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Diagnostic value of targeted next ‐generation sequencing (NGS) in suspected hemochromatosis patients with a single copy of the HFE p.Cys282Tyr causative allele
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 22, 2017 Category: Hematology Authors: Kevin Uguen, Virginie Scotet, Chandran Ka, Isabelle Gourlaouen, Carine L'Hostis, Marie ‐Christine Merour, Tania Cuppens, Claude Ferec, Gerald Le Gac Tags: Correspondence Source Type: research

The eutos long ‐term survival score (elts) accurately predicts the risk of death in chronic myeloid leukaemia patients treated outside of clinical trials
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 22, 2017 Category: Hematology Authors: Matteo Molica, Martina Canichella, Danilo Alunni Fegatelli, Gioia Colafigli, Fulvio Massaro, Roberto Latagliata, Robin Fo à, Massimo Breccia Tags: Correspondence Source Type: research

Safety and Pharmacokinetics of the Oral Iron Chelator SP ‐420 in β‐thalassemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 22, 2017 Category: Hematology Authors: Ali T Taher, Antoine N Saliba, Kevin H Kuo, Patricia J Giardina, Alan R Cohen, Ellis J Neufeld, Yesim Aydinok, Janet L Kwiatkowski, Brenda I Jeglinski, Keith Pietropaolo, Gregory Berk, Vip Viprakasit Tags: Research Article Source Type: research

Liver Dysfunction in Chronic Lymphocytic Leukemia: Prevalence, Outcomes, and Pathological Findings
Abstract The prevalence of liver dysfunction and its association with outcomes in patients with previously untreated chronic lymphocytic leukemia (CLL) is unknown. Newly diagnosed (
Source: American Journal of Hematology - September 22, 2017 Category: Hematology Authors: Paul J. Hampel, Kari G. Chaffee, Rebecca L. King, Douglas Simonetto, Melissa C. Larson, Sara Achenbach, Timothy G. Call, Wei Ding, Saad S. Kenderian, Jose F. Leis, Asher A. Chanan ‐Khan, Deborah A. Bowen, Michael J. Conte, Susan M. Schwager, Curtis A. H Tags: Research Article Source Type: research

Effects of Pre ‐ and Post‐transplantation Minimal Residual Disease on Outcomes in Pediatric Patients with Acute Myeloid Leukemia Receiving Human Leukocyte Antigen‐matched or Mismatched Related Donor Allografts
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 20, 2017 Category: Hematology Authors: Ying ‐Jun Chang, Xiao‐Su Zhao, Yu Wang, Yan‐Rong Liu, Lan‐Ping Xu, Xiao‐Hui Zhang, Huan Chen, Yu‐Hong Chen, Wei‐ Han, Yu‐Qian Sun, Chen‐Hua Yan, Xiao‐Dong Mo, Kai‐Yan Liu, Xiao‐Jun Huang Tags: Correspondence Source Type: research

Treatment of hepatitis C virus infection with direct ‐acting antiviral drugs is safe and effective in patients with hemoglobinopathies
In conclusion, the use of DAAs appears to be safe and effective in patients with hemoglobinopathies and advanced liver disease due to HCV. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 20, 2017 Category: Hematology Authors: Raffaella Origa, Maria Laura Ponti, Aldo Filosa, Alfonso Galeota Lanza, Antonio Piga, Giorgio Maria Saracco, Valeria Pinto, Antonino Picciotto, Paolo Rigano, Salvatore Madonia, Rosamaria Rosso, Domenico D'Ascola, Maria Domenica Cappellini, Roberta D'Ambro Tags: Research Article Source Type: research

Bone marrow xanthomas associated with hypertriglyceridemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 19, 2017 Category: Hematology Authors: Nelson CN Chan, Chak ‐Chung Chan, Natalie PH Chan Tags: Diagnostic Imaging in Hematology Source Type: research

Incidence and predictive score for delayed hemolytic transfusion reaction in adult patients with sickle cell disease
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 19, 2017 Category: Hematology Authors: David Narbey, Anoosha Habibi, Philippe Chadebech, Armand Mekontso ‐Dessap, Mehdi Khellaf, Jean‐Daniel Lelièvre, Bertrand Godeau, Marc Michel, Frédéric Galactéros, Rachid Djoudi, Pablo Bartolucci, France Pirenne Tags: Research Article Source Type: research

A Clinically Meaningful Fetal Hemoglobin Threshold for Children with Sickle Cell Anemia During Hydroxyurea Therapy
Abstract Hydroxyurea has proven clinical benefits and is recommended to be offered to all children with sickle cell anemia (SCA), but the optimal dosing regimen remains controversial. Induction of red blood cell fetal hemoglobin (HbF) by hydroxyurea appears to be dose‐dependent. However, it is unknown whether maximizing HbF% improves clinical outcomes. HUSTLE (NCT00305175) is a prospective observational study with a primary goal of describing the long‐term clinical effects of hydroxyurea escalated to maximal tolerated dose (MTD) in children with SCA. In 230 children, providing 610 patient‐years of follow up, the mean...
Source: American Journal of Hematology - September 15, 2017 Category: Hematology Authors: Jeremie H. Estepp, Matthew P. Smeltzer, Guolian Kang, Chen Li, Winfred C. Wang, Christina Abrams, Banu Aygun, Russell E. Ware, Kerri Nottage, Jane S. Hankins Tags: Research Article Source Type: research

A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study)
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 11, 2017 Category: Hematology Authors: Takashi Kobayashi, Yasuhito Nannya, Motoshi Ichikawa, Kenji Oritani, Yuzuru Kanakura, Akihiro Tomita, Hitoshi Kiyoi, Masayoshi Kobune, Junji Kato, Hiroshi Kawabata, Motohiro Shindo, Yoshihiro Torimoto, Yuji Yonemura, Nobuyoshi Hanaoka, Hideki Nakakuma, Da Tags: Research Article Source Type: research

Clinical management of peripherally ‐inserted central catheters (PICCs) compared to conventional central venous catheters (cCVCs) in patients with hematological malignancies: a large multicenter study of the REL GROUP (Rete Ematologica Lombarda ‐ Lombardy Hematologic Network, Italy)
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 11, 2017 Category: Hematology Authors: Nicola Stefano Fracchiolla, Elisabetta Todisco, Andrea Bilancia, Sara Gandolfi, Nicola Orofino, Francesca Guidotti, Valentina Mancini, Laura Marbello, Andrea Assanelli, Massimo Bernardi, Armando Santoro, Roberto Cairoli, Dario Consonni, Agostino Cortelezz Tags: Correspondence Source Type: research

Unrelated matched versus autologous transplantation in adult patients with good and intermediate risk acute myelogenous leukemia in first molecular remission
Abstract Patients with Acute Myelogenous Leukemia have a better outcome if reaching molecular remission. We compared the outcome of 373 patients autografted and 335 patients allografted with a 10/10 compatible unrelated donor in first molecular remission. Patients were stratified using the ELN European Leukemia Net classification. ELN favorable group: (234 auto and 70 unrelated transplants). By univariate analysis, in the auto group, the Non Relapse Mortality (NRM) was lower (3.7% versus 19%; p
Source: American Journal of Hematology - September 11, 2017 Category: Hematology Authors: Norbert ‐Claude Gorin, Myriam Labopin, Thomas Pabst, Peter Remenyi, Depei Wu, Anne Huynh, Liisa Volin, Jean Yves Cahn, Ibrahim Yakoub‐Agha, Melanie Mercier, Mohamed Houhou, Mohamad Mohty, Arnon Nagler, Tags: Research Article Source Type: research

Identification of novel mutations in the HbF repressor gene BCL11A in patients with autism and intelligence disabilities
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 10, 2017 Category: Hematology Authors: Tao Cai, Xiang Chen, Jinchen Li, Bingwu Xiang, Liu Yang, Yidian Liu, Qiuli Chen, Zhouwen He, Kevin Sun, P. Paul Liu Tags: Correspondence Source Type: research

Diagnosis of thrombotic thrombocytopenic purpura among patients with ADAMTS13 Activity 10% ‐20%
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 8, 2017 Category: Hematology Authors: Adanma Ayanambakkam, Johanna A. Kremer Hovinga, Sara K. Vesely, James N. George Tags: CORRESPONDENCE Source Type: research

Targeted next ‐generation sequencing in myelodysplastic syndromes and prognostic interaction between mutations and IPSS‐R
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 6, 2017 Category: Hematology Authors: Ayalew Tefferi, Terra L Lasho, Mrinal M Patnaik, Lyla Saeed, Mythri Mudireddy, Dame Idossa, Christy Finke, Rhett P Ketterling, Animesh Pardanani, Naseema Gangat Tags: Research Article Source Type: research

Cutaneous T ‐cell lymphoma: 2017 update on diagnosis, risk‐stratification, and management
Abstract Disease overviewCutaneous T‐cell lymphomas are a heterogenous group of T‐cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). DiagnosisThe diagnosis of MF or SS requires the integration of clinical and histopathologic data. Risk‐adapted therapyTNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a “risk‐adapted,” multi‐disciplinary approach to treatment. For patients with disease limited to the skin, expectant management or ...
Source: American Journal of Hematology - September 5, 2017 Category: Hematology Authors: Ryan A. Wilcox Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES Source Type: research

Issue Information – Table of Contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 5, 2017 Category: Hematology Tags: Issue Information – Table of Contents Source Type: research

Causes of Hospital Admission in β‐Thalassemia (CHAT) in Lebanon from 1995 to 2015: A pilot retrospective study from a tertiary care center
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 31, 2017 Category: Hematology Authors: Antoine N. Saliba, Hassan M. Moukhadder, Afif Harb, Hassan Beydoun, Rayan Bou ‐Fakhredin, Ali T. Taher Tags: Correspondence Source Type: research

Enhancing diversity in the hematology biomedical research workforce: A mentoring program to improve the odds of career success for early stage investigators
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 31, 2017 Category: Hematology Authors: Betty S. Pace, Levi H. Makala, Rita Sarkar, Li Liu, Mayuko Takezaki, Narla Mohandas, Glorias Dixon, Ellen M. Werner, Donna B. Jeffe, Treva K. Rice, Nita J. Maihle, Juan Gonz ález Tags: Commentary Source Type: research

Long ‐term survival of beta thalassemia major patients treated with hematopoietic stem cell transplantation compared with survival with conventional treatment
In conclusion, the 30‐year survival rate of ex‐thalassemia patients after HSCT was similar to that expected in CT thalassemia patients, with the vast majority of HSCT survivors cured from thalassemia. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 29, 2017 Category: Hematology Authors: Giovanni Caocci, Maria Grazia Orofino, Adriana Vacca, Antonio Piroddi, Eugenia Piras, Maria Carmen Addari, Rossella Caria, Maria Paola Pilia, Raffaella Origa, Paolo Moi, Giorgio La Nasa Tags: Research Article Source Type: research

Clinical Outcomes in Adult Patients with Aplastic Anemia ‐ a single institution experience
Abstract Newer treatment modalities are being investigated to improve upon historical outcomes with standard immunosuppressive therapy (IST) in aplastic anemia (AA). We analyzed outcomes of adult patients with AA sequentially treated with various combinatorial anti‐thymoglobulin‐based IST regimens in frontline and relapsed/refractory (R/R) settings. Pretreatment and on‐treatment clinical characteristics were analyzed for relationships to response and outcome. Among 126 patients reviewed, 95 were treatment‐naïve (TN) and 63, R/R (including 32 from the TN cohort); median ages were 49 and 50 years, respectively. ...
Source: American Journal of Hematology - August 29, 2017 Category: Hematology Authors: Prajwal Boddu, Guillermo Garcia ‐Manero, Farhad Ravandi, Gautam Borthakur, Elias Jabbour, Courtney DiNardo, Nitin Jain, Naval Daver, Naveen Pemmaraju, Paolo Anderlini, Simrit Parmar, Devendra KC, Mary Akosile, Sherry A. Pierce, Richard Champlin, Jorge C Tags: Research Article Source Type: research

Changes in intestinal microbiota and their effects on allogeneic stem cell transplantation
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 26, 2017 Category: Hematology Authors: Rory M Shallis, Christopher M Terry, Seah H Lim Tags: Critical Review Source Type: research

A Single Center Phase II Study of Ixazomib in Patients with Relapsed or Refractory Cutaneous or Peripheral T ‐cell Lymphomas
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 26, 2017 Category: Hematology Authors: Philip S. Boonstra, Avery Polk, Noah Brown, Alexandra C. Hristov, Nathanael G. Bailey, Mark S. Kaminski, Tycel Phillips, Sumana Devata, Tera Mayer, Ryan A. Wilcox Tags: Research Article Source Type: research

Imatinib ‐induced psoriasiform eruption in a patient with chronic myeloid leukemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 24, 2017 Category: Hematology Authors: Connie R. Shi, Vinod E. Nambudiri Tags: Images in Hematology Source Type: research

Limitations of poor bone marrow aspirations (for an accurate diagnosis) despite the multimodal analytical era: A longitudinal retrospective study
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 24, 2017 Category: Hematology Authors: John M. Astle, Mina L. Xu, Tamir Friedman, Elliott Brown Tags: CORRESPONDENCE Source Type: research

Risk factors and a prognostic model for postsplenectomy survival in myelofibrosis
Abstract Palliative treatment in myelofibrosis (MF) includes transfusion support, JAK2 inhibitors, involved field radiotherapy and splenectomy. To assist in selecting patients who are likely to benefit from splenectomy, we looked into risk factors for postsplenectomy survival, in 120 consecutive cases (median age 66 years); at the time of splenectomy, 61% displayed red cell transfusion need, 49% platelet count 25 × 10(9)/L, 60% constitutional symptoms and 13% circulating blasts ≥5%; dynamic international prognostic scoring system risk categories were 21% high, 55% intermediate‐2, 21% intermediate‐1 and 3% low....
Source: American Journal of Hematology - August 24, 2017 Category: Hematology Authors: Ayalew Tefferi, Mythri Mudireddy, Naseema Gangat, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, David M. Nagorney Tags: RESEARCH ARTICLE Source Type: research

Considerations on POEMS associated optic neuropathy
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 23, 2017 Category: Hematology Authors: Julio Gonz ález Martín‐Moro, Inés Contreras Martín, María Castro‐Rebollo, Belén Pilo de la Fuente Tags: Correspondence Source Type: research

Comprehensive Evaluation of the Revised International Staging System in Multiple Myeloma Patients Treated with Novel Agents as a Primary Therapy
Abstract The revised International Staging System (R‐ISS) has recently been developed to improve the risk stratification of multiple myeloma (MM) patients over the ISS. We assessed the R‐ISS in MM patients who were treated with novel agents as a primary therapy and evaluated its discriminative power and ability to reclassify patients from the ISS. A total of 514 newly diagnosed MM patients treated with novel agents including thalidomide, bortezomib, and lenalidomide as a primary therapy were included in this retrospective analysis. With a median follow‐up duration of 42.3 months (range, 40.5–44.1), the median o...
Source: American Journal of Hematology - August 22, 2017 Category: Hematology Authors: Hyungwoo Cho, Dok Hyun Yoon, Jung Bok Lee, Sung ‐Yong Kim, Joon Ho Moon, Young Rok Do, Jae Hoon Lee, Yong Park, Ho Sup Lee, Hyeon Seok Eom, Ho‐Jin Shin, Chang‐Ki Min, Jin Seok Kim, Jae‐Cheol Jo, Hye Jin Kang, Yeung‐Chul Mun, Won Sik Lee, Je‐Ju Tags: Research Article Source Type: research

Clinical and Laboratory Findings Associated with Sleep Disordered Breathing in Sickle Cell Disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 22, 2017 Category: Hematology Authors: Christopher M. Worsham, Stephon T. Martin, Mehdi Nouraie, Robyn T. Cohen, Elizabeth S. Klings Tags: Correspondence Source Type: research

First ‐line treatment selection and early monitoring patterns in chronic phase‐chronic myeloid leukemia in routine clinical practice: SIMPLICITY
Abstract Achieving successful outcomes in chronic phase‐chronic myeloid leukemia (CP‐CML) requires careful monitoring of cytogenetic/molecular responses (CyR/MR). SIMPLICITY (NCT01244750) is an observational study exploring tyrosine kinase inhibitor use and management patterns in patients with CP‐CML receiving first‐line imatinib (n=416), dasatinib (n=418) or nilotinib (n=408) in the US and 6 European countries in routine clinical practice. Twelve‐month follow‐up data of 1,242 prospective patients (enrolled October 01 2010–September 02 2015) are reported. 81% of patients had baseline comorbidities. Treatm...
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Stuart L. Goldberg, Jorge Cortes, Carlo Gambacorti ‐Passerini, Rüdiger Hehlmann, H. Jean Khoury, Mauricette Michallet, Ron Paquette, Bengt Simonsson, Teresa Zyczynski, Aimee Foreman, Elisabetta Abruzzese, David Andorsky, Aart Beeker, Pascale Cony‐Mak Tags: Research Article Source Type: research

A distinctive histidine residue is essential for in vivo glycation ‐inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Rupam Sahoo, Pamela Ghosh, Michael Chorev, Jose A Halperin Tags: Research Article Source Type: research

Diagnosis of thrombotic thrombocytopenic purpura among patients with adamts13 activity 10 ‐20%
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Adanma Ayanambakkam, Johanna A. Kremer Hovinga, Sara K. Vesely, James N. George Tags: Correspondence Source Type: research

Ibrutinib ‐associated Pneumocystis jirovecii pneumonia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Regina Lee, Afrouz Nayernama, S. Christopher Jones, Tanya Wroblewski, Peter E. Waldron Tags: Correspondence Source Type: research

Bmp2 controls iron homeostasis in mice independent of Bmp6
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Susanna Canali, Chia ‐Yu Wang, Kimberly B. Zumbrennen‐Bullough, Abraham Bayer, Jodie L. Babitt Tags: Research Article Source Type: research

Treatment of Individuals Who Cannot Receive Blood Products for Religious or Other Reasons
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Carlton D. Scharman, Joseph J. Shatzel, Edward Kim, Thomas G. DeLoughery Tags: Critical Review Source Type: research

Rare complication of treated immune thrombocytopenia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 12, 2017 Category: Hematology Authors: Radhika Gangaraju, Anton Rets, Kristi J Smock, Nahla M Heikal Tags: Solving Clinical Problems in Blood Diseases Source Type: research

Efficacy of daratumumab ‐based therapies in patients with relapsed, refractory multiple myeloma treated outside of clinical trials
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 11, 2017 Category: Hematology Authors: Arjun Lakshman, Jithma P. Abeykoon, Shaji K. Kumar, S. Vincent Rajkumar, David Dingli, Francis K. Buadi, Wilson I. Gonsalves, Nelson Leung, Angela Dispenzieri, Taxiarchis V. Kourelis, Ronald S. Go, Martha Q. Lacy, Miriam A. Hobbs, Yi Lin, Rahma Warsame, J Tags: Research Article Source Type: research

Gender and survival in essential thrombocythemia: A two ‐center study of 1,494 patients
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 10, 2017 Category: Hematology Authors: Ayalew Tefferi, Silvia Betti, Daniela Barraco, Mythri Mudireddy, Sahrish Shah, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, Naseema Gangat, Giacomo Coltro, Paola Guglielmelli, Alessandro M. Vannucchi Tags: Research Article Source Type: research

CLL progression after one cycle of FCR: Richter's transformation versus EBV ‐associated lympho‐proliferation
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 10, 2017 Category: Hematology Authors: Preetesh Jain, Jan A. Burger, Joseph D. Khoury Tags: DIAGNOSTIC IMAGING IN HEMATOLOGY Source Type: research

Risk factors and a prognostic model for post ‐splenectomy survival in myelofibrosis
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 7, 2017 Category: Hematology Authors: Ayalew Tefferi, Mythri Mudireddy, Naseema Gangat, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, David M. Nagorney Tags: Research Article Source Type: research

Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment
Abstract Disease OverviewChronic lymphocytic leukemia (CLL) is the commonest leukemia in western countries. The disease typically occurs in elderly patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that impair apoptosis of clonal B cells. DiagnosisThe diagnosis is established by blood counts, blood smears, and immunophenotyping of circulating B lymphocytes, which identify a clonal B‐cell population carrying the CD5 antigen and B‐cell markers. PrognosisTwo prognostic staging systems exist, the Rai and Binet staging systems, which are established by p...
Source: American Journal of Hematology - August 7, 2017 Category: Hematology Authors: Michael Hallek Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES Source Type: research

Issue Information – Table of Contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 7, 2017 Category: Hematology Tags: Issue Information – Table of Contents Source Type: research

SIRT1 Activates the Expression of Fetal Hemoglobin Genes
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 4, 2017 Category: Hematology Authors: Yan Dai, Tyngwei Chen, Heba Ijaz, Elizabeth H Cho, Martin H Steinberg Tags: Research Article Source Type: research

Emerging role of bevacizumab in management of patients with symptomatic hepatic involvement in Hereditary Hemorrhagic Telangiectasia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Ajay Chavan, Silke Schumann ‐Binarsch, Bernhard Schmuck, Franziska Oltmer, Urban Geisthoff, Florian Hoppe, Kornelia Wirsching, Juergen Klempnauer, Michael Manns, Rohit Philip Thomas, Claus‐Henning Köhne Tags: Correspondence Source Type: research

Outcomes after 18 Months of Eliglustat Therapy in Treatment ‐Naïve Adults with Gaucher Disease Type 1: The Phase 3 ENGAGE Trial
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Pramod K. Mistry, Elena Lukina, Hadhami Ben Turkia, Suma P. Shankar, Hagit Baris, Marwan Ghosn, Atul Mehta, Seymour Packman, Gregory Pastores, Milan Petakov, Sarit Assouline, Manisha Balwani, Sumita Danda, Evgueniy Hadjiev, Andres Ortega, Sebastiaan J.M. Tags: Research Article Source Type: research

The impact of antibody profile in thrombosis associated with primary antiphospholipid syndrome
Abstract Triple positivity (TP) for antiphospholipid antibodies(aPL) may identify aPL carriers with poorer prognosis. The clinical impact of TP in primary antiphospholipid syndrome(PAPS) remains unclear and further clinical evidences are needed to validate TP as a marker of severity. The aim of this study was to evaluate the impact of TP on the clinical course of PAPS with thrombosis(t‐PAPS). We performed a retrospective analysis of a cohort of t‐PAPS patients, comparing groups of patients with TP and non‐TP profiles according to their demographic, clinical and laboratory features. We included 105 patients with t‐P...
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Sabrina da Silva Saraiva, Bruna de Moraes Mazetto, Lais Quinteiro Tobaldine, Marina Pereira Colella, Erich Vin ícius De Paula, Joyce Annichinno‐Bizzachi, Fernanda Andrade Orsi Tags: Research Article Source Type: research

Engineered red blood cells as therapeutic agents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Mauro Magnani Tags: Commentary Source Type: research

Thrombotic and hemorrhagic complications in idiopathic erythrocytosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Irene Bertozzi, Marco Ruggeri, Ilaria Nichele, Giacomo Biagetti, Elisabetta Cosi, Maria Luigia Randi Tags: Correspondence Source Type: research

Clinical characteristics and outcomes of previously untreated patients with adult onset T ‐acute lymphoblastic leukemia and T‐lymphoblastic lymphoma with hyper‐CVAD based regimens
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 29, 2017 Category: Hematology Authors: Preetesh Jain, Hagop Kantarjian, Nitin Jain, Nicholas J. Short, Cameron C. Yin, Rashmi Kanagal ‐Shamanna, Joseph Khoury, Marina Konopleva, Koji Sasaki, Tapan M. Kadia, Rebecca Garris, Sherry Pierce, Zeev Estrov, William Wierda, Jorge Cortes, Susan O'Bri Tags: CORRESPONDENCE Source Type: research

History of consolidation is prognostic in acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation in minimal residual disease ‐negative first complete remission
ConclusionsIn AML patients undergoing allo‐HCT in MRD‐negative CR1, a history of prior consolidation was associated with favorable outcomes. If the path to pre‐HCT MRD negativity includes consolidation, it may identify patients with improved prognosis following HCT in MRD‐negative state. These results warrant validation in larger cohorts. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 29, 2017 Category: Hematology Authors: Armin Rashidi, Michael A. Linden, Todd E. DeFor, Erica Warlick, Nelli Bejanyan, Sophia Yohe, Daniel J. Weisdorf, Celalettin Ustun Tags: RESEARCH ARTICLE Source Type: research