-progenitors, an adult-type CD10+ve ProB-progenitor and a new CD10-ve PreProB-progenitor, and describe their molecular and functional characteristics. PreProB-progenitors and ProB-progenitors appear early in the first trimester in embryonic liver, followed by a sustained second wave of B-progenitor development in fetal bone marrow (BM), where together they form>40% of the total hematopoietic stem cell/progenitor pool. Almost one-third of fetal B-progenitors are CD10-ve PreProB-progenitors, whereas, by contrast, PreProB-progenitors are almost undetectable (0.53...
Source: Blood - September 26, 2019 Category: Hematology Authors: OByrne, S., Elliott, N., Rice, S., Buck, G., Fordham, N., Garnett, C., Godfrey, L., Crump, N. T., Wright, G., Inglott, S., Hua, P., Psaila, B., Povinelli, B., Knapp, D. J. H. F., Agraz-Doblas, A., Bueno, C., Varela, I., Bennett, P., Koohy, H., Watt, S. M. Tags: Immunobiology and Immunotherapy, Lymphoid Neoplasia Source Type: research

Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases
Although bone marrow niche cells are essential for hematopoietic stem cell (HSC) maintenance, their interaction in response to stress is not well defined. Here, we used a mouse model of acute thrombocytopenia to investigate the cross talk between HSCs and niche cells during restoration of the thrombocyte pool. This process required membrane-localized stem cell factor (m-SCF) in megakaryocytes, which was regulated, in turn, by vascular endothelial growth factor A (VEGF-A) and platelet-derived growth factor-BB (PDGF-BB). HSCs and multipotent progenitors type 2 (MPP2), but not MPP3/4, were subsequently activated by a dual-rec...
Source: Blood - September 26, 2019 Category: Hematology Authors: Ramasz, B., Krüger, A., Reinhardt, J., Sinha, A., Gerlach, M., Gerbaulet, A., Reinhardt, S., Dahl, A., Chavakis, T., Wielockx, B., Grinenko, T. Tags: Hematopoiesis and Stem Cells, Thrombocytopenia, Platelets and Thrombopoiesis Source Type: research

Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors
In conclusion, stroke is common after recovery from TTP and is associated with reduced ADAMTS13 activity during remission. (Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Upreti, H., Kasmani, J., Dane, K., Braunstein, E. M., Streiff, M. B., Shanbhag, S., Moliterno, A. R., Sperati, C. J., Gottesman, R. F., Brodsky, R. A., Kickler, T. S., Chaturvedi, S. Tags: Thrombosis and Hemostasis, Clinical Trials and Observations Source Type: research

Ibrutinib plus lenalidomide and rituximab has promising activity in relapsed/refractory non-germinal center B-cell-like DLBCL
This study was registered at www.clinicaltrials.gov as #NCT02077166. (Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Goy, A., Ramchandren, R., Ghosh, N., Munoz, J., Morgan, D. S., Dang, N. H., Knapp, M., Delioukina, M., Kingsley, E., Ping, J., Beaupre, D. M., Neuenburg, J. K., Ruan, J. Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research

Amino acid metabolism in hematologic malignancies and the era of targeted therapy
Tumor cells rewire metabolic pathways to adapt to their increased nutritional demands for energy, reducing equivalents, and cellular biosynthesis. Alternations in amino acid metabolism are 1 modality for satisfying those demands. Amino acids are not only components of proteins but also intermediate metabolites fueling multiple biosynthetic pathways. Amino acid–depletion therapies target amino acid uptake and catabolism using heterologous enzymes or recombinant or engineered human enzymes. Notably, such therapies have minimal effect on normal cells due to their lower demand for amino acids compared with tumor cells an...
Source: Blood - September 26, 2019 Category: Hematology Authors: Tabe, Y., Lorenzi, P. L., Konopleva, M. Tags: Myeloid Neoplasia, Review Articles Source Type: research

Effect of donor, component, and recipient characteristics on hemoglobin increments following red blood cell transfusion
Significant research has focused individually on blood donors, product preparation and storage, and optimal transfusion practice. To better understand the interplay between these factors on measures of red blood cell (RBC) transfusion efficacy, we conducted a linked analysis of blood donor and component data with patients who received single-unit RBC transfusions between 2008 and 2016. Hemoglobin levels before and after RBC transfusions and at 24- and 48-hour intervals after transfusion were analyzed. Generalized estimating equation linear regression models were fit to examine hemoglobin increments after RBC transfusion ad...
Source: Blood - September 26, 2019 Category: Hematology Authors: Roubinian, N. H., Plimier, C., Woo, J. P., Lee, C., Bruhn, R., Liu, V. X., Escobar, G. J., Kleinman, S. H., Triulzi, D. J., Murphy, E. L., Busch, M. P. Tags: Transfusion Medicine, Plenary Papers Source Type: research

Antibiotics can improve CTCL
(Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Vermeer, M. H. Tags: Free Research Articles COMMENTS Source Type: research

Origins of the human B-cell lineage
(Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Müschen, M. Tags: Free Research Articles COMMENTS Source Type: research

Ibrutinib and lenalidomide: when 1+1 = >2
(Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Westin, J. Tags: Free Research Articles COMMENTS Source Type: research

A rose is a rose is a rose, or not
(Source: Blood)
Source: Blood - September 26, 2019 Category: Hematology Authors: Spitalnik, S. L. Tags: Free Research Articles COMMENTS Source Type: research

NMDP/CIBMTR donor selection guidelines
(Source: Blood)
Source: Blood - September 19, 2019 Category: Hematology Tags: Free Research Articles, CME article CONTINUING MEDICAL EDUCATION (CME) QUESTIONS Source Type: research

Li-Fraumeni syndrome presenting as precursor B lymphoblastic leukemia mimicking intravascular large B-cell lymphoma
(Source: Blood)
Source: Blood - September 19, 2019 Category: Hematology Authors: Khatri, S. S., Kim, A. S. Tags: Free Research Articles, BloodWork, Lymphoid Neoplasia BLOOD WORK Source Type: research

Posttransplant lymphoproliferative disorder: EBV- plasma cell myeloma with large multinucleated plasma cells
(Source: Blood)
Source: Blood - September 19, 2019 Category: Hematology Authors: Annunziata, J. F., Bhagat, G. Tags: Hematopoiesis and Stem Cells, Transplantation, Free Research Articles, BloodWork BLOOD WORK Source Type: research

Recurrent somatic JAK3 mutations in NK-cell enteropathy
(Source: Blood)
Source: Blood - September 19, 2019 Category: Hematology Authors: Xiao, W., Gupta, G. K., Yao, J., Jang, Y. J., Xi, L., Baik, J., Sigler, A., Kumar, A., Moskowitz, A. J., Arcila, M. E., Raffeld, M., Pittaluga, S., Dogan, A., Jaffe, E. S. Tags: Lymphoid Neoplasia Letter to Blood Source Type: research

Hypertension is a modifiable risk factor for osteonecrosis in acute lymphoblastic leukemia
(Source: Blood)
Source: Blood - September 19, 2019 Category: Hematology Authors: Janke, L. J., Van Driest, S. L., Portera, M. V., Atreya, R. V., Denny, J. C., Pei, D., Cheng, C., Kaste, S. C., Inaba, H., Jeha, S., Pui, C.-H., Relling, M. V., Karol, S. E. Tags: Lymphoid Neoplasia, Clinical Trials and Observations Letter to Blood Source Type: research

Proximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of von Willebrand factor secretion
Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular hemostasis and local inflammation. Endothelial activation triggers rapid exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rolling (P-selectin) and platelet capture (von Willebrand factor [VWF]). Despite its role as an important secretory organelle, a comprehensive compilation of factors associated with WPB has not been carried out. We addressed this via a proximity proteomics approach employing the peroxidase APEX2 coupled with 2 known WPB-associated prote...
Source: Blood - September 19, 2019 Category: Hematology Authors: Holthenrich, A., Drexler, H. C. A., Chehab, T., Nass, J., Gerke, V. Tags: Thrombosis and Hemostasis, Vascular Biology, Brief Reports Source Type: research

Venous stasis-induced fibrinolysis prevents thrombosis in mice: role of {alpha}2-antiplasmin
We examined the relationship between stasis, fibrinolysis, and the development of experimental venous thrombosis. Effects of stasis-induced deep vein thrombosis and fibrinolysis on thrombosis were examined by inferior vena cava ligation in congenic mice with and without α2-antiplasmin (α2AP), the primary inhibitor of plasmin. Venous thrombus weights were measured and thrombus composition was determined by Martius scarlet blue and immunofluorescence staining. Venous thrombi from α2AP+/+ mice contained plasminogen activators, plasminogen activator inhibitor-1, plasminogen, and α2AP, which changed with...
Source: Blood - September 19, 2019 Category: Hematology Authors: Singh, S., Houng, A. K., Reed, G. L. Tags: Thrombosis and Hemostasis Source Type: research

Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk
Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematologica...
Source: Blood - September 19, 2019 Category: Hematology Authors: Sud, A., Chattopadhyay, S., Thomsen, H., Sundquist, K., Sundquist, J., Houlston, R. S., Hemminki, K. Tags: Pediatric Hematology, Free Research Articles, Myeloid Neoplasia, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research

Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia
By combining the analysis of mutations with aberrant expression of genes previously related to poorer prognosis in both acute promyelocytic leukemia (APL) and acute myeloid leukemia, we arrived at an integrative score in APL (ISAPL) and demonstrated its relationship with clinical outcomes of patients treated with all-trans retinoic acid (ATRA) in combination with anthracycline-based chemotherapy. Based on fms-like tyrosine kinase-3–internal tandem duplication mutational status; the Np73/TAp73 expression ratio; and ID1, BAALC, ERG, and KMT2E gene expression levels, we modeled ISAPL in 159 patients (median ISAPL score,...
Source: Blood - September 19, 2019 Category: Hematology Authors: Lucena-Araujo, A. R., Coelho-Silva, J. L., Pereira-Martins, D. A., Silveira, D. R., Koury, L. C., Melo, R. A. M., Bittencourt, R., Pagnano, K., Pasquini, R., Nunes, E. C., Fagundes, E. M., Gloria, A. B., Kerbauy, F., de Lourdes Chauffaille, M., Bendit, I. Tags: Myeloid Neoplasia Source Type: research

High frequency of inactivating tetraspanin CD37 mutations in diffuse large B-cell lymphoma at immune-privileged sites
This study provides novel insight into the molecular pathogenesis of IP-DLBCL and indicates that anti-CD37 therapies will be more beneficial for DLBCL patients without CD37 mutations. (Source: Blood)
Source: Blood - September 19, 2019 Category: Hematology Authors: Elfrink, S., de Winde, C. M., van den Brand, M., Berendsen, M., Roemer, M. G. M., Arnold, F., Janssen, L., van der Schaaf, A., Jansen, E., Groenen, P. J. T. A., Eijkelenboom, A., Stevens, W., Hess, C. J., van Krieken, J. H., Vermaat, J. S. P., Cleven, A. Tags: Lymphoid Neoplasia, Brief Reports Source Type: research

GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia
In conclusion, AuSCT may still have a role in FR and IR MRD-negative categories. In the IR MRD-positive category, AlloSCT prolongs OS and DFS to equal those of the FR category. Using all the available sources of stem cells, AlloSCT was delivered to 71% of the candidates.This trial was registered at www.clinicaltrials.gov as #NCT01452646 and EudraCT as #2010-023809-36. (Source: Blood)
Source: Blood - September 19, 2019 Category: Hematology Authors: Venditti, A., Piciocchi, A., Candoni, A., Melillo, L., Calafiore, V., Cairoli, R., de Fabritiis, P., Storti, G., Salutari, P., Lanza, F., Martinelli, G., Luppi, M., Mazza, P., Martelli, M. P., Cuneo, A., Albano, F., Fabbiano, F., Tafuri, A., Chierichini, Tags: Myeloid Neoplasia, Clinical Trials and Observations Source Type: research

Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
Allogeneic hematopoietic cell transplantation involves consideration of both donor and recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution donor–recipient HLA match is of primary importance in transplantation with adult unrelated donors, using conventional graft-versus-host disease prophylaxis. In cord blood transplantation, optimal unit selection requires consideration of unit quality, cell dose and HLA-match. In this summary, the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow Transplant Research, jointly with the NMDP Histocompatib...
Source: Blood - September 19, 2019 Category: Hematology Authors: Dehn, J., Spellman, S., Hurley, C. K., Shaw, B. E., Barker, J. N., Burns, L. J., Confer, D. L., Eapen, M., Fernandez-Vina, M., Hartzman, R., Maiers, M., Marino, S. R., Mueller, C., Perales, M.-A., Rajalingam, R., Pidala, J. Tags: Special Reports, Transplantation, Free Research Articles, CME article Source Type: research

Sepsis alters the transcriptional and translational landscape of human and murine platelets
There is increasing recognition that platelets have a functional role in the pathophysiology of sepsis, though this role has not been precisely defined. Whether sepsis alters the human platelet transcriptome and translational landscape has never been established. We used parallel techniques of RNA sequencing and ribosome footprint profiling to interrogate the platelet transcriptome and translatome in septic patients and healthy donors. We identified 1806 significantly differentially expressed (false discovery rate
Source: Blood - September 19, 2019 Category: Hematology Authors: Middleton, E. A., Rowley, J. W., Campbell, R. A., Grissom, C. K., Brown, S. M., Beesley, S. J., Schwertz, H., Kosaka, Y., Manne, B. K., Krauel, K., Tolley, N. D., Eustes, A. S., Guo, L., Paine, R., Harris, E. S., Zimmerman, G. A., Weyrich, A. S., Rondina, Tags: Plenary Papers, Platelets and Thrombopoiesis Source Type: research

WPBs: making a mark and leaving a trail
(Source: Blood)
Source: Blood - September 19, 2019 Category: Hematology Authors: Carter, T., Bierings, R. Tags: Free Research Articles COMMENTS Source Type: research

Martin P, Bartlett NL, Blum KA, et al. A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma. Blood. 2019;133(11):1201-1204.
(Source: Blood)
Source: Blood - September 12, 2019 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research

Pay attention to neutrophil inclusions in pediatric patients with thrombocytopenia
(Source: Blood)
Source: Blood - September 12, 2019 Category: Hematology Authors: Iqbal, N. T., Li, W. Tags: Free Research Articles, BloodWork, Platelets and Thrombopoiesis BLOOD WORK Source Type: research

CD138- plasma cell myeloma
(Source: Blood)
Source: Blood - September 12, 2019 Category: Hematology Authors: Shuai, W., Li, S. Tags: Free Research Articles, BloodWork, Lymphoid Neoplasia BLOOD WORK Source Type: research

Natural history and cell of origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL
(Source: Blood)
Source: Blood - September 12, 2019 Category: Hematology Authors: Bueno, C., Tejedor, J. R., Bashford-Rogers, R., Gonzalez-Silva, L., Valdes-Mas, R., Agraz-Doblas, A., Diaz de la Guardia, R., Ribera, J., Zamora, L., Bilhou-Nabera, C., Abermil, N., Guermouche, H., Gouache, E., Leverger, G., Fraga, M. F., Fernandez, A. F. Tags: Lymphoid Neoplasia Letter to Blood Source Type: research

Posttransplant cyclophosphamide vs antithymocyte globulin in HLA-mismatched unrelated donor transplantation
The use of anti-thymocyte globulin (ATG) has represented the standard of care in graft-versus-host disease (GVHD) prophylaxis in patients undergoing a mismatched unrelated donor (MMUD) transplant. The safety and feasibility of posttransplant cyclophosphamide (PTCY) in this setting have been reported recently, but no study has compared the outcomes of PTCY vs ATG in 9/10 MMUD transplants. Using the registry data of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we performed a matched-pair analysis comparing those 2 strategies in a 9/10 MMUD setting. Ninety-three patients recei...
Source: Blood - September 12, 2019 Category: Hematology Authors: Battipaglia, G., Labopin, M., Kröger, N., Vitek, A., Afanasyev, B., Hilgendorf, I., Schetelig, J., Ganser, A., Blaise, D., Itälä-Remes, M., Passweg, J. R., Bonifazi, F., Finke, J., Ruggeri, A., Nagler, A., Mohty, M. Tags: Transplantation, Myeloid Neoplasia, Clinical Trials and Observations Source Type: research

Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients
In this study, we aim to describe the genetic determinants that modify the FVIII PK profile in a population of 43 pediatric hemophilia A patients. We observed that VWF:Ag and VWF propeptide (VWFpp)/VWF:Ag, but not VWFpp, were associated with FVIII half-life. VWFpp/VWF:Ag negatively correlated with FVIII half-life in patients with non-O blood type, but no correlation was observed for type O patients, suggesting that von Willebrand factor (VWF) half-life, as modified by the ABO blood group, is a strong regulator of FVIII PK. The FVIII-binding activity of VWF positively correlated with FVIII half-life, and the rare or low-fre...
Source: Blood - September 12, 2019 Category: Hematology Authors: Swystun, L. L., Ogiwara, K., Rawley, O., Brown, C., Georgescu, I., Hopman, W., Labarque, V., Male, C., Thom, K., Blanchette, V. S., Carcao, M. D., Lillicrap, D. Tags: Thrombosis and Hemostasis Source Type: research

Genomic landscape of neutrophilic leukemias of ambiguous diagnosis
In conclusion, these groups of diseases represent a continuum of related diseases rather than discrete diagnostic entities. (Source: Blood)
Source: Blood - September 12, 2019 Category: Hematology Authors: Zhang, H., Wilmot, B., Bottomly, D., Dao, K.-H. T., Stevens, E., Eide, C. A., Khanna, V., Rofelty, A., Savage, S., Reister Schultz, A., Long, N., White, L., Carlos, A., Henson, R., Lin, C., Searles, R., Collins, R. H., DeAngelo, D. J., Deininger, M. W., D Tags: Myeloid Neoplasia Source Type: research