Chlamydophila pneumoniae endonuclease IV prefers to remove mismatched 3' ribonucleotides: Implication in proofreading mismatched 3'-terminal nucleotides in short-patch repair synthesis.
Abstract
DNA polymerase I (DNApolI) catalyzes DNA synthesis during Okazaki fragment maturation, base excision repair, and nucleotide excision repair. Some bacterial DNApolIs are deficient in 3'-5' exonuclease, which is required for removing an incorrectly incorporated 3'-terminal nucleotide during DNA elongation by DNA polymerase activity. The key amino acid residues in the exonuclease center of Chlamydophila pneumoniae DNApolI (CpDNApolI) are naturally mutated, resulting in the loss of 3'-5' exonuclease. Hence, the manner by which CpDNApolI proofreads the incorrectly incorporated nucleotide during DNA syn...
Source: DNA Repair - January 3, 2013 Category: Genetics & Stem Cells Authors: Xie JJ, Liu XP, Han Z, Yuan H, Wang Y, Hou JL, Liu JH Tags: DNA Repair (Amst) Source Type: research
Role of Atypical Pathogens in Nursing Home–Acquired Pneumonia
Conclusions: Atypical pathogens (APs) were not associated with mortality even in cases where the prescribed antibiotics did not cover APs. NHAP may not necessarily be treated with empirical antibiotics covering APs. (Source: Journal of the American Medical Directors Association)
Source: Journal of the American Medical Directors Association - December 3, 2012 Category: Health Management Authors: Hon Ming Ma, Margaret Ip, Elsie Hui, Paul K.S. Chan, David S.C. Hui, Jean Woo Tags: Original Studies Source Type: research
Community-acquired pneumonia.
Abstract
Community-acquired pneumonia (CAP) is one of the most common acute infections requiring admission to hospital. The main causative pathogens of CAP are Streptococcus pneumoniae, influenza A, Mycoplasma pneumoniae and Chlamydophila pneumoniae, and the dominant risk factors are age, smoking and comorbidities. The incidence of CAP and its common complications, such as the requirement for intensive care and complicated parapneumonic effusions, are increasing, making it essential for all physicians to have a good understanding of the management of CAP. Although the diagnosis and treatment of CAP is stra...
Source: Clinical Medicine - December 1, 2012 Category: Journals (General) Authors: Brown JS Tags: Clin Med Source Type: research
No evidence of Chlamydophila spp. or other intracellular bacteria in mitral valves
Mitral valve regurgitation is the second most common form of valvular heart disease in need of heart surgery in Europe . Worldwide, mitral valve regurgitation is mainly due to rheumatic heart disease . In developed countries this incidence has declined and instead the major cause is degenerative mitral valve disease (with mitral valve prolapse) where the underlying mechanism remains not completely understood . (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - July 17, 2012 Category: Cardiology Authors: Marie Edvinsson, Kenneth Nilsson, Stefan Thelin, Christina Nyström-Rosander Tags: Letters to the Editor Source Type: research
