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Prognosis in Myelodysplastic Syndromes: The Attractions and Limitations of Simplicity
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 16, 2018 Category: Hematology Authors: David P. Steensma Tags: Commentary Source Type: research

Concomitant cutaneous squamous cell carcinoma and chronic lymphocytic leukemia in a patient: The utility of 18F ‐FDG PET/CT in differentiation of nodal metastasis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Authors: Kerem Ozturk, Celalettin Ustun, Sobia Khaja, Faqian Li, Matthew Rischall, Zuzan Cayci Tags: DIAGNOSTIC IMAGING IN HEMATOLOGY Source Type: research

A prospective analysis for prevalence of complications in Thai nontransfusion ‐dependent Hb E/β‐thalassemia and α‐thalassemia (Hb H disease)
Recently, complications in patients with nontransfusion‐dependent thalassemia (NTDT), in particular those with β‐thalassemia intermedia (β‐TI), were found to be significantly different from those in patients with transfusion dependent thalassemia (TDT), mainly β‐thalassemia major (β–TM). However, this information is rather limited in other forms of NTDT. In this prospective study, adult Thai NTDT patients were interviewed and clinically evaluated for thalassemia related complications. Fifty‐seven NTDT patients (age 18‐74 years), 59.6% Hb E/β‐thalassemia and 40.4% Hb H disease, w...
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Authors: Supachai Ekwattanakit, Noppadol Siritanaratkul, Vip Viprakasit Tags: RESEARCH ARTICLE Source Type: research

EDTA ‐related degranulation mimicking storage pool disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 12, 2018 Category: Hematology Authors: Marco Amoruso, Lorenzo Alberio, Monika Nagy Tags: Images in Hematology Source Type: research

Predictive value of the new renal response criteria in AL amyloidosis treated with high dose melphalan and stem cell transplantation
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 12, 2018 Category: Hematology Authors: Andrea Havasi, Gheorghe Doros, Vaishali Sanchorawala Tags: Correspondence Source Type: research

Mayo CALR mutation type classification guide using alpha helix propensity
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 9, 2018 Category: Hematology Authors: Terra L. Lasho, Christy M. Finke, Alexander Tischer, Animesh Pardanani, Ayalew Tefferi Tags: Correspondence Source Type: research

Decitabine improves response rate and prolongs progression ‐free survival in older patients with newly diagnosed acute myeloid leukemia and with monosomal karyotype: A subgroup analysis of the DACO‐016 trial
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: Agnieszka Wierzbowska, Ewa Wawrzyniak, Agnieszka Pluta, Tadeusz Robak, Grzegorz J. Mazur, Anna Dmoszynska, Jaroslav Cermak, Albert Oriol, Daniel Lysak, Chris Arthur, Margaret Doyle, Liang Xiu, Farhad Ravandi, Hagop M. Kantarjian Tags: Correspondence Source Type: research

Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial
Abstract Few trials have examined rates of hypersensitivity reactions (HSRs) with intravenous iron formulations used to treat iron deficiency anemia. This randomized, multicenter, double‐blind clinical trial compared the safety and efficacy of ferumoxytol versus ferric carboxymaltose (FCM), focusing on rates of HSRs and hypotension as the primary end point. Patients with iron deficiency anemia of any etiology in whom oral iron was unsatisfactory or intolerable received ferumoxytol (n = 997) or FCM (n = 1000) intravenously over ≥15 minutes on days 1 and 8 or 9 for total respective doses of 1.02 g and 1.50 g. Composite ...
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: N. Franklin Adkinson, William E. Strauss, Iain C. Macdougall, Kristine E. Bernard, Michael Auerbach, Robert F. Kaper, Glenn M. Chertow, Julie S. Krop Tags: Research Article Source Type: research

Longitudinal detection of DNMT3AR882H transcripts in patients with acute myeloid leukemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: Tiziana Ottone, Valentina Alfonso, Licia Iaccarino, Syed Khizer Hasan, Melissa Mancini, Mariadomenica Divona, Serena Lavorgna, Laura Cicconi, Paola Panetta, Luca Maurillo, Maria Ilaria Del Principe, Maria Irno Consalvo, Luca Franceschini, Daniela Francesc Tags: Correspondence Source Type: research

Mutations and prognosis in myelodysplastic syndromes: Karyotype ‐adjusted analysis of targeted sequencing in 300 consecutive cases and development of a genetic risk model
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: Naseema Gangat, Mythri Mudireddy, Terra L. Lasho, Christy M. Finke, Maura Nicolosi, Natasha Szuber, Mrinal M. Patnaik, Animesh Pardanani, Curtis A. Hanson, Rhett P. Ketterling, Ayalew Tefferi Tags: Research Article Source Type: research

Ruxolitinib as First ‐Line Treatment in Secondary Hemophagocytic Lymphohistiocytosis: A Second Experience
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: Inuk Zandvakili, Caitlin B. Conboy, Ayed O. Ayed, Elizabeth J. Cathcart ‐Rake, Ayalew Tefferi Tags: Correspondence Source Type: research

Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring
Abstract Disease overviewChronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1‐2 cases per 100 000 adults. It accounts for approximately 15% of newly diagnosed cases of leukemia in adults. DiagnosisCML is characterized by a balanced genetic translocation, t(9;22)(q34;q11.2), involving a fusion of the Abelson gene (ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is known as the Philadelphia chromosome. The molecular consequence of this translocation is the generation of a BCR‐ABL1 fusion oncogene, which in turn translates...
Source: American Journal of Hematology - February 7, 2018 Category: Hematology Authors: Elias Jabbour, Hagop Kantarjian Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES Source Type: research

Issue information – table of contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 7, 2018 Category: Hematology Tags: ISSUE INFORMATION – TABLE OF CONTENTS Source Type: research

Effectiveness and Safety of Anticoagulants for the Treatment of Venous Thromboembolism in Patients With Cancer
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 3, 2018 Category: Hematology Authors: Michael Blake Streiff, Dejan Milentijevic, Keith McCrae, Daniel Yannicelli, Jonathan Fortier, Winnie W. Nelson, Fran çois Laliberté, Concetta Crivera, Patrick Lefebvre, Jeff Schein, Alok A. Khorana Tags: Research Article Source Type: research

Flai (fludarabine, cytarabine, idarubicin) plus low ‐dose gemtuzumab ozogamicin as induction therapy in cd33‐positive aml: Final results and long term outcome of a phase ii multicenter clinical trial
Abstract The aim of this prospective clinical trial was to evaluate the efficacy and safety of a combination of Gemtuzumab‐Ozogamicin (GO) and FLAI scheme (fludarabine, cytarabine, idarubicin) as a first‐line therapy in CD33 positive acute myeloid leukemia (AML). We treated 130 consecutive patients, aged
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Anna Candoni, Cristina Papayannidis, Giovanni Martinelli, Erica Simeone, Michele Gottardi, Ilaria Iacobucci, Filippo Gherlinzoni, Giuseppe Visani, Michele Baccarani, Renato Fanin Tags: Research Article Source Type: research

N ‐acetyl‐L‐cysteine Improves Bone Marrow Endothelial Progenitor Cells in Prolonged Isolated Thrombocytopenia Patients post Allogeneic Hematopoietic Stem Cell Transplantation
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Yuan Kong, Min ‐Min Shi, Yuan‐Yuan Zhang, Xie‐Na Cao, Yu Wang, Xiao‐Hui Zhang, Lan‐Ping Xu, Xiao‐Jun Huang Tags: Research Article Source Type: research

Phenotypes and survival in Erdheim ‐Chester disease: Results from a 165‐patient cohort
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Fleur Cohen ‐Aubart, Jean‐François Emile, Fabrice Carrat, Zofia Helias‐Rodzewicz, Valérie Taly, Frédéric Charlotte, Philippe Cluzel, Jean Donadieu, Ahmed Idbaih, Stéphane Barete, Zahir Amoura, Julien Haroche Tags: Correspondence Source Type: research

Current and potential use of pathological targets in the treatment of Hodgkin lymphoma
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Antonino Carbone, Annunziata Gloghini Tags: Correspondence Source Type: research

Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial)
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Najibah A. Galadanci, Shehu Umar Abdullahi, Leah D. Vance, Abdulkadir Musa Tabari, Shehi Ali, Raymond Belonwu, Auwal Salihu, Aisha Amal Galadanci, Binta Wudil Jibir, Halima Bello ‐Manga, Kathleen Neville, Fenella J. Kirkham, Yu Shyr, Sharon Phillips, Br Tags: ERRATUM Source Type: research

Multi ‐gene panel testing improves diagnosis and management of patients with hereditary anemias
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 1, 2018 Category: Hematology Authors: Roberta Russo, Immacolata Andolfo, Francesco Manna, Antonella Gambale, Roberta Marra, Barbara Eleni Rosato, Paola Caforio, Valeria Pinto, Piero Pignataro, Kottayam Radhakrishnan, Sule Unal, Giovanna Tomaiuolo, Gian Luca Forni, Achille Iolascon Tags: Research Article Source Type: research

Allogeneic hematopoietic stem cell transplant overcomes the adverse survival effect of very high risk and unfavorable karyotype in myelofibrosis
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 1, 2018 Category: Hematology Authors: Ayalew Tefferi, Daniel K. Partain, Jeanne M. Palmer, James L. Slack, Vivek Roy, William J. Hogan, Mark L. Litzow, Rhett P. Ketterling, Mrinal M. Patnaik Tags: Research Article Source Type: research

Microangiopathy and acute kidney injury in paroxysmal cold hemoglobinuria: A challenge for management
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 30, 2018 Category: Hematology Authors: Neill Storrar, Eve Miller ‐Hodges, John Neary, Jeremy Hughes, Nicole Priddee Tags: SOLVING CLINICAL PROBLEMS IN BLOOD DISEASES Source Type: research

Lymphoproliferative disorders in patients with chronic myeloproliferative neoplasms: A systematic review
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 28, 2018 Category: Hematology Authors: Monia Marchetti, Alessandra Carobbio, Enrica Capitoni, Tiziano Barbui Tags: Research Article Source Type: research

You don't always get what you want: Does hypoxia cause sickle cell crisis?
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Authors: Thomas D Coates Tags: Commentary Source Type: research

Glucose ‐6‐Phosphate‐Dehydrogenase Deficient Red Blood Cell Units are Associated with Decreased Post‐Transfusion Red Blood Cell Survival in Children with Sickle Cell Disease
Abstract Chronic transfusion therapy (CTT) for sickle cell disease (SCD) reduces disease morbidity by suppressing the amount of circulating hemoglobin S (HbS)‐containing red blood cells (RBC). The effectiveness of CTT depends on the rate of RBC clearance. Glucose‐6‐phosphate dehydrogenase (G6PD) deficient donor RBC may exhibit increased hemolysis, but it is unknown if transfusion of these units results in less effective transfusion outcomes in SCD. Children with SCD on CTT were followed prospectively for multiple transfusions. G6PD activity of transfused units was measured prior to expiration date. HbA clearance (&De...
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Authors: Eyal Sagiv, Ross M. Fasano, Naomi L.C. Luban, Cassandra D. Josephson, Sean R. Stowell, John D. Roback, Richard O. Francis, Marianne E.M. Yee Tags: Research Article Source Type: research

Nationwide Survey on the Use of Horse Antithymocyte Globulins (ATGAM) in Patients with Acquired Aplastic Anemia: A Report on Behalf of the French Reference Center for Aplastic Anemia
This study does illustrate the results of ATGAM with CSA in a true‐life perspective and confirms ATGAM as standard of care IST to treat patients with AA not eligible for HSCT. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Authors: R égis Peffault de Latour, Reza Tabrizi, Ambroise Marcais, Thierry Leblanc, Thierry Lamy, Mohamad Mohty, Suzanne Tavitian, Charlotte Jubert, Marlène Pasquet, Claire Galambrun, Stéphanie Nguyen, Jean Yves Cahn, Thorsten Braun, Eric Deconinck, Jacques Ol Tags: Research Article Source Type: research

Toward complement inhibition 2.0: Next generation anticomplement agents for paroxysmal nocturnal hemoglobinuria
Abstract Therapeutic complement inhibition by eculizumab has revolutionized the treatment of paroxysmal nocturnal hemoglobinuria (PNH) with a major impact on its natural history. Nevertheless, emerging unmet clinical needs may benefit from the development of novel complement inhibitors. Novel strategies of complement inhibition exploit different agents targeting C5, as well as compound intercepting the complement cascade at the level of its key component C3, or even upstream at the level of components involved in complement alternative pathway initiation. Many of these agents are already in their clinical development; prel...
Source: American Journal of Hematology - January 25, 2018 Category: Hematology Authors: Antonio M. Risitano, Serena Marotta Tags: UPDATES IN CLINICAL TRIALS FOR HEMATOLOGICAL DISEASES Source Type: research

Age is a predictor of a small decrease in lung function in children with sickle cell anemia
Abstract The longitudinal pattern of lung function in children with sickle cell anemia (SCA) has shown a decrease in FEV1% predicted, a risk factor for death in adults with SCA, but predictors for this decline are poorly characterized. In a prospective longitudinal multi‐center cohort of children with SCA, we tested the hypotheses that: (1) FEV1% predicted declines over time; and (2) SCA‐specific characteristics and therapy predict this decline. At three clinical centers, children with SCA (HbSS or HbSβ0 thalassemia), unselected for respiratory disease, were enrolled in the Sleep and Asthma Cohort (SAC) study. Stu...
Source: American Journal of Hematology - January 25, 2018 Category: Hematology Authors: Shaina M. Willen, Robyn Cohen, Mark Rodeghier, Fenella Kirkham, Susan S. Redline, Carol Rosen, Jane Kirkby, Michael R. DeBaun Tags: RESEARCH ARTICLE Source Type: research

Efficacy and safety of rituximab for systemic lupus erythematosus ‐associated immune cytopenias: A multicenter retrospective cohort study of 71 adults
In conclusion, RTX seems effective and relatively safe for treating SLE‐associated immune cytopenias. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 25, 2018 Category: Hematology Authors: Alexandra Serris, Zahir Amoura, Florence Canou ï‐Poitrine, Benjamin Terrier, Eric Hachulla, Nathalie Costedoat‐Chalumeau, Thomas Papo, Olivier Lambotte, David Saadoun, Miguel Hié, Philippe Blanche, Bertrand Lioger, Jacques‐Eric Gottenberg, Bertran Tags: RESEARCH ARTICLE Source Type: research

Centrifugation ‐free washing: A novel approach for removing immunoglobulin A from stored red blood cells
Abstract Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation‐based cell processors commonly used by hospital blood banks cannot consistently reduce IgA below the recommended levels, hence double washing is frequently required. Here, we describe a prototype of a simple, portable, disposable system capable of washing stored RBCs without centrifugation, while reducing IgA below 0.05 mg/dL in a single run. Samples from RBC units (n = 8, leukoreduced, 4‐6 weeks storage duration) were diluted with normal saline to a hematocrit of 10%, and then washed using...
Source: American Journal of Hematology - January 25, 2018 Category: Hematology Authors: Eszter V örös, Nathaniel Z. Piety, Briony C. Strachan, Madeleine Lu, Sergey S. Shevkoplyas Tags: RESEARCH ARTICLE Source Type: research

A prospective analysis for prevalence of complications in Thai non ‐transfusion‐dependent Hb E/β‐thalassemia and α‐thalassemia (Hb H disease)
Conclusions: For the first time, this prospective study provided the current prevalence of NTDT related complications in a Southeast Asian population with a different underlying genetic basis compared with previous studies. Although individual prevalence of each complication might differ from other studies, several important clinical factors such as splenectomy, degree of anemia, and iron overload seem to be determining risks of developing these complications consistently across different ethnicities. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 23, 2018 Category: Hematology Authors: Supachai Ekwattanakit, Noppadol Siritanaratkul, Vip Viprakasit Tags: Research Article Source Type: research

The spleen of patients with myelofibrosis harbors defective mesenchymal stromal cells
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 23, 2018 Category: Hematology Authors: Maria Antonietta Avanzini, Vittorio Abbonante, Paolo Catarsi, Irene Dambruoso, Melissa Mantelli, Valentina Poletto, Elisa Lenta, Paola Guglielmelli, Stefania Croce, Lorenzo Cobianchi, Basilio Jemos, Rita Campanelli, Elisa Bonetti, Christian Andrea Di Budu Tags: Research Article Source Type: research

Safety of anticoagulation in patients with atrial fibrillation and MDS/AML complicated by thrombocytopenia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 21, 2018 Category: Hematology Authors: Jessica Caro, Shyamala Navada Tags: Correspondence Source Type: research

Voxelotor (GBT440), a first ‐in‐class hemoglobin oxygen‐affinity modulator, has promising and reassuring preclinical and clinical data
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 20, 2018 Category: Hematology Authors: Jeremie H. Estepp Tags: Commentary Source Type: research

Long ‐term effects of crizotinib in ALK‐positive tumors (excluding NSCLC): A phase 1b open‐label study
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 20, 2018 Category: Hematology Authors: Carlo Gambacorti ‐Passerini, Sergey Orlov, Li Zhang, Fadi Braiteh, Huiqiang Huang, Taito Esaki, Keizo Horibe, Jin‐Seok Ahn, Joseph T. Beck, William Jeffrey Edenfield, Yuankai Shi, Matthew Taylor, Kenji Tamura, Brian A. Van Tine, Shang‐Ju Wu, Jolanda Tags: Research Article Source Type: research

Band 3 phosphorylation induces irreversible alterations of stored red blood cells
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 20, 2018 Category: Hematology Authors: Slim Azouzi, Marc Romana, Nobuto Arashiki, Yuichi Takakuwa, Wassim El Nemer, Thierry Peyrard, Yves Colin, Pascal Amireault, Caroline Le Van Kim Tags: Correspondence Source Type: research

Pan ‐Pseudothrombocytopenia: An Unusual Case of Platelet Clumping
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Authors: Hany Elmariah, Satish Shanbhag Tags: Images in Hematology Source Type: research

Evans syndrome secondary to undiagnosed chronic lymphocytic leukemia in a patient with unexplained bleeding
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Authors: Christopher B. Hergott, Olga Pozdnyakova Tags: Images in Hematology Source Type: research

Microangiopathy and acute kidney injury in paroxysmal cold haemoglobinuria – a challenge for management
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Authors: Neill Storrar, Eve Miller ‐Hodges, John Neary, Jeremy Hughes, Nicole Priddee Tags: Solving Clinical Problems in Blood Diseases Source Type: research

Concomitant cutaneous squamous cell carcinoma and CLL in a patient: The utility of 18F ‐ FDG PET/CT in differentiation of nodal metastasis
Conclusion: This report describes the role of 18F‐FDG PET/CT in differentiation of the single sub‐centimeter metastatic nodal disease from cSCC from the remainder innumerable leukemia infiltrated nodes. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Authors: Kerem Ozturk, Celalettin Ustun, Sobia Khaja, Faqian Li, Matthew Rischall, Zuzan Cayci Tags: Diagnostic Imaging in Hematology Source Type: research

Urinary Orosomucoid is Associated with Progressive Chronic Kidney Disease Stage in Patients with Sickle Cell Anemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Authors: Marina Jerebtsova, Santosh L. Saraf, Simran Soni, Nowah Afangbedji, Xionghao Lin, Rasha Raslan, Victor R. Gordeuk, Sergei Nekhai Tags: Correspondence Source Type: research

The role of extracellular matrix stiffness in megakaryocyte and platelet development and function
Abstract The extracellular matrix (ECM) is a key acellular structure in constant remodeling to provide tissue cohesion and rigidity. Deregulation of the balance between matrix deposition, degradation, and crosslinking results in fibrosis. Bone marrow fibrosis (BMF) is associated with several malignant and nonmalignant pathologies severely affecting blood cell production. BMF results from abnormal deposition of collagen fibers and enhanced lysyl oxidase‐mediated ECM crosslinking within the marrow, thereby increasing marrow stiffness. Bone marrow stiffness has been recently recognized as an important regulator of blood cel...
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Authors: Orly Leiva, Catherine Leon, Seng Kah Ng, Pierre Mangin, Christian Gachet, Katya Ravid Tags: CRITICAL REVIEW Source Type: research

A retrospective survey of exposure history to chemotherapy or radiotherapy in 940 consecutive patients with primary myelofibrosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Authors: Maura Nicolosi, Mythri Mudireddy, Mrinal M. Patnaik, Naseema Gangat, Animesh Pardanani, Ayalew Tefferi Tags: Correspondence Source Type: research

Inhaled Corticosteroid Use to Prevent Severe Vaso ‐occlusive Episode Recurrence in Children Between 1 and 4 With Sickle Cell Disease: A Multicenter Feasibility Trial
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 11, 2018 Category: Hematology Authors: Leah Vance Utset, Zalaya Ivy, Shaina M. Willen, Mark Rodeghier, Amanda Watt, Leann Schilling, Chantel L. Jenkins, Stefanie Pepper, Barbara Speller ‐Brown, Deepika S. Darbari, Suvankar Majumdar, Olufolake Adisa, Michael R. DeBaun Tags: Correspondence Source Type: research

Effect of Eptifibatide on Inflammation During Acute Pain Episodes in Sickle Cell Disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 11, 2018 Category: Hematology Authors: Julia E. Brittain, Ciprian Anea, Payal Desai, Jack Delaney, Adam McDonald, Stephen W. Looney, Nigel S. Key, Leslie V. Parise, Kenneth I. Ataga Tags: Correspondence Source Type: research

A Phase II study of Tacrolimus and Thymoglobulin as Graft ‐Versus‐Host‐Disease Prophylaxis in Related Donor Allogeneic Hematopoietic Cell Transplantation
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 10, 2018 Category: Hematology Authors: Dipenkumar Modi, Zaid Al ‐Kadhimi, Wei Chen, Hyejeong Jang, Abhinav Deol, Lois Ayash, Divaya Bhutani, Asif Alavi, Voravit Ratanatharathorn, Joseph P. Uberti Tags: Correspondence Source Type: research

Factor VII deficiency in major artery occlusion stroke
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 10, 2018 Category: Hematology Authors: Slaven Pikija, Simon Peter Gampenrieder, Katharina Millesi, Georg Pilz, Serge Weis, Johannes Sebastian Mutzenbach Tags: Images in Hematology Source Type: research

Realizing Effectiveness Across Continents with Hydroxyurea: Enrollment and Baseline Characteristics of the Multicenter REACH Study in sub ‐Saharan Africa
Abstract Despite its well‐described safety and efficacy in the treatment of sickle cell anemia (SCA) in high‐income settings, hydroxyurea remains largely unavailable in sub‐Saharan Africa, where more than 75% of annual SCA births occur and many comorbidities exist. Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) is a prospective, Phase I/II open‐label trial of hydroxyurea designed to evaluate the feasibility, safety, and benefits of hydroxyurea treatment for children with SCA in four sub‐Saharan African countries. Following comprehensive training of local researc...
Source: American Journal of Hematology - January 10, 2018 Category: Hematology Authors: Patrick T. McGann, Thomas N. Williams, Peter Olupot ‐Olupot, George A. Tomlinson, Adam Lane, José Luís Reis da Fonseca, Robert Kitenge, George Mochamah, Ham Wabwire, Susan Stuber, Thad A. Howard, Kathryn McElhinney, Banu Aygun, Teresa Latham, Brígida Tags: Research Article Source Type: research

Description and Prognostic Significance of the Kinetics of Minimal Residual Disease Status in Adults with Acute Lymphoblastic Leukemia Treated with HyperCVAD
Abstract HyperCVAD is a commonly‐used regimen for adults with newly‐diagnosed acute lymphoblastic leukemia (ALL). However, relatively little is known about the application of minimal residual disease (MRD) detection with this treatment. To address this, we studied 142 adults with ALL treated with hyperCVAD over a 10‐year period who had MRD assessed by either multi‐parameter flow cytometry or (for patients with Philadelphia chromosome positive ALL) reverse transcriptase polymerase chain reaction for the BCR‐ABL1 translocation. In a multivariate analysis, patients who achieved MRD negativity (MRDNeg) at any point h...
Source: American Journal of Hematology - January 10, 2018 Category: Hematology Authors: Ryan D. Cassaday, Philip A. Stevenson, Brent L. Wood, Pamela S. Becker, Paul C. Hendrie, Brenda M. Sandmaier, Jerald L. Radich, Andrei R. Shustov Tags: Research Article Source Type: research

Lack of correlation between heart, liver and pancreas MRI ‐R2*: Results from long‐term follow‐up in a cohort of adult β‐thalassemia major patients
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 9, 2018 Category: Hematology Authors: Valeria Maria Pinto, Lorenzo Bacigalupo, Barbara Gianesin, Manuela Balocco, Lucia De Franceschi, Roberto Malag ò, John Wood, Gian Luca Forni Tags: CORRESPONDENCE Source Type: research